Altered lipid raft-associated proximal signaling and translocation of CD45 tyrosine phosphatase in B lymphocytes from patients with systemic lupus erythematosus

Arthritis and Rheumatism

Volumn 56, Issue 1, 2007, Pages 291-302

  Flores Borja, Fabian ^a   Kabouridis, Panagiotis S ^a   Jury, Elizabeth C ^b   Isenberg, David A ^b   Mageed, Rizgar A ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; CD45 ANTIGEN; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; STEROID;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG MEGADOSE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIPID RAFT; LOW DRUG DOSE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; WESTERN BLOTTING;

ADULT; AGED; ANTIGENS, CD45; B-LYMPHOCYTES; CELLS, CULTURED; FEMALE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MEMBRANE MICRODOMAINS; MIDDLE AGED; PROTEIN TRANSPORT; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS C-CBL; PROTO-ONCOGENE PROTEINS PP60(C-SRC); SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 33846213501     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.22309     Document Type: Article

References (48)

1. Hardin JA. The lupus autoantigens and the pathogenesis of systemic lupus erythematosus. Arthritis Rheum 1986;29:457-60.
2. Mageed RA, Prud'homme G. Immunopathology and the gene therapy of lupus. Gene Ther 2003;10:861-73.
3. Wakeland EK, Wandstrat AE, Liu K, Morel L. Genetic dissection of systemic lupus erythematosus. Curr Opin Immunol 1999;11:701-7.
4. Ehrenstein MR, Isenberg DA. Systemic lupus erythematosus in adults: clinical features and aetiopathogenesis. In: Isenberg DA, Maddison P, Woo P, Glass D, Breedveld F, editors. Oxford textbook of rheumatology. 3rd ed. Oxford: Oxford University Press; 2004. p. 819-42.
5. Yu CC, Yen TS, Lowell CA, DeFranco AL. Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn. Curr Biol 2001;11:34-8.
6. O'Keefe TL, Williams GT, Batista FD, Neuberger MS. Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies. J Exp Med 1999;189:1307-13.
7. Pritchard NR, Cutler AJ, Uribe S, Chadban SJ, Morley BJ, Smith KG. Autoimmune-prone mice share a promoter haplotype associated with reduced expression and function of the Fc receptor FcγRII. Curr Biol 2000;10:227-30.
8. Pan C, Baumgarth N, Parnes JR. CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation. Immunity 1999;11:495-506.
9. Cherukuri A, Cheng PC, Sohn HW, Pierce SK. The CD19/CD21 complex functions to prolong B cell antigen receptor signaling from lipid rafts. Immunity 2001;4:169-79.
10. Flores-Borja F, Kabouridis PS, Jury EC, Isenberg DA, Mageed RA. Decreased Lyn expression and translocation to lipid raft signaling domains in B lymphocytes from patients with systemic lupus erythematosus. Arthritis Rheum 2005;52:3955-65.
11. Liossis SN, Solomou E, Dimopoulos MA, Panayiotidis P, Mavrikakis MM, Sfikakis PP. B-cell kinase lyn deficiency in patients with systemic lupus erythematosus. J Investig Med 2001;49:157-65.
12. Huck S, Corre RL, Youinou P, Zouali M. Expression of B cell receptor-associated signaling molecules in human lupus. Autoimmunity 2001;33:213-24.
13. Simons K, Ikonen E. Functional rafts in cell membranes. Nature 1997;387:569-72.
14. Cheng PC, Dykstra ML, Mitchell RN, Pierce SK. A role for lipid rafts in B cell antigen receptor signaling and antigen targeting. J Exp Med 1999;190:1549-60.
15. Simons K, Toomre D. Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 2000;1:31-9.
16. DeFranco AL, Chan VW, Lowell CA. Positive and negative roles of the tyrosine kinase Lyn in B cell function. Semin Immunol 1998;10:299-307.
17. Floto RA, Clatworthy MR, Heilbronn KR, Rosner DR, MacAry PA, Rankin A, et al. Loss of function of a lupus-associated FcγRIIb polymorphism through exclusion from lipid rafts. Nat Med 2005;11:1056-8.
18. Jury EC, Kabouridis PS, Abba A, Mageed RA, Isenberg DA. Increased ubiquitination and reduced expression of LCK in T lymphocytes from patients with systemic lupus erythematosus. Arthritis Rheum 2003;48:1343-54.
19. Kawabuchi M, Satomi Y, Takao T. Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases. Nature 2000;404:999-1003.
20. Justement LB, Campbell KS, Chien NC, Cambier JC. Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45. Science 1991;252:1839-42.
21. Hermiston ML, Xu Z, Weiss A. CD45: a critical regulator of signaling thresholds in immune cells. Ann Rev Immunol 2003;21:107-37.
22. Yanagi S, Sugawara H, Kurosaki M, Sabe H, Yamamura H, Kurosaki T. CD45 modulates phosphorylation of both autophosphorylation and negative regulatory tyrosines of Lyn in B cells. J Biol Chem 1996;271:30487-92.
23. Katagiri T, Ogimoto M, Hasegawa K. CD45 negatively regulates Lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells. J Immunol 1999;163;1321-6.
24. Thomas ML, Brown EJ. Positive and negative regulation of Src-family membrane kinases by CD45. Immunol Today 1999;20:406-11.
25. Shrivastava P, Katagiri T, Ogimoto M, Mizuno K, Yakura H. Dynamic regulation of Src-family kinases by CD45 in B cells. Blood 2004;103:1425-32.
26. Hay EM, Bacon PA, Gordon C, Isenberg DA, Madison P, Snaith M, et al. The BILAG index: a reliable and valid instrument for measuring clinical disease activity in systemic lupus erythematosus. QJM 1993;86:447-58.
27. Janes PW, Ley SC, Magee AI. Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor. J Cell Biol 1999;147:447-61.
28. Gupta N, DeFranco AL. Visualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B-lymphocyte activation. Mol Biol Cell 2003;14:432-44.
29. Irles C, Symons A, Michel F, Bakker TR, van der Merwe PA, Acuto O. CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling. Nat Immunol 2003;4:189-97.
30. Douglass AD, Vale RD. Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells. Cell 2005;121:937-50.
31. Pierce SK. Lipid rafts and B-cell activation. Nat Rev Immunol 2002;2:96-105.
32. Rodgers W, Rose J. Exclusion of CD45 inhibits activity of p561ck associated with glycolipid-enriched membrane domains. J Cell Biol 1996;135:1515-23,
33. Parolini I, Sargiacomo M, Lisanti M, Peschle C. Signal transduction and glycophosphatidylinositol-linked proteins (lyn, Ick, CD4, CD45, G proteins, and CD55) selectively localize in Triton-insoluble plasma membrane domains of human leukemic cell lines and normal granulocytes, Blood 1996;87:3783-94.
34. Edmonds SD, Ostergaard HL. Dynamic association of CD45 with detergent-insoluble microdomains in T lymphocytes. J Immunol 2002;169:5036-42.
35. Jury EC, Kabouridis PS, Flores-Borja F, Mageed RA, Isenberg DA. Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus. J Clin Invest 2004;113:1176-87.
36. Johnson KG, Bromley SK, Dustin ML, Thomas ML. A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation. Proc Natl Acad Sci U S A 2000;97:10138-43.
37. Alexander DR. The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function. Semin Immunol 2000;12:349-59.
38. Spronk PE, Horst GB, Gun TV, Limburg PC, Kallenberg CG. Anti-dsDNA production coincides with concurrent B and T cell activation during development of active disease in systemic lupus erythematosus. Clin Exp Immunol 1996;104:446-53.
39. Linnik MD, Hu JZ, Heilbrunn KR, Strand V, Hurley FL, Joh T, and the LJP 394 Investigator Consortium. Relationship between anti-double-stranded DNA antibodies and exacerbation of renal disease in patients with systemic lupus erythematosus. Arthritis Rheum 2005;52:1129-37.
40. Virts E, Barritt D, Raschke WC. Expression of CD45 isoforms lacking exons 7, 8 and 10. Mol Immunol 1998;35:167-76.
41. McNeill L, Cassady RL, Sarkardei S, Cooper JC, Morgan G, Alexander DR. CD45 isoforms in T cell signaling and development. Immunol Lett 2004;92:125-34.
42. Yu Y, Rabinowitz R, Polliack A, Ben-Bassat H, Schlesínger M. Hyposialated 185 kDa CD45RA+ molecules attain a high concentration in B lymphoma cells and in activated human B cells. Eur J Haematol 2002;68:22-30.
43. Chui D, Sellakumar G, Green RS, Sutton-Smith M, McQuistan T, Marek KW, et al. Genetic remodeling of protein glycosylation in vivo induces autoimmune disease. Proc Natl Acad Sci U S A 2001;98:1142-7.
44. Kumar S, Lopez AJ. Negative feedback regulation among SR splicing factors encoded by Rbp1 and Rbp1-like in Drosophila. EMBO J 2005;24:2646-55.
45. Yousaf N, Gould DJ, Aganna E, Hammond L, Mirakian RM, Turner MD, et al. Tumor necrosis factor receptor I from patients with tumor necrosis factor receptor-associated periodic syndrome interacts with wild-type tumor necrosis factor receptor I and induces ligand-independent NF-κB activation. Arthritis Rheum 2005;52:2906-16.
46. Renaudineau Y, Hillion S, Saraux A, Mageed RA, Youinou P. An alternative exon 1 of the CD5 gene regulates CD5 expression in human B lymphocytes. Blood 2005;106:2781-9.
47. Bunce C, Bell EB. CD45RC isoforms define two types of CD4 memory T cells, one of which depends on persisting antigen. J Exp Med 1997;185:767-76.
48. Xystrakis E, Cavailles P, Dejean AS, Cautain B, Colacios C, Lagrange D, et al. Functional and genetic analysis of two CD8 T cell subsets defined by the level of CD45RC expression in the rat. J Immunol 2004;173:3140-7.