Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3

Journal of Immunology

Volumn 193, Issue 11, 2014, Pages 5668-5677

  Bosmann, Markus ^a   Russkamp, Norman F ^a   Strobl, Birgit ^b   Roewe, Julian ^a   Balouzian, Liza ^c   Pache, Florence ^d   Radsak, Markus P ^a   Van Rooijen, Nico ^e   Zetoune, Firas S ^d   Vidya Sarma, J ^d   Núñez, Gabriel ^d   Müuller, Mathias ^b   Murray, Peter J ^c   Ward, Peter A ^d  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 27; LIPOSOME; MYELOID DIFFERENTIATION FACTOR 88; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TOLL LIKE RECEPTOR 4; BLOCKING ANTIBODY; CYTOKINE RECEPTOR; IL27 PROTEIN, MOUSE; IL27RA PROTEIN, MOUSE; INTERLEUKIN DERIVATIVE; SOCS3 PROTEIN, MOUSE; SUPPRESSOR OF CYTOKINE SIGNALING; TICAM-1 PROTEIN, MOUSE; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL CLEARANCE; CD8+ T LYMPHOCYTE; CELL FUNCTION; COLONY FORMING UNIT; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; FLUORESCENCE MICROSCOPY; GENE DISRUPTION; GENE EXPRESSION REGULATION; IN VIVO STUDY; MACROPHAGE; MALE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PROTEIN FOLDING; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY BURST; SEPSIS; SERODIAGNOSIS; SIGNAL TRANSDUCTION; SPLENECTOMY; SURVIVAL RATE; TH1 CELL; TH17 CELL; TH2 CELL; ANIMAL; BACTERIAL LOAD; C57BL MOUSE; CECUM; CELL CULTURE; DISEASE MODEL; DRUG EFFECTS; GENETICS; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; MICROBIOLOGY; OXIDATIVE STRESS; PHYSIOLOGY; SURGERY;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; ANTIBODIES, BLOCKING; BACTERIAL LOAD; CECUM; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HUMANS; INTERLEUKIN-10; INTERLEUKINS; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; OXIDATIVE STRESS; RECEPTORS, CYTOKINE; SEPSIS; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TOLL-LIKE RECEPTOR 4;

EID: 84912573231     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1302280     Document Type: Article

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