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Volumn 130, Issue 2, 2014, Pages 59-72

Alpha-synuclein in peripheral tissues and body fluids as a biomarker for Parkinson's disease - a systematic review

Author keywords

Alpha synuclein; Biomarker; Lewy body; Parkinson's disease

Indexed keywords

ALPHA SYNUCLEIN; BIOLOGICAL MARKER;

EID: 84904744897     PISSN: 00016314     EISSN: 16000404     Source Type: Journal    
DOI: 10.1111/ane.12247     Document Type: Review
Times cited : (138)

References (93)
  • 1
    • 84885461450 scopus 로고    scopus 로고
    • alpha-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?
    • Kiely AP, Asi YT, Kara E et al. alpha-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy? Acta Neuropathol 2013;125:753-69.
    • (2013) Acta Neuropathol , vol.125 , pp. 753-769
    • Kiely, A.P.1    Asi, Y.T.2    Kara, E.3
  • 5
    • 0027489773 scopus 로고
    • Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease
    • Ueda K, Fukushima H, Masliah E et al. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc Natl Acad Sci USA 1993;90:11282-6.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11282-11286
    • Ueda, K.1    Fukushima, H.2    Masliah, E.3
  • 6
    • 0028965513 scopus 로고
    • The NACP/synuclein gene: chromosomal assignment and screening for alterations in Alzheimer disease
    • Campion D, Martin C, Heilig R et al. The NACP/synuclein gene: chromosomal assignment and screening for alterations in Alzheimer disease. Genomics 1995;26:254-7.
    • (1995) Genomics , vol.26 , pp. 254-257
    • Campion, D.1    Martin, C.2    Heilig, R.3
  • 7
    • 84878577036 scopus 로고    scopus 로고
    • Alpha-synuclein posttranslational modification and alternative splicing as a trigger for neurodegeneration
    • Beyer K, Ariza A. Alpha-synuclein posttranslational modification and alternative splicing as a trigger for neurodegeneration. Mol Neurobiol 2013;47:509-24.
    • (2013) Mol Neurobiol , vol.47 , pp. 509-524
    • Beyer, K.1    Ariza, A.2
  • 8
    • 79960712793 scopus 로고    scopus 로고
    • Conserved C-terminal charge exerts a profound influence on the aggregation rate of alpha-synuclein
    • Levitan K, Chereau D, Cohen SI et al. Conserved C-terminal charge exerts a profound influence on the aggregation rate of alpha-synuclein. J Mol Biol 2011;411:329-33.
    • (2011) J Mol Biol , vol.411 , pp. 329-333
    • Levitan, K.1    Chereau, D.2    Cohen, S.I.3
  • 9
    • 34548620297 scopus 로고    scopus 로고
    • Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation
    • Uversky VN. Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation. J Neurochem 2007;103:17-37.
    • (2007) J Neurochem , vol.103 , pp. 17-37
    • Uversky, V.N.1
  • 10
    • 4744355097 scopus 로고    scopus 로고
    • Alpha-synuclein: stable compact and extended monomeric structures and pH dependence of dimer formation
    • Bernstein SL, Liu D, Wyttenbach T et al. Alpha-synuclein: stable compact and extended monomeric structures and pH dependence of dimer formation. J Am Soc Mass Spectrom 2004;15:1435-43.
    • (2004) J Am Soc Mass Spectrom , vol.15 , pp. 1435-1443
    • Bernstein, S.L.1    Liu, D.2    Wyttenbach, T.3
  • 11
    • 0028985267 scopus 로고
    • The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
    • Iwai A, Masliah E, Yoshimoto M et al. The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 1995;14:467-75.
    • (1995) Neuron , vol.14 , pp. 467-475
    • Iwai, A.1    Masliah, E.2    Yoshimoto, M.3
  • 12
    • 0037023699 scopus 로고    scopus 로고
    • Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins
    • Uversky VN, Li J, Souillac P et al. Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins. J Biol Chem 2002;277:11970-8.
    • (2002) J Biol Chem , vol.277 , pp. 11970-11978
    • Uversky, V.N.1    Li, J.2    Souillac, P.3
  • 13
    • 83455202793 scopus 로고    scopus 로고
    • Alpha-synuclein misfolding and Parkinson's disease
    • Breydo L, Wu JW, Uversky VN. Alpha-synuclein misfolding and Parkinson's disease. Biochim Biophys Acta 2012;1822:261-85.
    • (2012) Biochim Biophys Acta , vol.1822 , pp. 261-285
    • Breydo, L.1    Wu, J.W.2    Uversky, V.N.3
  • 14
    • 0037012778 scopus 로고    scopus 로고
    • An alternatively spliced form of rodent alpha-synuclein forms intracellular inclusions in vitro: role of the carboxy-terminus in alpha-synuclein aggregation
    • McLean PJ, Hyman BT. An alternatively spliced form of rodent alpha-synuclein forms intracellular inclusions in vitro: role of the carboxy-terminus in alpha-synuclein aggregation. Neurosci Lett 2002;323:219-23.
    • (2002) Neurosci Lett , vol.323 , pp. 219-223
    • McLean, P.J.1    Hyman, B.T.2
  • 15
    • 14344263884 scopus 로고    scopus 로고
    • The role of alpha-synuclein in neurodegenerative diseases
    • Bennett MC. The role of alpha-synuclein in neurodegenerative diseases. Pharmacol Ther 2005;105:311-31.
    • (2005) Pharmacol Ther , vol.105 , pp. 311-331
    • Bennett, M.C.1
  • 16
    • 0029981526 scopus 로고    scopus 로고
    • Neuropathology of Parkinson's disease
    • Forno LS. Neuropathology of Parkinson's disease. J Neuropathol Exp Neurol 1996;55:259-72.
    • (1996) J Neuropathol Exp Neurol , vol.55 , pp. 259-272
    • Forno, L.S.1
  • 17
    • 84855972240 scopus 로고    scopus 로고
    • Neuropathology of sporadic Parkinson's disease: evaluation and changes of concepts
    • Jellinger KA. Neuropathology of sporadic Parkinson's disease: evaluation and changes of concepts. Mov Disord 2012;27:8-30.
    • (2012) Mov Disord , vol.27 , pp. 8-30
    • Jellinger, K.A.1
  • 18
    • 70349503591 scopus 로고    scopus 로고
    • Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein
    • Uversky VN, Eliezer D. Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein. Curr Protein Pept Sci 2009;10:483-99.
    • (2009) Curr Protein Pept Sci , vol.10 , pp. 483-499
    • Uversky, V.N.1    Eliezer, D.2
  • 19
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos MH, Lavedan C, Leroy E et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997;276:2045-7.
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1    Lavedan, C.2    Leroy, E.3
  • 20
    • 0141725659 scopus 로고    scopus 로고
    • Neuropathological spectrum of synucleinopathies
    • Jellinger KA. Neuropathological spectrum of synucleinopathies. Mov Disord 2003;18(Suppl 6):S2-12.
    • (2003) Mov Disord , vol.18 , Issue.SUPPL. 6
    • Jellinger, K.A.1
  • 21
    • 34248205797 scopus 로고    scopus 로고
    • Expression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineage
    • Nakai M, Fujita M, Waragai M et al. Expression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineage. Biochem Biophys Res Commun 2007;358:104-10.
    • (2007) Biochem Biophys Res Commun , vol.358 , pp. 104-110
    • Nakai, M.1    Fujita, M.2    Waragai, M.3
  • 22
    • 21344456506 scopus 로고    scopus 로고
    • Intravesicular localization and exocytosis of alpha-synuclein and its aggregates
    • Lee HJ, Patel S, Lee SJ. Intravesicular localization and exocytosis of alpha-synuclein and its aggregates. J Neurosci 2005;25:6016-24.
    • (2005) J Neurosci , vol.25 , pp. 6016-6024
    • Lee, H.J.1    Patel, S.2    Lee, S.J.3
  • 23
    • 0032568534 scopus 로고    scopus 로고
    • alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
    • Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M. alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc Natl Acad Sci USA 1998;95:6469-73.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6469-6473
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Hasegawa, M.4    Goedert, M.5
  • 24
    • 84858630931 scopus 로고    scopus 로고
    • Presymptomatic Parkinson's disease: the Arizona experience
    • Caviness JN. Presymptomatic Parkinson's disease: the Arizona experience. Parkinsonism Relat Disord 2012;18(Suppl 1):S203-6.
    • (2012) Parkinsonism Relat Disord , vol.18 , Issue.SUPPL. 1
    • Caviness, J.N.1
  • 25
    • 32544442518 scopus 로고    scopus 로고
    • Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology
    • Braak H, de Vos RA, Bohl J, Del Tredici K. Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology. Neurosci Lett 2006;396:67-72.
    • (2006) Neurosci Lett , vol.396 , pp. 67-72
    • Braak, H.1    de Vos, R.A.2    Bohl, J.3    Del Tredici, K.4
  • 26
    • 33646109064 scopus 로고    scopus 로고
    • Alpha-synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals
    • Klos KJ, Ahlskog JE, Josephs KA et al. Alpha-synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals. Neurology 2006;66:1100-2.
    • (2006) Neurology , vol.66 , pp. 1100-1102
    • Klos, K.J.1    Ahlskog, J.E.2    Josephs, K.A.3
  • 27
    • 49449097043 scopus 로고    scopus 로고
    • Incidental Lewy body disease and preclinical Parkinson disease
    • DelleDonne A, Klos KJ, Fujishiro H et al. Incidental Lewy body disease and preclinical Parkinson disease. Arch Neurol 2008;65:1074-80.
    • (2008) Arch Neurol , vol.65 , pp. 1074-1080
    • DelleDonne, A.1    Klos, K.J.2    Fujishiro, H.3
  • 28
    • 77953021942 scopus 로고    scopus 로고
    • Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders
    • Beach TG, Adler CH, Sue LI et al. Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders. Acta Neuropathol 2010;119:689-702.
    • (2010) Acta Neuropathol , vol.119 , pp. 689-702
    • Beach, T.G.1    Adler, C.H.2    Sue, L.I.3
  • 29
    • 19344366060 scopus 로고    scopus 로고
    • Skin and platelha-synuclein as peripheral biomarkers of Parkinson's disease
    • Michell AW, Luheshi LM, Barker RA. Skin and platelet alpha-synuclein as peripheral biomarkers of Parkinson's disease. Neurosci Lett 2005;381:294-8.
    • (2005) Neurosci Lett , vol.381 , pp. 294-298
    • Michell, A.W.1    Luheshi, L.M.2    Barker, R.A.3
  • 30
    • 0032763540 scopus 로고    scopus 로고
    • The expression of alpha-, beta-, and gamma-synucleins in olfactory mucosa from patients with and without neurodegenerative diseases
    • Duda JE, Shah U, Arnold SE, Lee VM, Trojanowski JQ. The expression of alpha-, beta-, and gamma-synucleins in olfactory mucosa from patients with and without neurodegenerative diseases. Exp Neurol 1999;160:515-22.
    • (1999) Exp Neurol , vol.160 , pp. 515-522
    • Duda, J.E.1    Shah, U.2    Arnold, S.E.3    Lee, V.M.4    Trojanowski, J.Q.5
  • 31
    • 59249083870 scopus 로고    scopus 로고
    • Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders
    • Beach TG, White CL 3rd, Hladik CL et al. Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders. Acta Neuropathol 2009;117:169-74.
    • (2009) Acta Neuropathol , vol.117 , pp. 169-174
    • Beach, T.G.1    White 3rd, C.L.2    Hladik, C.L.3
  • 32
    • 67651160628 scopus 로고    scopus 로고
    • Biopsies of olfactory epithelium in patients with Parkinson's disease
    • Witt M, Bormann K, Gudziol V et al. Biopsies of olfactory epithelium in patients with Parkinson's disease. Mov Disord 2009;24:906-14.
    • (2009) Mov Disord , vol.24 , pp. 906-914
    • Witt, M.1    Bormann, K.2    Gudziol, V.3
  • 33
    • 56549121613 scopus 로고    scopus 로고
    • Pathological lesions in colonic biopsies during Parkinson's disease
    • Lebouvier T, Chaumette T, Damier P et al. Pathological lesions in colonic biopsies during Parkinson's disease. Gut 2008;57:1741-3.
    • (2008) Gut , vol.57 , pp. 1741-1743
    • Lebouvier, T.1    Chaumette, T.2    Damier, P.3
  • 34
    • 77958558412 scopus 로고    scopus 로고
    • Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms
    • Lebouvier T, Neunlist M, Bruley des Varannes S et al. Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms. PLoS ONE 2010;5:e12728.
    • (2010) PLoS ONE , vol.5
    • Lebouvier, T.1    Neunlist, M.2    Bruley des Varannes, S.3
  • 36
    • 81955167987 scopus 로고    scopus 로고
    • A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease
    • Pouclet H, Lebouvier T, Coron E et al. A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease. Neurobiol Dis 2012;45:305-9.
    • (2012) Neurobiol Dis , vol.45 , pp. 305-309
    • Pouclet, H.1    Lebouvier, T.2    Coron, E.3
  • 37
    • 84861692236 scopus 로고    scopus 로고
    • Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease
    • Shannon KM, Keshavarzian A, Mutlu E et al. Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease. Mov Disord 2012;27:709-15.
    • (2012) Mov Disord , vol.27 , pp. 709-715
    • Shannon, K.M.1    Keshavarzian, A.2    Mutlu, E.3
  • 38
    • 79951477375 scopus 로고    scopus 로고
    • Alpha-synuclein immunoreactivity in minor salivary gland biopsies of Parkinson's disease patients
    • Cersosimo MG, Perandones C, Micheli FE et al. Alpha-synuclein immunoreactivity in minor salivary gland biopsies of Parkinson's disease patients. Mov Disord 2011;26:188-90.
    • (2011) Mov Disord , vol.26 , pp. 188-190
    • Cersosimo, M.G.1    Perandones, C.2    Micheli, F.E.3
  • 39
    • 77953022918 scopus 로고    scopus 로고
    • Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease
    • Del Tredici K, Hawkes CH, Ghebremedhin E, Braak H. Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease. Acta Neuropathol 2010;119:703-13.
    • (2010) Acta Neuropathol , vol.119 , pp. 703-713
    • Del Tredici, K.1    Hawkes, C.H.2    Ghebremedhin, E.3    Braak, H.4
  • 40
    • 84872870323 scopus 로고    scopus 로고
    • Submandibular gland biopsy for the diagnosis of Parkinson disease
    • Beach TG, Adler CH, Dugger BN et al. Submandibular gland biopsy for the diagnosis of Parkinson disease. J Neuropathol Exp Neurol 2013;72:130-6.
    • (2013) J Neuropathol Exp Neurol , vol.72 , pp. 130-136
    • Beach, T.G.1    Adler, C.H.2    Dugger, B.N.3
  • 41
    • 84879904703 scopus 로고    scopus 로고
    • Parkinson disease affects peripheral sensory nerves in the pharynx
    • Mu L, Sobotka S, Chen J et al. Parkinson disease affects peripheral sensory nerves in the pharynx. J Neuropathol Exp Neurol 2013;72:614-23.
    • (2013) J Neuropathol Exp Neurol , vol.72 , pp. 614-623
    • Mu, L.1    Sobotka, S.2    Chen, J.3
  • 42
    • 0032926674 scopus 로고    scopus 로고
    • Lewy body-type degeneration in cardiac plexus in Parkinson's and incidental Lewy body diseases
    • Iwanaga K, Wakabayashi K, Yoshimoto M et al. Lewy body-type degeneration in cardiac plexus in Parkinson's and incidental Lewy body diseases. Neurology 1999;52:1269-71.
    • (1999) Neurology , vol.52 , pp. 1269-1271
    • Iwanaga, K.1    Wakabayashi, K.2    Yoshimoto, M.3
  • 43
    • 51649095345 scopus 로고    scopus 로고
    • Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease
    • Fujishiro H, Frigerio R, Burnett M et al. Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease. Mov Disord 2008;23:1085-92.
    • (2008) Mov Disord , vol.23 , pp. 1085-1092
    • Fujishiro, H.1    Frigerio, R.2    Burnett, M.3
  • 44
    • 39749123263 scopus 로고    scopus 로고
    • Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease
    • Orimo S, Uchihara T, Nakamura A et al. Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease. Brain 2008;131:642-50.
    • (2008) Brain , vol.131 , pp. 642-650
    • Orimo, S.1    Uchihara, T.2    Nakamura, A.3
  • 45
    • 54149109131 scopus 로고    scopus 로고
    • Cardiac sympathetic denervation in Parkinson's disease linked to SNCA duplication
    • Orimo S, Uchihara T, Nakamura A et al. Cardiac sympathetic denervation in Parkinson's disease linked to SNCA duplication. Acta Neuropathol 2008;116:575-7.
    • (2008) Acta Neuropathol , vol.116 , pp. 575-577
    • Orimo, S.1    Uchihara, T.2    Nakamura, A.3
  • 46
    • 71449128214 scopus 로고    scopus 로고
    • Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson's disease: an anatomical study
    • Ghebremedhin E, Del Tredici K, Langston JW, Braak H. Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson's disease: an anatomical study. Acta Neuropathol 2009;118:777-84.
    • (2009) Acta Neuropathol , vol.118 , pp. 777-784
    • Ghebremedhin, E.1    Del Tredici, K.2    Langston, J.W.3    Braak, H.4
  • 47
    • 33645833848 scopus 로고    scopus 로고
    • Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease
    • El-Agnaf OM, Salem SA, Paleologou KE et al. Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease. FASEB J 2006;20:419-25.
    • (2006) FASEB J , vol.20 , pp. 419-425
    • El-Agnaf, O.M.1    Salem, S.A.2    Paleologou, K.E.3
  • 48
    • 33748932543 scopus 로고    scopus 로고
    • The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy
    • Lee PH, Lee G, Park HJ, Bang OY, Joo IS, Huh K. The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy. J Neural Transm 2006;113:1435-9.
    • (2006) J Neural Transm , vol.113 , pp. 1435-1439
    • Lee, P.H.1    Lee, G.2    Park, H.J.3    Bang, O.Y.4    Joo, I.S.5    Huh, K.6
  • 49
    • 77949517145 scopus 로고    scopus 로고
    • Plasma alpha-synuclein in patients with Parkinson's disease with and without treatment
    • Duran R, Barrero FJ, Morales B, Luna JD, Ramirez M, Vives F. Plasma alpha-synuclein in patients with Parkinson's disease with and without treatment. Mov Disord 2010;25:489-93.
    • (2010) Mov Disord , vol.25 , pp. 489-493
    • Duran, R.1    Barrero, F.J.2    Morales, B.3    Luna, J.D.4    Ramirez, M.5    Vives, F.6
  • 50
    • 33947619003 scopus 로고    scopus 로고
    • Plasma alpha-synuclein is decreased in subjects with Parkinson's disease
    • Li QX, Mok SS, Laughton KM et al. Plasma alpha-synuclein is decreased in subjects with Parkinson's disease. Exp Neurol 2007;204:583-8.
    • (2007) Exp Neurol , vol.204 , pp. 583-588
    • Li, Q.X.1    Mok, S.S.2    Laughton, K.M.3
  • 51
    • 82655171636 scopus 로고    scopus 로고
    • Phosphorylated alpha-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease
    • Foulds PG, Mitchell JD, Parker A et al. Phosphorylated alpha-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease. FASEB J 2011;25:4127-37.
    • (2011) FASEB J , vol.25 , pp. 4127-4137
    • Foulds, P.G.1    Mitchell, J.D.2    Parker, A.3
  • 52
    • 78149489129 scopus 로고    scopus 로고
    • SNCA variant associated with Parkinson disease and plasma alpha-synuclein level
    • Mata IF, Shi M, Agarwal P et al. SNCA variant associated with Parkinson disease and plasma alpha-synuclein level. Arch Neurol 2010;67:1350-6.
    • (2010) Arch Neurol , vol.67 , pp. 1350-1356
    • Mata, I.F.1    Shi, M.2    Agarwal, P.3
  • 53
    • 0036669811 scopus 로고    scopus 로고
    • Platelha- and gamma-synucleins in Parkinson's disease and normal control subjects
    • Li QX, Campbell BC, McLean CA et al. Platelet alpha- and gamma-synucleins in Parkinson's disease and normal control subjects. J Alzheimers Dis 2002;4:309-15.
    • (2002) J Alzheimers Dis , vol.4 , pp. 309-315
    • Li, Q.X.1    Campbell, B.C.2    McLean, C.A.3
  • 54
    • 77950535153 scopus 로고    scopus 로고
    • Lymphomonocyte alpha-synuclein levels in aging and in Parkinson disease
    • Brighina L, Prigione A, Begni B et al. Lymphomonocyte alpha-synuclein levels in aging and in Parkinson disease. Neurobiol Aging 2010;31:884-5.
    • (2010) Neurobiol Aging , vol.31 , pp. 884-885
    • Brighina, L.1    Prigione, A.2    Begni, B.3
  • 55
    • 79958218653 scopus 로고    scopus 로고
    • Reduced content of alpha-synuclein in peripheral blood leukocytes of patients with LRRK2-associated Parkinson's disease
    • Pchelina SN, Emelyanov AK, Yakimovskii AF et al. Reduced content of alpha-synuclein in peripheral blood leukocytes of patients with LRRK2-associated Parkinson's disease. Bull Exp Biol Med 2011;150:679-81.
    • (2011) Bull Exp Biol Med , vol.150 , pp. 679-681
    • Pchelina, S.N.1    Emelyanov, A.K.2    Yakimovskii, A.F.3
  • 56
    • 84871664988 scopus 로고    scopus 로고
    • Alphalpha-synuclein levels in blood plasma from LRRK2 mutation carriers
    • Gorostidi A, Bergareche A, Ruiz-Martinez J et al. Alphalpha-synuclein levels in blood plasma from LRRK2 mutation carriers. PLoS ONE 2012;7:e52312.
    • (2012) PLoS ONE , vol.7
    • Gorostidi, A.1    Bergareche, A.2    Ruiz-Martinez, J.3
  • 57
    • 34247402084 scopus 로고    scopus 로고
    • Autoantibodies to alpha-synuclein in inherited Parkinson's disease
    • Papachroni KK, Ninkina N, Papapanagiotou A et al. Autoantibodies to alpha-synuclein in inherited Parkinson's disease. J Neurochem 2007;101:749-56.
    • (2007) J Neurochem , vol.101 , pp. 749-756
    • Papachroni, K.K.1    Ninkina, N.2    Papapanagiotou, A.3
  • 58
    • 79955554760 scopus 로고    scopus 로고
    • alpha-synuclein reactive antibodies as diagnostic biomarkers in blood sera of Parkinson's disease patients
    • Yanamandra K, Gruden MA, Casaite V, Meskys R, Forsgren L, Morozova-Roche LA. alpha-synuclein reactive antibodies as diagnostic biomarkers in blood sera of Parkinson's disease patients. PLoS ONE 2011;6:e18513.
    • (2011) PLoS ONE , vol.6
    • Yanamandra, K.1    Gruden, M.A.2    Casaite, V.3    Meskys, R.4    Forsgren, L.5    Morozova-Roche, L.A.6
  • 59
    • 84873641251 scopus 로고    scopus 로고
    • Naturally occurring alpha-synuclein autoantibody levels are lower in patients with Parkinson disease
    • Besong-Agbo D, Wolf E, Jessen F et al. Naturally occurring alpha-synuclein autoantibody levels are lower in patients with Parkinson disease. Neurology 2013;80:169-75.
    • (2013) Neurology , vol.80 , pp. 169-175
    • Besong-Agbo, D.1    Wolf, E.2    Jessen, F.3
  • 60
    • 84871324721 scopus 로고    scopus 로고
    • alpha-Synuclein and anti-alpha-synuclein antibodies in Parkinson's disease, atypical Parkinson syndromes, REM sleep behavior disorder, and healthy controls
    • Smith LM, Schiess MC, Coffey MP, Klaver AC, Loeffler DA. alpha-Synuclein and anti-alpha-synuclein antibodies in Parkinson's disease, atypical Parkinson syndromes, REM sleep behavior disorder, and healthy controls. PLoS ONE 2012;7:e52285.
    • (2012) PLoS ONE , vol.7
    • Smith, L.M.1    Schiess, M.C.2    Coffey, M.P.3    Klaver, A.C.4    Loeffler, D.A.5
  • 61
    • 2442700253 scopus 로고    scopus 로고
    • Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication
    • Miller DW, Hague SM, Clarimon J et al. Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication. Neurology 2004;62:1835-8.
    • (2004) Neurology , vol.62 , pp. 1835-1838
    • Miller, D.W.1    Hague, S.M.2    Clarimon, J.3
  • 62
    • 43249120160 scopus 로고    scopus 로고
    • Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain
    • Fuchs J, Tichopad A, Golub Y et al. Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain. FASEB J 2008;22:1327-34.
    • (2008) FASEB J , vol.22 , pp. 1327-1334
    • Fuchs, J.1    Tichopad, A.2    Golub, Y.3
  • 63
    • 9144266292 scopus 로고    scopus 로고
    • Alpha-synuclein haplotypes implicated in risk of Parkinson's disease
    • Tan EK, Chai A, Teo YY et al. Alpha-synuclein haplotypes implicated in risk of Parkinson's disease. Neurology 2004;62:128-31.
    • (2004) Neurology , vol.62 , pp. 128-131
    • Tan, E.K.1    Chai, A.2    Teo, Y.Y.3
  • 64
    • 0032575616 scopus 로고    scopus 로고
    • The native form of alpha-synuclein is not found in the cerebrospinal fluid of patients with Parkinson's disease or normal controls
    • Jakowec MW, Petzinger GM, Sastry S, Donaldson DM, McCormack A, Langston JW. The native form of alpha-synuclein is not found in the cerebrospinal fluid of patients with Parkinson's disease or normal controls. Neurosci Lett 1998;253:13-6.
    • (1998) Neurosci Lett , vol.253 , pp. 13-16
    • Jakowec, M.W.1    Petzinger, G.M.2    Sastry, S.3    Donaldson, D.M.4    McCormack, A.5    Langston, J.W.6
  • 66
    • 84871077687 scopus 로고    scopus 로고
    • Total CSF alpha-synuclein is lower in de novo Parkinson patients than in healthy subjects
    • Mollenhauer B, Trautmann E, Taylor P et al. Total CSF alpha-synuclein is lower in de novo Parkinson patients than in healthy subjects. Neurosci Lett 2013;532:44-8.
    • (2013) Neurosci Lett , vol.532 , pp. 44-48
    • Mollenhauer, B.1    Trautmann, E.2    Taylor, P.3
  • 67
    • 33748325848 scopus 로고    scopus 로고
    • Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease
    • Tokuda T, Salem SA, Allsop D et al. Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease. Biochem Biophys Res Commun 2006;349:162-6.
    • (2006) Biochem Biophys Res Commun , vol.349 , pp. 162-166
    • Tokuda, T.1    Salem, S.A.2    Allsop, D.3
  • 68
    • 77950223687 scopus 로고    scopus 로고
    • DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease
    • Hong Z, Shi M, Chung KA et al. DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease. Brain 2010;133:713-26.
    • (2010) Brain , vol.133 , pp. 713-726
    • Hong, Z.1    Shi, M.2    Chung, K.A.3
  • 69
    • 77954384099 scopus 로고    scopus 로고
    • Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease
    • Shi M, Zabetian CP, Hancock AM et al. Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease. Neurosci Lett 2010;480:78-82.
    • (2010) Neurosci Lett , vol.480 , pp. 78-82
    • Shi, M.1    Zabetian, C.P.2    Hancock, A.M.3
  • 70
    • 84868585835 scopus 로고    scopus 로고
    • Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders
    • Hall S, Ohrfelt A, Constantinescu R et al. Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders. Arch Neurol 2012;69:1445-52.
    • (2012) Arch Neurol , vol.69 , pp. 1445-1452
    • Hall, S.1    Ohrfelt, A.2    Constantinescu, R.3
  • 71
    • 0034674376 scopus 로고    scopus 로고
    • Full length alpha-synuclein is present in cerebrospinal fluid from Parkinson's disease and normal subjects
    • Borghi R, Marchese R, Negro A et al. Full length alpha-synuclein is present in cerebrospinal fluid from Parkinson's disease and normal subjects. Neurosci Lett 2000;287:65-7.
    • (2000) Neurosci Lett , vol.287 , pp. 65-67
    • Borghi, R.1    Marchese, R.2    Negro, A.3
  • 72
    • 58149469520 scopus 로고    scopus 로고
    • Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?
    • Ohrfelt A, Grognet P, Andreasen N et al. Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss? Neurosci Lett 2009;450:332-5.
    • (2009) Neurosci Lett , vol.450 , pp. 332-335
    • Ohrfelt, A.1    Grognet, P.2    Andreasen, N.3
  • 73
    • 84862916400 scopus 로고    scopus 로고
    • Elevated levels of alpha-synuclein oligomer in the cerebrospinal fluid of drug-naive patients with Parkinson's disease
    • Park MJ, Cheon SM, Bae HR, Kim SH, Kim JW. Elevated levels of alpha-synuclein oligomer in the cerebrospinal fluid of drug-naive patients with Parkinson's disease. J Clin Neurol 2011;7:215-22.
    • (2011) J Clin Neurol , vol.7 , pp. 215-222
    • Park, M.J.1    Cheon, S.M.2    Bae, H.R.3    Kim, S.H.4    Kim, J.W.5
  • 74
    • 81955167983 scopus 로고    scopus 로고
    • Post mortem cerebrospinal fluid alpha-synuclein levels are raised in multiple system atrophy and distinguish this from the other alpha-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies
    • Foulds PG, Yokota O, Thurston A et al. Post mortem cerebrospinal fluid alpha-synuclein levels are raised in multiple system atrophy and distinguish this from the other alpha-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies. Neurobiol Dis 2012;45:188-95.
    • (2012) Neurobiol Dis , vol.45 , pp. 188-195
    • Foulds, P.G.1    Yokota, O.2    Thurston, A.3
  • 75
    • 79960613150 scopus 로고    scopus 로고
    • Cerebrospinal fluid Tau/alpha-synuclein ratio in Parkinson's disease and degenerative dementias
    • Parnetti L, Chiasserini D, Bellomo G et al. Cerebrospinal fluid Tau/alpha-synuclein ratio in Parkinson's disease and degenerative dementias. Mov Disord 2011;26:1428-35.
    • (2011) Mov Disord , vol.26 , pp. 1428-1435
    • Parnetti, L.1    Chiasserini, D.2    Bellomo, G.3
  • 76
    • 79958233724 scopus 로고    scopus 로고
    • Salivary alpha-synuclein and DJ-1: potential biomarkers for Parkinson's disease
    • Devic I, Hwang H, Edgar JS et al. Salivary alpha-synuclein and DJ-1: potential biomarkers for Parkinson's disease. Brain 2011;134:e178.
    • (2011) Brain , vol.134
    • Devic, I.1    Hwang, H.2    Edgar, J.S.3
  • 77
    • 84860484992 scopus 로고    scopus 로고
    • Targeting alpha-synuclein for the treatment of Parkinson's disease
    • Rohn TT. Targeting alpha-synuclein for the treatment of Parkinson's disease. CNS Neurol Disord Drug Targets 2012;11:174-9.
    • (2012) CNS Neurol Disord Drug Targets , vol.11 , pp. 174-179
    • Rohn, T.T.1
  • 78
    • 84858290153 scopus 로고    scopus 로고
    • Impaired olfaction and other prodromal features in the Parkinson At-Risk Syndrome Study
    • Siderowf A, Jennings D, Eberly S et al. Impaired olfaction and other prodromal features in the Parkinson At-Risk Syndrome Study. Mov Disord 2012;27:406-12.
    • (2012) Mov Disord , vol.27 , pp. 406-412
    • Siderowf, A.1    Jennings, D.2    Eberly, S.3
  • 79
    • 69549116777 scopus 로고    scopus 로고
    • Formation and development of Lewy pathology: a critical update
    • Jellinger KA. Formation and development of Lewy pathology: a critical update. J Neurol 2009;256(Suppl 3):270-9.
    • (2009) J Neurol , vol.256 , Issue.SUPPL. 3 , pp. 270-279
    • Jellinger, K.A.1
  • 80
    • 77953417539 scopus 로고    scopus 로고
    • Basic mechanisms of neurodegeneration: a critical update
    • Jellinger KA. Basic mechanisms of neurodegeneration: a critical update. J Cell Mol Med 2010;14:457-87.
    • (2010) J Cell Mol Med , vol.14 , pp. 457-487
    • Jellinger, K.A.1
  • 81
    • 80855144132 scopus 로고    scopus 로고
    • Incidental Lewy body disease: electrophysiological findings suggesting pre-clinical Lewy body disorders
    • Caviness JN, Adler CH, Hentz JG et al. Incidental Lewy body disease: electrophysiological findings suggesting pre-clinical Lewy body disorders. Clin Neurophysiol 2011;122:2426-32.
    • (2011) Clin Neurophysiol , vol.122 , pp. 2426-2432
    • Caviness, J.N.1    Adler, C.H.2    Hentz, J.G.3
  • 82
    • 23644461006 scopus 로고    scopus 로고
    • Lewy bodies in Parkinson's disease: protectors or perpetrators?
    • Harrower TP, Michell AW, Barker RA. Lewy bodies in Parkinson's disease: protectors or perpetrators? Exp Neurol 2005;195:1-6.
    • (2005) Exp Neurol , vol.195 , pp. 1-6
    • Harrower, T.P.1    Michell, A.W.2    Barker, R.A.3
  • 83
    • 84871477116 scopus 로고    scopus 로고
    • Alpha-synuclein aggregates in epicardial fat tissue in living subjects without parkinsonism
    • discussion 27.
    • Navarro-Otano J, Gelpi E, Mestres CA et al. Alpha-synuclein aggregates in epicardial fat tissue in living subjects without parkinsonism. Parkinsonism Relat Disord 2013;19:27-31; discussion 27.
    • (2013) Parkinsonism Relat Disord , vol.19 , pp. 27-31
    • Navarro-Otano, J.1    Gelpi, E.2    Mestres, C.A.3
  • 84
    • 84876333515 scopus 로고    scopus 로고
    • alpha-Synuclein pathology is related to postoperative delirium in patients undergoing gastrectomy
    • Sunwoo MK, Hong JY, Choi J, Park HJ, Kim SH, Lee PH. alpha-Synuclein pathology is related to postoperative delirium in patients undergoing gastrectomy. Neurology 2013;80:810-3.
    • (2013) Neurology , vol.80 , pp. 810-813
    • Sunwoo, M.K.1    Hong, J.Y.2    Choi, J.3    Park, H.J.4    Kim, S.H.5    Lee, P.H.6
  • 85
    • 34249907298 scopus 로고    scopus 로고
    • Do alpha-synuclein aggregates in autonomic plexuses predate Lewy body disorders?: a cohort study
    • Minguez-Castellanos A, Chamorro CE, Escamilla-Sevilla F et al. Do alpha-synuclein aggregates in autonomic plexuses predate Lewy body disorders?: a cohort study. Neurology 2007;68:2012-8.
    • (2007) Neurology , vol.68 , pp. 2012-2018
    • Minguez-Castellanos, A.1    Chamorro, C.E.2    Escamilla-Sevilla, F.3
  • 86
    • 0014525843 scopus 로고
    • Concentric hyaline intraneuronal inclusions of Lewy type in the brains of elderly persons (50 incidental cases): relationship to parkinsonism
    • Forno LS. Concentric hyaline intraneuronal inclusions of Lewy type in the brains of elderly persons (50 incidental cases): relationship to parkinsonism. J Am Geriatr Soc 1969;17:557-75.
    • (1969) J Am Geriatr Soc , vol.17 , pp. 557-575
    • Forno, L.S.1
  • 87
    • 49049114460 scopus 로고    scopus 로고
    • Evaluation of alpha-synuclein immunohistochemical methods used by invited experts
    • Beach TG, White CL, Hamilton RL et al. Evaluation of alpha-synuclein immunohistochemical methods used by invited experts. Acta Neuropathol 2008;116:277-88.
    • (2008) Acta Neuropathol , vol.116 , pp. 277-288
    • Beach, T.G.1    White, C.L.2    Hamilton, R.L.3
  • 88
    • 37849028683 scopus 로고    scopus 로고
    • Red blood cells are the major source of alpha-synuclein in blood
    • Barbour R, Kling K, Anderson JP et al. Red blood cells are the major source of alpha-synuclein in blood. Neurodegener Dis 2008;5:55-9.
    • (2008) Neurodegener Dis , vol.5 , pp. 55-59
    • Barbour, R.1    Kling, K.2    Anderson, J.P.3
  • 89
    • 84863229691 scopus 로고    scopus 로고
    • Accumulation of toxic alpha-synuclein oligomer within endoplasmic reticulum occurs in alpha-synucleinopathy in vivo
    • Colla E, Jensen PH, Pletnikova O, Troncoso JC, Glabe C, Lee MK. Accumulation of toxic alpha-synuclein oligomer within endoplasmic reticulum occurs in alpha-synucleinopathy in vivo. J Neurosci 2012;32:3301-5.
    • (2012) J Neurosci , vol.32 , pp. 3301-3305
    • Colla, E.1    Jensen, P.H.2    Pletnikova, O.3    Troncoso, J.C.4    Glabe, C.5    Lee, M.K.6
  • 90
    • 77952648551 scopus 로고    scopus 로고
    • Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival
    • Emmanouilidou E, Melachroinou K, Roumeliotis T et al. Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival. J Neurosci 2010;30:6838-51.
    • (2010) J Neurosci , vol.30 , pp. 6838-6851
    • Emmanouilidou, E.1    Melachroinou, K.2    Roumeliotis, T.3
  • 91
    • 79953283868 scopus 로고    scopus 로고
    • Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression
    • Shi M, Bradner J, Hancock AM et al. Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression. Ann Neurol 2011;69:570-80.
    • (2011) Ann Neurol , vol.69 , pp. 570-580
    • Shi, M.1    Bradner, J.2    Hancock, A.M.3
  • 92
    • 33646112656 scopus 로고    scopus 로고
    • Comparative study of commercially available anti-alpha-synuclein antibodies
    • Croisier E, MRes DE, Deprez M et al. Comparative study of commercially available anti-alpha-synuclein antibodies. Neuropathol Appl Neurobiol 2006;32:351-6.
    • (2006) Neuropathol Appl Neurobiol , vol.32 , pp. 351-356
    • Croisier, E.1    MRes, D.E.2    Deprez, M.3


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