C-1027 Taiho Pharmaceutical Co Ltd

Current Opinion in Oncologic, Endocrine and Metabolic Investigational Drugs

Volumn 2, Issue 3, 2000, Pages 344-352

  Brukner, I ^a  

^a Signalgene Inc Canada   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC C 1027; APOPROTEIN; BASIC FIBROBLAST GROWTH FACTOR; CALICHEAMICIN; CALICHEAMICIN GAMMA1; ESPERAMICIN; GREEN FLUORESCENT PROTEIN; KEDARCIDIN; LIDAMYCIN; MAGNESIUM; MITOMYCIN; THIOL; UNCLASSIFIED DRUG; ZINOSTATIN;

APOPTOSIS; CANCER; CLINICAL TRIAL; DOSE RESPONSE; DRUG INHIBITION; DRUG MARKETING; DRUG METABOLISM; DRUG SYNTHESIS; HUMAN; LIVER CELL CARCINOMA; NONHUMAN; REVIEW; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TREATMENT OUTCOME;

EID: 0033868890     PISSN: 14648466     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (100)

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3. Mechanistic studies of enediyne C-1027-mediated DNA damage at a model 5'GTTAT-5'ATAAC site
4. Effects of the DNA-damaging enediyne C-1027 on intracellular SV-40 and genomic DNA in green monkey kidney BSC-1 cells
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7. Organic synthesis and cell biology: Partners in controlling gene expression
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10. Induction of apoptosis by enediyne antitumour antibiotic C1027 in HL-60 human promyelocytic leukaemia cells
11. RNA cleavage by C-1027 chromophore, an enediyne antitumor antibiotic: High selectivity to an anticodon arm.
12. NMR studies of the post-activated neocarzinostatin chromophore-DNA complex. Conformational changes induced in drug and DNA
13. DNA intercalation by chromophore of the antitumour antibiotic C-1027
14. Mechanistic studies of enediyne C-1027-mediated DNA damage at a model 5' GTTAT - 5' ATAAC site
15. DNA cleavage kinetics of the enediyne anticancer drug C-1027
16. Synthesis and absolute stereochemistry fo the amino sugar moiety of antibiotic C-1027 chromophore
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18. Structure of an aromatization product of C-1027 chromophore
19. The amino acid sequence of actinoxanthin apoprotein deduced from the bas sequence of the gene
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29. Studies on the synthesis of the core structures of the antitumor agents neocarzinostatin, kedarcidin, C-1027 and maduropeptin
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31. Absolute configuration of C-1027 chromophore
32. Interaction of C-1027 chromophore with d(GTATAC)2: A binding model based on NMR experiments
33. Synthesis of 10-membered masked oxaenediyne analogue of Kedarcidin-chr. and C-1027-chr., and its DNA cleaving activity
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36. Effects of the DNA-reactive antitumor enediyne C-1027 on replicating DNA
37. A single binding mode of activated enediyne C1027 generates two types of double-strand DNA lesions: Deuterium isotope-induced shuttling between adjacent nucleotide target sites
38. The benzoxazolinate of C-1027 confers intercalative DNA binding
39. Synthesis and characterization of nine-membered cyclic enediynes, models of C-1027 and kedarcidin chromophore: Equilibration with a p-benzyne biradical and kinetic stabilization
40. Preliminary X-ray diffraction study of a new crystal form of C-1027-AG, the apoprotein of the macromolecular antitumor antibiotic C-1027 from Streptomyces globisporus
41. Enediyne-mediated cleavage of RNA
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51. Monoclonal antibody raised against apoprotein of C-1027: Effect on biochemical and biological activities of the holoantibiotic
52. Biodistribution of monoclonal antibody and Fab fragment and antitumor effect of their conjugates on hepatoma xenografts
53. Antitumor activity of the new enediyne antibiotic C1027
54. Synthesis and absolute stereochemistry of the aminosugar moiety of antibiotic C-1027 chromophore
55. Structure and cycloaromatization of a novel enediyne, C-1027 chromophore
56. Structure of an aromatization product of C-1027 chromophore
57. Conformation studies on and assessment by spectral analysis of the protein-chromophore interaction of the macromolecular antitumor antibiotic C-1027
58. Crystallization and preliminary X-ray diffraction studies of C-1027-AG, the apoprotein of the macromolecular antitumor antibiotic C-1027 from Streptomyces globisporus
59. Cloning and nucleotide sequencing of the antitumor antibiotic C-1027 apoprotein gene
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61. Isolation and construction of restriction endonuclease map of plasmid pSGL1 from antitumor antibiotic C-1027 production strain Streptomyces globisporus
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