Inorganic arsenic causes cell apoptosis in mouse cerebrum through an oxidative stress-regulated signaling pathway

Archives of Toxicology

Volumn 85, Issue 6, 2011, Pages 565-575

  Yen, Cheng Chien ^a,b   Ho, Tsung Jung ^c   Wu, Chin Ching ^c   Chang, Chun Fang ^d   Su, Chin Chuan ^e   Chen, Ya Wen ^c   Jinn, Tzyy Rong ^c   Lu, Tien Hui ^c   Cheng, Po Wen ^f   Su, Yi Chang ^c   Liu, Shing Hwa ^g   Huang, Chun Fa ^c  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d Chiayi Yang Ming Hospital   (Taiwan)

^e CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^f FAR EASTERN MEMORIAL HOSPITAL   (Taiwan)

^g NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; ER stress; ERK1 2; Inorganic arsenic; Oxidative stress; p38

Indexed keywords

ACETYLCYSTEINE; ARSENIC; CASPASE 3; GLUTATHIONE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BAK GENE; BAX GENE; BRAIN CORTEX; C EBP HOMOLOGOUS PROTEIN GENE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE; GENE EXPRESSION; GLUCOSE RELATED PROTEIN 78 GENE; GLUCOSE RELATED PROTEIN 94 GENE; GLUTATHIONE PEROXIDASE GENE; LIPID PEROXIDATION; MALE; MCL 1 GENE; MOUSE; NAD(P)H QUINONE OXIDOREDUCTASE 1 GENE; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PLASMA; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; UPREGULATION;

ACETYLCYSTEINE; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; ARSENIC POISONING; ARSENICALS; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LIPID PEROXIDES; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED ICR; NAD(P)H DEHYDROGENASE (QUINONE); NERVE TISSUE PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXIDES; RANDOM ALLOCATION; RNA, MESSENGER;

MUS;

EID: 79959621373     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-011-0709-y     Document Type: Article

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