메뉴 건너뛰기




Volumn 9, Issue 5, 2014, Pages 519-535

Role of the Lyn tyrosine kinase in the development of autoimmune disease

Author keywords

autoimmune disease; glomerulonephritis; inflammation; lupus; Lyn

Indexed keywords

B LYMPHOCYTE RECEPTOR; BAFETINIB; BOSUTINIB; DASATINIB; ENZYME ACTIVATOR; MLR 1023; PROTEIN KINASE LYN; UNCLASSIFIED DRUG;

EID: 84913592716     PISSN: 17584272     EISSN: 17584280     Source Type: Journal    
DOI: 10.2217/ijr.14.44     Document Type: Review
Times cited : (8)

References (106)
  • 1
    • 38349014380 scopus 로고    scopus 로고
    • Src family kinases: Regulation of their activities, levels and identification of new pathways
    • Ingley E. Src family kinases: regulation of their activities, levels and identification of new pathways. Biochim. Biophys. Acta 1784(1), 56-65 (2008).
    • (2008) Biochim. Biophys. Acta , vol.1784 , Issue.1 , pp. 56-65
    • Ingley, E.1
  • 2
    • 0023066222 scopus 로고
    • The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck
    • Yamanashi Y, Fukushige S, Semba K et al. The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck. Mol. Cell. Biol. 7(1), 237-243 (1987).
    • (1987) Mol. Cell. Biol. , vol.7 , Issue.1 , pp. 237-243
    • Yamanashi, Y.1    Fukushige, S.2    Semba, K.3
  • 3
    • 0023885305 scopus 로고
    • The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains
    • Hanks SK, Quinn AM, Hunter T. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science 241(4861), 42-52 (1988).
    • (1988) Science , vol.241 , Issue.4861 , pp. 42-52
    • Hanks, S.K.1    Quinn, A.M.2    Hunter, T.3
  • 4
    • 0028910092 scopus 로고
    • Identification of a duplication of the mouse Lyn gene
    • Hibbs ML, Stanley E, Maglitto R, Dunn AR. Identification of a duplication of the mouse Lyn gene. Gene 156, 175-181 (1995).
    • (1995) Gene , vol.156 , pp. 175-181
    • Hibbs, M.L.1    Stanley, E.2    Maglitto, R.3    Dunn, A.R.4
  • 5
    • 0026350671 scopus 로고
    • Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus
    • Yi T, Bolen JB, Ihle JN. Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus. Mol. Cell. Biol. 11(5), 2391-2398 (1991).
    • (1991) Mol. Cell. Biol. , vol.11 , Issue.5 , pp. 2391-2398
    • Yi, T.1    Bolen, J.B.2    Ihle, J.N.3
  • 6
    • 0025762041 scopus 로고
    • Alternatively spliced murine lyn mRNAs encode distinct proteins
    • Stanley E, Ralph S, Mcewen S et al. Alternatively spliced murine lyn mRNAs encode distinct proteins. Mol. Cell. Biol. 11(7), 3399-3406 (1991).
    • (1991) Mol. Cell. Biol. , vol.11 , Issue.7 , pp. 3399-3406
    • Stanley, E.1    Ralph, S.2    McEwen, S.3
  • 7
    • 0028282010 scopus 로고
    • The cDNAs encoding two forms of the LYN protein tyrosine kinase are expressed in rat mast cells and human myeloid cells
    • Rider LG, Raben N, Miller L, Jelsema C. The cDNAs encoding two forms of the LYN protein tyrosine kinase are expressed in rat mast cells and human myeloid cells. Gene 138(1-2), 219-222 (1994).
    • (1994) Gene , vol.138 , Issue.1-2 , pp. 219-222
    • Rider, L.G.1    Raben, N.2    Miller, L.3    Jelsema, C.4
  • 8
    • 77954470691 scopus 로고    scopus 로고
    • Functional analysis of Lyn kinase A and B isoforms reveals redundant and distinct roles in Fc epsilon RI-dependent mast cell activation
    • Alvarez-Errico D, Yamashita Y, Suzuki R et al. Functional analysis of Lyn kinase A and B isoforms reveals redundant and distinct roles in Fc epsilon RI-dependent mast cell activation. J. Immunol. 184(9), 5000-5008 (2010).
    • (2010) J. Immunol. , vol.184 , Issue.9 , pp. 5000-5008
    • Alvarez-Errico, D.1    Yamashita, Y.2    Suzuki, R.3
  • 9
    • 22544465537 scopus 로고    scopus 로고
    • Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity
    • Beavitt SJ, Harder KW, Kemp JM et al. Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity. J. Immunol. 175(3), 1867-1875 (2005).
    • (2005) J. Immunol. , vol.175 , Issue.3 , pp. 1867-1875
    • Beavitt, S.J.1    Harder, K.W.2    Kemp, J.M.3
  • 10
    • 0024313880 scopus 로고
    • Selective expression of a protein-tyrosine kinase, p56 lyn, in hematopoietic cells and association with production of human T-cell lymphotropic virus type i
    • Yamanashi Y, Mori S, Yoshida M et al. Selective expression of a protein-tyrosine kinase, p56 lyn, in hematopoietic cells and association with production of human T-cell lymphotropic virus type I. Proc. Natl Acad. Sci. USA 86, 6538-6542 (1989).
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 6538-6542
    • Yamanashi, Y.1    Mori, S.2    Yoshida, M.3
  • 11
    • 0026755892 scopus 로고
    • Phenotypic changes induced by interleukin-2 (IL-2) and IL-3 in an immature T-lymphocytic leukemia are associated with regulated expression of IL-2 receptor beta chain and of protein tyrosine kinases LCK and LYN
    • O'connor R, Torigoe T, Reed JC, Santoli D. Phenotypic changes induced by interleukin-2 (IL-2) and IL-3 in an immature T-lymphocytic leukemia are associated with regulated expression of IL-2 receptor beta chain and of protein tyrosine kinases LCK and LYN. Blood 80, 1017-1025 (1992).
    • (1992) Blood , vol.80 , pp. 1017-1025
    • O'connor, R.1    Torigoe, T.2    Reed, J.C.3    Santoli, D.4
  • 12
    • 0026746482 scopus 로고
    • Characterization of the promoter region of the Src family gene Lyn and its transactivation by human T-cell leukemia virus type I-encoded p40tax
    • Uchiumi F, Semba K, Yamanashi Y et al. Characterization of the promoter region of the Src family gene Lyn and its transactivation by human T-cell leukemia virus type I-encoded p40tax. Mol. Cell. Biol. 12(9), 3784-3795 (1992).
    • (1992) Mol. Cell. Biol. , vol.12 , Issue.9 , pp. 3784-3795
    • Uchiumi, F.1    Semba, K.2    Yamanashi, Y.3
  • 13
    • 0021927037 scopus 로고
    • Myristic acid, a rare fatty acid, is the lipid attached to the transforming protein of Rous sarcoma virus and its cellular homolog
    • Buss JE, Sefton BM. Myristic acid, a rare fatty acid, is the lipid attached to the transforming protein of Rous sarcoma virus and its cellular homolog. J. Virol. 53(1), 7-12 (1985).
    • (1985) J. Virol. , vol.53 , Issue.1 , pp. 7-12
    • Buss, J.E.1    Sefton, B.M.2
  • 14
    • 0035367576 scopus 로고    scopus 로고
    • Proximal protein tyrosine kinases in immunoreceptor signaling
    • Latour S, Veillette A. Proximal protein tyrosine kinases in immunoreceptor signaling. Curr. Opin. Immunol. 13, 299-306 (2001).
    • (2001) Curr. Opin. Immunol. , vol.13 , pp. 299-306
    • Latour, S.1    Veillette, A.2
  • 15
    • 0034695748 scopus 로고    scopus 로고
    • Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn
    • Fitzer-Attas CJ, Lowry M, Crowley MT et al. Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn. J. Exp. Med. 191(4), 669-682 (2000).
    • (2000) J. Exp. Med. , vol.191 , Issue.4 , pp. 669-682
    • Fitzer-Attas, C.J.1    Lowry, M.2    Crowley, M.T.3
  • 16
    • 0026637001 scopus 로고
    • Association between B-lymphocyte membrane immunoglobulin and multiple members of the Src family of protein tyrosine kinases
    • Campbell MA, Sefton BM. Association between B-lymphocyte membrane immunoglobulin and multiple members of the Src family of protein tyrosine kinases. Mol. Cell. Biol. 12, 2315-2321 (1992).
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 2315-2321
    • Campbell, M.A.1    Sefton, B.M.2
  • 17
    • 0027336585 scopus 로고
    • Association of Srcfamily kinase Lyn with B-cell antigen receptor
    • Yamamoto T, Yamanashi Y, Toyoshima K. Association of Srcfamily kinase Lyn with B-cell antigen receptor. Immunol. Rev. 132, 187-206 (1993).
    • (1993) Immunol. Rev. , vol.132 , pp. 187-206
    • Yamamoto, T.1    Yamanashi, Y.2    Toyoshima, K.3
  • 18
    • 0028784215 scopus 로고
    • Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease
    • Hibbs ML, Tarlinton DM, Armes J et al. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell 83, 301-311 (1995).
    • (1995) Cell , vol.83 , pp. 301-311
    • Hibbs, M.L.1    Tarlinton, D.M.2    Armes, J.3
  • 19
    • 0028806216 scopus 로고
    • Impaired proliferation of peripheral B cells and indication of autoimmune disease in Lyn-deficient mice
    • Nishizumi H, Taniuchi I, Yamanashi Y et al. Impaired proliferation of peripheral B cells and indication of autoimmune disease in Lyn-deficient mice. Immunity 3, 549-560 (1995).
    • (1995) Immunity , vol.3 , pp. 549-560
    • Nishizumi, H.1    Taniuchi, I.2    Yamanashi, Y.3
  • 21
    • 0023787831 scopus 로고
    • Identification of a novel protein tyrosine kinase that phosphorylates pp60c-src and regulates its activity in neonatal rat brain
    • Okada M, Nakagawa H. Identification of a novel protein tyrosine kinase that phosphorylates pp60c-src and regulates its activity in neonatal rat brain. Biochem. Biophys. Res. Commun. 154(2), 796-802 (1988).
    • (1988) Biochem. Biophys. Res. Commun. , vol.154 , Issue.2 , pp. 796-802
    • Okada, M.1    Nakagawa, H.2
  • 22
    • 0029896163 scopus 로고    scopus 로고
    • Regulation, substrates and functions of src
    • Brown MT, Cooper JA. Regulation, substrates and functions of src. Biochim. Biophys. Acta 1287(2-3), 121-149 (1996).
    • (1996) Biochim. Biophys. Acta , vol.1287 , Issue.2-3 , pp. 121-149
    • Brown, M.T.1    Cooper, J.A.2
  • 23
    • 0029846429 scopus 로고    scopus 로고
    • CD45 modulates phosphorylation of both autophosphorylation and negative regulatory tyrosines of Lyn in B cells
    • Yanagi S, Sugawara H, Kurosaki M, Sabe H, Yamamura H, Kurosaki T. CD45 modulates phosphorylation of both autophosphorylation and negative regulatory tyrosines of Lyn in B cells. J. Biol. Chem. 271(48), 30487-30492 (1996).
    • (1996) J. Biol. Chem. , vol.271 , Issue.48 , pp. 30487-30492
    • Yanagi, S.1    Sugawara, H.2    Kurosaki, M.3    Sabe, H.4    Yamamura, H.5    Kurosaki, T.6
  • 24
    • 0028863574 scopus 로고
    • Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells
    • Katagiri T, Ogimoto M, Hasegawa K, Mizuno K, Yakura H. Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells. J. Biol. Chem. 270(47), 27987-27990 (1995).
    • (1995) J. Biol. Chem. , vol.270 , Issue.47 , pp. 27987-27990
    • Katagiri, T.1    Ogimoto, M.2    Hasegawa, K.3    Mizuno, K.4    Yakura, H.5
  • 25
    • 0035910564 scopus 로고    scopus 로고
    • The SH2 domain containing tyrosine phosphatase-1 down-regulates activation of Lyn and Lyninduced tyrosine phosphorylation of the CD19 receptor in B cells
    • Somani AK, Yuen K, Xu F, Zhang J, Branch DR, Siminovitch KA. The SH2 domain containing tyrosine phosphatase-1 down-regulates activation of Lyn and Lyninduced tyrosine phosphorylation of the CD19 receptor in B cells. J. Biol. Chem. 276(3), 1938-1944 (2001).
    • (2001) J. Biol. Chem. , vol.276 , Issue.3 , pp. 1938-1944
    • Somani, A.K.1    Yuen, K.2    Xu, F.3    Zhang, J.4    Branch, D.R.5    Siminovitch, K.A.6
  • 26
    • 17944381147 scopus 로고    scopus 로고
    • Gain-and loss-offunction Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage
    • Harder KW, Parsons LM, Armes J et al. Gain-and loss-offunction Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage. Immunity 15(4), 603-615 (2001).
    • (2001) Immunity , vol.15 , Issue.4 , pp. 603-615
    • Harder, K.W.1    Parsons, L.M.2    Armes, J.3
  • 27
    • 0037121973 scopus 로고    scopus 로고
    • Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity
    • Hibbs ML, Harder KW, Armes J et al. Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity. J. Exp. Med. 196(12), 1593-1604 (2002).
    • (2002) J. Exp. Med. , vol.196 , Issue.12 , pp. 1593-1604
    • Hibbs, M.L.1    Harder, K.W.2    Armes, J.3
  • 28
    • 58649122152 scopus 로고    scopus 로고
    • Crystal structures of the Lyn protein tyrosine kinase domain in its Apo-and inhibitor-bound state
    • Williams NK, Lucet IS, Klinken SP, Ingley E, Rossjohn J. Crystal structures of the Lyn protein tyrosine kinase domain in its Apo-and inhibitor-bound state. J. Biol. Chem. 284(1), 284-291 (2009).
    • (2009) J. Biol. Chem. , vol.284 , Issue.1 , pp. 284-291
    • Williams, N.K.1    Lucet, I.S.2    Klinken, S.P.3    Ingley, E.4    Rossjohn, J.5
  • 29
    • 0025739498 scopus 로고
    • Antiimmunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases
    • Burkhardt AL, Brunswick M, Bolen JB, Mond JJ. Antiimmunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases. Proc. Natl Acad. Sci. USA 88, 7410-7414 (1991).
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 7410-7414
    • Burkhardt, A.L.1    Brunswick, M.2    Bolen, J.B.3    Mond, J.J.4
  • 30
    • 0025972582 scopus 로고
    • Association of B cell antigen receptor with protein tyrosine kinase Lyn
    • Yamanashi Y, Kakiuchi T, Mizuguchi J, Yamamoto T, Toyoshima K. Association of B cell antigen receptor with protein tyrosine kinase Lyn. Science 251, 192-194 (1991).
    • (1991) Science , vol.251 , pp. 192-194
    • Yamanashi, Y.1    Kakiuchi, T.2    Mizuguchi, J.3    Yamamoto, T.4    Toyoshima, K.5
  • 31
    • 0026593547 scopus 로고
    • Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptormediated signaling
    • Yamanashi Y, Fukui Y, Wongsasant B et al. Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptormediated signaling. Proc. Natl Acad. Sci. USA 89, 1118-1122 (1992).
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 1118-1122
    • Yamanashi, Y.1    Fukui, Y.2    Wongsasant, B.3
  • 32
    • 0028060150 scopus 로고
    • Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement
    • Saouaf SJ, Mahajan S, Rowley RB et al. Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement. Proc. Natl Acad. Sci. USA 91(20), 9524-9528 (1994).
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , Issue.20 , pp. 9524-9528
    • Saouaf, S.J.1    Mahajan, S.2    Rowley, R.B.3
  • 33
    • 0030564833 scopus 로고    scopus 로고
    • Catalytic specificity of phosphotyrosine kinases Blk, Lyn, c-Src and Syk as assessed by phage display
    • Schmitz R, Baumann G, Gram H. Catalytic specificity of phosphotyrosine kinases Blk, Lyn, c-Src and Syk as assessed by phage display. J. Mol. Biol. 260(5), 664-677 (1996).
    • (1996) J. Mol. Biol. , vol.260 , Issue.5 , pp. 664-677
    • Schmitz, R.1    Baumann, G.2    Gram, H.3
  • 34
    • 0028198388 scopus 로고
    • Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit
    • Pleiman CM, Hertz WM, Cambier JC. Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit. Science 263(5153), 1609-1612 (1994).
    • (1994) Science , vol.263 , Issue.5153 , pp. 1609-1612
    • Pleiman, C.M.1    Hertz, W.M.2    Cambier, J.C.3
  • 36
    • 0032055828 scopus 로고    scopus 로고
    • Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection
    • Cornall RJ, Cyster JG, Hibbs ML et al. Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. Immunity 8(4), 497-508 (1998).
    • (1998) Immunity , vol.8 , Issue.4 , pp. 497-508
    • Cornall, R.J.1    Cyster, J.G.2    Hibbs, M.L.3
  • 37
    • 0030740148 scopus 로고    scopus 로고
    • Characterization of the B lymphocyte populations in Lyn deficient mice and the role of Lyn in signal initiation and down regulation
    • Chan VWF, Meng F, Soriano P, Defranco AL, Lowell CA. Characterization of the B lymphocyte populations in Lyn deficient mice and the role of Lyn in signal initiation and down regulation. Immunity 7, 69-81 (1997).
    • (1997) Immunity , vol.7 , pp. 69-81
    • Chan, V.W.F.1    Meng, F.2    Soriano, P.3    Defranco, A.L.4    Lowell, C.A.5
  • 38
    • 0032492994 scopus 로고    scopus 로고
    • Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes
    • Chan VWF, Lowell CA, Defranco AL. Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes. Curr. Biol. 8(10), 545-553 (1998).
    • (1998) Curr. Biol. , vol.8 , Issue.10 , pp. 545-553
    • Chan, V.W.F.1    Lowell, C.A.2    Defranco, A.L.3
  • 39
    • 0033592854 scopus 로고    scopus 로고
    • Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B
    • Ho LH, Uehara T, Chen CC, Kubagawa H, Cooper MD. Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B. Proc. Natl Acad. Sci. USA 96(26), 15086-15090 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , Issue.26 , pp. 15086-15090
    • Ho, L.H.1    Uehara, T.2    Chen, C.C.3    Kubagawa, H.4    Cooper, M.D.5
  • 41
    • 0032550365 scopus 로고    scopus 로고
    • A double-edged kinase Lyn: A positive and negative regulator for antigen receptor-mediated signals
    • Nishizumi H, Horikawa K, Mlinaric-Rascan I, Yamamoto T. A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals. J. Exp. Med. 187(8), 1343-1348 (1998).
    • (1998) J. Exp. Med. , vol.187 , Issue.8 , pp. 1343-1348
    • Nishizumi, H.1    Horikawa, K.2    Mlinaric-Rascan, I.3    Yamamoto, T.4
  • 42
    • 0029835940 scopus 로고    scopus 로고
    • Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB
    • Ono M, Bolland S, Tempst P, Ravetch JV. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB. Nature 383(6597), 263-266 (1996).
    • (1996) Nature , vol.383 , Issue.6597 , pp. 263-266
    • Ono, M.1    Bolland, S.2    Tempst, P.3    Ravetch, J.V.4
  • 43
    • 0033535614 scopus 로고    scopus 로고
    • Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1
    • Maeda A, Scharenberg AM, Tsukada S, Bolen JB, Kinet JP, Kurosaki T. Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1. Oncogene 18(14), 2291-2297 (1999).
    • (1999) Oncogene , vol.18 , Issue.14 , pp. 2291-2297
    • Maeda, A.1    Scharenberg, A.M.2    Tsukada, S.3    Bolen, J.B.4    Kinet, J.P.5    Kurosaki, T.6
  • 44
    • 10244225231 scopus 로고    scopus 로고
    • Perturbed myelo/ erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1
    • Harder KW, Quilici C, Naik E et al. Perturbed myelo/ erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1. Blood 104(13), 3901-3910 (2004).
    • (2004) Blood , vol.104 , Issue.13 , pp. 3901-3910
    • Harder, K.W.1    Quilici, C.2    Naik, E.3
  • 45
    • 0343307005 scopus 로고    scopus 로고
    • Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling
    • Ono M, Okada H, Bolland S, Yanagi S, Kurosaki T, Ravetch JV. Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling. Cell 90(2), 293-301 (1997).
    • (1997) Cell , vol.90 , Issue.2 , pp. 293-301
    • Ono, M.1    Okada, H.2    Bolland, S.3    Yanagi, S.4    Kurosaki, T.5    Ravetch, J.V.6
  • 46
    • 0032478126 scopus 로고    scopus 로고
    • The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1
    • Blery M, Kubagawa H, Chen CC, Vely F, Cooper MD, Vivier E. The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1. Proc. Natl Acad. Sci. USA 95(5), 2446-2451 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , Issue.5 , pp. 2446-2451
    • Blery, M.1    Kubagawa, H.2    Chen, C.C.3    Vely, F.4    Cooper, M.D.5    Vivier, E.6
  • 47
    • 23844518326 scopus 로고    scopus 로고
    • The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation
    • Chu CL, Lowell CA. The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation. J. Immunol. 175(5), 2880-2889 (2005).
    • (2005) J. Immunol. , vol.175 , Issue.5 , pp. 2880-2889
    • Chu, C.L.1    Lowell, C.A.2
  • 48
    • 2942659761 scopus 로고    scopus 로고
    • Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase
    • Odom S, Gomez G, Kovarova M et al. Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase. J. Exp. Med. 199(11), 1491-1502 (2004).
    • (2004) J. Exp. Med. , vol.199 , Issue.11 , pp. 1491-1502
    • Odom, S.1    Gomez, G.2    Kovarova, M.3
  • 49
    • 29144496947 scopus 로고    scopus 로고
    • Increased expression of genes linked to FcepsilonRI signaling and to cytokine and chemokine production in Lyn-deficient mast cells
    • Hernandez-Hansen V, Bard JD, Tarleton CA et al. Increased expression of genes linked to FcepsilonRI signaling and to cytokine and chemokine production in Lyn-deficient mast cells. J. Immunol. 175(12), 7880-7888 (2005).
    • (2005) J. Immunol. , vol.175 , Issue.12 , pp. 7880-7888
    • Hernandez-Hansen, V.1    Bard, J.D.2    Tarleton, C.A.3
  • 50
    • 0030829551 scopus 로고    scopus 로고
    • A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages
    • Crowley MT, Costello PS, Fitzer-Attas CJ et al. A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages. J. Exp. Med. 186(7), 1027-1039 (1997).
    • (1997) J. Exp. Med. , vol.186 , Issue.7 , pp. 1027-1039
    • Crowley, M.T.1    Costello, P.S.2    Fitzer-Attas, C.J.3
  • 51
    • 77949322552 scopus 로고    scopus 로고
    • Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6
    • Tsantikos E, Oracki SA, Quilici C, Anderson GP, Tarlinton DM, Hibbs ML. Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6. J. Immunol. 184(3), 1348-1360 (2010).
    • (2010) J. Immunol. , vol.184 , Issue.3 , pp. 1348-1360
    • Tsantikos, E.1    Oracki, S.A.2    Quilici, C.3    Anderson, G.P.4    Tarlinton, D.M.5    Hibbs, M.L.6
  • 53
    • 76249110020 scopus 로고    scopus 로고
    • CTLA4Ig alters the course of autoimmune disease development in Lyn-/-mice
    • Oracki SA, Tsantikos E, Quilici C et al. CTLA4Ig alters the course of autoimmune disease development in Lyn-/-mice. J. Immunol. 184(2), 757-763 (2010).
    • (2010) J. Immunol. , vol.184 , Issue.2 , pp. 757-763
    • Oracki, S.A.1    Tsantikos, E.2    Quilici, C.3
  • 54
    • 70149103642 scopus 로고    scopus 로고
    • Perturbation of the CD4 T cell compartment and expansion of regulatory T cells in autoimmune-prone Lyn-deficient mice
    • Tsantikos E, Quilici C, Harder KW et al. Perturbation of the CD4 T cell compartment and expansion of regulatory T cells in autoimmune-prone Lyn-deficient mice. J. Immunol. 183(4), 2484-2494 (2009).
    • (2009) J. Immunol. , vol.183 , Issue.4 , pp. 2484-2494
    • Tsantikos, E.1    Quilici, C.2    Harder, K.W.3
  • 55
    • 84885126530 scopus 로고    scopus 로고
    • Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice
    • Tsantikos E, Maxwell MJ, Putoczki T et al. Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice. Arthritis Rheum. 65(10), 2691-2702 (2013).
    • (2013) Arthritis Rheum. , vol.65 , Issue.10 , pp. 2691-2702
    • Tsantikos, E.1    Maxwell, M.J.2    Putoczki, T.3
  • 56
    • 79952481036 scopus 로고    scopus 로고
    • Targeting B cells for the treatment of SLE. The beginning of the end or the end of the beginning?
    • Calero I, Sanz I. Targeting B cells for the treatment of SLE. The beginning of the end or the end of the beginning? Discov. Med. 10(54), 416-424 (2010).
    • (2010) Discov. Med. , vol.10 , Issue.54 , pp. 416-424
    • Calero, I.1    Sanz, I.2
  • 57
    • 84875935281 scopus 로고    scopus 로고
    • Breaking the ice in systemic lupus erythematosus: Belimumab, a promising new therapy
    • Mosak J, Furie R. Breaking the ice in systemic lupus erythematosus: belimumab, a promising new therapy. Lupus 22(4), 361-371 (2013).
    • (2013) Lupus , vol.22 , Issue.4 , pp. 361-371
    • Mosak, J.1    Furie, R.2
  • 58
    • 84896338154 scopus 로고    scopus 로고
    • Therapeutic targeting of the BAFF/APRIL axis in systemic lupus erythematosus
    • Stohl W. Therapeutic targeting of the BAFF/APRIL axis in systemic lupus erythematosus. Exp. Opin. Ther. Targets 18(4), 473-489 (2014).
    • (2014) Exp. Opin. Ther. Targets , vol.18 , Issue.4 , pp. 473-489
    • Stohl, W.1
  • 59
    • 38449101693 scopus 로고    scopus 로고
    • B cell biology and dysfunction in SLE
    • Anolik JH. B cell biology and dysfunction in SLE. Bull. NYU Hosp. Jt. Dis. 65(3), 182-186 (2007).
    • (2007) Bull. NYU Hosp. Jt. Dis. , vol.65 , Issue.3 , pp. 182-186
    • Anolik, J.H.1
  • 60
    • 0029829026 scopus 로고    scopus 로고
    • B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events
    • Liossis SN, Kovacs B, Dennis G, Kammer GM, Tsokos GC. B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events. J. Clin. Invest. 98(11), 2549-2557 (1996).
    • (1996) J. Clin. Invest. , vol.98 , Issue.11 , pp. 2549-2557
    • Liossis, S.N.1    Kovacs, B.2    Dennis, G.3    Kammer, G.M.4    Tsokos, G.C.5
  • 62
    • 0034911522 scopus 로고    scopus 로고
    • Expression of B cell receptor-associated signaling molecules in human lupus
    • Huck S, Le Corre R, Youinou P, Zouali M. Expression of B cell receptor-associated signaling molecules in human lupus. Autoimmunity 33, 213-224 (2001).
    • (2001) Autoimmunity , vol.33 , pp. 213-224
    • Huck, S.1    Le Corre, R.2    Youinou, P.3    Zouali, M.4
  • 63
    • 29144478403 scopus 로고    scopus 로고
    • Decreased Lyn expression and translocation to lipid raft signaling domains in B lymphocytes from patients with systemic lupus erythematosus
    • Flores-Borja F, Kabouridis PS, Jury EC, Isenberg DA, Mageed RA. Decreased Lyn expression and translocation to lipid raft signaling domains in B lymphocytes from patients with systemic lupus erythematosus. Arthritis Rheum. 52(12), 3955-3965 (2005).
    • (2005) Arthritis Rheum. , vol.52 , Issue.12 , pp. 3955-3965
    • Flores-Borja, F.1    Kabouridis, P.S.2    Jury, E.C.3    Isenberg, D.A.4    Mageed, R.A.5
  • 64
    • 33846213501 scopus 로고    scopus 로고
    • Altered lipid raft-associated proximal signaling and translocation of CD45 tyrosine phosphatase in B lymphocytes from patients with systemic lupus erythematosus
    • Flores-Borja F, Kabouridis PS, Jury EC, Isenberg DA, Mageed RA. Altered lipid raft-associated proximal signaling and translocation of CD45 tyrosine phosphatase in B lymphocytes from patients with systemic lupus erythematosus. Arthritis Rheum. 56(1), 291-302 (2007).
    • (2007) Arthritis Rheum. , vol.56 , Issue.1 , pp. 291-302
    • Flores-Borja, F.1    Kabouridis, P.S.2    Jury, E.C.3    Isenberg, D.A.4    Mageed, R.A.5
  • 65
    • 79958772962 scopus 로고    scopus 로고
    • Treatment with TNFalpha blockers induces phenotypical and functional aberrations in peripheral B cells
    • Karampetsou MP, Andonopoulos AP, Liossis SN. Treatment with TNFalpha blockers induces phenotypical and functional aberrations in peripheral B cells. Clin. Immunol. 140(1), 8-17 (2011).
    • (2011) Clin. Immunol. , vol.140 , Issue.1 , pp. 8-17
    • Karampetsou, M.P.1    Andonopoulos, A.P.2    Liossis, S.N.3
  • 66
    • 38649125210 scopus 로고    scopus 로고
    • Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    • Harley JB, Alarcon-Riquelme ME, Criswell LA et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat. Genet. 40(2), 204-210 (2008).
    • (2008) Nat. Genet. , vol.40 , Issue.2 , pp. 204-210
    • Harley, J.B.1    Alarcon-Riquelme, M.E.2    Criswell, L.A.3
  • 67
    • 67849097322 scopus 로고    scopus 로고
    • Genetic associations of LYN with systemic lupus erythematosus
    • Lu R, Vidal GS, Kelly JA et al. Genetic associations of LYN with systemic lupus erythematosus. Genes Immun. 10(5), 397-403 (2009).
    • (2009) Genes Immun. , vol.10 , Issue.5 , pp. 397-403
    • Lu, R.1    Vidal, G.S.2    Kelly, J.A.3
  • 68
    • 84855179152 scopus 로고    scopus 로고
    • Replication of GWAS-identified systemic lupus erythematosus susceptibility genes affirms B-cell receptor pathway signalling and strengthens the role of IRF5 in disease susceptibility in a Northern European population
    • Jarvinen TM, Hellquist A, Zucchelli M et al. Replication of GWAS-identified systemic lupus erythematosus susceptibility genes affirms B-cell receptor pathway signalling and strengthens the role of IRF5 in disease susceptibility in a Northern European population. Rheumatology 51(1), 87-92 (2012).
    • (2012) Rheumatology , vol.51 , Issue.1 , pp. 87-92
    • Jarvinen, T.M.1    Hellquist, A.2    Zucchelli, M.3
  • 69
    • 84868208900 scopus 로고    scopus 로고
    • CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation
    • Manjarrez-Orduno N, Marasco E, Chung SA et al. CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation. Nat. Genet. 44(11), 1227-1230 (2012).
    • (2012) Nat. Genet. , vol.44 , Issue.11 , pp. 1227-1230
    • Manjarrez-Orduno, N.1    Marasco, E.2    Chung, S.A.3
  • 70
    • 23644432242 scopus 로고    scopus 로고
    • Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: Increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease
    • Wu H, Cantor RM, Graham DS et al. Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease. Arthritis Rheum. 52(8), 2396-2402 (2005).
    • (2005) Arthritis Rheum. , vol.52 , Issue.8 , pp. 2396-2402
    • Wu, H.1    Cantor, R.M.2    Graham, D.S.3
  • 71
    • 33845578510 scopus 로고    scopus 로고
    • The PTPN22 C1858T functional polymorphism and autoimmune diseases-A meta-analysis
    • Lee YH, Rho YH, Choi SJ et al. The PTPN22 C1858T functional polymorphism and autoimmune diseases-a meta-analysis. Rheumatology 46(1), 49-56 (2007).
    • (2007) Rheumatology , vol.46 , Issue.1 , pp. 49-56
    • Lee, Y.H.1    Rho, Y.H.2    Choi, S.J.3
  • 72
    • 0033521239 scopus 로고    scopus 로고
    • Deletion of fcgamma receptor IIB renders H-2(b) mice susceptible to collageninduced arthritis
    • Yuasa T, Kubo S, Yoshino T et al. Deletion of fcgamma receptor IIB renders H-2(b) mice susceptible to collageninduced arthritis. J. Exp. Med. 189(1), 187-194 (1999).
    • (1999) J. Exp. Med. , vol.189 , Issue.1 , pp. 187-194
    • Yuasa, T.1    Kubo, S.2    Yoshino, T.3
  • 73
    • 0033695963 scopus 로고    scopus 로고
    • Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis
    • Bolland S, Ravetch JV. Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis. Immunity 13(2), 277-285 (2000).
    • (2000) Immunity , vol.13 , Issue.2 , pp. 277-285
    • Bolland, S.1    Ravetch, J.V.2
  • 74
    • 0035983742 scopus 로고    scopus 로고
    • Fcgamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: Contribution of FCGR2B to genetic susceptibility
    • Kyogoku C, Dijstelbloem HM, Tsuchiya N et al. Fcgamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility. Arthritis Rheum. 46(5), 1242-1254 (2002).
    • (2002) Arthritis Rheum. , vol.46 , Issue.5 , pp. 1242-1254
    • Kyogoku, C.1    Dijstelbloem, H.M.2    Tsuchiya, N.3
  • 75
    • 2442679050 scopus 로고    scopus 로고
    • A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. II. Differential binding of GATA4 and Yin-Yang1 transcription factors and correlated receptor expression and function
    • Su K, Li X, Edberg JC, Wu J, Ferguson P, Kimberly RP. A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. II. Differential binding of GATA4 and Yin-Yang1 transcription factors and correlated receptor expression and function. J. Immunol. 172(11), 7192-7199 (2004).
    • (2004) J. Immunol. , vol.172 , Issue.11 , pp. 7192-7199
    • Su, K.1    Li, X.2    Edberg, J.C.3    Wu, J.4    Ferguson, P.5    Kimberly, R.P.6
  • 76
    • 84864806973 scopus 로고    scopus 로고
    • Genetic interdependence of Lyn and negative regulators of B cell receptor signaling in autoimmune disease development
    • Tsantikos E, Maxwell MJ, Kountouri N, Harder KW, Tarlinton DM, Hibbs ML. Genetic interdependence of Lyn and negative regulators of B cell receptor signaling in autoimmune disease development. J. Immunol. 189(4), 1726-1736 (2012).
    • (2012) J. Immunol. , vol.189 , Issue.4 , pp. 1726-1736
    • Tsantikos, E.1    Maxwell, M.J.2    Kountouri, N.3    Harder, K.W.4    Tarlinton, D.M.5    Hibbs, M.L.6
  • 77
    • 0035451678 scopus 로고    scopus 로고
    • A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice
    • Hasegawa M, Fujimoto M, Poe JC, Steeber DA, Lowell CA, Tedder TF. A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice. J. Immunol. 167(5), 2469-2478 (2001).
    • (2001) J. Immunol. , vol.167 , Issue.5 , pp. 2469-2478
    • Hasegawa, M.1    Fujimoto, M.2    Poe, J.C.3    Steeber, D.A.4    Lowell, C.A.5    Tedder, T.F.6
  • 79
    • 0031920417 scopus 로고    scopus 로고
    • Abrogation of autoimmune disease in Lyn-deficient mice by the mutation of the Btk gene
    • Takeshita H, Taniuchi I, Kato J, Watanabe T. Abrogation of autoimmune disease in Lyn-deficient mice by the mutation of the Btk gene. Int. Immunol. 10(4), 435-444 (1998).
    • (1998) Int. Immunol. , vol.10 , Issue.4 , pp. 435-444
    • Takeshita, H.1    Taniuchi, I.2    Kato, J.3    Watanabe, T.4
  • 80
    • 0043092190 scopus 로고    scopus 로고
    • Reduced dosage of Bruton's tyrosine kinase uncouples B cell hyperresponsiveness from autoimmunity in lyn-/-mice
    • Whyburn LR, Halcomb KE, Contreras CM, Lowell CA, Witte ON, Satterthwaite AB. Reduced dosage of Bruton's tyrosine kinase uncouples B cell hyperresponsiveness from autoimmunity in lyn-/-mice. J. Immunol. 171(4), 1850-1858 (2003).
    • (2003) J. Immunol. , vol.171 , Issue.4 , pp. 1850-1858
    • Whyburn, L.R.1    Halcomb, K.E.2    Contreras, C.M.3    Lowell, C.A.4    Witte, O.N.5    Satterthwaite, A.B.6
  • 81
    • 77954130384 scopus 로고    scopus 로고
    • Separate checkpoints regulate splenic plasma cell accumulation and IgG autoantibody production in Lyndeficient mice
    • Gutierrez T, Halcomb KE, Coughran AJ, Li QZ, Satterthwaite AB. Separate checkpoints regulate splenic plasma cell accumulation and IgG autoantibody production in Lyndeficient mice. Eur. J. Immunol. 40(7), 1897-1905 (2010).
    • (2010) Eur. J. Immunol. , vol.40 , Issue.7 , pp. 1897-1905
    • Gutierrez, T.1    Halcomb, K.E.2    Coughran, A.J.3    Li, Q.Z.4    Satterthwaite, A.B.5
  • 82
    • 61449176058 scopus 로고    scopus 로고
    • A kinasedead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency
    • Verhagen AM, Wallace ME, Goradia A et al. A kinasedead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency. J. Immunol. 182(4), 2020-2029 (2009).
    • (2009) J. Immunol. , vol.182 , Issue.4 , pp. 2020-2029
    • Verhagen, A.M.1    Wallace, M.E.2    Goradia, A.3
  • 83
    • 58149287842 scopus 로고    scopus 로고
    • A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function
    • Barouch-Bentov R, Che J, Lee CC et al. A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function. Mol. Cell 33(1), 43-52 (2009).
    • (2009) Mol. Cell , vol.33 , Issue.1 , pp. 43-52
    • Barouch-Bentov, R.1    Che, J.2    Lee, C.C.3
  • 84
    • 69249215198 scopus 로고    scopus 로고
    • The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice
    • Marchetti S, Gamas P, Belhacene N et al. The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice. EMBO J. 28(16), 2449-2460 (2009).
    • (2009) EMBO J. , vol.28 , Issue.16 , pp. 2449-2460
    • Marchetti, S.1    Gamas, P.2    Belhacene, N.3
  • 85
    • 77953212872 scopus 로고    scopus 로고
    • Basophils and the T helper 2 environment can promote the development of lupus nephritis
    • Charles N, Hardwick D, Daugas E, Illei GG, Rivera J. Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat. Med. 16(6), 701-707 (2010).
    • (2010) Nat. Med. , vol.16 , Issue.6 , pp. 701-707
    • Charles, N.1    Hardwick, D.2    Daugas, E.3    Illei, G.G.4    Rivera, J.5
  • 87
    • 84873750047 scopus 로고    scopus 로고
    • IL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage in Lyn-/-mice
    • Gutierrez T, Mayeux JM, Ortega SB et al. IL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage in Lyn-/-mice. Eur. J. Immunol. 43(2), 382-393 (2013).
    • (2013) Eur. J. Immunol. , vol.43 , Issue.2 , pp. 382-393
    • Gutierrez, T.1    Mayeux, J.M.2    Ortega, S.B.3
  • 88
    • 84893364183 scopus 로고    scopus 로고
    • Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice
    • Hua Z, Gross AJ, Lamagna C et al. Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice. J. Immunol. 192(3), 875-885 (2014).
    • (2014) J. Immunol. , vol.192 , Issue.3 , pp. 875-885
    • Hua, Z.1    Gross, A.J.2    Lamagna, C.3
  • 89
    • 0035182146 scopus 로고    scopus 로고
    • Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn
    • Yu CC, Yen TS, Lowell CA, Defranco AL. Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn. Curr. Biol. 11(1), 34-38 (2001).
    • (2001) Curr. Biol. , vol.11 , Issue.1 , pp. 34-38
    • Yu, C.C.1    Yen, T.S.2    Lowell, C.A.3    Defranco, A.L.4
  • 90
    • 0037342034 scopus 로고    scopus 로고
    • Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development
    • Saijo K, Schmedt C, Su IH et al. Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat. Immunol. 4(3), 274-279 (2003).
    • (2003) Nat. Immunol. , vol.4 , Issue.3 , pp. 274-279
    • Saijo, K.1    Schmedt, C.2    Su, I.H.3
  • 91
    • 77955343903 scopus 로고    scopus 로고
    • Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice
    • Scapini P, Hu Y, Chu CL et al. Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J. Exp. Med. 207(8), 1757-1773 (2010).
    • (2010) J. Exp. Med. , vol.207 , Issue.8 , pp. 1757-1773
    • Scapini, P.1    Hu, Y.2    Chu, C.L.3
  • 92
    • 3042511949 scopus 로고    scopus 로고
    • Abrogation of autoimmune disease in Lyn-deficient mice by the deletion of IL-5 receptor alpha chain gene
    • Moon BG, Takaki S, Nishizumi H, Yamamoto T, Takatsu K. Abrogation of autoimmune disease in Lyn-deficient mice by the deletion of IL-5 receptor alpha chain gene. Cell. Immunol. 228(2), 110-118 (2004).
    • (2004) Cell. Immunol. , vol.228 , Issue.2 , pp. 110-118
    • Moon, B.G.1    Takaki, S.2    Nishizumi, H.3    Yamamoto, T.4    Takatsu, K.5
  • 93
    • 80054743853 scopus 로고    scopus 로고
    • B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice
    • Scapini P, Lamagna C, Hu Y et al. B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice. Proc. Natl Acad. Sci. USA 108(41), E823-E832 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , Issue.41 , pp. E823-E832
    • Scapini, P.1    Lamagna, C.2    Hu, Y.3
  • 95
    • 84883338848 scopus 로고    scopus 로고
    • Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation
    • Lamagna C, Scapini P, Van Ziffle JA, Defranco AL, Lowell CA. Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation. Proc. Natl Acad. Sci. USA 110(35), E3311-E3320 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , Issue.35 , pp. E3311-E3320
    • Lamagna, C.1    Scapini, P.2    Van Ziffle, J.A.3    Defranco, A.L.4    Lowell, C.A.5
  • 96
    • 84893392428 scopus 로고    scopus 로고
    • B cell-specific loss of Lyn kinase leads to autoimmunity
    • Lamagna C, Hu Y, Defranco AL, Lowell CA. B cell-specific loss of Lyn kinase leads to autoimmunity. J. Immunol. 192(3), 919-928 (2014).
    • (2014) J. Immunol. , vol.192 , Issue.3 , pp. 919-928
    • Lamagna, C.1    Hu, Y.2    Defranco, A.L.3    Lowell, C.A.4
  • 97
    • 19344369383 scopus 로고    scopus 로고
    • Spontaneous autoimmunity in 129 and C57BL/6 miceimplications for autoimmunity described in gene-targeted mice
    • Bygrave AE, Rose KL, Cortes-Hernandez J et al. Spontaneous autoimmunity in 129 and C57BL/6 miceimplications for autoimmunity described in gene-targeted mice. PLoS Biol. 2(8), E243 (2004).
    • (2004) PLoS Biol. , vol.2 , Issue.8 , pp. E243
    • Bygrave, A.E.1    Rose, K.L.2    Cortes-Hernandez, J.3
  • 98
    • 84899979288 scopus 로고    scopus 로고
    • Interleukin-21: A double-edged sword with therapeutic potential
    • Spolski R, Leonard WJ. Interleukin-21: a double-edged sword with therapeutic potential. Nat. Rev. Drug Rev. 13(5), 379-395 (2014).
    • (2014) Nat. Rev. Drug Rev. , vol.13 , Issue.5 , pp. 379-395
    • Spolski, R.1    Leonard, W.J.2
  • 99
    • 0033969955 scopus 로고    scopus 로고
    • The B-cell-specific Src-family kinase Blk is dispensable for B-cell development and activation
    • Texido G, Su IH, Mecklenbrauker I et al. The B-cell-specific Src-family kinase Blk is dispensable for B-cell development and activation. Mol. Cell. Biol. 20(4), 1227-1233 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , Issue.4 , pp. 1227-1233
    • Texido, G.1    Su, I.H.2    Mecklenbrauker, I.3
  • 100
    • 0037389275 scopus 로고    scopus 로고
    • The p54 cleaved form of the tyrosine kinase Lyn generated by caspases during BCR-induced cell death in B lymphoma acts as a negative regulator of apoptosis
    • Luciano F, Herrant M, Jacquel A, Ricci JE, Auberger P. The p54 cleaved form of the tyrosine kinase Lyn generated by caspases during BCR-induced cell death in B lymphoma acts as a negative regulator of apoptosis. FASEB J. 17(6), 711-713 (2003).
    • (2003) FASEB J. , vol.17 , Issue.6 , pp. 711-713
    • Luciano, F.1    Herrant, M.2    Jacquel, A.3    Ricci, J.E.4    Auberger, P.5
  • 101
    • 40849135781 scopus 로고    scopus 로고
    • Comparison of imatinib, dasatinib, nilotinib and INNO-406 in imatinibresistant cell lines
    • Deguchi Y, Kimura S, Ashihara E et al. Comparison of imatinib, dasatinib, nilotinib and INNO-406 in imatinibresistant cell lines. Leukemia Res. 32(6), 980-983 (2008).
    • (2008) Leukemia Res. , vol.32 , Issue.6 , pp. 980-983
    • Deguchi, Y.1    Kimura, S.2    Ashihara, E.3
  • 102
    • 33845806858 scopus 로고    scopus 로고
    • In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cells
    • Puttini M, Coluccia AM, Boschelli F et al. In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cells. Cancer Res. 66(23), 11314-11322 (2006).
    • (2006) Cancer Res. , vol.66 , Issue.23 , pp. 11314-11322
    • Puttini, M.1    Coluccia, A.M.2    Boschelli, F.3
  • 103
    • 84913542089 scopus 로고    scopus 로고
    • ClinicalTrials.gov database. http://clinicaltrials.gov/
  • 104
    • 34247470836 scopus 로고    scopus 로고
    • Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia
    • Weisberg E, Manley PW, Cowan-Jacob SW, Hochhaus A, Griffin JD. Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia. Nat. Rev. Cancer 7(5), 345-356 (2007).
    • (2007) Nat. Rev. Cancer , vol.7 , Issue.5 , pp. 345-356
    • Weisberg, E.1    Manley, P.W.2    Cowan-Jacob, S.W.3    Hochhaus, A.4    Griffin, J.D.5
  • 105
    • 84862503641 scopus 로고    scopus 로고
    • MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo
    • Saporito MS, Ochman AR, Lipinski CA, Handler JA, Reaume AG. MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo. J. Pharmacol. Exp. Ther. 342(1), 15-22 (2012).
    • (2012) J. Pharmacol. Exp. Ther. , vol.342 , Issue.1 , pp. 15-22
    • Saporito, M.S.1    Ochman, A.R.2    Lipinski, C.A.3    Handler, J.A.4    Reaume, A.G.5
  • 106
    • 84862492511 scopus 로고    scopus 로고
    • The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of Type 2 diabetes
    • Ochman AR, Lipinski CA, Handler JA, Reaume AG, Saporito MS. The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of Type 2 diabetes. J. Pharmacol. Exp. Ther. 342(1), 23-32 (2012).
    • (2012) J. Pharmacol. Exp. Ther. , vol.342 , Issue.1 , pp. 23-32
    • Ochman, A.R.1    Lipinski, C.A.2    Handler, J.A.3    Reaume, A.G.4    Saporito, M.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.