Flavonoids inhibit cell growth and induce apoptosis in b16 melanoma 4A5 cells

Bioscience, Biotechnology and Biochemistry

Volumn 64, Issue 9, 2000, Pages 1813-1820

  Iwashita, Keiko ^a   Kobori, Masuko ^b   Yamaki, Kohji ^b   Tsushida, Tojiro ^b  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b NATIONAL FOOD RESEARCH INSTITUTE   (Japan)

Author keywords

Antiproliferation; Apoptosis; Bcl 2 family; Flavonoid; Melanoma cells

Indexed keywords

APIGENIN; BAX PROTEIN, MOUSE; BCL2L1 PROTEIN, MOUSE; BUTEIN; CHALCONE; CHALCONE DERIVATIVE; DAIDZEIN; DRUG DERIVATIVE; FLAVANONE DERIVATIVE; FLAVONOID; GENISTEIN; ISOFLAVONE DERIVATIVE; ISOLIQUIRITIGENIN; LUTEOLIN; NARINGENIN; ONCOPROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; QUERCETIN;

ANIMAL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DIVISION; DRUG EFFECT; EXPERIMENTAL MELANOMA; MOUSE; STRUCTURE ACTIVITY RELATION;

ANIMALS; APIGENIN; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CELL DIVISION; CHALCONE; CHALCONES; FLAVANONES; FLAVONOIDS; GENISTEIN; ISOFLAVONES; LUTEOLIN; MELANOMA, EXPERIMENTAL; MICE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; QUERCETIN; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0034280608     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.64.1813     Document Type: Article

References (22)

1. Kuo, S. M., Dietary flavonoids and cancer prevention: Evidence and potential mechanisms. Critical Reviews in Oncogenesis, 8, 47-69 (1997).
2. Mark, C. and Nagarathnam, D., Cytotoxicities of some flavonoid analogues. J. Natur. Products., 54, 1656-1660 (1991).
3. Wei, Y., Zha, X., Kariya, Y., Fukata, H., Teshigawara, K., and Uchida, A., Induction of apop-tosis by quercetin: involvement of heat shock protein. Cancer Res., 54, 4952-4957 (1994).
4. Csokay, B., Prajda, N., Weber, G., and Olah, E., Molecular mechanisms in the antiproliferative action of quercetin. Life Sci., 60, 2157-2163 (1997).
5. Kuo, S. M., Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells. Cancer Lett., 110, 41-48 (1996).
6. Felicia, V. So, Najla, G., Ann, F. C., and Kenneth, K. C., Inhibition of proliferation of estrogen receptor-responsive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen. Cancer Lett., 112, 127-133 (1997).
7. Gorczyca, W., Gong, J., Ardelt, B., Traganos, F., and Darzynkiewicz, Z., The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res., 53, 3186-3192 (1993).
8. McCabe, M. J. Jr., and Orrenius, S., Genistein induces apoptosis in immature human thymocytes by inhibiting topoisomerase-II. Biochem. Biophys. Res. Commun., 194, 944-950 (1993).
9. Bergamaschi, G., Rosti, V., Danova, M., Ponchio, L., Lucotti, C., and Cazzola, M., Inhibition of tyrosine phosphorylation induces apoptosis in human leukemia cells. Leukemia, 7, 2012-2018 (1993).
10. Rauth, S., Kichina, J., and Green, A., Inhibition of growth and induction of differentiation of metastatic melanoma cells in vitro by genistein: chemosensitivity is regulated by cellular p53. British J. Cancer, 75, 1559-1566 (1997).
11. Wakabayashi, C., Murakami, K., Hasegawa, H., Murata, J., and Saiki, I., An intestinal bacterial metabolite of ginseng propanaxadiol saponins has the ability to induce apoptosis in tumor cells. Biochem. Biophys. Res. Commun., 246, 725-730 (1998).
12. Zong, Z. P., Fujikawa-Yamamoto, K., Tanino, M., Teraoka, K., Yamagishi, H., and Odashima S., Saikosaponin b2-induced apoptosis of cultured B16 melanoma cell line through down-regulation of PKC activity. Biochem. Biophys. Res. Commun., 219, 480-485 (1996).
13. Kobori, M., Shinmoto, H., Tsushida, T., and Shinohara, K., Phloretin-induced apoptosis in B16 melanoma 4A5 cells by inhibition of glucose transmembrane transport. Cancer Lett., 119, 207-212 (1997).
14. Kobori, M., Iwashita, K., Shinmoto, H., and Tsushida, T., Phloretin-induced apoptosis in B16 melanoma 4A5 cells and HL60 human leukemia cells. Biosci. Biotechnol. Biochem., 63, 719-725 (1999).
15. Agullo, G., Gamet-Payrastre, L., Fernandez, Y., Anciaux, N., Demigne, C., and Remesy, C., Comparative effect of flavonoids on the growth, viability and metabolism of a colonic adenocarcinoma cell line (HT29 cells). Cancer Lett., 105, 61-70 (1996).
16. Yamamoto, S., Aizu, E., Jiang, H., Nakadate, T., Itsumi, K., Wang, J., and Kato, R., The potent antitumor-promoting agent isoliquiritigenin. Carcinogenesis, 12, 317-323, (1991).
17. Yit, C. C. and Das, N. P., Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation. Cancer Lett., 82, 65-72, (1994).
18. Ramanathan, R., Tan, C. H., and Das, N. P., Cytotoxic effect of plant polyphenols and fat-soluble vitamins on malignant human cultured cells. Cancer Lett., 62, 217-224, (1992).
19. Yang, E., Zang, K., Chengl, Y., and Mack, P., Butein, a specific protein tyrosine kinase inhibitor. Biochem. Biophys. Res. Commun., 245, 435-438 (1998).
20. Srivastava, R. K., Srivastava, A. R., Korsmeyer, S. J., Nesterova, M., Cho-chung, Y. S., and Longo, D. L., Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Mol. Cell. Biol., 18, 3509-3517, (1998)
21. Tomkova, H., Fujimoto, W., and Arata, J., Expression of bcl-2 homologue bax in normal human skin, psoriasis vulgaris and non-melanoma skin cancers. Eur. J. Dermatol., 8, 256-260 (1998).
22. Selzer, E., Schlagdauer-Wadl, H., Okamoto, I., Pehamberger, H., Potter, R., and Jansen, B., Expression of Bcl-2 family members in human melanocytes, in melanoma metastases and melanoma cell lines. Melanoma Res., 8, 197-203 (1998).