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Volumn 207, Issue 8, 2010, Pages 1757-1773

Myeloid cells, BAFF, and IFN-γ establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice

Author keywords

[No Author keywords available]

Indexed keywords

B CELL ACTIVATING FACTOR; GAMMA INTERFERON; MONOCLONAL ANTIBODY; AUTOANTIBODY; B CELL ACTIVATING FACTOR RECEPTOR; HCK PROTEIN, MOUSE; HEMATOPOIETIC CELL KINASE; LYN PROTEIN-TYROSINE KINASE; ONCOPROTEIN; PROTEIN TYROSINE KINASE; PROTO-ONCOGENE PROTEINS C-FGR; TNFRSF13C PROTEIN, MOUSE; TNFSF13B PROTEIN, MOUSE;

EID: 77955343903     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20100086     Document Type: Article
Times cited : (93)

References (59)
  • 1
    • 27344457161 scopus 로고    scopus 로고
    • New insights from murine lupus: Disassociation of autoimmunity and end organ damage and the role of T cells
    • doi:10.1097/01.bor.0000169361.23325.1e
    • Bagavant, H., and S.M. Fu. 2005. New insights from murine lupus: disassociation of autoimmunity and end organ damage and the role of T cells. Curr. Opin. Rheumatol. 17:523-528. doi:10.1097/01.bor.0000169361.23325.1e
    • (2005) Curr. Opin. Rheumatol. , vol.17 , pp. 523-528
    • Bagavant, H.1    Fu, S.M.2
  • 2
    • 0032518439 scopus 로고    scopus 로고
    • Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice
    • Balomenos, D., R. Rumold, and A.N. Theofilopoulos. 1998. Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J. Clin. Invest. 101:364-371. doi:10.1172/JCI750 (Pubitemid 28067333)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.2 , pp. 364-371
    • Balomenos, D.1    Rumold, R.2    Theofilopoulos, A.N.3
  • 3
    • 20044363664 scopus 로고    scopus 로고
    • Src and Syk kinases: Key regulators of phagocytic cell activation
    • DOI 10.1016/j.it.2005.02.002
    • Berton, G., A. Mócsai, and C.A. Lowell. 2005. Src and Syk kinases: key regulators of phagocytic cell activation. Trends Immunol. 26:208-214. doi:10.1016/j.it.2005.02.002 (Pubitemid 41556858)
    • (2005) Trends in Immunology , vol.26 , Issue.4 , pp. 208-214
    • Berton, G.1    Mocsai, A.2    Lowell, C.A.3
  • 4
    • 73649123508 scopus 로고    scopus 로고
    • Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-Faslpr mice: The IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus
    • doi:10.3899/jrheum.090194
    • Cash, H., M. Relle, J. Menke, C. Brochhausen, S.A. Jones, N. Topley, P.R. Galle, and A. Schwarting. 2010. Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-Faslpr mice: the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus. J. Rheumatol. 37:60-70. doi:10.3899/jrheum.090194
    • (2010) J. Rheumatol. , vol.37 , pp. 60-70
    • Cash, H.1    Relle, M.2    Menke, J.3    Brochhausen, C.4    Jones, S.A.5    Topley, N.6    Galle, P.R.7    Schwarting, A.8
  • 5
    • 0030740148 scopus 로고    scopus 로고
    • Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation
    • doi:10.1016/S1074-7613(00)80511-7
    • Chan, V.W., F. Meng, P. Soriano, A.L. DeFranco, and C.A. Lowell. 1997. Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity. 7:69-81. doi:10.1016/S1074-7613(00)80511-7
    • (1997) Immunity , vol.7 , pp. 69-81
    • Chan, V.W.1    Meng, F.2    Soriano, P.3    DeFranco, A.L.4    Lowell, C.A.5
  • 6
    • 0032492994 scopus 로고    scopus 로고
    • Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes
    • Chan, V.W., C.A. Lowell, and A.L. DeFranco. 1998. Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes. Curr. Biol. 8:545-553. doi:10.1016/S0960-9822(98)70223-4 (Pubitemid 28222888)
    • (1998) Current Biology , vol.8 , Issue.10 , pp. 545-553
    • Chan, V.W.F.1    Lowell, C.A.2    DeFranco, A.L.3
  • 7
    • 0033577903 scopus 로고    scopus 로고
    • A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus
    • doi:10.1084/jem.189.10.1639
    • Chan, O.T., L.G. Hannum, A.M. Haberman, M.P. Madaio, and M.J. Shlomchik. 1999. A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus. J. Exp. Med. 189:1639-1648. doi:10.1084/jem.189.10.1639
    • (1999) J. Exp. Med. , vol.189 , pp. 1639-1648
    • Chan, O.T.1    Hannum, L.G.2    Haberman, A.M.3    Madaio, M.P.4    Shlomchik, M.J.5
  • 8
    • 23844518326 scopus 로고    scopus 로고
    • The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation
    • Chu, C.L., and C.A. Lowell. 2005. The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation. J. Immunol. 175:2880-2889.
    • (2005) J. Immunol. , vol.175 , pp. 2880-2889
    • Chu, C.L.1    Lowell, C.A.2
  • 10
    • 56249101045 scopus 로고    scopus 로고
    • Belimumab, an anti-BLyS human monoclonal antibody for potential treatment of inflammatory autoimmune diseases
    • doi:10.1517/14712598.8.11.1805
    • Ding, C. 2008. Belimumab, an anti-BLyS human monoclonal antibody for potential treatment of inflammatory autoimmune diseases. Expert Opin. Biol. Ther. 8:1805-1814. doi:10.1517/14712598.8.11.1805
    • (2008) Expert Opin. Biol. Ther. , vol.8 , pp. 1805-1814
    • Ding, C.1
  • 11
    • 73349131124 scopus 로고    scopus 로고
    • B-cell-directed therapies for autoimmune disease
    • doi:10.1038/nrrheum.2009.141
    • Dörner, T., A. Radbruch, and G.R. Burmester. 2009. B-cell-directed therapies for autoimmune disease. Nat. Rev. Rheumatol. 5:433-441. doi:10.1038/nrrheum.2009.141
    • (2009) Nat. Rev. Rheumatol. , vol.5 , pp. 433-441
    • Dörner, T.1    Radbruch, A.2    Burmester, G.R.3
  • 12
    • 33847342813 scopus 로고    scopus 로고
    • IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells
    • Ettinger, R., G.P. Sims, R. Robbins, D. Withers, R.T. Fischer, A.C. Grammer, S. Kuchen, and P.E. Lipsky. 2007. IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells. J. Immunol. 178:2872-2882.
    • (2007) J. Immunol. , vol.178 , pp. 2872-2882
    • Ettinger, R.1    Sims, G.P.2    Robbins, R.3    Withers, D.4    Fischer, R.T.5    Grammer, A.C.6    Kuchen, S.7    Lipsky, P.E.8
  • 13
    • 66949130737 scopus 로고    scopus 로고
    • Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance
    • doi:10.4049/jimmunol.0803941
    • Gross, A.J., J.R. Lyandres, A.K. Panigrahi, E.T. Prak, and A.L. DeFranco. 2009. Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance. J. Immunol. 182:5382-5392. doi:10.4049/jimmunol. 0803941
    • (2009) J. Immunol. , vol.182 , pp. 5382-5392
    • Gross, A.J.1    Lyandres, J.R.2    Panigrahi, A.K.3    Prak, E.T.4    DeFranco, A.L.5
  • 14
    • 46249090513 scopus 로고    scopus 로고
    • Colony-stimulating factors in inflammation and autoimmunity
    • doi:10.1038/nri2356
    • Hamilton, J.A. 2008. Colony-stimulating factors in inflammation and autoimmunity. Nat. Rev. Immunol. 8:533-544. doi:10.1038/nri2356
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 533-544
    • Hamilton, J.A.1
  • 15
    • 10744223505 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity
    • doi:10.1016/S1074-7613(03)00240-1
    • Hanada, T., H. Yoshida, S. Kato, K. Tanaka, K. Masutani, J. Tsukada, Y. Nomura, H. Mimata, M. Kubo, and A. Yoshimura. 2003. Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. Immunity. 19:437-450. doi:10.1016/S1074-7613(03)00240-1
    • (2003) Immunity , vol.19 , pp. 437-450
    • Hanada, T.1    Yoshida, H.2    Kato, S.3    Tanaka, K.4    Masutani, K.5    Tsukada, J.6    Nomura, Y.7    Mimata, H.8    Kubo, M.9    Yoshimura, A.10
  • 17
    • 10244225231 scopus 로고    scopus 로고
    • Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1
    • doi:10.1182/blood-2003-12-4396
    • Harder, K.W., C. Quilici, E. Naik, M. Inglese, N. Kountouri, A. Turner, K. Zlatic, D.M. Tarlinton, and M.L. Hibbs. 2004. Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1. Blood. 104:3901-3910. doi:10.1182/blood-2003-12- 4396
    • (2004) Blood , vol.104 , pp. 3901-3910
    • Harder, K.W.1    Quilici, C.2    Naik, E.3    Inglese, M.4    Kountouri, N.5    Turner, A.6    Zlatic, K.7    Tarlinton, D.M.8    Hibbs, M.L.9
  • 18
    • 49649119208 scopus 로고    scopus 로고
    • Excessive production of IFN-gamma in patients with systemic lupus erythematosus and its contribution to induction of B lymphocyte stimulator/B cell-activating factor/TNF ligand superfamily-13B
    • Harigai, M., M. Kawamoto, M. Hara, T. Kubota, N. Kamatani, and N. Miyasaka. 2008. Excessive production of IFN-gamma in patients with systemic lupus erythematosus and its contribution to induction of B lymphocyte stimulator/B cell-activating factor/TNF ligand superfamily-13B. J. Immunol. 181:2211-2219.
    • (2008) J. Immunol. , vol.181 , pp. 2211-2219
    • Harigai, M.1    Kawamoto, M.2    Hara, M.3    Kubota, T.4    Kamatani, N.5    Miyasaka, N.6
  • 19
    • 0028784215 scopus 로고
    • Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease
    • doi:10.1016/0092-8674(95)90171-X
    • Hibbs, M.L., D.M. Tarlinton, J. Armes, D. Grail, G. Hodgson, R. Maglitto, S.A. Stacker, and A.R. Dunn. 1995. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell. 83:301-311. doi:10.1016/0092-8674(95)90171-X
    • (1995) Cell , vol.83 , pp. 301-311
    • Hibbs, M.L.1    Tarlinton, D.M.2    Armes, J.3    Grail, D.4    Hodgson, G.5    Maglitto, R.6    Stacker, S.A.7    Dunn, A.R.8
  • 21
    • 16244423682 scopus 로고    scopus 로고
    • The role of BAFF in immune function and implications for autoimmunity
    • DOI 10.1111/j.0105-2896.2005.00219.x
    • Kalled, S.L. 2005. The role of BAFF in immune function and implications for autoimmunity. Immunol. Rev. 204:43-54. doi:10.1111/j.0105-2896.2005.00219.x (Pubitemid 40460492)
    • (2005) Immunological Reviews , vol.204 , pp. 43-54
    • Kalled, S.L.1
  • 22
    • 33645080442 scopus 로고    scopus 로고
    • Pathology and protection in nephrotoxic nephritis is determined by selective engagement of specific Fc receptors
    • doi: 10.1084/jem.20051900
    • Kaneko, Y., F. Nimmerjahn, M.P. Madaio, and J.V. Ravetch. 2006. Pathology and protection in nephrotoxic nephritis is determined by selective engagement of specific Fc receptors. J. Exp. Med. 203:789-797. doi: 10.1084/jem.20051900
    • (2006) J. Exp. Med. , vol.203 , pp. 789-797
    • Kaneko, Y.1    Nimmerjahn, F.2    Madaio, M.P.3    Ravetch, J.V.4
  • 23
    • 54449087291 scopus 로고    scopus 로고
    • Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis
    • doi:10.1073/pnas.0806044105
    • Lai Kwan Lam, Q., O. King Hung Ko, B.J. Zheng, and L. Lu. 2008. Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis. Proc. Natl. Acad. Sci. USA. 105:14993-14998. doi:10.1073/pnas. 0806044105
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 14993-14998
    • Lai Kwan Lam, Q.1    King Hung Ko, O.2    Zheng, B.J.3    Lu, L.4
  • 24
    • 1842633887 scopus 로고    scopus 로고
    • Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF
    • doi:10.1016/S1074-7613(04)00079-2
    • Lesley, R., Y. Xu, S.L. Kalled, D.M. Hess, S.R. Schwab, H.B. Shu, and J.G. Cyster. 2004. Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity. 20:441-453. doi:10.1016/S1074-7613(04) 00079-2
    • (2004) Immunity , vol.20 , pp. 441-453
    • Lesley, R.1    Xu, Y.2    Kalled, S.L.3    Hess, D.M.4    Schwab, S.R.5    Shu, H.B.6    Cyster, J.G.7
  • 25
    • 33750011260 scopus 로고    scopus 로고
    • Anti-interleukin-6 monoclonal antibody inhibits autoimmune responses in a murine model of systemic lupus erythematosus
    • doi:10.1111/j.1365-2567.2006.02433.x
    • Liang, B., D.B. Gardner, D.E. Griswold, P.J. Bugelski, and X.Y. Song. 2006. Anti-interleukin-6 monoclonal antibody inhibits autoimmune responses in a murine model of systemic lupus erythematosus. Immunology. 119:296-305. doi:10.1111/j.1365-2567.2006.02433.x
    • (2006) Immunology , vol.119 , pp. 296-305
    • Liang, B.1    Gardner, D.B.2    Griswold, D.E.3    Bugelski, P.J.4    Song, X.Y.5
  • 26
    • 3042615397 scopus 로고    scopus 로고
    • Src-family kinases: Rheostats of immune cell signaling
    • DOI 10.1016/j.molimm.2004.04.010, PII S0161589004001269
    • Lowell, C.A. 2004. Src-family kinases: rheostats of immune cell signaling. Mol. Immunol. 41:631-643. doi:10.1016/j.molimm.2004.04.010 (Pubitemid 38824619)
    • (2004) Molecular Immunology , vol.41 , Issue.6-7 , pp. 631-643
    • Lowell, C.A.1
  • 27
    • 33747858998 scopus 로고    scopus 로고
    • The role of the BAFF/APRIL system on T cell function
    • doi:10.1016/j.smim.2006.04.005
    • Mackay, F., and H. Leung. 2006. The role of the BAFF/APRIL system on T cell function. Semin. Immunol. 18:284-289. doi:10.1016/j.smim.2006.04.005
    • (2006) Semin. Immunol. , vol.18 , pp. 284-289
    • Mackay, F.1    Leung, H.2
  • 28
    • 67649853099 scopus 로고    scopus 로고
    • Cracking the BAFF code
    • doi:10.1038/nri2572
    • Mackay, F., and P. Schneider. 2009. Cracking the BAFF code. Nat. Rev. Immunol. 9:491-502. doi:10.1038/nri2572
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 491-502
    • Mackay, F.1    Schneider, P.2
  • 29
    • 34247574625 scopus 로고    scopus 로고
    • B cells and the BAFF/APRIL axis: Fast-forward on autoimmunity and signaling
    • doi:10.1016/j.coi.2007.04.008
    • Mackay, F., P.A. Silveira, and R. Brink. 2007. B cells and the BAFF/APRIL axis: fast-forward on autoimmunity and signaling. Curr. Opin. Immunol. 19:327-336. doi:10.1016/j.coi.2007.04.008
    • (2007) Curr. Opin. Immunol. , vol.19 , pp. 327-336
    • Mackay, F.1    Silveira, P.A.2    Brink, R.3
  • 30
    • 66549091971 scopus 로고    scopus 로고
    • Interleukin-6 aborts lymphopoiesis and elevates production of myeloid cells in systemic lupus erythematosus-prone B6.Sle1.Yaa animals
    • doi:10.1182/blood-2008-12-192559
    • Maeda, K., A. Malykhin, B.N. Teague-Weber, X.H. Sun, A.D. Farris, and K.M. Coggeshall. 2009. Interleukin-6 aborts lymphopoiesis and elevates production of myeloid cells in systemic lupus erythematosus-prone B6.Sle1.Yaa animals. Blood. 113:4534-4540. doi:10.1182/blood-2008-12-192559
    • (2009) Blood , vol.113 , pp. 4534-4540
    • Maeda, K.1    Malykhin, A.2    Teague-Weber, B.N.3    Sun, X.H.4    Farris, A.D.5    Coggeshall, K.M.6
  • 31
    • 0030912071 scopus 로고    scopus 로고
    • Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn
    • doi:10.1084/jem.185.9.1661
    • Meng, F., and C.A. Lowell. 1997. Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn. J. Exp. Med. 185:1661-1670. doi:10.1084/jem.185.9. 1661
    • (1997) J. Exp. Med. , vol.185 , pp. 1661-1670
    • Meng, F.1    Lowell, C.A.2
  • 32
    • 33846295127 scopus 로고    scopus 로고
    • Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs
    • doi:10.1038/ni1407
    • Mócsai, A., C.L. Abram, Z. Jakus, Y. Hu, L.L. Lanier, and C.A. Lowell. 2006. Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat. Immunol. 7:1326-1333. doi:10.1038/ni1407
    • (2006) Nat. Immunol. , vol.7 , pp. 1326-1333
    • Mócsai, A.1    Abram, C.L.2    Jakus, Z.3    Hu, Y.4    Lanier, L.L.5    Lowell, C.A.6
  • 33
    • 70349658717 scopus 로고    scopus 로고
    • BAFF: A local and systemic target in autoimmune diseases
    • doi:10.1111/j.1365-2249.2009.04007.x
    • Moisini, I., and A. Davidson. 2009. BAFF: a local and systemic target in autoimmune diseases. Clin. Exp. Immunol. 158:155-163. doi:10.1111/j.1365-2249. 2009.04007.x
    • (2009) Clin. Exp. Immunol. , vol.158 , pp. 155-163
    • Moisini, I.1    Davidson, A.2
  • 34
    • 3142671331 scopus 로고    scopus 로고
    • B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells
    • Ng, L.G., A.P. Sutherland, R. Newton, F. Qian, T.G. Cachero, M.L. Scott, J.S. Thompson, J. Wheway, T. Chtanova, J. Groom, et al. 2004. B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J. Immunol. 173:807-817.
    • (2004) J. Immunol. , vol.173 , pp. 807-817
    • Ng, L.G.1    Sutherland, A.P.2    Newton, R.3    Qian, F.4    Cachero, T.G.5    Scott, M.L.6    Thompson, J.S.7    Wheway, J.8    Chtanova, T.9    Groom, J.10
  • 35
    • 16844364286 scopus 로고    scopus 로고
    • The BAFF/APRIL system: Life beyond B lymphocytes
    • DOI 10.1016/j.molimm.2004.06.041
    • Ng, L.G., C.R. Mackay, and F. Mackay. 2005. The BAFF/APRIL system: life beyond B lymphocytes. Mol. Immunol. 42:763-772. doi:10.1016/j.molimm.2004.06.041 (Pubitemid 40489025)
    • (2005) Molecular Immunology , vol.42 , Issue.7 , pp. 763-772
    • Ng, L.G.1    Mackay, C.R.2    Mackay, F.3
  • 36
    • 0028806216 scopus 로고
    • Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice
    • doi:10.1016/1074-7613(95)90126-4
    • Nishizumi, H., I. Taniuchi, Y. Yamanashi, D. Kitamura, D. Ilic, S. Mori, T. Watanabe, and T. Yamamoto. 1995. Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity. 3:549-560. doi:10.1016/1074-7613(95)90126-4
    • (1995) Immunity , vol.3 , pp. 549-560
    • Nishizumi, H.1    Taniuchi, I.2    Yamanashi, Y.3    Kitamura, D.4    Ilic, D.5    Mori, S.6    Watanabe, T.7    Yamamoto, T.8
  • 37
    • 0041344445 scopus 로고    scopus 로고
    • The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling
    • Pereira, S., and C. Lowell. 2003. The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling. J. Immunol. 171:1319-1327.
    • (2003) J. Immunol. , vol.171 , pp. 1319-1327
    • Pereira, S.1    Lowell, C.2
  • 38
    • 40049093765 scopus 로고    scopus 로고
    • Systemic lupus erythematosus
    • doi:10.1056/NEJMra071297
    • Rahman, A., and D.A. Isenberg. 2008. Systemic lupus erythematosus. N. Engl. J. Med. 358:929-939. doi:10.1056/NEJMra071297
    • (2008) N. Engl. J. Med. , vol.358 , pp. 929-939
    • Rahman, A.1    Isenberg, D.A.2
  • 39
    • 47249111687 scopus 로고    scopus 로고
    • BAFF blockade for systemic lupus erythematosus: Will the promise be fulfilled?
    • doi:10.1111/j.1600-065X.2008.00625.x
    • Ramanujam, M., and A. Davidson. 2008. BAFF blockade for systemic lupus erythematosus: will the promise be fulfilled? Immunol. Rev. 223:156-174. doi:10.1111/j.1600-065X.2008.00625.x
    • (2008) Immunol. Rev. , vol.223 , pp. 156-174
    • Ramanujam, M.1    Davidson, A.2
  • 41
    • 0037071409 scopus 로고    scopus 로고
    • JAKs, STATs and Src kinases in hematopoiesis
    • doi:10.1038/sj.onc.1205398
    • Rane, S.G., and E.P. Reddy. 2002. JAKs, STATs and Src kinases in hematopoiesis. Oncogene. 21:3334-3358. doi:10.1038/sj.onc.1205398
    • (2002) Oncogene , vol.21 , pp. 3334-3358
    • Rane, S.G.1    Reddy, E.P.2
  • 42
    • 35948938957 scopus 로고    scopus 로고
    • High levels of B-cell activating factor in patients with active chronic graft-versus-host disease
    • doi:10.1158/1078-0432.CCR-07-1290
    • Sarantopoulos, S., K.E. Stevenson, H.T. Kim, N.S. Bhuiya, C.S. Cutler, R.J. Soiffer, J.H. Antin, and J. Ritz. 2007. High levels of B-cell activating factor in patients with active chronic graft-versus-host disease. Clin. Cancer Res. 13:6107-6114. doi:10.1158/1078-0432.CCR-07-1290
    • (2007) Clin. Cancer Res. , vol.13 , pp. 6107-6114
    • Sarantopoulos, S.1    Stevenson, K.E.2    Kim, H.T.3    Bhuiya, N.S.4    Cutler, C.S.5    Soiffer, R.J.6    Antin, J.H.7    Ritz, J.8
  • 43
    • 38549098133 scopus 로고    scopus 로고
    • Regulation of B-cell-activating factor (BAFF)/B lymphocyte stimulator (BLyS) expression in human neutrophils
    • Scapini, P., F. Bazzoni, and M.A. Cassatella. 2008. Regulation of B-cell-activating factor (BAFF)/B lymphocyte stimulator (BLyS) expression in human neutrophils. Immunol. Lett. 116:1-6.
    • (2008) Immunol. Lett. , vol.116 , pp. 1-6
    • Scapini, P.1    Bazzoni, F.2    Cassatella, M.A.3
  • 44
    • 61849152775 scopus 로고    scopus 로고
    • Multiple roles of Lyn kinase in myeloid cell signaling and function
    • doi:10.1111/j.1600-065X.2008.00758.x
    • Scapini, P., S. Pereira, H. Zhang, and C.A. Lowell. 2009. Multiple roles of Lyn kinase in myeloid cell signaling and function. Immunol. Rev. 228:23-40. doi:10.1111/j.1600-065X.2008.00758.x
    • (2009) Immunol. Rev. , vol.228 , pp. 23-40
    • Scapini, P.1    Pereira, S.2    Zhang, H.3    Lowell, C.A.4
  • 45
    • 18844447818 scopus 로고    scopus 로고
    • The role of APRIL and BAFF in lymphocyte activation
    • DOI 10.1016/j.coi.2005.04.005, PII S095279150500049X, Lymphocyte Activation/Lymphocyte Effector Functions
    • Schneider, P. 2005. The role of APRIL and BAFF in lymphocyte activation. Curr. Opin. Immunol. 17:282-289. doi:10.1016/j.coi.2005.04.005 (Pubitemid 40692663)
    • (2005) Current Opinion in Immunology , vol.17 , Issue.3 , pp. 282-289
    • Schneider, P.1
  • 47
    • 0035525528 scopus 로고    scopus 로고
    • From T to B and back again: Positive feedback in systemic autoimmune disease
    • doi:10.1038/35100573
    • Shlomchik, M.J., J.E. Craft, and M.J. Mamula. 2001. From T to B and back again: positive feedback in systemic autoimmune disease. Nat. Rev. Immunol. 1:147-153. doi:10.1038/35100573
    • (2001) Nat. Rev. Immunol. , vol.1 , pp. 147-153
    • Shlomchik, M.J.1    Craft, J.E.2    Mamula, M.J.3
  • 49
    • 44749093822 scopus 로고    scopus 로고
    • BAFF and the plasticity of peripheral B cell tolerance
    • doi:10.1016/j.coi.2008.03.015
    • Stadanlick, J.E., and M.P. Cancro. 2008. BAFF and the plasticity of peripheral B cell tolerance. Curr. Opin. Immunol. 20:158-161. doi:10.1016/j.coi.2008.03.015
    • (2008) Curr. Opin. Immunol. , vol.20 , pp. 158-161
    • Stadanlick, J.E.1    Cancro, M.P.2
  • 50
    • 22244484101 scopus 로고    scopus 로고
    • BAFF overexpression and accelerated glomerular disease in mice with an incomplete genetic predisposition to systemic lupus erythematosus
    • doi:10.1002/art.21138
    • Stohl, W., D. Xu, K.S. Kim, M.N. Koss, T.N. Jorgensen, B. Deocharan, T.E. Metzger, S.A. Bixler, Y.S. Hong, C.M. Ambrose, et al. 2005. BAFF overexpression and accelerated glomerular disease in mice with an incomplete genetic predisposition to systemic lupus erythematosus. Arthritis Rheum. 52:2080-2091. doi:10.1002/art.21138
    • (2005) Arthritis Rheum. , vol.52 , pp. 2080-2091
    • Stohl, W.1    Xu, D.2    Kim, K.S.3    Koss, M.N.4    Jorgensen, T.N.5    Deocharan, B.6    Metzger, T.E.7    Bixler, S.A.8    Hong, Y.S.9    Ambrose, C.M.10
  • 53
    • 0035053491 scopus 로고    scopus 로고
    • The role of IFN-gamma in systemic lupus erythematosus: A challenge to the Th1/Th2 paradigm in autoimmunity
    • doi:10.1186/ar290
    • Theofilopoulos, A.N., S. Koundouris, D.H. Kono, and B.R. Lawson. 2001. The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity. Arthritis Res. 3:136-141. doi:10.1186/ar290
    • (2001) Arthritis Res. , vol.3 , pp. 136-141
    • Theofilopoulos, A.N.1    Koundouris, S.2    Kono, D.H.3    Lawson, B.R.4
  • 54
    • 77949322552 scopus 로고    scopus 로고
    • Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6
    • Tsantikos, E., S.A. Oracki, C. Quilici, G.P. Anderson, D.M. Tarlinton, and M.L. Hibbs. 2009. Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6. J. Immunol. 184:1348-1360.
    • (2009) J. Immunol. , vol.184 , pp. 1348-1360
    • Tsantikos, E.1    Oracki, S.A.2    Quilici, C.3    Anderson, G.P.4    Tarlinton, D.M.5    Hibbs, M.L.6
  • 56
    • 47249103832 scopus 로고    scopus 로고
    • B-lymphocyte contributions to human autoimmune disease
    • doi:10.1111/j.1600-065X.2008.00646.x
    • Yanaba, K., J.D. Bouaziz, T. Matsushita, C.M. Magro, E.W. St.Clair, and T.F. Tedder. 2008. B-lymphocyte contributions to human autoimmune disease. Immunol. Rev. 223:284-299. doi:10.1111/j.1600-065X.2008.00646.x
    • (2008) Immunol. Rev. , vol.223 , pp. 284-299
    • Yanaba, K.1    Bouaziz, J.D.2    Matsushita, T.3    Magro, C.M.4    St.Clair, E.W.5    Tedder, T.F.6
  • 57
    • 7244223338 scopus 로고    scopus 로고
    • BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses
    • doi:10.1002/eji.200425198
    • Ye, Q., L. Wang, A.D. Wells, R. Tao, R. Han, A. Davidson, M.L. Scott, and W.W. Hancock. 2004. BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses. Eur. J. Immunol. 34:2750-2759. doi:10.1002/eji.200425198
    • (2004) Eur. J. Immunol. , vol.34 , pp. 2750-2759
    • Ye, Q.1    Wang, L.2    Wells, A.D.3    Tao, R.4    Han, R.5    Davidson, A.6    Scott, M.L.7    Hancock, W.W.8
  • 58
    • 0035182146 scopus 로고    scopus 로고
    • Lupuslike kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn
    • doi:10.1016/S0960-9822(00)00024-5
    • Yu, C.C., T.S. Yen, C.A. Lowell, and A.L. DeFranco. 2001. Lupuslike kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn. Curr. Biol. 11:34-38. doi:10.1016/S0960-9822(00)00024-5
    • (2001) Curr. Biol. , vol.11 , pp. 34-38
    • Yu, C.C.1    Yen, T.S.2    Lowell, C.A.3    DeFranco, A.L.4
  • 59
    • 22144457050 scopus 로고    scopus 로고
    • T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells
    • doi:10.1172/JCI23049
    • Zhu, J., X. Liu, C. Xie, M. Yan, Y. Yu, E.S. Sobel, E.K. Wakeland, and C. Mohan. 2005. T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells. J. Clin. Invest. 115:1869-1878. doi:10.1172/JCI23049
    • (2005) J. Clin. Invest. , vol.115 , pp. 1869-1878
    • Zhu, J.1    Liu, X.2    Xie, C.3    Yan, M.4    Yu, Y.5    Sobel, E.S.6    Wakeland, E.K.7    Mohan, C.8


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