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Volumn 18, Issue 3-4, 2013, Pages 155-162

Biomarkers of Parkinson's disease: Current status and future perspectives

Author keywords

[No Author keywords available]

Indexed keywords

6 FLUORODOPA F 18; ALPHA SYNUCLEIN; AROMATIC LEVO AMINO ACID DECARBOXYLASE; BIOCHEMICAL MARKER; BIOLOGICAL MARKER; DJ 1 PROTEIN; DOPAMINE TRANSPORTER; TAU PROTEIN; VESICULAR MONOAMINE TRANSPORTER 2;

EID: 84873094123     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2012.09.001     Document Type: Review
Times cited : (48)

References (87)
  • 1
    • 0037333666 scopus 로고    scopus 로고
    • Staging of brain pathology related to sporadic Parkinson's disease
    • H. Braak Staging of brain pathology related to sporadic Parkinson's disease Neurobiol. Aging 24 2003 197 211
    • (2003) Neurobiol. Aging , vol.24 , pp. 197-211
    • Braak, H.1
  • 2
    • 0032950701 scopus 로고    scopus 로고
    • Accuracy of diagnosis in patients with presumed Parkinson's disease
    • J. Meara Accuracy of diagnosis in patients with presumed Parkinson's disease Age Ageing 28 1999 99 102
    • (1999) Age Ageing , vol.28 , pp. 99-102
    • Meara, J.1
  • 4
    • 0025954066 scopus 로고
    • Ageing and Parkinson's disease: Substantia nigra regional selectivity
    • J.M. Fearnley, and A.J. Lees Ageing and Parkinson's disease: substantia nigra regional selectivity Brain 114 1991 2283 2301
    • (1991) Brain , vol.114 , pp. 2283-2301
    • Fearnley, J.M.1    Lees, A.J.2
  • 5
    • 0028786098 scopus 로고
    • 18F] dopa PET findings in early Parkinson's disease
    • 18F] dopa PET findings in early Parkinson's disease J. Neurol. Neurosurg. Psychiatry 59 1995 597 600
    • (1995) J. Neurol. Neurosurg. Psychiatry , vol.59 , pp. 597-600
    • Morrish, P.K.1
  • 6
    • 0025185168 scopus 로고
    • The relationship between locomotor disability, autonomic dysfunction, and the integrity of the striatal dopaminergic system in patients with multiple system atrophy, pure autonomic failure, and Parkinson's disease, studied with PET
    • D.J. Brooks The relationship between locomotor disability, autonomic dysfunction, and the integrity of the striatal dopaminergic system in patients with multiple system atrophy, pure autonomic failure, and Parkinson's disease, studied with PET Brain 113 1990 1539 1552
    • (1990) Brain , vol.113 , pp. 1539-1552
    • Brooks, D.J.1
  • 7
    • 1842290405 scopus 로고    scopus 로고
    • Which clinical sign of Parkinson's disease best reflects the nigrostriatal lesion?
    • F.J. Vingerhoets Which clinical sign of Parkinson's disease best reflects the nigrostriatal lesion? Ann. Neurol. 41 1997 58 64
    • (1997) Ann. Neurol. , vol.41 , pp. 58-64
    • Vingerhoets, F.J.1
  • 8
    • 0036220185 scopus 로고    scopus 로고
    • Dopaminergic function and dopamine transporter binding assessed with positron emission tomography in Parkinson disease
    • M.J. Ribeiro Dopaminergic function and dopamine transporter binding assessed with positron emission tomography in Parkinson disease Arch. Neurol. 59 2002 580 586
    • (2002) Arch. Neurol. , vol.59 , pp. 580-586
    • Ribeiro, M.J.1
  • 9
    • 82755197075 scopus 로고    scopus 로고
    • Imaging biomarkers in Parkinson's disease
    • D.J. Brooks, and N. Pavese Imaging biomarkers in Parkinson's disease Prog. Neurobiol. 95 2011 614 628
    • (2011) Prog. Neurobiol. , vol.95 , pp. 614-628
    • Brooks, D.J.1    Pavese, N.2
  • 10
    • 0034029152 scopus 로고    scopus 로고
    • 123I]-FP-CIT study group
    • 123I]-FP-CIT study group Mov. Disord. 15 2000 503 510
    • (2000) Mov. Disord. , vol.15 , pp. 503-510
    • Benamer, T.S.1
  • 11
    • 33750713354 scopus 로고    scopus 로고
    • Two-year follow-up in 150 consecutive cases with normal dopamine transporter imaging
    • V.L. Marshall Two-year follow-up in 150 consecutive cases with normal dopamine transporter imaging Nucl. Med. Commun. 27 2006 933 937
    • (2006) Nucl. Med. Commun. , vol.27 , pp. 933-937
    • Marshall, V.L.1
  • 12
    • 33847662099 scopus 로고    scopus 로고
    • 18F-FP-CIT PET imaging and SPM analysis of dopamine transporters in Parkinson's disease in various Hoehn & Yahr stages
    • 18F-FP-CIT PET imaging and SPM analysis of dopamine transporters in Parkinson's disease in various Hoehn & Yahr stages J. Neurol. 254 2007 185 190
    • (2007) J. Neurol. , vol.254 , pp. 185-190
    • Wang, J.1
  • 13
    • 19744378296 scopus 로고    scopus 로고
    • Levodopa and the progression of Parkinson's disease
    • S. Fahn Levodopa and the progression of Parkinson's disease N. Engl. J. Med. 351 2004 2498 2508
    • (2004) N. Engl. J. Med. , vol.351 , pp. 2498-2508
    • Fahn, S.1
  • 14
    • 33747348188 scopus 로고    scopus 로고
    • Positron emission tomography of monoaminergic vesicular binding in aging and Parkinson disease
    • N.I. Bohnen Positron emission tomography of monoaminergic vesicular binding in aging and Parkinson disease J. Cereb. Blood Flow Metab. 26 2006 1198 1212
    • (2006) J. Cereb. Blood Flow Metab. , vol.26 , pp. 1198-1212
    • Bohnen, N.I.1
  • 15
    • 18844471416 scopus 로고    scopus 로고
    • In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson's disease
    • C.S. Lee In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson's disease Ann. Neurol. 47 2000 493 503
    • (2000) Ann. Neurol. , vol.47 , pp. 493-503
    • Lee, C.S.1
  • 16
    • 75749084489 scopus 로고    scopus 로고
    • In vivo measurement of vesicular monoamine transporter type 2 density in Parkinson disease with (18)F-AV-133
    • N. Okamura In vivo measurement of vesicular monoamine transporter type 2 density in Parkinson disease with (18)F-AV-133 J. Nucl. Med. 51 2010 223 228
    • (2010) J. Nucl. Med. , vol.51 , pp. 223-228
    • Okamura, N.1
  • 17
    • 84856229179 scopus 로고    scopus 로고
    • Do we still need to develop new imaging biomarkers of dopamine denervation for Parkinson's disease?
    • N. Pavese Do we still need to develop new imaging biomarkers of dopamine denervation for Parkinson's disease? Exp. Neurol. 233 2011 118 120
    • (2011) Exp. Neurol. , vol.233 , pp. 118-120
    • Pavese, N.1
  • 18
    • 4043084987 scopus 로고    scopus 로고
    • 123I) beta-CIT and single-photon emission computed tomographic imaging vs clinical evaluation in Parkinsonian syndrome: Unmasking an early diagnosis
    • 123I) beta-CIT and single-photon emission computed tomographic imaging vs clinical evaluation in Parkinsonian syndrome: unmasking an early diagnosis Arch. Neurol. 61 2004 1224 1229
    • (2004) Arch. Neurol. , vol.61 , pp. 1224-1229
    • Jennings, D.L.1
  • 19
    • 77958492669 scopus 로고    scopus 로고
    • (18)F-FECNT: Validation as PET dopamine transporter ligand in parkinsonism
    • G. Masilamoni (18)F-FECNT: validation as PET dopamine transporter ligand in parkinsonism Exp. Neurol. 226 2010 265 273
    • (2010) Exp. Neurol. , vol.226 , pp. 265-273
    • Masilamoni, G.1
  • 20
    • 0027176890 scopus 로고
    • PET study on striatal dopamine D2 receptor changes during the progression of early Parkinson's disease
    • J.O. Rinne PET study on striatal dopamine D2 receptor changes during the progression of early Parkinson's disease Mov. Disord. 8 1993 134 138
    • (1993) Mov. Disord. , vol.8 , pp. 134-138
    • Rinne, J.O.1
  • 21
    • 17844398549 scopus 로고    scopus 로고
    • 123I-IBZM SPECT for the diagnosis of parkinsonian syndromes: Study on 72 patients
    • 123I-IBZM SPECT for the diagnosis of parkinsonian syndromes: study on 72 patients J. Neural. Transm. 112 2005 677 692
    • (2005) J. Neural. Transm. , vol.112 , pp. 677-692
    • Plotkin, M.1
  • 22
    • 0031467450 scopus 로고    scopus 로고
    • Complementary PET studies of striatal neuronal function in the differential diagnosis between multiple system atrophy and Parkinson's disease
    • A. Antonini Complementary PET studies of striatal neuronal function in the differential diagnosis between multiple system atrophy and Parkinson's disease Brain 120 1997 2187 2195
    • (1997) Brain , vol.120 , pp. 2187-2195
    • Antonini, A.1
  • 23
    • 0028094841 scopus 로고
    • The metabolic topography of parkinsonism
    • D. Eidelberg The metabolic topography of parkinsonism J. Cereb. Blood Flow Metab. 14 1994 783 801
    • (1994) J. Cereb. Blood Flow Metab. , vol.14 , pp. 783-801
    • Eidelberg, D.1
  • 24
    • 76249130565 scopus 로고    scopus 로고
    • Differential diagnosis of parkinsonism: A metabolic imaging study using pattern analysis
    • C.C. Tang Differential diagnosis of parkinsonism: a metabolic imaging study using pattern analysis Lancet Neurol. 9 2010 149 158
    • (2010) Lancet Neurol. , vol.9 , pp. 149-158
    • Tang, C.C.1
  • 25
    • 75749128636 scopus 로고    scopus 로고
    • Abnormalities in metabolic network activity precede the onset of motor symptoms in Parkinson's disease
    • C.C. Tang Abnormalities in metabolic network activity precede the onset of motor symptoms in Parkinson's disease J. Neurosci. 30 2010 1049 1056
    • (2010) J. Neurosci. , vol.30 , pp. 1049-1056
    • Tang, C.C.1
  • 26
    • 33847188067 scopus 로고    scopus 로고
    • Abnormal metabolic network activity in Parkinson's disease: Test-retest reproducibility
    • Y. Ma Abnormal metabolic network activity in Parkinson's disease: test-retest reproducibility J. Cereb. Blood Flow Metab. 27 2007 597 605
    • (2007) J. Cereb. Blood Flow Metab. , vol.27 , pp. 597-605
    • Ma, Y.1
  • 27
    • 33749468221 scopus 로고    scopus 로고
    • Network modulation in the treatment of Parkinson's disease
    • K. Asanuma Network modulation in the treatment of Parkinson's disease Brain 129 2006 2667 2678
    • (2006) Brain , vol.129 , pp. 2667-2678
    • Asanuma, K.1
  • 28
    • 37349011012 scopus 로고    scopus 로고
    • Modulation of metabolic brain networks after subthalamic gene therapy for Parkinson's disease
    • A. Feigin Modulation of metabolic brain networks after subthalamic gene therapy for Parkinson's disease Proc. Natl. Acad. Sci. U.S.A. 104 2007 19559 19564
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 19559-19564
    • Feigin, A.1
  • 29
    • 33645078446 scopus 로고    scopus 로고
    • Dementia in Parkinson disease: Functional imaging of cholinergic and dopaminergic pathways
    • R. Hilker Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathways Neurology 65 2005 1716 1722
    • (2005) Neurology , vol.65 , pp. 1716-1722
    • Hilker, R.1
  • 30
    • 42049123661 scopus 로고    scopus 로고
    • Midbrain iron content in early Parkinson disease: A potential biomarker of disease status
    • W.R. Martin Midbrain iron content in early Parkinson disease: a potential biomarker of disease status Neurology 70 2008 1411 1417
    • (2008) Neurology , vol.70 , pp. 1411-1417
    • Martin, W.R.1
  • 31
    • 31544440460 scopus 로고    scopus 로고
    • Voxel-wise analysis of diffusion weighted imaging reveals disruption of the olfactory tract in Parkinson's disease
    • C. Scherfler Voxel-wise analysis of diffusion weighted imaging reveals disruption of the olfactory tract in Parkinson's disease Brain 129 2006 538 542
    • (2006) Brain , vol.129 , pp. 538-542
    • Scherfler, C.1
  • 32
    • 67449123263 scopus 로고    scopus 로고
    • High-resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease
    • D.E. Vaillancourt High-resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease Neurology 72 2009 1378 1384
    • (2009) Neurology , vol.72 , pp. 1378-1384
    • Vaillancourt, D.E.1
  • 33
    • 36849068879 scopus 로고    scopus 로고
    • Case control study of diffusion tensor imaging in Parkinson's disease
    • L.L. Chan Case control study of diffusion tensor imaging in Parkinson's disease J. Neurol. Neurosurg. Psychiatry 78 2007 1383 1386
    • (2007) J. Neurol. Neurosurg. Psychiatry , vol.78 , pp. 1383-1386
    • Chan, L.L.1
  • 34
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    • M.H. Polymeropoulos Mutation in the alpha-synuclein gene identified in families with Parkinson's disease Science 276 1997 2045 2047
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1
  • 35
    • 37849012348 scopus 로고    scopus 로고
    • Alpha-Synuclein gene duplication is present in sporadic Parkinson disease
    • T.B. Ahn alpha-Synuclein gene duplication is present in sporadic Parkinson disease Neurology 70 2008 43 49
    • (2008) Neurology , vol.70 , pp. 43-49
    • Ahn, T.B.1
  • 36
    • 33748325848 scopus 로고    scopus 로고
    • Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease
    • T. Tokuda Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease Biochem. Biophys. Res. Commun. 349 2006 162 166
    • (2006) Biochem. Biophys. Res. Commun. , vol.349 , pp. 162-166
    • Tokuda, T.1
  • 37
    • 49449105990 scopus 로고    scopus 로고
    • Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration
    • B. Mollenhauer Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration Exp. Neurol. 213 2008 315 325
    • (2008) Exp. Neurol. , vol.213 , pp. 315-325
    • Mollenhauer, B.1
  • 38
    • 77950223687 scopus 로고    scopus 로고
    • DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease
    • Z. Hong DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease Brain 133 2010 713 726
    • (2010) Brain , vol.133 , pp. 713-726
    • Hong, Z.1
  • 39
    • 79951720856 scopus 로고    scopus 로고
    • α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: A cohort study
    • B. Mollenhauer α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study Lancet Neurol. 10 2011 230 240
    • (2011) Lancet Neurol. , vol.10 , pp. 230-240
    • Mollenhauer, B.1
  • 40
    • 78649990079 scopus 로고    scopus 로고
    • Detection of elevated levels of {alpha}-synuclein oligomers in CSF from patients with Parkinson disease
    • T. Tokuda Detection of elevated levels of {alpha}-synuclein oligomers in CSF from patients with Parkinson disease Neurology 75 2010 1766 1770
    • (2010) Neurology , vol.75 , pp. 1766-1770
    • Tokuda, T.1
  • 41
    • 33645833848 scopus 로고    scopus 로고
    • Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease
    • O.M. El-Agnaf Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease FASEB J. 20 2006 419 425
    • (2006) FASEB J. , vol.20 , pp. 419-425
    • El-Agnaf, O.M.1
  • 42
    • 84863164994 scopus 로고    scopus 로고
    • Phosphorylated α-synuclein in Parkinson's disease
    • Y. Wang Phosphorylated α-synuclein in Parkinson's disease Sci. Transl. Med. 4 2012 121ra120
    • (2012) Sci. Transl. Med. , vol.4
    • Wang, Y.1
  • 43
    • 33646833404 scopus 로고    scopus 로고
    • Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson's disease
    • M. Waragai Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson's disease Biochem. Biophys. Res. Commun. 345 2006 967 972
    • (2006) Biochem. Biophys. Res. Commun. , vol.345 , pp. 967-972
    • Waragai, M.1
  • 44
    • 34548645355 scopus 로고    scopus 로고
    • Plasma levels of DJ-1 as a possible marker for progression of sporadic Parkinson's disease
    • M. Waragai Plasma levels of DJ-1 as a possible marker for progression of sporadic Parkinson's disease Neurosci. Lett. 425 2007 18 22
    • (2007) Neurosci. Lett. , vol.425 , pp. 18-22
    • Waragai, M.1
  • 45
    • 77954384099 scopus 로고    scopus 로고
    • Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease
    • M. Shi Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease Neurosci. Lett. 480 2010 78 82
    • (2010) Neurosci. Lett. , vol.480 , pp. 78-82
    • Shi, M.1
  • 46
    • 58149100151 scopus 로고    scopus 로고
    • Genomewide association study for susceptibility genes contributing to familial Parkinson disease
    • N. Pankratz Genomewide association study for susceptibility genes contributing to familial Parkinson disease Hum. Genet. 124 2009 593 605
    • (2009) Hum. Genet. , vol.124 , pp. 593-605
    • Pankratz, N.1
  • 47
    • 70549084415 scopus 로고    scopus 로고
    • Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
    • W. Satake Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease Nat. Genet. 41 2009 1303 1307
    • (2009) Nat. Genet. , vol.41 , pp. 1303-1307
    • Satake, W.1
  • 48
    • 78349237282 scopus 로고    scopus 로고
    • CSF Aβ(42) and tau in Parkinson's disease with cognitive impairment
    • T.J. Montine CSF Aβ(42) and tau in Parkinson's disease with cognitive impairment Mov. Disord. 25 2010 2682 2685
    • (2010) Mov. Disord. , vol.25 , pp. 2682-2685
    • Montine, T.J.1
  • 49
    • 79953283868 scopus 로고    scopus 로고
    • Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression
    • M. Shi Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression Ann. Neurol. 69 2011 570 580
    • (2011) Ann. Neurol. , vol.69 , pp. 570-580
    • Shi, M.1
  • 50
    • 77958071837 scopus 로고    scopus 로고
    • CSF amyloid-beta and tau proteins, and cognitive performance, in early and untreated Parkinson's disease: The Norwegian ParkWest study
    • G. Alves CSF amyloid-beta and tau proteins, and cognitive performance, in early and untreated Parkinson's disease: the Norwegian ParkWest study J. Neurol. Neurosurg. Psychiatry 81 2010 1080 1086
    • (2010) J. Neurol. Neurosurg. Psychiatry , vol.81 , pp. 1080-1086
    • Alves, G.1
  • 51
    • 80054115170 scopus 로고    scopus 로고
    • Amyloid-β and τ-biomarkers in Parkinson's disease-dementia
    • M. Buongiorno Amyloid-β and τ-biomarkers in Parkinson's disease-dementia J. Neurol. Sci. 310 2011 25 30
    • (2011) J. Neurol. Sci. , vol.310 , pp. 25-30
    • Buongiorno, M.1
  • 52
    • 38849159145 scopus 로고    scopus 로고
    • Metabolomic profiling to develop blood biomarkers for Parkinson's disease
    • M. Bogdanov Metabolomic profiling to develop blood biomarkers for Parkinson's disease Brain 131 2008 389 396
    • (2008) Brain , vol.131 , pp. 389-396
    • Bogdanov, M.1
  • 53
    • 79951492876 scopus 로고    scopus 로고
    • Reduced but not oxidized cerebrospinal fluid glutathione levels are lowered in Lewy body diseases
    • W. Maetzler Reduced but not oxidized cerebrospinal fluid glutathione levels are lowered in Lewy body diseases Mov. Disord. 26 2011 176 181
    • (2011) Mov. Disord. , vol.26 , pp. 176-181
    • Maetzler, W.1
  • 54
    • 70449552850 scopus 로고    scopus 로고
    • Metabolomic profiling in LRRK2-related Parkinson's disease
    • K.K. Johansen Metabolomic profiling in LRRK2-related Parkinson's disease PLoS One 4 2009 E7551
    • (2009) PLoS One , vol.4 , pp. 7551
    • Johansen, K.K.1
  • 55
    • 73549111772 scopus 로고    scopus 로고
    • Urate as a predictor of the rate of clinical decline in Parkinson disease
    • A. Ascherio Urate as a predictor of the rate of clinical decline in Parkinson disease Arch. Neurol. 66 2009 1460 1468
    • (2009) Arch. Neurol. , vol.66 , pp. 1460-1468
    • Ascherio, A.1
  • 56
    • 84863161476 scopus 로고    scopus 로고
    • Association of serum uric acid levels with the progression of Parkinson's disease in Chinese patients
    • C.C. Sun Association of serum uric acid levels with the progression of Parkinson's disease in Chinese patients Chin. Med. J. (Engl.) 125 2012 583 587
    • (2012) Chin. Med. J. (Engl.) , vol.125 , pp. 583-587
    • Sun, C.C.1
  • 57
    • 68949110561 scopus 로고    scopus 로고
    • Metabolic profiling of Parkinson's disease: Evidence of biomarker from gene expression analysis and rapid neural network detection
    • S.S. Ahmed Metabolic profiling of Parkinson's disease: evidence of biomarker from gene expression analysis and rapid neural network detection J. Biomed. Sci. 16 2009 63
    • (2009) J. Biomed. Sci. , vol.16 , pp. 63
    • Ahmed, S.S.1
  • 58
    • 33846465545 scopus 로고    scopus 로고
    • Molecular markers of early Parkinson's disease based on gene expression in blood
    • C.R. Scherzer Molecular markers of early Parkinson's disease based on gene expression in blood Proc. Natl. Acad. Sci. U.S.A. 104 2007 955 960
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 955-960
    • Scherzer, C.R.1
  • 59
    • 77950324877 scopus 로고    scopus 로고
    • Expression analysis of suppression of tumorigenicity 13 gene in patients with Parkinson's disease
    • M.I. Shadrina Expression analysis of suppression of tumorigenicity 13 gene in patients with Parkinson's disease Neurosci. Lett. 473 2010 257 259
    • (2010) Neurosci. Lett. , vol.473 , pp. 257-259
    • Shadrina, M.I.1
  • 60
    • 80052384920 scopus 로고    scopus 로고
    • Expression of GSK3B gene in peripheral blood in patient with Parkinson's disease
    • E.V. Filatova Expression of GSK3B gene in peripheral blood in patient with Parkinson's disease Mol. Biol. 45 2011 459 463
    • (2011) Mol. Biol. , vol.45 , pp. 459-463
    • Filatova, E.V.1
  • 61
    • 78651237174 scopus 로고    scopus 로고
    • Pilot study: Peripheral biomarkers for diagnosing sporadic Parkinson's disease
    • E. Grünblatt Pilot study: peripheral biomarkers for diagnosing sporadic Parkinson's disease J. Neural. Transm. 117 2010 1387 1393
    • (2010) J. Neural. Transm. , vol.117 , pp. 1387-1393
    • Grünblatt, E.1
  • 62
    • 84861651595 scopus 로고    scopus 로고
    • A molecular signature in blood identifies early Parkinson's disease
    • L. Molochnikov A molecular signature in blood identifies early Parkinson's disease Mol. Neurodegener. 7 2012 26
    • (2012) Mol. Neurodegener. , vol.7 , pp. 26
    • Molochnikov, L.1
  • 63
    • 33747409456 scopus 로고    scopus 로고
    • Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disorders
    • F. Abdi Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disorders J. Alzheimers Dis. 9 2006 293 348
    • (2006) J. Alzheimers Dis. , vol.9 , pp. 293-348
    • Abdi, F.1
  • 64
    • 42949119345 scopus 로고    scopus 로고
    • CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases
    • J. Zhang CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases Am. J. Clin. Pathol. 129 2008 526 529
    • (2008) Am. J. Clin. Pathol. , vol.129 , pp. 526-529
    • Zhang, J.1
  • 65
    • 57949085678 scopus 로고    scopus 로고
    • Identification of differentially displayed proteins in cerebrospinal fluid of Parkinson's disease patients: A proteomic approach
    • A. Sinha Identification of differentially displayed proteins in cerebrospinal fluid of Parkinson's disease patients: a proteomic approach Clin. Chim. Acta 400 2009 14 20
    • (2009) Clin. Chim. Acta , vol.400 , pp. 14-20
    • Sinha, A.1
  • 66
    • 78649372310 scopus 로고    scopus 로고
    • Tetranectin and apolipoprotein A-I in cerebrospinal fluid as potential biomarkers for Parkinson's disease
    • E.S. Wang Tetranectin and apolipoprotein A-I in cerebrospinal fluid as potential biomarkers for Parkinson's disease Acta Neurol. Scand. 122 2010 350 359
    • (2010) Acta Neurol. Scand. , vol.122 , pp. 350-359
    • Wang, E.S.1
  • 67
    • 0034935922 scopus 로고    scopus 로고
    • Echogenicity of the substantia nigra in Parkinson's disease and its relation to clinical findings
    • D. Berg Echogenicity of the substantia nigra in Parkinson's disease and its relation to clinical findings J. Neurol. 248 2001 684 689
    • (2001) J. Neurol. , vol.248 , pp. 684-689
    • Berg, D.1
  • 68
    • 41949137200 scopus 로고    scopus 로고
    • The specificity and sensitivity of transcranial ultrasound in the differential diagnosis of Parkinson's disease: A prospective blinded study
    • A. Gaenslen The specificity and sensitivity of transcranial ultrasound in the differential diagnosis of Parkinson's disease: a prospective blinded study Lancet Neurol. 7 2008 417 424
    • (2008) Lancet Neurol. , vol.7 , pp. 417-424
    • Gaenslen, A.1
  • 69
    • 77957970097 scopus 로고    scopus 로고
    • Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: A prospective study [corrected]
    • A. Iranzo Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study [corrected] Lancet Neurol. 9 2010 1070 1077
    • (2010) Lancet Neurol. , vol.9 , pp. 1070-1077
    • Iranzo, A.1
  • 70
    • 79960173762 scopus 로고    scopus 로고
    • Enlarged substantia nigra hyperechogenicity and risk for Parkinson disease: A 37-month 3-center study of 1847 older persons
    • D. Berg Enlarged substantia nigra hyperechogenicity and risk for Parkinson disease: a 37-month 3-center study of 1847 older persons Arch. Neurol. 68 2011 932 937
    • (2011) Arch. Neurol. , vol.68 , pp. 932-937
    • Berg, D.1
  • 71
    • 18144397394 scopus 로고    scopus 로고
    • Five-year follow-up study of hyperechogenicity of the substantia nigra in Parkinson's disease
    • D. Berg Five-year follow-up study of hyperechogenicity of the substantia nigra in Parkinson's disease Mov. Disord. 20 2005 383 385
    • (2005) Mov. Disord. , vol.20 , pp. 383-385
    • Berg, D.1
  • 72
    • 50049104725 scopus 로고    scopus 로고
    • Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: A case-control study
    • D.G. Healy Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study Lancet Neurol. 7 2008 583 590
    • (2008) Lancet Neurol. , vol.7 , pp. 583-590
    • Healy, D.G.1
  • 73
    • 28544434193 scopus 로고    scopus 로고
    • PET in LRRK2 mutations: Comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation
    • J.R. Adams PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation Brain 128 2005 2777 2785
    • (2005) Brain , vol.128 , pp. 2777-2785
    • Adams, J.R.1
  • 74
    • 58149242840 scopus 로고    scopus 로고
    • Progression of dopaminergic dysfunction in a LRRK2 kindred: A multitracer PET study
    • R. Nandhagopal Progression of dopaminergic dysfunction in a LRRK2 kindred: a multitracer PET study Neurology 71 2008 1790 1795
    • (2008) Neurology , vol.71 , pp. 1790-1795
    • Nandhagopal, R.1
  • 75
    • 77956812150 scopus 로고    scopus 로고
    • Functional brain imaging in glucocerebrosidase mutation carriers with and without parkinsonism
    • S. Kono Functional brain imaging in glucocerebrosidase mutation carriers with and without parkinsonism Mov. Disord. 25 2010 1823 1829
    • (2010) Mov. Disord. , vol.25 , pp. 1823-1829
    • Kono, S.1
  • 76
    • 0026507474 scopus 로고
    • Bilateral olfactory dysfunction in early stage treated and untreated idiopathic Parkinson's disease
    • R.L. Doty Bilateral olfactory dysfunction in early stage treated and untreated idiopathic Parkinson's disease J. Neurol. Neurosurg. Psychiatry 55 1992 138 142
    • (1992) J. Neurol. Neurosurg. Psychiatry , vol.55 , pp. 138-142
    • Doty, R.L.1
  • 77
    • 0027246274 scopus 로고
    • Olfactory testing differentiates between progressive supranuclear palsy and idiopathic Parkinson's disease
    • R.L. Doty Olfactory testing differentiates between progressive supranuclear palsy and idiopathic Parkinson's disease Neurology 43 1993 962 965
    • (1993) Neurology , vol.43 , pp. 962-965
    • Doty, R.L.1
  • 78
    • 0029878953 scopus 로고    scopus 로고
    • Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder
    • C.H. Schenck Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder Neurology 46 1996 388 393
    • (1996) Neurology , vol.46 , pp. 388-393
    • Schenck, C.H.1
  • 79
    • 33749261280 scopus 로고    scopus 로고
    • Olfactory deficit in idiopathic rapid eye movements sleep behavior disorder
    • M.L. Fantini Olfactory deficit in idiopathic rapid eye movements sleep behavior disorder Brain Res. Bull. 70 2006 386 390
    • (2006) Brain Res. Bull. , vol.70 , pp. 386-390
    • Fantini, M.L.1
  • 80
    • 77950601138 scopus 로고    scopus 로고
    • Olfactory testing combined with dopamine transporter imaging as a method to detect prodromal Parkinson's disease
    • M.M. Ponsen Olfactory testing combined with dopamine transporter imaging as a method to detect prodromal Parkinson's disease J. Neurol. Neurosurg. Psychiatry 81 2010 396 399
    • (2010) J. Neurol. Neurosurg. Psychiatry , vol.81 , pp. 396-399
    • Ponsen, M.M.1
  • 81
    • 0034073545 scopus 로고    scopus 로고
    • Reduced striatal dopamine transporters in idiopathic rapid eye movement sleep behaviour disorder. Comparison with Parkinson's disease and controls
    • I. Eisensehr Reduced striatal dopamine transporters in idiopathic rapid eye movement sleep behaviour disorder. Comparison with Parkinson's disease and controls Brain 123 2000 1155 1160
    • (2000) Brain , vol.123 , pp. 1155-1160
    • Eisensehr, I.1
  • 82
    • 11244260421 scopus 로고    scopus 로고
    • Combination of 'idiopathic' REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT
    • K. Stiasny-Kolster Combination of 'idiopathic' REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT Brain 128 2005 126 137
    • (2005) Brain , vol.128 , pp. 126-137
    • Stiasny-Kolster, K.1
  • 83
    • 84863287993 scopus 로고    scopus 로고
    • Cerebrospinal fluid amyloid β and tau in LRRK2 mutation carriers
    • J.O. Aasly Cerebrospinal fluid amyloid β and tau in LRRK2 mutation carriers Neurology 78 2012 55 61
    • (2012) Neurology , vol.78 , pp. 55-61
    • Aasly, J.O.1
  • 84
    • 84856970318 scopus 로고    scopus 로고
    • DJ-1 and αsYN in LRRK2 CSF do not correlate with striatal dopaminergic function
    • 836.E835-836.E837
    • M. Shi DJ-1 and αSYN in LRRK2 CSF do not correlate with striatal dopaminergic function Neurobiol. Aging 33 2012 836.E835-836.E837
    • (2012) Neurobiol. Aging , vol.33
    • Shi, M.1
  • 85
    • 79958233724 scopus 로고    scopus 로고
    • Salivary alpha-synuclein and DJ-1: Potential biomarkers for Parkinson's disease
    • I. Devic Salivary alpha-synuclein and DJ-1: potential biomarkers for Parkinson's disease Brain 134 2011 E178
    • (2011) Brain , vol.134 , pp. 178
    • Devic, I.1
  • 86
    • 0031897730 scopus 로고    scopus 로고
    • Altropane, a SPECT or PET imaging probe for dopamine neurons: III. Human dopamine transporter in postmortem normal and Parkinson's diseased brain
    • B.K. Madras Altropane, a SPECT or PET imaging probe for dopamine neurons: III. Human dopamine transporter in postmortem normal and Parkinson's diseased brain Synapse 29 1998 116 127
    • (1998) Synapse , vol.29 , pp. 116-127
    • Madras, B.K.1
  • 87
    • 20444436869 scopus 로고    scopus 로고
    • FDG PET in the differential diagnosis of parkinsonian disorders
    • T. Eckert FDG PET in the differential diagnosis of parkinsonian disorders Neuroimage 26 2005 912 921
    • (2005) Neuroimage , vol.26 , pp. 912-921
    • Eckert, T.1


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