Chloroacetic acid induced neuronal cells death through oxidative stress-mediated p38-MAPK activation pathway regulated mitochondria-dependent apoptotic signals

Toxicology

Volumn 303, Issue , 2013, Pages 72-82

  Chen, Chun Hung ^a,b   Chen, Sz Jie ^a   Su, Chin Chuan ^c   Yen, Cheng Chieh ^d,e   Tseng, To Jung ^f   Jinn, Tzyy Rong ^a   Tang, Feng Cheng ^c   Chen, Kuo Liang ^g   Su, Yi Chang ^a   Lee, kuan I ^h   Hung, Dong Zong ^b   Huang, Chun Fa ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^d CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^e CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f CHINA MEDICAL UNIVERSITY   (Taiwan)

^g CHINA MEDICAL UNIVERSITY   (Taiwan)

^h BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

Author keywords

Apoptosis; Chloroacetic acid (CA); Mitochondrial dysfunction; Neurotoxicity; Oxidative stress; P38 MAPK

Indexed keywords

CASPASE; CHLOROACETIC ACID; GLUTATHIONE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; MITOCHONDRION; NERVE CELL NECROSIS; NEUROTOXICITY; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION;

ACETATES; ANIMALS; ANTHRACENES; APOPTOSIS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; IMIDAZOLES; MICE; MITOCHONDRIA; NEUROBLASTOMA; NEURONS; NEUROTOXICITY SYNDROMES; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES;

MAMMALIA;

EID: 84871132239     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.10.008     Document Type: Article

References (80)

1. An J.M., Kim S.S., Rhie J.H., Shin D.M., Seo S.R., Seo J.T. Carmustine induces ERK- and JNK-dependent cell death of neuronally-differentiated PC12 cells via generation of reactive oxygen species. Toxicol. In Vitro 2011, 25:1359-1365.
2. Berardi M.R., Snyder R., Waritz R.S., Cooper K.R. Monochloroacetic acid toxicity in the mouse associated with blood-brain barrier damage. Fundam. Appl. Toxicol. 1987, 9:469-479.
3. Bharathi, Ravid R., Rao K.S. Role of metals in neuronal apoptosis: challenges associated with neurodegeneration. Curr. Alzheimer Res. 2006, 3:311-326.
4. Bhat H.K., Ahmed A.E., Ansari G.A. Toxicokinetics of monochloroacetic acid: a whole-body autoradiography study. Toxicology 1990, 63:35-43.
5. Bhat H.K., Ansari G.A. Covalent interaction of chloroacetic and acetic acids with cholesterol. J. Biochem. Toxicol. 1989, 4:189-193.
6. Bhat H.K., Kanz M.F., Campbell G.A., Ansari G.A. Ninety day toxicity study of chloroacetic acids in rats. Fundam. Appl. Toxicol. 1991, 17:240-253.
7. Boorman G.A. Drinking water disinfection byproducts: review and approach to toxicity evaluation. Environ. Health Perspect. 1999, 107(Suppl 1):207-217.
8. Boutros T., Chevet E., Metrakos P. Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer. Pharmacol. Rev. 2008, 60:261-310.
9. Bryant B.J., Jokinen M.P., Eustis S.L., Thompson M.B., Abdo K.M. Toxicity of monochloroacetic acid administered by gavage to F344 rats and B6C3F1 mice for up to 13 weeks. Toxicology 1992, 72:77-87.
10. Bruschi S.A., Bull R.J. In vitro cytotoxicity of mono-, di-, and trichloroacetate and its modulation by hepatic peroxisome proliferation. Fundam. Appl. Toxicol. 1993, 21:366-375.
11. The Merck Index. An Encyclopedia of Chemicals, Drugs and Biologicals 1989, Merck & Co, Rahway, N.J. 11th ed. S.M. Budavari (Ed.).
12. Cargnello M., Roux P.P. Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol. Mol. Biol. Rev. 2011, 75:50-83.
13. Chang L., Karin M. Mammalian MAP kinase signalling cascades. Nature 2001, 410:37-40.
14. Chen X., Lan X., Mo S., Qin J., Li W., Liu P., Han Y., Pi R. p38 and ERK, but not JNK, are involved in copper-induced apoptosis in cultured cerebellar granule neurons. Biochem. Biophys. Res. Commun. 2009, 379:944-948.
15. Chen Y.W., Huang C.F., Yang C.Y., Yen C.C., Tsai K.S., Liu S.H. Inorganic mercury causes pancreatic beta-cell death via the oxidative stress-induced apoptotic and necrotic pathways. Toxicol. Appl. Pharmacol. 2010, 243:323-331.
16. Choi W.S., Eom D.S., Han B.S., Kim W.K., Han B.H., Choi E.J., Oh T.H., Markelonis G.J., Cho J.W., Oh Y.J. Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons. J. Biol. Chem. 2004, 279:20451-20460.
17. Cowan K.J., Storey K.B. Mitogen-activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress. J. Exp. Biol. 2003, 206:1107-1115.
18. Coyle J.T., Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science 1993, 262:689-695.
19. Daniel F.B., Robinson M., Stober J.A., Page N.P., Olson G.R. Ninety-day toxicity study of sodium monochloroacetate in Sprague-Dawley rats. Toxicology 1991, 67:171-185.
20. Daniel P.T., Schulze-Osthoff K., Belka C., Guner D. Guardians of cell death: the Bcl-2 family proteins. Essays Biochem. 2003, 39:73-88.
21. Dartsch P.C., Wolburg H., Al Makdessi S., Schiek D., Sweidan H., Kimmel R., Schmahl F.W. Sodium monochloroacetate causes cytotoxic effects, an increased lactate and pyruvate level and induces ultra structural and cytoskeletal alterations in cultured kidney and liver epithelial cells. Hum. Exp. Toxicol. 2000, 19:138-148.
22. Desjardins P., Ledoux S. The role of apoptosis in neurodegenerative diseases. Metab. Brain Dis. 1998, 13:79-96.
23. Doedens D., Ashmore J. Inhibition of pyruvate carboxylase by chloropyruvic acid and related compounds. Biochem. Pharmacol. 1972, 21:1745-1751.
24. Dosunmu R., Wu J., Basha M.R., Zawia N.H. Environmental and dietary risk factors in Alzheimer's disease. Expert Rev. Neurother. 2007, 7:887-900.
25. Dote T., Kono K., Usuda K., Shimizu H., Tanimoto Y., Dote E., Hayashi S. Systemic effects and skin injury after experimental dermal exposure to monochloroacetic acid. Toxicol. Ind. Health 2003, 19:165-169.
26. Duchen M.R. Mitochondria in health and disease: perspectives on a new mitochondrial biology. Mol. Aspects Med. 2004, 25:365-451.
27. Emerit J., Edeas M., Bricaire F. Neurodegenerative diseases and oxidative stress. Biomed. Pharmacother. 2004, 58:39-46.
28. Finkel T., Holbrook N.J. Oxidants, oxidative stress and the biology of ageing. Nature 2000, 408:239-247.
29. Hathway D.E. Comparative mammalian metabolism of vinyl chloride and vinylidene chloride in relation to oncogenic potential. Environ. Health Perspect. 1977, 21:55-59.
30. Hua G., Reckhow D.A. Comparison of disinfection byproduct formation from chlorine and alternative disinfectants. Water Res. 2007, 41:1667-1678.
31. Huang C.F., Liu S.H., Lin-Shiau S.Y. Pyrrolidine dithiocarbamate augments Hg(2+)-mediated induction of macrophage cell death via oxidative stress-induced apoptosis and necrosis signaling pathways. Toxicol. Lett. 2012, 214:33-45.
32. Jomova K., Vondrakova D., Lawson M., Valko M. Metals, oxidative stress and neurodegenerative disorders. Mol. Cell Biochem. 2010, 345:91-104.
33. Kang D., Hamasaki N. Alterations of mitochondrial DNA in common diseases and disease states: aging, neurodegeneration, heart failure, diabetes, and cancer. Curr. Med. Chem. 2005, 12:429-441.
34. Kannan K., Jain S.K. Oxidative stress and apoptosis. Pathophysiology 2000, 7:153-163.
35. Kasof G.M., Gomes B.C. Livin, a novel inhibitor of apoptosis protein family member. J. Biol. Chem. 2001, 276:3238-3246.
36. Kefaloyianni E., Gaitanaki C., Beis I. ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-kappaB transactivation during oxidative stress in skeletal myoblasts. Cell Signal. 2006, 18:2238-2251.
37. Kerr J.F. History of the events leading to the formulation of the apoptosis concept. Toxicology 2002, 181-182:471-474.
38. Kim E.K., Choi E.J. Pathological roles of MAPK signaling pathways in human diseases. Biochim. Biophys. Acta 2010, 1802:396-405.
39. Kim J.Y., Yu S.J., Oh H.J., Lee J.Y., Kim Y., Sohn J. Panaxydol induces apoptosis through an increased intracellular calcium level, activation of JNK and p38 MAPK and NADPH oxidase-dependent generation of reactive oxygen species. Apoptosis 2011, 16:347-358.
40. Kitamura M., Hiramatsu N. The oxidative stress: endoplasmic reticulum stress axis in cadmium toxicity. Biometals 2010, 23:941-950.
41. Krasner S.W., McGuire M.J., Jacangelo J.G., Patania N.L., Reagan K.M., Aieta E.M. The occurrence of disinfection by-products in U.S. drinking water. J. Am. Water Works Assoc. 1989, 81:41-53.
42. Kroemer G., Reed J.C. Mitochondrial control of cell death. Nat. Med. 2000, 6:513-519.
43. Kroemer G., Zamzami N., Susin S.A. Mitochondrial control of apoptosis. Immunol. Today 1997, 18:44-51.
44. Kulling P., Andersson H., Bostrom K., Johansson L.A., Lindstrom B., Nystrom B. Fatal systemic poisoning after skin exposure to monochloroacetic acid. J. Toxicol. Clin. Toxicol. 1992, 30:643-652.
45. Kupfer A., Aeschlimann C., Wermuth B., Cerny T. Prophylaxis and reversal of ifosfamide encephalopathy with methylene-blue. Lancet 1994, 343:763-764.
46. Kusch G.D., McCarty L.P., Lanham J.M. Monochloroacetic acid exposure: a case report. Pol. J. Occup. Med. 1990, 3:409-414.
47. Lan A., Liao X., Mo L., Yang C., Yang Z., Wang X., Hu F., Chen P., Feng J., Zheng D., Xiao L. Hydrogen sulfide protects against chemical hypoxia-induced injury by inhibiting ROS-activated ERK1/2 and p38MAPK signaling pathways in PC12 cells. PLoS One 2011, 6:e25921-e25934.
48. Leibowitz B., Yu J. Mitochondrial signaling in cell death via the Bcl-2 family. Cancer Biol. Ther. 2010, 9:417-422.
49. Lee J.E., Park J.H., Shin I.C., Koh H.C. Reactive oxygen species regulated mitochondria-mediated apoptosis in PC12 cells exposed to chlorpyrifos. Toxicol. Appl. Pharmacol. 2012, 263:148-162.
50. LePage K.T., Dickey R.W., Gerwick W.H., Jester E.L., Murray T.F. On the use of neuro-2a neuroblastoma cells versus intact neurons in primary culture for neurotoxicity studies. Crit. Rev. Neurobiol. 2005, 17:27-50.
51. Loh K.P., Huang S.H., De Silva R., Tan B.K., Zhu Y.Z. Oxidative stress: apoptosis in neuronal injury. Curr. Alzheimer Res. 2006, 3:327-337.
52. Lopes J.P., Oliveira S.M., Soares Fortunato J. Oxidative stress and its effects on insulin resistance and pancreatic beta-cells dysfunction: relationship with type 2 diabetes mellitus complications. Acta Med. Port 2008, 21:293-302.
53. Lu T.H., Hsieh S.Y., Yen C.C., Wu H.C., Chen K.L., Hung D.Z., Chen C.H., Wu C.C., Su Y.C., Chen Y.W., Liu S.H., Huang C.F. Involvement of oxidative stress-mediated ERK1/2 and p38 activation regulated mitochondria-dependent apoptotic signals in methylmercury-induced neuronal cell injury. Toxicol. Lett. 2011, 204:71-80.
54. Lu T.H., Su C.C., Chen Y.W., Yang C.Y., Wu C.C., Hung D.Z., Chen C.H., Cheng P.W., Liu S.H., Huang C.F. Arsenic induces pancreatic beta-cell apoptosis via the oxidative stress-regulated mitochondria-dependent and endoplasmic reticulum stress-triggered signaling pathways. Toxicol. Lett. 2011, 201:15-26.
55. Marques C.A., Keil U., Bonert A., Steiner B., Haass C., Muller W.E., Eckert A. Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway. J. Biol. Chem. 2003, 278:28294-28302.
56. Mates J.M., Segura J.A., Alonso F.J., Marquez J. Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms. Free Radic. Biol. Med. 2010, 49:1328-1341.
57. Nagata S. Apoptosis by death factor. Cell 1997, 88:355-365.
58. Pearson G., Robinson F., Beers Gibson T., Xu B.E., Karandikar M., Berman K., Cobb M.H. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev. 2001, 22:153-183.
59. Perry G., Raina A.K., Nunomura A., Wataya T., Sayre L.M., Smith M.A. How important is oxidative damage? Lessons from Alzheimer's disease. Free Radic. Biol. Med. 2000, 28:831-834.
60. Pieczenik S.R., Neustadt J. Mitochondrial dysfunction and molecular pathways of disease. Exp. Mol. Pathol. 2007, 83:84-92.
61. Pirson J., Toussaint P., Segers N. An unusual cause of burn injury: skin exposure to monochloroacetic acid. J. Burn. Care Rehabil. 2003, 24:407-409.
62. Pruss-Ustun A., Vickers C., Haefliger P., Bertollini R. Knowns and unknowns on burden of disease due to chemicals: a systematic review. Environ. Health 2011, 10:9.
63. Quick M.P., Manser P.A., Stevens H., Bolton J.F. Sodium monochloroacetate poisoning of cattle and sheep. Vet. Rec. 1983, 113:155-156.
64. Rannug U., Gothe R., Wachtmeister C.A. The mutagenicity of chloroethylene oxide, chloroacetaldehyde, 2-chloroethanol and chloroacetic acid, conceivable metabolites of vinyl chloride. Chem. Biol. Interact. 1976, 12:251-263.
65. Reimann S., Grob K., Frank H. Chloroacetic acids in rainwater. Environ. Sci. Toxicol. 1996, 30:2340-2344.
66. Rogers D.R. Accidental fatal monochloroacetic acid poisoning. Am. J. Forensic Med. Pathol. 1995, 16:115-116.
67. Schroeter H., Boyd C., Spencer J.P., Williams R.J., Cadenas E., Rice-Evans C. MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide. Neurobiol. Aging 2002, 23:861-880.
68. Son Y., Cheong Y.K., Kim N.H., Chung H.T., Kang D.G., Pae H.O. Mitogen-activated protein kinases and reactive oxygen species: how can ROS activate MAPK pathways?. J. Signal. Transduct. 2011, 2011:792639.
69. Spector A. Review: oxidative stress and disease. J. Ocul. Pharmacol. Ther. 2000, 16:193-201.
70. Susin S.A., Lorenzo H.K., Zamzami N., Marzo I., Snow B.E., Brothers G.M., Mangion J., Jacotot E., Costantini P., Loeffler M., Larochette N., Goodlett D.R., Aebersold R., Siderovski D.P., Penninger J.M., Kroemer G. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 1999, 397:441-446.
71. Tang C.H., Chiu Y.C., Huang C.F., Chen Y.W., Chen P.C. Arsenic induces cell apoptosis in cultured osteoblasts through endoplasmic reticulum stress. Toxicol. Appl. Pharmacol. 2009, 241:173-181.
72. Toshina Y., Dote T., Usuda K., Shimizu H., Tominaga M., Kono K. Hepatic injury and gluconeogenesis after subcutaneous injection of monochloroacetic acid in rats. Environ. Health Prev. Med. 2004, 9:58-62.
73. U.S. Environmental Protection Agency, 2002. Final draft for the addendum to drinking water criteria document for monochloroacetic acid and trichloroacetic acid. Prepared for Health and Ecological Criteria Division, Office of Science and Technology, Office of Water, US Environmental Protection Agency, Washington, DC (EPA-822-R-02-036).
74. U.S. Environmental Protection Agency, 1988. Health and Environmental Effects Document for Chloroacetic Acid. ECAO-CIN-G038. Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Office of Research and Development, Cincinnati, OH.
75. The Merck Index 1983, Merck, Rahway, N.J., p. 296. 10th ed. M.G. Windholz (Ed.).
76. Xu B., Chen S., Luo Y., Chen Z., Liu L., Zhou H., Chen W., Shen T., Han X., Chen L., Huang S. Calcium signaling is involved in cadmium-induced neuronal apoptosis via induction of reactive oxygen species and activation of MAPK/mTOR network. PLoS One 2011, 6:e19052-e19063.
77. Yen C.C., Ho T.J., Wu C.C., Chang C.F., Su C.C., Chen Y.W., Jinn T.R., Lu T.H., Cheng P.W., Su Y.C., Liu S.H., Huang C.F. Inorganic arsenic causes cell apoptosis in mouse cerebrum through an oxidative stress-regulated signaling pathway. Arch. Toxicol. 2011, 85:565-575.
78. Yen Y.P., Tsai K.S., Chen Y.W., Huang C.F., Yang R.S., Liu S.H. Arsenic induces apoptosis in myoblasts through a reactive oxygen species-induced endoplasmic reticulum stress and mitochondrial dysfunction pathway. Arch. Toxicol. 2012, 86:923-933.
79. Yllner S. Metabolism of 1,2-dichloroethane-14 C in the mouse. Acta Pharmacol. Toxicol. (Copenh.) 1971, 30:257-265.
80. Yuan J., Yankner B.A. Apoptosis in the nervous system. Nature 2000, 407:802-809.