CTLA4Ig alters the course of autoimmune disease development in Lyn -/- mice

Journal of Immunology

Volumn 184, Issue 2, 2010, Pages 757-763

  Oracki, Sarah A ^a   Tsantikos, Evelyn ^b   Quilici, Cathy ^b   Light, Amanda ^a   Schmidt, Thomas ^a   Lew, Andrew M ^a   Martin, Joanne E ^c   Smith, Ken G ^d   Hibbs, Margaret L ^b   Tarlinton, David M ^a  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; ANTINUCLEAR ANTIBODY; AUTOANTIBODY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; PROTEIN KINASE LYN; ANTIBODY CONJUGATE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4; LEUKOCYTE ANTIGEN; LYN PROTEIN-TYROSINE KINASE; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY TITER; ANTIGEN ANTIBODY COMPLEX; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE; BONE MARROW; CELL CLONE; CELL COUNT; CELL FUNCTION; CELL MATURATION; CONTROLLED STUDY; DISEASE COURSE; GLOMERULONEPHRITIS; HYPERPLASIA; IMMUNE COMPLEX DEPOSITION; IMMUNOGLOBULIN DEPOSITION; KIDNEY INJURY; LYMPHOCYTE ACTIVATION; MALE; MOUSE; MYELOPOIESIS; NONHUMAN; PHENOTYPE; PLASMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLENOMEGALY; T LYMPHOCYTE; ANIMAL; BIOSYNTHESIS; IMMUNOLOGY; KIDNEY DISEASE; MOUSE MUTANT; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; ANTIGEN-ANTIBODY COMPLEX; ANTIGENS, CD; AUTOANTIBODIES; AUTOIMMUNE DISEASES; B-LYMPHOCYTES; CLONE CELLS; IMMUNOCONJUGATES; IMMUNOGLOBULIN G; KIDNEY DISEASES; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, KNOCKOUT; SRC-FAMILY KINASES; T-LYMPHOCYTES;

EID: 76249110020     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0804349     Document Type: Article

References (56)

1. Xu, Y., K. W. Harder, N. D. Huntington, M. L. Hibbs, and D. M. Tarlinton. 2005. Lyn tyrosine kinase: accentuating the positive and the negative. Immunity 22: 9-18.
2. Beavitt, S. J., K. W. Harder, J. M. Kemp, J. Jones, C. Quilici, F. Casagranda, E. Lam, D. Turner, S. Brennan, P. D. Sly, et al. 2005. Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity. J. Immunol. 175: 1867-1875.
3. Hibbs, M. L., and K. W. Harder. 2006. The duplicitous nature of the Lyn tyrosine kinase in growth factor signaling. Growth Factors 24: 137-149.
4. Hibbs, M. L., D. M. Tarlinton, J. Armes, D. Grail, G. Hodgson, R. Maglitto, S. A. Stacker, and A. R. Dunn. 1995. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell 83: 301-311.
5. Liossis, S. N., E. E. Solomou, M. A. Dimopoulos, P. Panayiotidis, M. M. Mavrikakis, and P. P. Sfikakis. 2001. B-cell kinase lyn deficiency in patients with systemic lupus erythematosus. J. Investig. Med. 49: 157-165.
6. Flores-Borja, F., P. S. Kabouridis, E. C. Jury, D. A. Isenberg, and R. A. Mageed. 2005. Decreased Lyn expression and translocation to lipid raft signaling domains in B lymphocytes from patients with systemic lupus erythematosus. Arthritis Rheum. 52: 3955-3965.
7. Nishizumi, H., I. Taniuchi, Y. Yamanashi, D. Kitamura, D. Ilic, S. Mori, T. Watanabe, and T. Yamamoto. 1995. Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity 3: 549-560.
8. Harder, K. W., L. M. Parsons, J. Armes, N. Evans, N. Kountouri, R. Clark, C. Quilici, D. Grail, G. S. Hodgson, A. R. Dunn, and M. L. Hibbs. 2001. Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage. Immunity 15: 603-615.
9. Goodnow, C. C., J. Crosbie, H. Jorgensen, R. A. Brink, and A. Basten. 1989. Induction of self-tolerance in mature peripheral B lymphocytes. Nature 342: 385-391.
10. Madaio, M. P., S. Hodder, R. S. Schwartz, and B. D. Stollar. 1984. Responsiveness of autoimmune and normal mice to nucleic acid antigens. J. Immunol. 132: 872-876.
11. Varela, F., A. Andersson, G. Dietrich, A. Sundblad, D. Holmberg, M. Kazatchkine, and A. Coutinho. 1991. Population dynamics of natural antibodies in normal and autoimmune individuals. Proc. Natl. Acad. Sci. USA 88: 5917-5921.
12. Means, T. K., E. Latz, F. Hayashi, M. R. Murali, D. T. Golenbock, and A. D. Luster. 2005. Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J. Clin. Invest. 115: 407-417.
13. Bajtay, Z., E. Csomor, N. Sándor, and A. Erdei. 2006. Expression and role of Fcand complement-receptors on human dendritic cells. Immunol. Lett. 104: 46-52.
14. Ehlers, M., H. Fukuyama, T. L. McGaha, A. Aderem, and J. V. Ravetch. 2006. TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. J. Exp. Med. 203: 553-561.
15. Silver, K. L., T. L. Crockford, T. Bouriez-Jones, S. Milling, T. Lambe, and R. J. Cornall. 2007. MyD88-dependent autoimmune disease in Lyn-deficient mice. Eur. J. Immunol. 37: 2734-2743.
16. Sutherland, R. M., J. L. Brady, H. M. Georgiou, H. E. Thomas, and A. M. Lew. 2000. Protective effect of CTLA4Ig secreted by transgenic fetal pancreas allografts. Transplantation 69: 1806-1812.
17. + T cells and defective antibody production in vivo. J. Exp. Med. 179: 809-817.
18. Levisetti, M. G., P. A. Padrid, G. L. Szot, N. Mittal, S. M. Meehan, C. L. Wardrip, G. S. Gray, D. S. Bruce, J. R. Thistlethwaite, Jr., and J. A. Bluestone. 1997. Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation. J. Immunol. 159: 5187-5191.
19. National Institute of Allergy and Infectious Diseases. 2008. Identifier: NCT00774852. Abatacept and Cyclophosphamide Combination Therapy for Lupus Nephritis (ACCESS). Available at: www.ClinicalTrials.gov.
20. Hibbs, M. L., K. W. Harder, J. Armes, N. Kountouri, C. Quilici, F. Casagranda, A. R. Dunn, and D. M. Tarlinton. 2002. Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity. J. Exp. Med. 196: 1593-1604.
21. Polli, M., A. Dakic, A. Light, L. Wu, D. M. Tarlinton, and S. L. Nutt. 2005. The development of functional B lymphocytes in conditional PU.1 knock-out mice. Blood 106: 2083-2090.
22. Harder, K. W., C. Quilici, E. Naik, M. Inglese, N. Kountouri, A. Turner, K. Zlatic, D. M. Tarlinton, and M. L. Hibbs. 2004. Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1. Blood 104: 3901-3910.
23. Cornall, R. J., J. G. Cyster, M. L. Hibbs, A. R. Dunn, K. L. Otipoby, E. A. Clark, and C. C. Goodnow. 1998. Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. Immunity 8: 497-508.
24. Hang, L. M., M. T. Aguado, F. J. Dixon, and A. N. Theofilopoulos. 1985. Induction of severe autoimmune disease in normal mice by simultaneous action of multiple immunostimulators. J. Exp. Med. 161: 423-428.
25. Klinman, D. M., R. A. Eisenberg, and A. D. Steinberg. 1990. Development of the autoimmune B cell repertoire in MRL-lpr/lpr mice. J. Immunol. 144: 506-511.
26. Sfikakis, P. P., J. N. Boletis, S. Lionaki, V. Vigklis, K. G. Fragiadaki, A. Iniotaki, and H. M. Moutsopoulos. 2005. Remission of proliferative lupus nephritis following B cell depletion therapy is preceded by down-regulation of the T cell costimulatory molecule CD40 ligand: an open-label trial. Arthritis Rheum. 52: 501-513.
27. Shlomchik, M. J., J. E. Craft, and M. J. Mamula. 2001. From T to B and back again: positive feedback in systemic autoimmune disease. Nat. Rev. Immunol. 1: 147-153.
28. Baran, C. P., S. Tridandapani, C. D. Helgason, R. K. Humphries, G. Krystal, and C. B. Marsh. 2003. The inositol 5′-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity. J. Biol. Chem. 278: 38628-38636.
29. Chu, C. L., and C. A. Lowell. 2005. The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation. J. Immunol. 175: 2880-2889.
30. Litinskiy, M. B., B. Nardelli, D. M. Hilbert, B. He, A. Schaffer, P. Casali, and A. Cerutti. 2002. DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat. Immunol. 3: 822-829.
31. Ueda, Y., M. Kondo, and G. Kelsoe. 2005. Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow. J. Exp. Med. 201: 1771-1780.
32. Maeda, K., Y. Baba, Y. Nagai, K. Miyazaki, A. Malykhin, K. Nakamura, P. W. Kincade, N. Sakaguchi, and K. M. Coggeshall. 2005. IL-6 blocks a discrete early step in lymphopoiesis. Blood 106: 879-885.
33. Takahashi, T., T. Shirasawa, K. Miyake, Y. Yahagi, N. Maruyama, N. Kasahara, T. Kawamura, O. Matsumura, T. Mitarai, and O. Sakai. 1995. Protein tyrosine kinases expressed in glomeruli and cultured glomerular cells: Flt-1 and VEGF expression in renal mesangial cells. Biochem. Biophys. Res. Commun. 209: 218-226.
34. Hartley, S. B., J. Crosbie, R. Brink, A. B. Kantor, A. Basten, and C. C. Goodnow. 1991. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature 353: 765-769.
35. Klinman, D. M., A. Shirai, and Y. Ishigatsubo. 1994. Polyclonal B cell activation and B cell cross-reactivity during autoantibody production in systemic lupus erythematosus. Adv. Exp. Med. Biol. 347: 115-123.
36. Cassese, G., S. Lindenau, B. de Boer, S. Arce, A. Hauser, G. Riemekasten, C. Berek, F. Hiepe, V. Krenn, A. Radbruch, and R. A. Manz. 2001. Inflamed kidneys of NZB/W mice are a major site for the homeostasis of plasma cells. Eur. J. Immunol. 31: 2726-2732.
37. Hoyer, B. F., K. Moser, A. E. Hauser, A. Peddinghaus, C. Voigt, D. Eilat, A. Radbruch, F. Hiepe, and R. A. Manz. 2004. Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W mice. J. Exp. Med. 199: 1577-1584.
38. Cassese, G., S. Arce, A. E. Hauser, K. Lehnert, B. Moewes, M. Mostarac, G. Muehlinghaus, M. Szyska, A. Radbruch, and R. A. Manz. 2003. Plasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals. J. Immunol. 171: 1684-1690.
39. Emancipator, S. N. 1998. IgAN and Henoch-Shonlein syndrome. In Heptinstall's Pathology of the Kidney. J. C. O. J. L. Jennette, M. M. Schwartz, and F. G. Silva, eds. Lippincott-Raven Publishers, Philadelphia, p. 479-539.
40. Chintalacharuvu, S. R., M. Yamashita, N. Bagheri, T. G. Blanchard, J. G. Nedrud, M. E. Lamm, Y. Tomino, and S. N. Emancipator. 2008. T cell cytokine polarity as a determinant of immunoglobulin A (IgA) glycosylation and the severity of experimental IgA nephropathy. Clin. Exp. Immunol. 153: 456-462.
41. Czerkinsky, C., W. J. Koopman, S. Jackson, J. E. Collins, S. S. Crago, R. E. Schrohenloher, B. A. Julian, J. H. Galla, and J. Mestecky. 1986. Circulating immune complexes and immunoglobulin A rheumatoid factor in patients with mesangial immunoglobulin A nephropathies. J. Clin. Invest. 77: 1931-1938.
42. Groom, J. R., C. A. Fletcher, S. N. Walters, S. T. Grey, S. V. Watt, M. J. Sweet, M. J. Smyth, C. R. Mackay, and F. Mackay. 2007. BAFF and MyD88 signals promote a lupuslike disease independent of T cells. J. Exp. Med. 204: 1959-1971.
43. + T cells on intestinal IgA immune responses. Dev. Immunol. 6: 53-60.
44. Oka, Y., A. G. Rolink, S. Suematsu, T. Kishimoto, and F. Melchers. 1995. An interleukin-6 transgene expressed in B lymphocyte lineage cells overcomes the T cell-dependent establishment of normal levels of switched immunoglobulin isotypes. Eur. J. Immunol. 25: 1332-1337.
45. Tomino, Y., K. Funabiki, H. Ohmuro, M. Shimizu, K. Yokoyama, I. Shirato, T. Shirai, M. Takahashi, and H. Koide. 1991. Urinary levels of interleukin-6 and disease activity in patients with IgA nephropathy. Am. J. Nephrol. 11: 459-464.
46. Dohi, K., M. Iwano, A. Muraguchi, Y. Horii, T. Hirayama, S. Ogawa, H. Shiiki, T. Hirano, T. Kishimoto, and H. Ishikawa. 1991. The prognostic significance of urinary interleukin 6 in IgA nephropathy. Clin. Nephrol. 35: 1-5.
47. Feeney, A. J., B. R. Lawson, D. H. Kono, and A. N. Theofilopoulos. 2001. Terminal deoxynucleotidyl transferase deficiency decreases autoimmune disease in MRL-Fas(lpr) mice. J. Immunol. 167: 3486-3493.
48. Jiang, C., J. Foley, N. Clayton, G. Kissling, M. Jokinen, R. Herbert, and M. Diaz. 2007. Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice. J. Immunol. 178: 7422-7431. (Pubitemid 46847470)
49. Moon, B. G., S. Takaki, H. Nishizumi, T. Yamamoto, and K. Takatsu. 2004. Abrogation of autoimmune disease in Lyn-deficient mice by the deletion of IL-5 receptor a chain gene. Cell. Immunol. 228: 110-118.
50. Kikawada, E., D. M. Lenda, and V. R. Kelley. 2003. IL-12 deficiency in MRL-Fas(lpr) mice delays nephritis and intrarenal IFN-γ expression, and diminishes systemic pathology. J. Immunol. 170: 3915-3925. (Pubitemid 36359263)
51. Kinoshita, K., T. Yamagata, Y. Nozaki, M. Sugiyama, S. Ikoma, M. Funauchi, and A. Kanamaru. 2004. Blockade of IL-18 receptor signaling delays the onset of autoimmune disease in MRL-Faslpr mice. J. Immunol. 173: 5312-5318. (Pubitemid 39387816)
52. Herber, D., T. P. Brown, S. Liang, D. A. Young, M. Collins, and K. Dunussi-Joannopoulos. 2007. IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression. J. Immunol. 178: 3822-3830. (Pubitemid 46417651)
53. Peng, S. L., J. Moslehi, and J. Craft. 1997. Roles of interferon-g and interleukin-4 in murine lupus. J. Clin. Invest. 99: 1936-1946.
54. Schwarting, A., T. Wada, K. Kinoshita, G. Tesch, and V. R. Kelley. 1998. IFN-γ receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL-Fas(lpr) mice. J. Immunol. 161: 494-503. (Pubitemid 28285560)
55. Takeshita, H., I. Taniuchi, J. Kato, and T. Watanabe. 1998. Abrogation of autoimmune disease in Lyn-deficient mice by the mutation of the Btk gene. Int. Immunol. 10: 435-444.
56. Hasegawa, M., M. Fujimoto, J. C. Poe, D. A. Steeber, C. A. Lowell, and T. F. Tedder. 2001. A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice. J. Immunol. 167: 2469-2478. (Pubitemid 32768872)