Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027

Journal of Antibiotics

Volumn 63, Issue 8, 2010, Pages 482-485

  Chen, Yihua ^a   Yin, Min ^a   Horsman, Geoff P ^a   Huang, Shengxiong ^a   Shen, Ben ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

biosynthesis; C 1027; enediyne; heptaene; regulation; Streptomyces globisporus

Indexed keywords

ANTIBIOTIC AGENT; ENEDIYNE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BIOSYNTHESIS; CONTROLLED STUDY; GENE CLUSTER; METABOLITE; NONHUMAN; PRIORITY JOURNAL; REGULATOR GENE; REGULATORY MECHANISM; SGCR1 GENE; SGCR2 GENE; SGCR3 GENE; STATISTICAL SIGNIFICANCE; STREPTOMYCES; TYPE STRAIN; UPREGULATION; WILD TYPE;

AMINOGLYCOSIDES; ANTINEOPLASTIC AGENTS; BACTERIAL PROTEINS; BIOSYNTHETIC PATHWAYS; ENEDIYNES; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; GENETIC ENGINEERING; HUMANS; STREPTOMYCES; TRANSCRIPTION FACTORS;

STREPTOMYCES GLOBISPORUS;

EID: 77956257592     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2010.55     Document Type: Article

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