Cadmium Induces Apoptosis in Pancreatic β-Cells through a Mitochondria-Dependent Pathway: The Role of Oxidative Stress-Mediated c-Jun N-Terminal Kinase Activation

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Chang, Kai Chih ^a   Hsu, Ching Cheng ^a   Liu, Shing Hwa ^b   Su, Chin Chuan ^c   Yen, Cheng Chieh ^d,e   Lee, Ming Jye ^f,g   Chen, Kuo Liang ^h   Ho, Tsung Jung ⁱ   Hung, Dong Zong ^h   Wu, Chin Ching ⁱ   Lu, Tien Hui ^a   Su, Yi Chang ⁱ   Chen, Ya Wen ^a   Huang, Chun Fa ⁱ  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^d CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^e CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f Penghu Hospital   (Taiwan)

^g Department of Health Executive Yuan ^*  (Taiwan)

^h CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

ⁱ CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CADMIUM; CASPASE; CELL PROTEIN; CYTOCHROME C; LIPOCORTIN 5; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; PROTEIN CY3; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL MEDIATED CYTOTOXICITY; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY TEST; DIPLOIDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; METABOLISM; MITOCHONDRION; PHYSIOLOGY; SECRETION (PROCESS);

ANIMALS; APOPTOSIS; CADMIUM; CASPASES; CELL LINE; CELL SURVIVAL; CYTOCHROMES C; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INSULIN; INSULIN-SECRETING CELLS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MALONDIALDEHYDE; MAP KINASE SIGNALING SYSTEM; MICE, INBRED ICR; MITOCHONDRIA; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84873557177     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054374     Document Type: Article

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