Biosynthesis of the enediyne antitumor antibiotic C-1027

Science

Volumn 297, Issue 5584, 2002, Pages 1170-1173

  Liu, Wen ^a   Christenson, Steven D ^b   Standage, Scott ^b   Shen, Ben ^a,b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; ENZYMES; GENES; TUMORS;

ANTITUMOR AGENTS;

BIOSYNTHESIS;

ANTIBIOTIC C 1027; ANTINEOPLASTIC ANTIBIOTIC; POLYKETIDE SYNTHASE;

ANTIBIOTICS; BIOCHEMISTRY;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; GENE CLUSTER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STREPTOMYCES;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; ANTIBIOTICS, ANTINEOPLASTIC; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONING, MOLECULAR; ENEDIYNES; GENES, BACTERIAL; MULTIENZYME COMPLEXES; MULTIGENE FAMILY; MUTATION; OPEN READING FRAMES; PROTEIN STRUCTURE, TERTIARY; STREPTOMYCES;

BACTERIA (MICROORGANISMS); STREPTOMYCES; STREPTOMYCES GLOBISPORUS;

EID: 0347721776     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1072110     Document Type: Article

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28. We thank Y. Li, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing, China, for the wild-type S. globisporus strain; and Ecopia BioSciences Inc., Montreal, Canada, for assistance in sequencing the neocarzinostatin gene cluster and for sharing unpublished data. Supported in part by NIH grant CA78747. B.S. is a recipient of an NSF CAREER Award (MCB9733938) and an NIH Independent Scientist Award (AI51689). S.D.C. was supported in part by NIH gra-T32 GM07377.