Enediynes: Exploration of microbial genomics to discover new anticancer drug leads

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 1, 2015, Pages 9-15

  Shen, Ben ^a   Hindra, ^a   Yan, Xiaohui ^a   Huang, Tingting ^a   Ge, Huiming ^a   Yang, Dong ^a   Teng, Qihui ^a   Rudolf, Jeffrey D ^a   Lohman, Jeremy R ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

ADC payload; Biosynthetic gene cluster; Enediyne polyketide synthase; Genome mining; Natural products

Indexed keywords

ANTIBIOTIC C 1027; ANTINEOPLASTIC AGENT; AURISTATIN; CALICHEAMICIN; CAMPTOTHECIN; DOXORUBICIN; DUOCARMYCIN DERIVATIVE; ENEDIYNE; MAYTANSINOID; UNCLASSIFIED DRUG;

ACTINOMADURA; ACTINOMADURA MADURAE; ACTINOMYCETALES; ANTIGEN BINDING; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL LINE; CHROMATOPHORE; DNA SEQUENCE; DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; GENE CASSETTE; GENE CLUSTER; IC50; MICROBIAL GENOME; NONHUMAN; PHARMACOGENOMICS; STREPTOMYCES; STREPTOMYCES CARZINOSTATICUS; STREPTOMYCES GLOBISPORUS; ANIMAL; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; GENETICS; GENOMICS; HUMAN; TRENDS;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG DISCOVERY; ENEDIYNES; GENOME, MICROBIAL; GENOMICS; HUMANS;

EID: 84913534816     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.11.019     Document Type: Review

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