Improvement of the enediyne antitumor antibiotic C-1027 production by manipulating its biosynthetic pathway regulation in Streptomyces globisporus

Journal of Natural Products

Volumn 74, Issue 3, 2011, Pages 420-424

  Chen, Yihua ^a   Yin, Min ^a   Horsman, Geoff P ^a   Shen, Ben ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC C 1027; BACTERIAL PROTEIN; DNA BINDING PROTEIN; SGCE1 PROTEIN; SGCR PROTEIN; UNCLASSIFIED DRUG;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BACTERIAL STRAIN; BACTERIUM MUTANT; CONTROLLED STUDY; DRUG MANUFACTURE; GENE INACTIVATION; GENE OVEREXPRESSION; IN VIVO STUDY; NONHUMAN; STRAIN DIFFERENCE; STREPTOMYCES; STREPTOMYCES GLOBISPORUS; WILD TYPE;

AMINOGLYCOSIDES; ANTIBIOTICS, ANTINEOPLASTIC; BASE SEQUENCE; BIOSYNTHETIC PATHWAYS; ENEDIYNES; GENE EXPRESSION REGULATION, BACTERIAL; MOLECULAR STRUCTURE; STREPTOMYCES;

STREPTOMYCES GLOBISPORUS;

EID: 79953236131     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np100825y     Document Type: Article

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