메뉴 건너뛰기




Volumn 26, Issue 4, 2013, Pages 268-276

Involvement of the mitochondrion-dependent and the endoplasmic reticulum stress-signaling pathways in isoliquiritigenin-induced apoptosis of HeLa cell

Author keywords

Apoptosis; ER stress; HeLa cells; ISL; Mitochondria; ROS

Indexed keywords

EUKARYOTA; GLYCYRRHIZA; TETRA;

EID: 84880223942     PISSN: 08953988     EISSN: None     Source Type: Journal    
DOI: 10.3967/0895-3988.2013.04.005     Document Type: Article
Times cited : (38)

References (51)
  • 1
    • 0026625373 scopus 로고
    • Isoliquiritigenin a strong nod gene-and glyceollin resistance-inducing flavonoid from soybean root exudate
    • Kape R, Parniske M, Brandt S, et al. Isoliquiritigenin a strong nod gene-and glyceollin resistance-inducing flavonoid from soybean root exudate. Appl Environ Microb, 1992;58, 1705-10.
    • (1992) Appl Environ Microb , vol.58 , pp. 1705-1710
    • Kape, R.1    Parniske, M.2    Brandt, S.3
  • 2
    • 3042606520 scopus 로고    scopus 로고
    • Determination of liquiritigenin and isoliquiritigenin in Glycyrrhiza uralensis and its medicinal preparations by capillary electrophoresis with electrochemical detection
    • Cao Y, Wang Y, Ji C, et al. Determination of liquiritigenin and isoliquiritigenin in Glycyrrhiza uralensis and its medicinal preparations by capillary electrophoresis with electrochemical detection. J Chromatogr A, 2004;1042, 203-9.
    • (2004) J Chromatogr A , vol.1042 , pp. 203-209
    • Cao, Y.1    Wang, Y.2    Ji, C.3
  • 3
    • 0031919215 scopus 로고    scopus 로고
    • Antioxidative and superoxide scavenging activities of retrochalcones in Glycyrrhiza inflate
    • Haraguchi H, Ishikawa H, Mizutani K, et al. Antioxidative and superoxide scavenging activities of retrochalcones in Glycyrrhiza inflate. Bioorg Med Chem, 1998;6, 339-47.
    • (1998) Bioorg Med Chem , vol.6 , pp. 339-347
    • Haraguchi, H.1    Ishikawa, H.2    Mizutani, K.3
  • 4
    • 34250692468 scopus 로고    scopus 로고
    • Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra)
    • Chin YW, Jung HA, Liu Y, et al. Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra). J Agric Food Chem, 2007;55, 4691-7.
    • (2007) J Agric Food Chem , vol.55 , pp. 4691-4697
    • Chin, Y.W.1    Jung, H.A.2    Liu, Y.3
  • 5
    • 41149091553 scopus 로고    scopus 로고
    • Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-kappaB in RAW 264. 7 macrophages
    • Kim JY, Park SJ, Yun KJ, et al. Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-kappaB in RAW 264. 7 macrophages. Eur J Pharmacol, 2008;584, 175-84.
    • (2008) Eur J Pharmacol , vol.584 , pp. 175-184
    • Kim, J.Y.1    Park, S.J.2    Yun, K.J.3
  • 6
    • 0034786301 scopus 로고    scopus 로고
    • Estrogen-like activity of glabrene and other constituents isolated from licorice root
    • Tamir S, Eizenberg M, Somjen D, et al. Estrogen-like activity of glabrene and other constituents isolated from licorice root. J Steroid Biochem Mol Biol, 2001;78, 291-8.
    • (2001) J Steroid Biochem Mol Biol , vol.78 , pp. 291-298
    • Tamir, S.1    Eizenberg, M.2    Somjen, D.3
  • 7
    • 0026070546 scopus 로고
    • The potent antiumor-promoting agent isoliquiritigenin
    • Yamamoto S, Aizu E, Jiang H, et al. The potent antiumor-promoting agent isoliquiritigenin. Carcinogenesis, 1991;2, 317-23.
    • (1991) Carcinogenesis , vol.2 , pp. 317-323
    • Yamamoto, S.1    Aizu, E.2    Jiang, H.3
  • 8
    • 9944237767 scopus 로고    scopus 로고
    • Studies on cancer chemoprevention by traditional folk medicines, XXV. Inhibitory effect of isoliquiritigenin on azoxymethane-induced murine colon aberrant crypt focus formation and carcinogenesis
    • Baba M, Asano R, Takigami I, et al. Studies on cancer chemoprevention by traditional folk medicines, XXV. Inhibitory effect of isoliquiritigenin on azoxymethane-induced murine colon aberrant crypt focus formation and carcinogenesis. Biol Pharm Bull, 2002;25, 247-50.
    • (2002) Biol Pharm Bull , vol.25 , pp. 247-250
    • Baba, M.1    Asano, R.2    Takigami, I.3
  • 9
    • 41549142696 scopus 로고    scopus 로고
    • Isoliquiritigenin inhibits tumor growth and protects the kidney and liver against chemotherapy-induced toxicity in a mouse xenograft model of colon carcinoma
    • Lee CK, Son SH, Park KK, et al. Isoliquiritigenin inhibits tumor growth and protects the kidney and liver against chemotherapy-induced toxicity in a mouse xenograft model of colon carcinoma. J Pharmacol Sci, 2008;106, 444-51.
    • (2008) J Pharmacol Sci , vol.106 , pp. 444-451
    • Lee, C.K.1    Son, S.H.2    Park, K.K.3
  • 10
    • 1842577637 scopus 로고    scopus 로고
    • Induction of cell cycle arrest and p21 (CIPl/WAFl) expression in human lung cancer cells by isoliquiritigenin
    • li T, Satomi Y, Katoh D, et al. Induction of cell cycle arrest and p21 (CIPl/WAFl) expression in human lung cancer cells by isoliquiritigenin. Cancer Lett, 2004;207, 27-35.
    • (2004) Cancer Lett , vol.207 , pp. 27-35
    • Li, T.1    Satomi, Y.2    Katoh, D.3
  • 11
    • 0034765176 scopus 로고    scopus 로고
    • Apoptosis induced by isoliquiritigenin in human gastric cancer MGC-803 cells
    • Ma J, Fu NY, Pang DB, et al. Apoptosis induced by isoliquiritigenin in human gastric cancer MGC-803 cells. Planta Med, 2001;67, 754-7.
    • (2001) Planta Med , vol.67 , pp. 754-757
    • Ma, J.1    Fu, N.Y.2    Pang, D.B.3
  • 12
    • 18844373926 scopus 로고    scopus 로고
    • Isoliquiritigenin induces apoptosis and cell cycle arrest through p53-dependent pathway in Hep G2 cells
    • Hsu YL, Kuo PL, Lin CC. Isoliquiritigenin induces apoptosis and cell cycle arrest through p53-dependent pathway in Hep G2 cells, Life Sci, 2005, 77, 279-92.
    • (2005) Life Sci , vol.77 , pp. 279-292
    • Hsu, Y.L.1    Kuo, P.L.2    Lin, C.C.3
  • 13
    • 34250353135 scopus 로고    scopus 로고
    • Isoliquiritigenin (ISL) inhibits ErbB3 signaling in prostate cancer cells
    • Jung JI, Chung E, Seon MR, et al. Isoliquiritigenin (ISL) inhibits ErbB3 signaling in prostate cancer cells. Biofactors, 2006;28, 159-68.
    • (2006) Biofactors , vol.28 , pp. 159-168
    • Jung, J.I.1    Chung, E.2    Seon, M.R.3
  • 14
    • 33748586228 scopus 로고    scopus 로고
    • Isoliquiritigenin induces apoptosis by depolarizing mitochondrial membranes in prostate cancer cells
    • Jung JI, Lim SS, Choi HJ, et al. Isoliquiritigenin induces apoptosis by depolarizing mitochondrial membranes in prostate cancer cells. J Nutr Biochem, 2006;17, 689-96.
    • (2006) J Nutr Biochem , vol.17 , pp. 689-696
    • Jung, J.I.1    Lim, S.S.2    Choi, H.J.3
  • 15
    • 29844446274 scopus 로고    scopus 로고
    • Cyclooxygenase-2 plays a suppressive role for induction of apoptosis in isoliquiritigenin-treated mouse colon cancer cells
    • Takahashi T, Baba M, Nishino H, et al. Cyclooxygenase-2 plays a suppressive role for induction of apoptosis in isoliquiritigenin-treated mouse colon cancer cells. Cancer Lett, 2006;231, 319-25.
    • (2006) Cancer Lett , vol.231 , pp. 319-325
    • Takahashi, T.1    Baba, M.2    Nishino, H.3
  • 16
    • 67349188370 scopus 로고    scopus 로고
    • Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells
    • Yoshida T, Horinaka M, Takara M, et al. Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells. Environ Health Prev Med, 2008;13, 281-7.
    • (2008) Environ Health Prev Med , vol.13 , pp. 281-287
    • Yoshida, T.1    Horinaka, M.2    Takara, M.3
  • 17
    • 74149085539 scopus 로고    scopus 로고
    • Novel herbal flavonoids promote apoptosis but differentially induce cell cycle arrest in human colon cancer cell
    • Auyeung KK, Ko JK. Novel herbal flavonoids promote apoptosis but differentially induce cell cycle arrest in human colon cancer cell. Invest New Drugs, 2010;28, 1-13.
    • (2010) Invest New Drugs , vol.28 , pp. 1-13
    • Auyeung, K.K.1    Ko, J.K.2
  • 18
    • 0034280608 scopus 로고    scopus 로고
    • Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells
    • lwashita K, Kobori M, Yamaki K, et al. Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells. Biosci Biotechnol Biochem, 2000;64, 1813-20.
    • (2000) Biosci Biotechnol Biochem , vol.64 , pp. 1813-1820
    • Lwashita, K.1    Kobori, M.2    Yamaki, K.3
  • 19
    • 10444226462 scopus 로고    scopus 로고
    • ER stress and the unfolded protein response
    • Schröder M, Kaufman RJ. ER stress and the unfolded protein response. Mutat Res, 2005;569, 29-63.
    • (2005) Mutat Res , vol.569 , pp. 29-63
    • Schröder, M.1    Kaufman, R.J.2
  • 20
    • 0346096508 scopus 로고    scopus 로고
    • Quality control in the endoplasmic reticulum protein factory
    • Sitia R, Braakman I. Quality control in the endoplasmic reticulum protein factory. Nature, 2003;426, 891-4.
    • (2003) Nature , vol.426 , pp. 891-894
    • Sitia, R.1    Braakman, I.2
  • 21
    • 0034716887 scopus 로고    scopus 로고
    • Tripartite management of unfolded proteins in the endoplasmic reticulum
    • Mori K. Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell, 2000;101, 451-4.
    • (2000) Cell , vol.101 , pp. 451-454
    • Mori, K.1
  • 22
    • 38149090207 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and alteration in calcium homeostasis are involved in cadmium-induced apoptosis
    • Biagioli M, Pifferi S, Ragghianti M, et al. Endoplasmic reticulum stress and alteration in calcium homeostasis are involved in cadmium-induced apoptosis. Cell Calcium, 2008;43, 184-95.
    • (2008) Cell Calcium , vol.43 , pp. 184-195
    • Biagioli, M.1    Pifferi, S.2    Ragghianti, M.3
  • 23
    • 20744435138 scopus 로고    scopus 로고
    • Fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation
    • Kubota K, Lee DH, Tsuchiya M, et al. Fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation. J Biol Chem, 2005;280, 23194-202.
    • (2005) J Biol Chem , vol.280 , pp. 23194-23202
    • Kubota, K.1    Lee, D.H.2    Tsuchiya, M.3
  • 24
    • 77952543940 scopus 로고    scopus 로고
    • Oxidative and endoplasmic reticulum stress signaling are involved in dehydrocostuslactone-mediated apoptosis in human non-small cell lung cancer cells
    • Hung JY, Hsu YL, Ni WC, et al. Oxidative and endoplasmic reticulum stress signaling are involved in dehydrocostuslactone-mediated apoptosis in human non-small cell lung cancer cells. Lung Cancer, 2010;68, 355-65.
    • (2010) Lung Cancer , vol.68 , pp. 355-365
    • Hung, J.Y.1    Hsu, Y.L.2    Ni, W.C.3
  • 25
    • 57449092891 scopus 로고    scopus 로고
    • Antioxidants reduce endoplasmic reticulum stress and improve protein secretion
    • Malhotra JD, Miao H, Zhang K, et al. Antioxidants reduce endoplasmic reticulum stress and improve protein secretion. Proc Natl Acad Sci USA, 2008;105, 18525-30.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 18525-18530
    • Malhotra, J.D.1    Miao, H.2    Zhang, K.3
  • 26
    • 18844412788 scopus 로고    scopus 로고
    • Reactive oxygen species and the modulation of stroke
    • Crack PJ, Taylor JM. Reactive oxygen species and the modulation of stroke. Free Radic Biol Med, 2005;38, 1433-44.
    • (2005) Free Radic Biol Med , vol.38 , pp. 1433-1444
    • Crack, P.J.1    Taylor, J.M.2
  • 27
    • 0035873869 scopus 로고    scopus 로고
    • Imbalance of antioxidant defense in mice lacking cellular prion protein
    • Klamt F, Dal-Pizzol F, Conte da Frota ML Jr, et al. Imbalance of antioxidant defense in mice lacking cellular prion protein. Free Radic Biol Med, 2001;30, 1137-44.
    • (2001) Free Radic Biol Med , vol.30 , pp. 1137-1144
    • Klamt, F.1    Dal-Pizzol, F.2    Contedafrota Jr., M.L.3
  • 28
    • 0036182380 scopus 로고    scopus 로고
    • Calcium and oxidative stress: From cell signaling to cell death
    • Ermak G, Davies KJ. Calcium and oxidative stress: from cell signaling to cell death. Mol Immunol, 2002;38, 713-21.
    • (2002) Mol Immunol , vol.38 , pp. 713-721
    • Ermak, G.1    Davies, K.J.2
  • 29
    • 34247850953 scopus 로고    scopus 로고
    • Involvement of Bcl-2 family members, phosphatidylinositol 3 ¢-kinase/AKT and mitochondrial p53 in curcumin (diferulolylmethane)-induced apoptosis in Prostate Cancer
    • Shankar S, Srivastava RK. Involvement of Bcl-2 family members, phosphatidylinositol 3 ¢-kinase/AKT and mitochondrial p53 in curcumin (diferulolylmethane)-induced apoptosis in Prostate Cancer. Inter J Oncol, 2007;30, 905-18.
    • (2007) Inter J Oncol , vol.30 , pp. 905-918
    • Shankar, S.1    Srivastava, R.K.2
  • 30
    • 3142536557 scopus 로고    scopus 로고
    • Prooxidant property of green tea polyphenols epicatechin and epigallocatechin-3-gallate: Implications for anticancer properties
    • Azam S, Hadi N, Khan NU, et al. Prooxidant property of green tea polyphenols epicatechin and epigallocatechin-3-gallate: implications for anticancer properties. Toxicol In Vitro, 2004;18, 555-61.
    • (2004) Toxicol in Vitro , vol.18 , pp. 555-561
    • Azam, S.1    Hadi, N.2    Khan, N.U.3
  • 31
    • 30844471546 scopus 로고    scopus 로고
    • Anti-and pro-oxidant effects of oxidized quercetin, curcumin or curcumin-related compounds with thiols or ascorbate as measured by the induction period method
    • Fujisawa S, Kadoma Y. Anti-and pro-oxidant effects of oxidized quercetin, curcumin or curcumin-related compounds with thiols or ascorbate as measured by the induction period method. In Vivo, 2006;20, 39-44.
    • (2006) Vivo , vol.20 , pp. 39-44
    • Fujisawa, S.1    Kadoma, Y.2
  • 32
    • 3042545271 scopus 로고    scopus 로고
    • Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development
    • Takahashi T, Takasuka N, ligo M, et al. Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development. Cancer Sci, 2004;95, 448-53.
    • (2004) Cancer Sci , vol.95 , pp. 448-453
    • Takahashi, T.1    Takasuka, N.2    Ligo, M.3
  • 33
    • 64949183401 scopus 로고    scopus 로고
    • Induction of cell cycle arrest in prostate cancer cells by the dietary compound isoliquiritigenin
    • Lee YM, Lim do Y, Choi HJ, et al. Induction of cell cycle arrest in prostate cancer cells by the dietary compound isoliquiritigenin. J Med Food, 2009;12, 8-14.
    • (2009) J Med Food , vol.12 , pp. 8-14
    • Lee, Y.M.1    Lim Do, Y.2    Choi, H.J.3
  • 34
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods, 1983;65, 55-63.
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 35
    • 0030178535 scopus 로고    scopus 로고
    • Spontaneous apoptosis in human colon tumor cell lines and the relation of wt p53 to apoptosis
    • Wang C, Eshleman J, Lutterbaugh J, et al. Spontaneous apoptosis in human colon tumor cell lines and the relation of wt p53 to apoptosis. Chin Med J (Engl), 1996;109, 537-41.
    • (1996) Chin Med J (Engl) , vol.109 , pp. 537-541
    • Wang, C.1    Eshleman, J.2    Lutterbaugh, J.3
  • 36
    • 0031239737 scopus 로고    scopus 로고
    • Significant levels of oxidants are generated by isolated cardiomyocytes during ischemia prior to reperfusion
    • Vanden Hoek TL, Li C, Shao Z, et al. Significant levels of oxidants are generated by isolated cardiomyocytes during ischemia prior to reperfusion. J Mol Cell Cardiol, 1997;29, 2571-83.
    • (1997) J Mol Cell Cardiol , vol.29 , pp. 2571-2583
    • Vanden Hoek, T.L.1    Li, C.2    Shao, Z.3
  • 37
    • 37449018547 scopus 로고    scopus 로고
    • Effect of a neuroprotective exercise protocol on oxidative state and BDNF levels in the rat hippocampus
    • Cechetti F, Fochesatto C, Scopel D, et al. Effect of a neuroprotective exercise protocol on oxidative state and BDNF levels in the rat hippocampus. Brain Res, 2008;1188, 182-8.
    • (2008) Brain Res , vol.1188 , pp. 182-188
    • Cechetti, F.1    Fochesatto, C.2    Scopel, D.3
  • 38
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgramquantities of protein utilizing the principle of protein-dye bingding
    • Bradford MM. A Rapid and Sensitive Method for the Quantitation of MicrogramQuantities of Protein Utilizing the Principle of Protein-Dye Bingding. Anal Biochem, 1976;72, 248-54.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 39
    • 0025204548 scopus 로고
    • Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
    • Hockenbery D, Nunez G, Milliman C, et al. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature, 1990;348, 334-46.
    • (1990) Nature , vol.348 , pp. 334-346
    • Hockenbery, D.1    Nunez, G.2    Milliman, C.3
  • 40
    • 0025830873 scopus 로고
    • J-Aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential
    • Reers M, Smith TW, Chen LB. J-Aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential. Biochemistry, 1991;30, 4480-6.
    • (1991) Biochemistry , vol.30 , pp. 4480-4486
    • Reers, M.1    Smith, T.W.2    Chen, L.B.3
  • 41
    • 0025806764 scopus 로고
    • Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1
    • Smiley ST, Reers M, Mottola-Hartshorn C, et al. Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Proc Natl Acad Sci USA, 1991;88, 3671-5.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 3671-3675
    • Smiley, S.T.1    Reers, M.2    Mottola-Hartshorn, C.3
  • 42
    • 79952284127 scopus 로고    scopus 로고
    • Weinberg. Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Weinberg. Hallmarks of Cancer: The Next Generation. Cell, 2011;44, 646-74.
    • (2011) Cell , vol.44 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 43
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner MO. The biochemistry of apoptosis. Nature, 2000;407, 770-6.
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 44
    • 0033118475 scopus 로고    scopus 로고
    • Apoptosis, p53, and tumor cell sensitivity to anticancer agents
    • Brown JM, Wouters BG. Apoptosis, p53, and tumor cell sensitivity to anticancer agents. Cancer Res, 1999;59, 1391-9.
    • (1999) Cancer Res , vol.59 , pp. 1391-1399
    • Brown, J.M.1    Wouters, B.G.2
  • 45
    • 80052612789 scopus 로고    scopus 로고
    • Increased oxidative stress induces apoptosis in human cystic fibrosis cells
    • Rottner M, Tual-Chalot S, Mostefai HA, et al. Increased oxidative stress induces apoptosis in human cystic fibrosis cells. PLoS One, 2011;6, e24880.
    • (2011) PLoS One , vol.6
    • Rottner, M.1    Tual-Chalot, S.2    Mostefai, H.A.3
  • 46
    • 28044457872 scopus 로고    scopus 로고
    • Oxidative stress and pancreatic beta-cell dysfunction
    • Kaneto H, Kawamori D, Matsuoka TA, et al. Oxidative stress and pancreatic beta-cell dysfunction. Am J Ther, 2005;12, 529-33.
    • (2005) Am J Ther , vol.12 , pp. 529-533
    • Kaneto, H.1    Kawamori, D.2    Matsuoka, T.A.3
  • 47
    • 77649240586 scopus 로고    scopus 로고
    • In vitro anti-leukaemia activity of pyrrolo[l, 2-b][l, 2, 5]benzothiadiazepines (PBTDs)
    • Marfe G, Di Stefano C. In vitro anti-leukaemia activity of pyrrolo[l, 2-b][l, 2, 5]benzothiadiazepines (PBTDs). Recent Pat Anticancer Drug Discov, 2010;5, 58-68.
    • (2010) Recent Pat Anticancer Drug Discov , vol.5 , pp. 58-68
    • Marfe, G.1    Di Stefano, C.2
  • 48
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol, 2007;8, 519-29.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 49
    • 50249116184 scopus 로고    scopus 로고
    • The endoplasmic reticulum stress response in immunity and autoimmunity
    • Todd DJ, Lee AH, Glimcher LH. The endoplasmic reticulum stress response in immunity and autoimmunity. Nat Rev Immunol, 2008;8, 663-74.
    • (2008) Nat Rev Immunol , vol.8 , pp. 663-674
    • Todd, D.J.1    Lee, A.H.2    Glimcher, L.H.3
  • 50
    • 0034610743 scopus 로고    scopus 로고
    • Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyliod-h
    • Nakagawa T, Zhu H, Morishima N, et al. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyliod-h. Nature, 2000;403, 98-103.
    • (2000) Nature , vol.403 , pp. 98-103
    • Nakagawa, T.1    Zhu, H.2    Morishima, N.3
  • 51
    • 32644454395 scopus 로고    scopus 로고
    • Protective effects of isoliquiritigenin in transient middle cerebral artery occlusion-induced focal cerebral ischemia in rats
    • Zhan C, Yang J. Protective effects of isoliquiritigenin in transient middle cerebral artery occlusion-induced focal cerebral ischemia in rats. Pharmacol Res, 2006;53, 303-9.
    • (2006) Pharmacol Res , vol.53 , pp. 303-309
    • Zhan, C.1    Yang, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.