Chloroacetic acid triggers apoptosis in neuronal cells via a reactive oxygen species-induced endoplasmic reticulum stress signaling pathway

Chemico-Biological Interactions

Volumn 225, Issue , 2015, Pages 1-12

  Lu, Tien Hui ^a   Su, Chin Chuan ^b   Tang, Feng Cheng ^b   Chen, Chun Hung ^c   Yen, Cheng Chieh ^d,e   Fang, Kai Min ^a,f   Lee, Kuan I ^g   Hung, Dong Zong ^c   Chen, Ya Wen ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^e CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f FAR EASTERN MEMORIAL HOSPITAL   (Taiwan)

^g Buddhist Compassion Relief Tzu Chi Foundation   (Taiwan)

Author keywords

Apoptosis; Chloroacetic acid; Endoplasmic reticulum stress; Neurotoxicity; ROS

Indexed keywords

ACETYLCYSTEINE; ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; CALPAIN; CASPASE 12; CASPASE 3; CASPASE 7; CHLOROACETIC ACID; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; INOSITOL REQUIRING ENZYME 1; LACTATE DEHYDROGENASE; MARKER; PHOSPHATIDYLSERINE; PROTEIN KINASE R; PROTEIN KINASE R LIKE ENDOPLASMIC RETICULUM KINASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; ACETIC ACID DERIVATIVE; CAPN1 PROTEIN, MOUSE; CASPASE; ENDOPLASMIN; HEAT SHOCK PROTEIN; MEMBRANE PROTEIN; MOLECULAR CHAPERONE GRP78; RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; LIPID PEROXIDATION; NERVE CELL NECROSIS; NONHUMAN; UNFOLDED PROTEIN RESPONSE; ANIMAL; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; FLOW CYTOMETRY; GENETICS; METABOLISM; MOUSE; NERVE CELL; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOXICITY; TUMOR CELL LINE;

ACETATES; ANIMALS; APOPTOSIS; CALPAIN; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; HEAT-SHOCK PROTEINS; MEMBRANE GLYCOPROTEINS; MICE; NEURONS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; RNA; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP;

EID: 84913530181     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2014.10.022     Document Type: Article

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