Correlation of AIM2 expression in peripheral blood mononuclear cells from humans with acute and chronic hepatitis B

Human Immunology

Volumn 74, Issue 5, 2013, Pages 514-521

  Wu, Dian Lei ^a,b   Xu, Guang Hua ^b   Lu, She Min ^a   Ma, Bo Lin ^b   Miao, Nai Zhou ^b   Liu, Xiao Bin ^b   Cheng, Yan ping ^b   Feng, Ji Hong ^b   Liu, Zhi Gang ^b   Feng Ding, ^b   Na Liu, ^b   Li, Wei qin ^b   Zhao, Ying Ren ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b YAN'AN UNIVERSITY   (China)

Author keywords

AHB; AIM2; ALT; BUS; CHB; CTL; DsDNA; FQ PCR; HB; HBeAg; HBV; HBV M; HCV; PBMC; Pro IL1 ; TRFIA

Indexed keywords

ABSENT IN MELANOMA 2 PROTEIN; HEPATITIS B(E) ANTIGEN; INTERLEUKIN 18; INTERLEUKIN 1BETA; MESSENGER RNA; PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATITIS B; HUMAN; IMMUNE STATUS; IMMUNOLOGICAL TOLERANCE; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; RNA ISOLATION; VIRAL CLEARANCE; WESTERN BLOTTING;

ACUTE DISEASE; ADULT; BLOTTING, WESTERN; DNA, VIRAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; HEPATITIS B; HEPATITIS B E ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HOST-PATHOGEN INTERACTIONS; HUMANS; INTERLEUKIN-18; INTERLEUKIN-1BETA; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; NUCLEAR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; YOUNG ADULT;

EID: 84876335304     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2013.01.022     Document Type: Article

References (35)

1. Ganem D., Varmus H.E. The molecular biology of the hepatitis B viruses. Annu Rev Biochem 1987, 56:651-693.
2. Lok A.S. Chronic hepatitis B. N Engl J Med 2002, 346:1682-1683.
3. Kao J.H., Chen D.S. Global control of hepatitis B virus infection. Lancet Infect Dis 2002, 2:395-403.
4. Visvanathan K., Lewin S.R. Immunopathogenesis: role of innate and adaptive immune responses. Semin Liver Dis 2006, 26:104-115.
5. Rehermann B., Fowler P., Sidney J., Person J., Redeker A., Brown M., et al. The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis. J Exp Med 1995, 181:1047-1058.
6. Petrilli V., Dostert C., Muruve D.A., Tschopp J. The inflammasome: a danger sensing complex triggering innate immunity. Curr Opin Immunol 2007, 19:615-622.
7. Hornung V., Ablasser A., Charrel-Dennis M., Bauernfeind F., Horvath G., Caffrey D.R., et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 2009, 458:514-518.
8. Burckstummer T., Baumann C., Bluml S., Dixit E., Durnberger G., Jahn H., et al. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol 2009, 10:266-272.
9. Fernandes-Alnemri T., Yu J.W., Datta P., Wu J. Alnemri ES.AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 2009, 458:509-513.
10. Rathinam V.A., Jiang Z., Waggoner S.N., Sharma S., Cole L.E., Waggoner L., et al. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol 2010, 11:395-402.
11. Jones J.W., Kayagaki N., Broz P., Henry T., Newton K., O'Rourke K., et al. Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis. Proc Natl Acad Sci USA 2010, 107:9771-9776.
12. Roberts T.L., Idris A., Dunn J.A., Kelly G.M., Burnton C.M., Hodgson S., et al. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science 2009, 323:1057-1060.
13. Muruve D.A., Petrilli V., Zaiss A.K., White L.R., Clark S.A., Ross P.J., et al. The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 2008, 452:103-107.
14. Fernandes-Alnemri T., Yu J.W., Juliana C., Solorzano L., Kang S., Wu J., et al. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nat Immunol 2010, 11:385-393.
15. Xu N., Yao H.P., Sun Z., Chen Z. Toll-like receptor 7 and 9 expression in peripheral blood mononuclear cells from patients with chronic hepatitis B and related hepatocellular carcinoma. Acta Pharmacol Sin 2008, 29:239-244.
16. Chen Z., Cheng Y., Xu Y., Liao J., Zhang X., Hu Y., et al. Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients. Clin Immunol 2008, 128:400-408.
17. Brincks E.L., Kucaba T.A., Legge K.L., Griffith T.S. Influenza-induced expression of functional tumor necrosis factor-related apoptosis-inducing ligand on human peripheral blood mononuclear cells. Hum Immunol 2008, 69:634-646.
18. Lok A.S., McMahon B.J. Chronic hepatitis B. Hepatology 2007, 45:507-539.
19. Strowig T., Henao-Mejia J., Elinav E., Flavell R. Inflammasomes in health and disease. Nature 2012, 481:278-286.
20. Ross J.W., Ashworth M.D., Hurst A.G., Malayer J.R., Geisert R.D. Analysis and characterization of differential gene expression during rapid trophoblastic elongation in the pig using suppression subtractive hybridization. Reprod Biol Endocrinol 2003, 1:23.
21. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254.
22. Chisari F.V., Ferrari C. Hepatitis B virus immunopathogenesis. Annu Rev Immunol 1995, 13:29-60.
23. Chisari F.V. Cytotoxic T cells and viral hepatitis. J Clin Invest 1997, 99:1472-1477.
24. Maini M.K., Boni C., Ogg G.S., King A.S., Reignat S., Lee C.K., et al. Direct ex vivo analysis of hepatitis B virus-specific CD8(+) T cells associated with the control of infection. Gastroenterology 1999, 117:1386-1396.
25. Guidotti L.G., Rochford R., Chung J., Shapiro M., Purcell R., Chisari F.V. Viral clearance without destruction of infected cells during acute HBV infection. Science 1999, 284:825-829.
26. Nakamura I., Nupp J.T., Cowlen M., Hall W.C., Tennant B.C., Casey J.L., et al. Pathogenesis of experimental neonatal woodchuck hepatitis virus infection: chronicity as an outcome of infection is associated with a diminished acute hepatitis that is temporally deficient for the expression of interferon gamma and tumor necrosis factor-alpha messenger RNAs. Hepatology 2001, 33:439-447.
27. Roux-Lombard P. The interleukin-1 family. Eur Cytokine Network 1998, 9:565-576.
28. van D.M., der Ven-Jongekrijg J.V., Vannier E., van D.R., Pesman G., Bartelink A.K., et al. The pattern of interleukin-1beta (IL-1beta) and its modulating agents IL-1 receptor antagonist and IL-1 soluble receptor type II in acute meningococcal infections. Blood 1997, 90:1101-1108.
29. Gu Y., Kuida K., Tsutsui H., Ku G., Hsiao K., Fleming M.A., et al. Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme. Science 1997, 275:206-209.
30. Kuida K., Lippke J.A., Ku G., Harding M.W., Livingston D.J., Su M.S., et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 1995, 267:2000-2003.
31. Ghayur T., Banerjee S., Hugunin M., Butler D., Herzog L., Carter A., et al. Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. Nature 1997, 386:619-623.
32. Li P., Allen H., Banerjee S., Franklin S., Herzog L., Johnston C., et al. Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 1995, 80:401-411.
33. Sims J.E., Smith D.E. The IL-1 family: regulators of immunity. Nat Rev Immunol 2010, 10:89-102.
34. Okamura H., Tsutsi H., Komatsu T., Yutsudo M., Hakura A., Tanimoto T., et al. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 1995, 378:88-91.
35. Manigold T., Bocker U., Chen J., Gundt J., Traber P., Singer M.V., et al. Hepatitis B core antigen is a potent inductor of interleukin-18 in peripheral blood mononuclear cells of healthy controls and patients with hepatitis B infection. J Med Virol 2003, 71:31-40.