Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage

Immunity

Volumn 15, Issue 4, 2001, Pages 603-615

  Harder, Kenneth W ^a   Parsons, Linda M ^a   Armes, Jane ^b,c   Evans, Natalie ^a   Kountouri, Nicole ^a   Clark, Roslyn ^a   Quilici, Cathy ^a   Grail, Dianne ^a   Hodgson, George S ^a   Dunn, Ashley R ^a   Hibbs, Margaret L ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b ROYAL WOMEN'S HOSPITAL   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE LYN; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CELL COUNT; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION; GENE MUTATION; GENETIC SUSCEPTIBILITY; HEMATOPOIETIC CELL; MACROPHAGE; MONOCYTE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROMYELOCYTE; PROTO ONCOGENE; SIGNAL TRANSDUCTION; SPLENOMEGALY; TUMOR CELL;

EID: 17944381147     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00208-4     Document Type: Article

References (59)

1. Thymic tumorigenesis induced by overexpression of p56lck
2. Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice
3. The major SHP-1-binding, tyrosine-phosphorylated protein in macrophages is a member of the KIR/LIR family and an SHP-1 substrate
4. SHP-1 regulation of p62(DOK) tyrosine phosphorylation in macrophages
5. Identification of PTP1C mutation as the genetic defect in motheaten and viable motheaten mice: A step toward defining the roles of protein tyrosine phosphatases in the regulation of hemopoietic cell differentiation and function
6. The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1
7. SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1
8. Regulation, substrates and functions of src
9. Identification of a transformation-specific antigen induced by an avian sarcoma virus
10. Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation
11. Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes
12. Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1
13. Src-related protein tyrosine kinases in hematopoiesis
14. Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection
15. A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion
16. Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice
17. Ubiquitin-dependent degradation of active Src
18. Characterization and kinetic analysis of the intracellular domain of human protein tyrosine phosphatase β (HPTP β) using synthetic phosphopeptides
19. Protein-tyrosine phosphatase α regulates Src family kinases and alters cell-substratum adhesion
20. Ubiquitin-mediated degradation of active Src tyrosine kinase
21. Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span
22. Identification of a duplication of the mouse Lyn gene
23. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease
24. Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B
25. Integrin-associated protein is a ligand for the P84 neural adhesion molecule
26. Macrophages from motheaten and viable motheaten mutant mice show increased proliferative responses to GM-CSF: Detection of potential HCP substrates in GM-CSF signal transduction
27. Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells
28. CD45 negatively regulates lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells
29. A family of proteins that inhibit signalling through tyrosine kinase receptors
30. Targeted disruption of μ chain membrane exon causes loss of heavy-chain allelic exclusion
31. A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells
32. SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival
33. Requirement of SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 for paired immunoglobulin-like receptor B (PIR-B)-mediated inhibitory signal
34. Malignant transformation of early lymphoid progenitors in mice expressing an activated Blk tyrosine kinase
35. Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement
36. Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice
37. A double-edged kinase Lyn: A positive and negative regulator for antigen receptor-mediated signals
38. Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination
39. Enzymatic activity of the Src homology 2 domain-containing inositol phosphatase is regulated by a plasma membrane location
40. Differential detergent fractionation of eukaryotic cells. Analysis by two-dimensional gel electrophoresis
41. Immune inhibitory receptors
42. CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion
43. Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways
44. Human signal-regulatory protein is expressed on normal, but not on subsets of leukemic myeloid cells and mediates cellular adhesion involving its counterreceptor CD47
45. "Viable motheaten," a new allele at the motheaten locus. I. Pathology
46. Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene
47. Inhibition of the B cell by CD22: A requirement for Lyn
48. SH2 domain containing tyrosine phosphatase-1 downregulates activation of Lyn and Lyn-induced tyrosine phosphorylation of the CD19 receptor in B cells
49. DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA
50. Abrogation of autoimmune disease in Lyn-deficient mice by the mutation of the Btk gene
51. Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages
52. SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages
53. Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2. Roles of Fak and Src family kinases
54. Hematologic abnormalities of the immunodeficient mouse mutant, viable motheaten (mev)
55. High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages
56. Induction of mammary epithelial hyperplasias and mammary tumors in transgenic mice expressing a murine mammary tumor virus/activated c-src fusion gene
57. Development and malignant progression of astrocytomas in GFAP-v-src transgenic mice
58. SHP-1 deficiency in B-lineage cells is associated with heightened lyn protein expression and increased lyn kinase activity
59. Functional interaction between SHPTP1 and the Lyn tyrosine kinase in the apoptotic response to DNA damage