Arsenic induces reactive oxygen species-caused neuronal cell apoptosis through JNK/ERK-mediated mitochondria-dependent and GRP 78/CHOP-regulated pathways

Toxicology Letters

Volumn 224, Issue 1, 2014, Pages 130-140

  Lu, Tien Hui ^a   Tseng, To Jung ^a   Su, Chin Chuan ^b   Tang, Feng Cheng ^b   Yen, Cheng Chieh ^c,d   Liu, Yu Yun ^c   Yang, Ching Yao ^e,f   Wu, Chin Ching ^g   Chen, Kuo Liang ^h   Hung, Dong Zong ⁱ   Chen, Ya Wen ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^d CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^f NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^g CHINA MEDICAL UNIVERSITY   (Taiwan)

^h CHINA MEDICAL UNIVERSITY   (Taiwan)

ⁱ CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Apoptosis; Arsenic; Endoplasmic reticulum stress (ER stress); Mitogen activated protein kinases (MAPKs); Neurotoxicity; Reactive oxygen species (ROS)

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ARSENIC; CASPASE 12; CASPASE 3; CASPASE 7; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1; THIOREDOXIN; TRANSCRIPTION FACTOR NRF2; X BOX BINDING PROTEIN 1;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; GENETIC TRANSFECTION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NERVE CELL; NEUROBLASTOMA CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

APOPTOSIS; ARSENIC; C-JUN N-TERMINAL KINASE; C/EBP HOMOLOGUE PROTEIN; CHOP; ENDOPLASMIC RETICULUM STRESS; ENDOPLASMIC RETICULUM STRESS (ER STRESS); ER STRESS; ERK; EXTRACELLULAR SIGNAL-RELATED KINASE; GLUCOSE-REGULATED PROTEIN; GRP; JNK; MAPKS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES (MAPKS); MMP; N-ACETYLCYSTEINE; NAC; NEUROTOXICITY; NRF2; NUCLEAR-FACTOR-E2-RELATED FACTOR 2; PARP; POLY (ADP-RIBOSE) POLYMERASE; REACTIVE OXYGEN SPECIES; REACTIVE OXYGEN SPECIES (ROS); ROS; SI-RNA; SMALL INTERFERENCE RNA; X-BOX BINDING PROTEIN-1; XBP-1;

ANIMALS; APOPTOSIS; ARSENIC; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEAT-SHOCK PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MICE; MITOCHONDRIA; NEURONS; REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTOR CHOP;

EID: 84887550914     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.10.013     Document Type: Article

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