Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

Nature Immunology

Volumn 14, Issue 12, 2013, Pages 1247-1255

  Hara, Hideki ^a   Tsuchiya, Kohsuke ^a   Kawamura, Ikuo ^a   Fang, Rendong ^a   Hernandez Cuellar, Eduardo ^a   Shen, Yanna ^a,b   Mizuguchi, Junichiro ^c   Schweighoffer, Edina ^d   Tybulewicz, Victor ^d   Mitsuyama, Masao ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c TOKYO MEDICAL UNIVERSITY   (Japan)

^d NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AIM2 PROTEIN; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN; PROTEIN KINASE SYK; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; CYTOKINE RELEASE; DENDRITIC CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; PERITONEUM MACROPHAGE; PERITONITIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; BONE MARROW CELLS; CARRIER PROTEINS; CASPASE 1; CELLS, CULTURED; CYTOSKELETAL PROTEINS; DENDRITIC CELLS; FEMALE; HEK293 CELLS; HUMANS; IMMUNOBLOTTING; INFLAMMASOMES; INTERLEUKIN-18; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NIGERICIN; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RNA INTERFERENCE; TYROSINE;

EID: 84887897805     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2749     Document Type: Article

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