-
1
-
-
66949152096
-
Parkinson's disease
-
Lees, A. J., Hardy, J. & Revesz, T. Parkinson's disease. Lancet 373, 2055-2066 (2009).
-
(2009)
Lancet
, vol.373
, pp. 2055-2066
-
-
Lees, A.J.1
Hardy, J.2
Revesz, T.3
-
2
-
-
78651315861
-
Preclinical biomarkers of Parkinson disease
-
Wu, Y., Le, W. & Jankovic, J. Preclinical biomarkers of Parkinson disease. Arch. Neurol. 68, 22-30 (2011).
-
(2011)
Arch. Neurol
, vol.68
, pp. 22-30
-
-
Wu, Y.1
Le, W.2
Jankovic, J.3
-
3
-
-
84875226362
-
Parkinson's disease subtypes: Lost in translation?
-
Marras, C. & Lang, A. Parkinson's disease subtypes: lost in translation? J. Neurol. Neurosurg. Psychiatry http://dx.doi.org/10.1136/jnnp- 2012-303455.
-
J. Neurol. Neurosurg. Psychiatry
-
-
Marras, C.1
Lang, A.2
-
4
-
-
77954954518
-
Diagnostic cerebrospinal fluid biomarkers for Parkinson's disease: A pathogenetically based approach
-
van Dijk, K. D. et al. Diagnostic cerebrospinal fluid biomarkers for Parkinson's disease: a pathogenetically based approach. Neurobiol. Dis. 39, 229-241 (2010).
-
(2010)
Neurobiol. Dis
, vol.39
, pp. 229-241
-
-
Van Dijk, K.D.1
-
5
-
-
77957951112
-
Revising the definition of Alzheimer's disease: A new lexicon
-
Dubois, B. et al. Revising the definition of Alzheimer's disease: a new lexicon. Lancet Neurol. 9, 1118-1127 (2010).
-
(2010)
Lancet Neurol
, vol.9
, pp. 1118-1127
-
-
Dubois, B.1
-
6
-
-
79958724629
-
Changing concepts of Alzheimer disease
-
McKhann, G. M. Changing concepts of Alzheimer disease. JAMA 305, 2458-2459 (2011).
-
(2011)
JAMA
, vol.305
, pp. 2458-2459
-
-
McKhann, G.M.1
-
7
-
-
77958065565
-
Problems associated with fluid biomarkers for Parkinson's disease
-
Nyhlen, J., Constantinescu, R. & Zetterberg, H. Problems associated with fluid biomarkers for Parkinson's disease. Biomark. Med. 4, 671-681 (2010).
-
(2010)
Biomark. Med
, vol.4
, pp. 671-681
-
-
Nyhlen, J.1
Constantinescu, R.2
Zetterberg, H.3
-
8
-
-
79960613150
-
Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementias
-
Parnetti, L. et al. Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementias. Mov. Disord. 26, 1428-1435 (2011).
-
(2011)
Mov. Disord
, vol.26
, pp. 1428-1435
-
-
Parnetti, L.1
-
9
-
-
0142200945
-
Interactions of amyloidogenic proteins
-
Giasson, B. I., Lee, V. M. & Trojanowski, J. Q. Interactions of amyloidogenic proteins. Neuromolecular Med. 4, 49-58 (2003).
-
(2003)
Neuromolecular Med
, vol.4
, pp. 49-58
-
-
Giasson, B.I.1
Lee, V.M.2
Trojanowski, J.Q.3
-
10
-
-
0037466656
-
Initiation and synergistic fibrillization of tau and alpha-synuclein
-
Giasson, B. I. et al. Initiation and synergistic fibrillization of tau and alpha-synuclein. Science 300, 636-640 (2003).
-
(2003)
Science
, vol.300
, pp. 636-640
-
-
Giasson, B.I.1
-
11
-
-
79957636327
-
Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau
-
Waxman, E. A. & Giasson, B. I. Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau. J. Neurosci. 31, 7604-7618 (2011).
-
(2011)
J. Neurosci
, vol.31
, pp. 7604-7618
-
-
Waxman, E.A.1
Giasson, B.I.2
-
12
-
-
1342321775
-
More than just two peas in a pod: Common amyloidogenic properties of tau and α-synuclein in neurodegenerative diseases
-
Lee, V. M., Giasson, B. I. & Trojanowski, J. Q. More than just two peas in a pod: common amyloidogenic properties of tau and α-synuclein in neurodegenerative diseases. Trends Neurosci. 27, 129-134 (2004).
-
(2004)
Trends Neurosci
, vol.27
, pp. 129-134
-
-
Lee, V.M.1
Giasson, B.I.2
Trojanowski, J.Q.3
-
13
-
-
80054755695
-
Pathological roles of α-synuclein in neurological disorders
-
Vekrellis, K., Xilouri, M., Emmanouilidou, E., Rideout, H. J. & Stefanis, L. Pathological roles of α-synuclein in neurological disorders. Lancet Neurol. 10, 1015-1025 (2011).
-
(2011)
Lancet Neurol
, vol.10
, pp. 1015-1025
-
-
Vekrellis, K.1
Xilouri, M.2
Emmanouilidou, E.3
Rideout, H.J.4
Stefanis, L.5
-
14
-
-
80052028927
-
Exploring the link between glucocerebrosidase mutations and parkinsonism
-
Westbroek, W., Gustafson, A. M. & Sidransky, E. Exploring the link between glucocerebrosidase mutations and parkinsonism. Trends Mol. Med. 17, 485-493 (2011).
-
(2011)
Trends Mol. Med
, vol.17
, pp. 485-493
-
-
Westbroek, W.1
Gustafson, A.M.2
Sidransky, E.3
-
15
-
-
70350319531
-
Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease
-
Sidransky, E. et al. Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease. N. Engl. J. Med. 361, 1651-1661 (2009).
-
(2009)
N. Engl. J. Med
, vol.361
, pp. 1651-1661
-
-
Sidransky, E.1
-
16
-
-
77954933661
-
The role of glucocerebrosidase mutations in Parkinson disease and Lewy body disorders
-
Velayati, A., Yu, W. H. & Sidransky, E. The role of glucocerebrosidase mutations in Parkinson disease and Lewy body disorders. Curr. Neurol. Neurosci. Rep. 10, 190-198 (2010).
-
(2010)
Curr. Neurol. Neurosci. Rep
, vol.10
, pp. 190-198
-
-
Velayati, A.1
Yu, W.H.2
Sidransky, E.3
-
17
-
-
77956855813
-
Pathogenic lysosomal depletion in Parkinson's disease
-
Dehay, B. et al. Pathogenic lysosomal depletion in Parkinson's disease. J. Neurosci. 30, 12535-12544 (2010).
-
(2010)
J. Neurosci
, vol.30
, pp. 12535-12544
-
-
Dehay, B.1
-
18
-
-
84867036900
-
Glucocerebrosidase deficiency in substantia nigra of Parkinson disease brains
-
Gegg, M. E. et al. Glucocerebrosidase deficiency in substantia nigra of Parkinson disease brains. Ann. Neurol. 72, 455-463 (2012).
-
(2012)
Ann. Neurol
, vol.72
, pp. 455-463
-
-
Gegg, M.E.1
-
19
-
-
79960360692
-
Lysosomal storage disorders and Parkinson's disease: Gaucher disease and beyond
-
Shachar, T. et al. Lysosomal storage disorders and Parkinson's disease: Gaucher disease and beyond. Mov. Disord. 26, 1593-1604 (2011).
-
(2011)
Mov. Disord
, vol.26
, pp. 1593-1604
-
-
Shachar, T.1
-
20
-
-
77950223687
-
DJ 1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease
-
Hong, Z. et al. DJ 1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease. Brain 133, 713-726 (2010).
-
(2010)
Brain
, vol.133
, pp. 713-726
-
-
Hong, Z.1
-
21
-
-
0028277520
-
Identification of two distinct synucleins from human brain
-
Jakes, R., Spillantini, M. G. & Goedert, M. Identification of two distinct synucleins from human brain. FEBS Lett. 345, 27-32 (1994).
-
(1994)
FEBS Lett
, vol.345
, pp. 27-32
-
-
Jakes, R.1
Spillantini, M.G.2
Goedert, M.3
-
22
-
-
0036150971
-
The synucleins
-
George, J. M. The synucleins. Genome Biol. 3, reviews3002.1-reviews3002.6 (2002).
-
(2002)
Genome Biol
, vol.3
, pp. 1-6
-
-
George, J.M.1
-
23
-
-
84861898518
-
Mechanisms underlying altered striatal synaptic plasticity in old A53T-α synuclein overexpressing mice
-
Tozzi, A. et al. Mechanisms underlying altered striatal synaptic plasticity in old A53T-α synuclein overexpressing mice. Neurobiol. Aging 33, 1792-1799 (2012).
-
(2012)
Neurobiol. Aging
, vol.33
, pp. 1792-1799
-
-
Tozzi, A.1
-
24
-
-
48149108245
-
Protein aggregation in the brain: The molecular basis for Alzheimer's and Parkinson's diseases
-
Irvine, G. B., El Agnaf, O. M., Shankar, G. M. & Walsh, D. M. Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases. Mol. Med. 14, 451-464 (2008).
-
(2008)
Mol. Med
, vol.14
, pp. 451-464
-
-
Irvine, G.B.1
El Agnaf, O.M.2
Shankar, G.M.3
Walsh, D.M.4
-
25
-
-
0032568534
-
α-synuclein in filamentous inclusions of lewy bodies from parkinson's disease and dementia with lewy bodies
-
Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M. & Goedert, M. α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl Acad. Sci. USA 95, 6469-6473 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 6469-6473
-
-
Spillantini, M.G.1
Crowther, R.A.2
Jakes, R.3
Hasegawa, M.4
Goedert, M.5
-
26
-
-
0032584686
-
Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies
-
Spillantini, M. G. et al. Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neurosci. Lett. 251, 205-208 (1998).
-
(1998)
Neurosci. Lett
, vol.251
, pp. 205-208
-
-
Spillantini, M.G.1
-
27
-
-
0030744876
-
Mutation in the α-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos, M. H. et al. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276, 2045-2047 (1997).
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
-
28
-
-
0031990490
-
Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease
-
Kruger, R. et al. Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nat. Genet. 18, 106-108 (1998).
-
(1998)
Nat. Genet
, vol.18
, pp. 106-108
-
-
Kruger, R.1
-
29
-
-
10744230149
-
The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia
-
Zarranz, J. J. et al. The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia. Ann. Neurol. 55, 164-173 (2004).
-
(2004)
Ann. Neurol
, vol.55
, pp. 164-173
-
-
Zarranz, J.J.1
-
30
-
-
0242300619
-
α-synuclein locus triplication causes Parkinson's disease
-
Singleton, A. B. et al. α-Synuclein locus triplication causes Parkinson's disease. Science 302, 841-841 (2003).
-
(2003)
Science
, vol.302
, pp. 841-841
-
-
Singleton, A.B.1
-
31
-
-
4644290985
-
α-synuclein locus duplication as a cause of familial Parkinson's disease
-
Chartier Harlin, M. C. et al. α-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet 364, 1167-1169 (2004).
-
(2004)
Lancet
, vol.364
, pp. 1167-1169
-
-
Chartier Harlin, M.C.1
-
32
-
-
70549084415
-
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
-
Satake, W. et al. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat. Genet. 41, 1303-1307 (2009).
-
(2009)
Nat. Genet
, vol.41
, pp. 1303-1307
-
-
Satake, W.1
-
33
-
-
70549088602
-
Genome-wide association study reveals genetic risk underlying Parkinson's disease
-
Simon-Sanchez, J. et al. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat. Genet. 41, 1308-1312 (2009).
-
(2009)
Nat. Genet
, vol.41
, pp. 1308-1312
-
-
Simon-Sanchez, J.1
-
34
-
-
0032573289
-
53 to Thr on the physical and morphological properties of α-synuclein protein implicated in Parkinson's disease
-
El-Agnaf, O. M., Jakes, R., Curran, M. D. & Wallace, A. Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of α-synuclein protein implicated in Parkinson's disease. FEBS Lett. 440, 67-70 (1998).
-
(1998)
FEBS Lett
, vol.440
, pp. 67-70
-
-
El-Agnaf, O.M.1
Jakes, R.2
Curran, M.D.3
Wallace, A.4
-
35
-
-
0032551656
-
Human recombinant NACP/α-synuclein is aggregated and fibrillated in vitro: Relevance for Lewy body disease
-
Hashimoto, M. et al. Human recombinant NACP/α-synuclein is aggregated and fibrillated in vitro: relevance for Lewy body disease. Brain Res. 799, 301-306 (1998).
-
(1998)
Brain Res
, vol.799
, pp. 301-306
-
-
Hashimoto, M.1
-
36
-
-
0034646391
-
Fibrils formed in vitro from α-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid
-
Conway, K. A., Harper, J. D. & Lansbury, P. T. Jr. Fibrils formed in vitro from α-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid. Biochemistry 39, 2552-2563 (2000).
-
(2000)
Biochemistry
, vol.39
, pp. 2552-2563
-
-
Conway, K.A.1
Harper, J.D.2
Lansbury Jr., P.T.3
-
37
-
-
0032573597
-
Aggregates from mutant and wild-type α-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β-sheet and amyloid like filaments
-
El-Agnaf, O. M. et al. Aggregates from mutant and wild-type α-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β-sheet and amyloid like filaments. FEBS Lett. 440, 71-75 (1998).
-
(1998)
FEBS Lett
, vol.440
, pp. 71-75
-
-
El-Agnaf, O.M.1
-
38
-
-
0034674376
-
Full length α-synuclein is present in cerebrospinal fluid from Parkinson's disease and normal subjects
-
Borghi, R. et al. Full length α-synuclein is present in cerebrospinal fluid from Parkinson's disease and normal subjects. Neurosci. Lett. 287, 65-67 (2000).
-
(2000)
Neurosci. Lett
, vol.287
, pp. 65-67
-
-
Borghi, R.1
-
39
-
-
49449105990
-
Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration
-
Mollenhauer, B. et al. Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration. Exp. Neurol. 213, 315-325 (2008).
-
(2008)
Exp. Neurol
, vol.213
, pp. 315-325
-
-
Mollenhauer, B.1
-
40
-
-
79951720856
-
α-synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: A cohort study
-
Mollenhauer, B. et al. α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study. Lancet Neurol. 10, 230-240 (2011).
-
(2011)
Lancet Neurol
, vol.10
, pp. 230-240
-
-
Mollenhauer, B.1
-
41
-
-
33748325848
-
Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease
-
Tokuda, T. et al. Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease. Biochem. Biophys. Res. Commun. 349, 162-166 (2006).
-
(2006)
Biochem. Biophys. Res. Commun
, vol.349
, pp. 162-166
-
-
Tokuda, T.1
-
42
-
-
84865756966
-
α-synuclein in the cerebrospinal fluid differentiates synucleinopathies (Parkinson disease, dementia with Lewy bodies, multiple system atrophy) from Alzheimer disease
-
Tateno, F., Sakakibara, R., Kawai, T., Kishi, M. & Murano, T. α-synuclein in the cerebrospinal fluid differentiates synucleinopathies (Parkinson disease, dementia with Lewy bodies, multiple system atrophy) from Alzheimer disease. Alzheimer Dis. Assoc. Disord. 26, 213-216 (2012).
-
(2012)
Alzheimer Dis. Assoc. Disord
, vol.26
, pp. 213-216
-
-
Tateno, F.1
Sakakibara, R.2
Kawai, T.3
Kishi, M.4
Murano, T.5
-
43
-
-
58149374375
-
CSF α-synuclein levels in dementia with Lewy bodies and Alzheimer's disease
-
Noguchi-Shinohara, M. et al. CSF α-synuclein levels in dementia with Lewy bodies and Alzheimer's disease. Brain Res. 1251, 1-6 (2009).
-
(2009)
Brain Res
, vol.1251
, pp. 1-6
-
-
Noguchi-Shinohara, M.1
-
44
-
-
58149469520
-
Cerebrospinal fluid α-synuclein in neurodegenerative disorders-A marker of synapse loss?
-
Ohrfelt, A. et al. Cerebrospinal fluid α-synuclein in neurodegenerative disorders-a marker of synapse loss? Neurosci. Lett. 450, 332-335 (2009).
-
(2009)
Neurosci. Lett
, vol.450
, pp. 332-335
-
-
Ohrfelt, A.1
-
45
-
-
60349122813
-
Cerebrospinal fluid α-synuclein does not discriminate between dementia disorders
-
Spies, P. E., Melis, R. J., Sjögren, M. J., Rikkert, M. G. & Verbeek, M. M. Cerebrospinal fluid α-synuclein does not discriminate between dementia disorders. J. Alzheimers Dis. 16, 363-369 (2009).
-
(2009)
J. Alzheimers Dis
, vol.16
, pp. 363-369
-
-
Spies, P.E.1
Melis, R.J.2
Sjögren, M.J.3
Rikkert, M.G.4
Verbeek, M.M.5
-
46
-
-
82755194923
-
CSF α-synuclein does not differentiate between parkinsonian disorders
-
Aerts, M. B., Esselink, R. A., Abdo, W. F., Bloem, B. R. & Verbeek, M. M. CSF α-synuclein does not differentiate between parkinsonian disorders. Neurobiol. Aging 33, 430.e1-430.e3 (2012).
-
(2012)
Neurobiol. Aging
, vol.33
-
-
Aerts, M.B.1
Esselink, R.A.2
Abdo, W.F.3
Bloem, B.R.4
Verbeek, M.M.5
-
47
-
-
33748325848
-
Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease
-
Tokuda, T. et al. Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease. Biochem. Biophys. Res. Commun. 349, 162-166 (2006).
-
(2006)
Biochem. Biophys. Res. Commun
, vol.349
, pp. 162-166
-
-
Tokuda, T.1
-
48
-
-
79952742454
-
In vivo demonstration that α-synuclein oligomers are toxic
-
Winner, B. et al. In vivo demonstration that α-synuclein oligomers are toxic. Proc. Natl Acad. Sci. USA 108, 4194-4199 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 4194-4199
-
-
Winner, B.1
-
49
-
-
0036278335
-
Dopamine-dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson disease
-
Xu, J. et al. Dopamine-dependent neurotoxicity of α-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat. Med. 8, 600-606 (2002).
-
(2002)
Nat. Med
, vol.8
, pp. 600-606
-
-
Xu, J.1
-
50
-
-
65249162241
-
Detection of elevated levels of soluble α-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies
-
Paleologou, K. E. et al. Detection of elevated levels of soluble α-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies. Brain 132, 1093-1101 (2009).
-
(2009)
Brain
, vol.132
, pp. 1093-1101
-
-
Paleologou, K.E.1
-
51
-
-
0037456578
-
The formation of highly soluble oligomers of α-synuclein is regulated by fatty acids and enhanced in Parkinson's disease
-
Sharon, R. et al. The formation of highly soluble oligomers of α-synuclein is regulated by fatty acids and enhanced in Parkinson's disease. Neuron 37, 583-595 (2003).
-
(2003)
Neuron
, vol.37
, pp. 583-595
-
-
Sharon, R.1
-
52
-
-
0038038389
-
Soluble oligomers for the diagnosis of neurodegenerative diseases
-
El-Agnaf, O. M., Walsh, D. M. & Allsop, D. Soluble oligomers for the diagnosis of neurodegenerative diseases. Lancet Neurol. 2, 461-462 (2003).
-
(2003)
Lancet Neurol
, vol.2
, pp. 461-462
-
-
El-Agnaf, O.M.1
Walsh, D.M.2
Allsop, D.3
-
53
-
-
78649990079
-
Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease
-
Tokuda, T. et al. Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease. Neurology 75, 1766-1772 (2010).
-
(2010)
Neurology
, vol.75
, pp. 1766-1772
-
-
Tokuda, T.1
-
54
-
-
84862916400
-
Elevated levels of α-synuclein oligomer in the cerebrospinal fluid of drug-naive patients with Parkinson's disease
-
Park, M. J., Cheon, S. M., Bae, H. R., Kim, S. H. & Kim, J. W. Elevated levels of α-synuclein oligomer in the cerebrospinal fluid of drug-naive patients with Parkinson's disease. J. Clin. Neurol. 7, 215-222 (2011).
-
(2011)
J. Clin. Neurol
, vol.7
, pp. 215-222
-
-
Park, M.J.1
Cheon, S.M.2
Bae, H.R.3
Kim, S.H.4
Kim, J.W.5
-
55
-
-
82355191922
-
CSF levels of oligomeric alpha synuclein and beta amyloid as biomarkers for neurodegenerative disease
-
Sierks, M. R. et al. CSF levels of oligomeric alpha synuclein and beta amyloid as biomarkers for neurodegenerative disease. Integr. Biol. (Camb.) 3, 1188-1196 (2011).
-
(2011)
Integr. Biol. (Camb.)
, vol.3
, pp. 1188-1196
-
-
Sierks, M.R.1
-
56
-
-
81955167983
-
Post mortem cerebrospinal fluid α-synuclein levels are raised in multiple system atrophy and distinguish this from the other α- synucleinopathies, Parkinson's disease and Dementia with Lewy bodies
-
Foulds, P. G. et al. Post mortem cerebrospinal fluid α-synuclein levels are raised in multiple system atrophy and distinguish this from the other α-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies. Neurobiol. Dis. 45, 188-195 (2011).
-
(2011)
Neurobiol. Dis
, vol.45
, pp. 188-195
-
-
Foulds, P.G.1
-
57
-
-
84863164994
-
Phosphorylated α-synuclein in Parkinson's disease
-
Wang, Y. et al. Phosphorylated α-synuclein in Parkinson's disease. Sci. Transl. Med. 4, 121ra20 (2012).
-
(2012)
Sci. Transl. Med
, vol.4
-
-
Wang, Y.1
-
58
-
-
80052398365
-
α-synuclein occurs physiologically as a helically folded tetramer that resists aggregation
-
Bartels, T., Choi, J. G. & Selkoe, D. J. α-synuclein occurs physiologically as a helically folded tetramer that resists aggregation. Nature 477, 107-110 (2011).
-
(2011)
Nature
, vol.477
, pp. 107-110
-
-
Bartels, T.1
Choi, J.G.2
Selkoe, D.J.3
-
59
-
-
80055078029
-
A soluble α-synuclein construct forms a dynamic tetramer
-
Wang, W. et al. A soluble α-synuclein construct forms a dynamic tetramer. Proc. Natl Acad. Sci. USA 108, 17797-17802 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 17797-17802
-
-
Wang, W.1
-
60
-
-
84859577559
-
α-synuclein in the central nervous system and from erythrocytes, mammalian cells and Escherichia coli exists predominantly as a disordered monomer
-
Fauvet, B. et al. α-synuclein in the central nervous system and from erythrocytes, mammalian cells and Escherichia coli exists predominantly as a disordered monomer. J. Biol. Chem. 287, 15345-15364 (2012).
-
(2012)
J. Biol. Chem
, vol.287
, pp. 15345-15364
-
-
Fauvet, B.1
-
61
-
-
0037428241
-
Mutations in the DJ 1 gene associated with autosomal recessive early-onset parkinsonism
-
Bonifati, V. et al. Mutations in the DJ 1 gene associated with autosomal recessive early-onset parkinsonism. Science 299, 256-259 (2003).
-
(2003)
Science
, vol.299
, pp. 256-259
-
-
Bonifati, V.1
-
62
-
-
33646833404
-
Increased level of DJ 1 in the cerebrospinal fluids of sporadic Parkinson's disease
-
Waragai, M. et al. Increased level of DJ 1 in the cerebrospinal fluids of sporadic Parkinson's disease. Biochem. Biophys. Res. Commun. 345, 967-972 (2006).
-
(2006)
Biochem. Biophys. Res. Commun
, vol.345
, pp. 967-972
-
-
Waragai, M.1
-
63
-
-
79953283868
-
Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression
-
Shi, M. et al. Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression. Ann. Neurol. 69, 570-580 (2011).
-
(2011)
Ann. Neurol
, vol.69
, pp. 570-580
-
-
Shi, M.1
-
64
-
-
84856970318
-
DJ 1 and αs YN in LRRK2 CSF do not correlate with striatal dopaminergic function
-
Shi, M. et al. DJ 1 and αSYN in LRRK2 CSF do not correlate with striatal dopaminergic function. Neurobiol. Aging 33, 836.e5-836.e7 (2011).
-
(2011)
Neurobiol. Aging
, vol.33
-
-
Shi, M.1
-
65
-
-
65249115240
-
Cognitive impairment in incident, untreated Parkinson disease: The Norwegian Park West study
-
Aarsland, D., Bronnick, K., Larsen, J. P., Tysnes, O. B. & Alves, G. Cognitive impairment in incident, untreated Parkinson disease: the Norwegian Park West study. Neurology 72, 1121-1126 (2009).
-
(2009)
Neurology
, vol.72
, pp. 1121-1126
-
-
Aarsland, D.1
Bronnick, K.2
Larsen, J.P.3
Tysnes, O.B.4
Alves, G.5
-
66
-
-
74149085154
-
The epidemiology of dementia associated with Parkinson disease
-
Aarsland, D. & Kurz, M. W. The epidemiology of dementia associated with Parkinson disease. J. Neurol. Sci. 289, 18-22 (2010).
-
(2010)
J. Neurol. Sci
, vol.289
, pp. 18-22
-
-
Aarsland, D.1
Kurz, M.W.2
-
67
-
-
41149173996
-
The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years
-
Hely, M. A., Reid, W. G., Adena, M. A., Halliday, G. M. & Morris, J. G. The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years. Mov. Disord. 23, 837-844 (2008).
-
(2008)
Mov. Disord
, vol.23
, pp. 837-844
-
-
Hely, M.A.1
Reid, W.G.2
Adena, M.A.3
Halliday, G.M.4
Morris, J.G.5
-
68
-
-
33845709899
-
Differences in neuropathologic characteristics across the Lewy body dementia spectrum
-
Ballard, C. et al. Differences in neuropathologic characteristics across the Lewy body dementia spectrum. Neurology 67, 1931-1934 (2006).
-
(2006)
Neurology
, vol.67
, pp. 1931-1934
-
-
Ballard, C.1
-
69
-
-
0037333666
-
Staging of brain pathology related to sporadic Parkinson's disease
-
Braak, H. et al. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol. Aging 24, 197-211 (2003).
-
(2003)
Neurobiol. Aging
, vol.24
, pp. 197-211
-
-
Braak, H.1
-
70
-
-
41149152169
-
Prevalence and impact of vascular and Alzheimer pathologies in Lewy body disease
-
Jellinger, K. A. & Attems, J. Prevalence and impact of vascular and Alzheimer pathologies in Lewy body disease. Acta Neuropathol. 115, 427-436 (2008).
-
(2008)
Acta Neuropathol
, vol.115
, pp. 427-436
-
-
Jellinger, K.A.1
Attems, J.2
-
71
-
-
0025061059
-
The Lewy body variant of Alzheimer's disease: A clinical and pathologic entity
-
Hansen, L. et al. The Lewy body variant of Alzheimer's disease: a clinical and pathologic entity. Neurology 40, 1-8 (1990).
-
(1990)
Neurology
, vol.40
, pp. 1-8
-
-
Hansen, L.1
-
72
-
-
77953068390
-
Synergistic interactions between Aβ, tau, and α-synuclein: Acceleration of neuropathology and cognitive decline
-
Clinton, L. K., Blurton Jones, M., Myczek, K., Trojanowski, J. Q. & LaFerla, F. M. Synergistic interactions between Aβ, tau, and α-synuclein: acceleration of neuropathology and cognitive decline. J. Neurosci. 30, 7281-7289 (2010).
-
(2010)
J. Neurosci
, vol.30
, pp. 7281-7289
-
-
Clinton, L.K.1
Blurton Jones, M.2
Myczek, K.3
Trojanowski, J.Q.4
Laferla, F.M.5
-
73
-
-
0035078270
-
Recent advances in the understanding of the role of synaptic proteins in Alzheimer's Disease and other neurodegenerative disorders
-
Masliah, E. Recent advances in the understanding of the role of synaptic proteins in Alzheimer's Disease and other neurodegenerative disorders. J. Alzheimers Dis. 3, 121-129 (2001).
-
(2001)
J. Alzheimers Dis
, vol.3
, pp. 121-129
-
-
Masliah, E.1
-
74
-
-
33749672231
-
A convergent model for cognitive dysfunctions in Parkinson's disease: The critical dopamine-acetylcholine synaptic balance
-
Calabresi, P., Picconi, B., Parnetti, L. & Di Filippo, M. A convergent model for cognitive dysfunctions in Parkinson's disease: the critical dopamine-acetylcholine synaptic balance. Lancet Neurol. 5, 974-983 (2006).
-
(2006)
Lancet Neurol
, vol.5
, pp. 974-983
-
-
Calabresi, P.1
Picconi, B.2
Parnetti, L.3
Di Filippo, M.4
-
75
-
-
40449127705
-
Neuropathological aspects of Alzheimer disease, Parkinson disease and frontotemporal dementia
-
Jellinger, K. A. Neuropathological aspects of Alzheimer disease, Parkinson disease and frontotemporal dementia. Neurodegener. Dis. 5, 118-121 (2008).
-
(2008)
Neurodegener. Dis
, vol.5
, pp. 118-121
-
-
Jellinger, K.A.1
-
76
-
-
0141738373
-
CSF markers for incipient Alzheimer's disease
-
Blennow, K. & Hampel, H. CSF markers for incipient Alzheimer's disease. Lancet Neurol. 2, 605-613 (2003).
-
(2003)
Lancet Neurol
, vol.2
, pp. 605-613
-
-
Blennow, K.1
Hampel, H.2
-
77
-
-
78651266932
-
Autosomal-dominant Alzheimer's disease: A review and proposal for the prevention of Alzheimer's disease
-
Bateman, R. J. et al. Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease. Alzheimers Res. Ther. 3, 1 (2012).
-
(2012)
Alzheimers Res. Ther
, vol.3
, pp. 1
-
-
Bateman, R.J.1
-
78
-
-
33748163112
-
Beta-amlyoid 1-42 and tau-protein in cerebrospinal fluid of patients with Parkinson's disease dementia
-
Mollenhauer, B. et al. Beta-amlyoid 1-42 and tau-protein in cerebrospinal fluid of patients with Parkinson's disease dementia. Dement. Geriatr. Cogn. Disord. 22, 200-208 (2006).
-
(2006)
Dement. Geriatr. Cogn. Disord
, vol.22
, pp. 200-208
-
-
Mollenhauer, B.1
-
79
-
-
78349237282
-
42 and tau in Parkinson's disease with cognitive impairment
-
42 and tau in Parkinson's disease with cognitive impairment. Mov. Disord. 25, 2682-2685 (2010).
-
(2010)
Mov. Disord
, vol.25
, pp. 2682-2685
-
-
Montine, T.J.1
-
80
-
-
47049100511
-
Cerebrospinal fluid biomarkers in Parkinson's disease with dementia and dementia with Lewy bodies
-
Parnetti, L. et al. Cerebrospinal fluid biomarkers in Parkinson's disease with dementia and dementia with Lewy bodies. Biol. Psychiatry 64, 850-855 (2008).
-
(2008)
Biol. Psychiatry
, vol.64
, pp. 850-855
-
-
Parnetti, L.1
-
81
-
-
0036182732
-
Decreased CSF-β-amyloid 42 in Alzheimer's disease and amyotrophic lateral sclerosis may reflect mismetabolism of β-amyloid induced by disparate mechanisms
-
Sjögren, M. et al. Decreased CSF-β-amyloid 42 in Alzheimer's disease and amyotrophic lateral sclerosis may reflect mismetabolism of β-amyloid induced by disparate mechanisms. Dement. Geriatr. Cogn. Disord. 13, 112-118 (2002).
-
(2002)
Dement. Geriatr. Cogn. Disord
, vol.13
, pp. 112-118
-
-
Sjögren, M.1
-
82
-
-
77958071837
-
CSF amyloid-β and tau proteins, and cognitive performance, in early and untreated Parkinson's disease: The Norwegian Park West study
-
Alves, G. et al. CSF amyloid-β and tau proteins, and cognitive performance, in early and untreated Parkinson's disease: the Norwegian Park West study. J. Neurol. Neurosurg. Psychiatry 81, 1080-1086 (2010).
-
(2010)
J. Neurol. Neurosurg. Psychiatry
, vol.81
, pp. 1080-1086
-
-
Alves, G.1
-
83
-
-
84857627966
-
1-42 CSF levels in different phenotypes of Parkinson's disease
-
1-42 CSF levels in different phenotypes of Parkinson's disease. J. Neural Transm. 119, 353-362 (2011).
-
(2011)
J. Neural Transm
, vol.119
, pp. 353-362
-
-
Přikrylová-Vranová, H.1
-
84
-
-
77957220702
-
CSF amyloid β 1-42 predicts cognitive decline in Parkinson disease
-
Siderowf, A. et al. CSF amyloid β 1-42 predicts cognitive decline in Parkinson disease. Neurology 75, 1055-1061 (2010).
-
(2010)
Neurology
, vol.75
, pp. 1055-1061
-
-
Siderowf, A.1
-
85
-
-
0029609264
-
Tau protein in cerebrospinal fluid: A biochemical marker for axonal degeneration in Alzheimer disease?
-
Blennow, K. et al. Tau protein in cerebrospinal fluid: a biochemical marker for axonal degeneration in Alzheimer disease? Mol. Chem. Neuropathol. 26, 231-245 (1995).
-
(1995)
Mol. Chem. Neuropathol
, vol.26
, pp. 231-245
-
-
Blennow, K.1
-
86
-
-
34347360619
-
Tauopathies and synucleinopathies: Do cerebrospinal fluid β-amyloid peptides reflect disease-specific pathogenesis?
-
Mollenhauer, B. et al. Tauopathies and synucleinopathies: do cerebrospinal fluid β-amyloid peptides reflect disease-specific pathogenesis? J. Neural Transm. 114, 919-927 (2007).
-
(2007)
J. Neural Transm
, vol.114
, pp. 919-927
-
-
Mollenhauer, B.1
-
87
-
-
42949119345
-
CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases
-
Zhang, J. et al. CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases. Am. J. Clin. Pathol. 129, 526-529 (2008).
-
(2008)
Am. J. Clin. Pathol
, vol.129
, pp. 526-529
-
-
Zhang, J.1
-
88
-
-
78651289426
-
CSF markers of neurodegeneration in Parkinson's disease
-
Přikrylová Vranová, H. et al. CSF markers of neurodegeneration in Parkinson's disease. J. Neural Transm. 117, 1177-1181 (2010).
-
(2010)
J. Neural Transm
, vol.117
, pp. 1177-1181
-
-
Přikrylová-Vranová, H.1
-
89
-
-
78650315484
-
The cognitive profile and CSF biomarkers in dementia with Lewy bodies and Parkinson's disease dementia
-
Andersson, M., Zetterberg, H., Minthon, L., Blennow, K. & Londos, E. The cognitive profile and CSF biomarkers in dementia with Lewy bodies and Parkinson's disease dementia. Int. J. Geriatr. Psychiatry 26, 100-105 (2011).
-
(2011)
Int. J. Geriatr. Psychiatry
, vol.26
, pp. 100-105
-
-
Andersson, M.1
Zetterberg, H.2
Minthon, L.3
Blennow, K.4
Londos, E.5
-
90
-
-
84655161556
-
Amyloid related biomarkers and axonal damage proteins in parkinsonian syndromes
-
Bech, S. et al. Amyloid related biomarkers and axonal damage proteins in parkinsonian syndromes. Parkinsonism Relat. Disord. 18, 69-72 (2012).
-
(2012)
Parkinsonism Relat. Disord
, vol.18
, pp. 69-72
-
-
Bech, S.1
-
91
-
-
80054115170
-
Amyloid-β and τ biomarkers in Parkinson's disease-dementia
-
Buongiorno, M., Compta, Y. & Marti, M. J. Amyloid-β and τ biomarkers in Parkinson's disease-dementia. J. Neurol. Sci. 310, 25-30 (2011).
-
(2011)
J. Neurol. Sci
, vol.310
, pp. 25-30
-
-
Buongiorno, M.1
Compta, Y.2
Marti, M.J.3
-
92
-
-
33646266021
-
CSF amyloid-β-peptides in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementia
-
Bibl, M. et al. CSF amyloid-β-peptides in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementia. Brain 129, 1177-1187 (2006).
-
(2006)
Brain
, vol.129
, pp. 1177-1187
-
-
Bibl, M.1
-
93
-
-
72849127362
-
Cerebrospinal tau, phospho-tau, and beta amyloid and neuropsychological functions in Parkinson's disease
-
Compta, Y. et al. Cerebrospinal tau, phospho-tau, and beta amyloid and neuropsychological functions in Parkinson's disease. Mov. Disord. 24, 2203-2210 (2009).
-
(2009)
Mov. Disord
, vol.24
, pp. 2203-2210
-
-
Compta, Y.1
-
94
-
-
78651080087
-
Cerebrospinal fluid biomarkers and cognitive performance in non-demented patients with Parkinson's disease
-
Leverenz, J. B. et al. Cerebrospinal fluid biomarkers and cognitive performance in non-demented patients with Parkinson's disease. Parkinsonism Relat. Disord. 17, 61-64 (2011).
-
(2011)
Parkinsonism Relat. Disord
, vol.17
, pp. 61-64
-
-
Leverenz, J.B.1
-
95
-
-
74049124939
-
In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia
-
Burack, M. A. et al. In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia. Neurology 74, 77-84 (2010).
-
(2010)
Neurology
, vol.74
, pp. 77-84
-
-
Burack, M.A.1
-
96
-
-
37849039499
-
11C]PIB binding in Parkinson's disease dementia
-
11C]PIB binding in Parkinson's disease dementia. Neuroimage 39, 1027-1033 (2008).
-
(2008)
Neuroimage
, vol.39
, pp. 1027-1033
-
-
Maetzler, W.1
-
97
-
-
84876133397
-
Cerebrospinal fluid amyloid-β and phenotypic heterogeneity in de novo Parkinson's disease
-
Alves, G. et al. Cerebrospinal fluid amyloid-β and phenotypic heterogeneity in de novo Parkinson's disease. J. Neurol. Neurosurg. Psychiatry http://dx.doi.org/10.1136/jnnp-2012-303808.
-
J. Neurol. Neurosurg. Psychiatry
-
-
Alves, G.1
-
98
-
-
84863478529
-
CSF biomarkers in different phenotypes of Parkinson disease
-
Jellinger, K. A. CSF biomarkers in different phenotypes of Parkinson disease. J. Neural Transm. 119, 455-456 (2012).
-
(2012)
J. Neural Transm
, vol.119
, pp. 455-456
-
-
Jellinger, K.A.1
-
99
-
-
78650656088
-
42 levels in Lewy body disease
-
42 levels in Lewy body disease. J. Alzheimers Dis. 22, 933-938 (2010).
-
(2010)
J. Alzheimers Dis
, vol.22
, pp. 933-938
-
-
Maetzler, W.1
-
100
-
-
79953667345
-
Complement 3 and factor H in human cerebrospinal fluid in Parkinson's disease, Alzheimer's disease, and multiple-system atrophy
-
Wang, Y. et al. Complement 3 and factor H in human cerebrospinal fluid in Parkinson's disease, Alzheimer's disease, and multiple-system atrophy. Am. J. Pathol. 178, 1509-1516 (2011).
-
(2011)
Am. J. Pathol
, vol.178
, pp. 1509-1516
-
-
Wang, Y.1
-
101
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine, B. & Kroemer, G. Autophagy in the pathogenesis of disease. Cell 132, 27-42 (2008).
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
102
-
-
36249025723
-
Autophagy: Process and function
-
Mizushima, N. Autophagy: process and function. Genes Dev. 21, 2861-2873 (2007).
-
(2007)
Genes Dev
, vol.21
, pp. 2861-2873
-
-
Mizushima, N.1
-
103
-
-
53049098471
-
Wild type α-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
-
Vogiatzi, T., Xilouri, M., Vekrellis, K. & Stefanis, L. Wild type α-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J. Biol. Chem. 283, 23542-23556 (2008).
-
(2008)
J. Biol. Chem
, vol.283
, pp. 23542-23556
-
-
Vogiatzi, T.1
Xilouri, M.2
Vekrellis, K.3
Stefanis, L.4
-
104
-
-
0031036896
-
Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease
-
Anglade, P. et al. Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol. Histopathol. 12, 25-31 (1997).
-
(1997)
Histol. Histopathol
, vol.12
, pp. 25-31
-
-
Anglade, P.1
-
105
-
-
38349043984
-
Mitochondrial electron transport chain inhibitors of complexes i and II induce autophagic cell death mediated by reactive oxygen species
-
Chen, Y., McMillan Ward, E., Kong, J., Israels, S. J. & Gibson, S. B. Mitochondrial electron transport chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species. J. Cell Sci. 120, 4155-4166 (2007).
-
(2007)
J. Cell Sci
, vol.120
, pp. 4155-4166
-
-
Chen, Y.1
McMillan Ward, E.2
Kong, J.3
Israels, S.J.4
Gibson, S.B.5
-
106
-
-
50249168137
-
Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: Implications for Parkinson's disease
-
Dagda, R. K., Zhu, J., Kulich, S. M. & Chu, C. T. Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease. Autophagy 4, 770-782 (2008).
-
(2008)
Autophagy
, vol.4
, pp. 770-782
-
-
Dagda, R.K.1
Zhu, J.2
Kulich, S.M.3
Chu, C.T.4
-
107
-
-
33847048316
-
Regulation of autophagy by extracellular signal regulated protein kinases during 1 methyl 4 phenylpyridinium induced cell death
-
Zhu, J. H. et al. Regulation of autophagy by extracellular signal regulated protein kinases during 1 methyl 4 phenylpyridinium induced cell death. Am. J. Pathol. 170, 75-86 (2007).
-
(2007)
Am. J. Pathol
, vol.170
, pp. 75-86
-
-
Zhu, J.H.1
-
108
-
-
0030836345
-
Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: Neuropathologic evidence for a mechanism of increased β-amyloidogenesis
-
Cataldo, A. M., Barnett, J. L., Pieroni, C. & Nixon, R. A. Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased β-amyloidogenesis. J. Neurosci. 17, 6142-6151 (1997).
-
(1997)
J. Neurosci
, vol.17
, pp. 6142-6151
-
-
Cataldo, A.M.1
Barnett, J.L.2
Pieroni, C.3
Nixon, R.A.4
-
109
-
-
33748754701
-
Lysosome associated membrane protein 1 (LAMP 1) in Alzheimer's disease
-
Barrachina, M., Maes, T., Buesa, C. & Ferrer, I. Lysosome associated membrane protein 1 (LAMP 1) in Alzheimer's disease. Neuropathol. Appl. Neurobiol. 32, 505-516 (2006).
-
(2006)
Neuropathol. Appl. Neurobiol
, vol.32
, pp. 505-516
-
-
Barrachina, M.1
Maes, T.2
Buesa, C.3
Ferrer, I.4
-
110
-
-
0029773625
-
Occurrence of Parkinson's syndrome in type i Gaucher disease
-
Neudorfer, O. et al. Occurrence of Parkinson's syndrome in type I Gaucher disease. QJM 89, 691-694 (1996).
-
(1996)
QJM
, vol.89
, pp. 691-694
-
-
Neudorfer, O.1
-
111
-
-
77953229340
-
The risk of Parkinson's disease in type 1 Gaucher disease
-
Bultron, G. et al. The risk of Parkinson's disease in type 1 Gaucher disease. J. Inherit. Metab. Dis. 33, 167-173 (2010).
-
(2010)
J. Inherit. Metab. Dis
, vol.33
, pp. 167-173
-
-
Bultron, G.1
-
112
-
-
77956059558
-
The neurological manifestations of Gaucher disease type 1: The French Observatoire on Gaucher disease (FROG)
-
Cherin, P. et al. The neurological manifestations of Gaucher disease type 1: the French Observatoire on Gaucher disease (FROG). J. Inherit. Metab. Dis. 33, 331-338 (2010).
-
(2010)
J. Inherit. Metab. Dis
, vol.33
, pp. 331-338
-
-
Cherin, P.1
-
113
-
-
53049096591
-
Phenotype, diagnosis, and treatment of Gaucher's disease
-
Grabowski, G. A. Phenotype, diagnosis, and treatment of Gaucher's disease. Lancet 372, 1263-1271 (2008).
-
(2008)
Lancet
, vol.372
, pp. 1263-1271
-
-
Grabowski, G.A.1
-
114
-
-
27644455088
-
Mutations in the glucocerebrosidase gene and Parkinson disease: Phenotype genotype correlation
-
Aharon-Peretz, J., Badarny, S., Rosenbaum, H. & Gershoni Baruch, R. Mutations in the glucocerebrosidase gene and Parkinson disease: phenotype genotype correlation. Neurology 65, 1460-1461 (2005).
-
(2005)
Neurology
, vol.65
, pp. 1460-1461
-
-
Aharon-Peretz, J.1
Badarny, S.2
Rosenbaum, H.3
Gershoni Baruch, R.4
-
115
-
-
43049170734
-
Glucocerebrosidase gene mutations are associated with Parkinson's disease in southern Italy
-
De Marco, E. V. et al. Glucocerebrosidase gene mutations are associated with Parkinson's disease in southern Italy. Mov. Disord. 23, 460-463 (2008).
-
(2008)
Mov. Disord
, vol.23
, pp. 460-463
-
-
De Marco, E.V.1
-
116
-
-
38349120445
-
Association between Parkinson's disease and glucocerebrosidase mutations in Brazil
-
Spitz, M., Rozenberg, R., Pereira Lda, V. & Reis Barbosa, E. Association between Parkinson's disease and glucocerebrosidase mutations in Brazil. Parkinsonism Relat. Disord. 14, 58-62 (2008).
-
(2008)
Parkinsonism Relat. Disord
, vol.14
, pp. 58-62
-
-
Spitz, M.1
Rozenberg, R.2
Pereira Lda, V.3
Reis Barbosa, E.4
-
117
-
-
77953485608
-
Glucocerebrosidase gene L444P mutation is a risk factor for Parkinson's disease in Chinese population
-
Sun, Q. Y. et al. Glucocerebrosidase gene L444P mutation is a risk factor for Parkinson's disease in Chinese population. Mov. Disord. 25, 1005-11 (2010).
-
(2010)
Mov. Disord
, vol.25
, pp. 1005-1011
-
-
Sun, Q.Y.1
-
118
-
-
14044262300
-
Pilot association study of the β-glucocerebrosidase N370S allele and Parkinson's disease in subjects of Jewish ethnicity
-
Clark, L. N. et al. Pilot association study of the β- glucocerebrosidase N370S allele and Parkinson's disease in subjects of Jewish ethnicity. Mov. Disord. 20, 100-103 (2005).
-
(2005)
Mov. Disord
, vol.20
, pp. 100-103
-
-
Clark, L.N.1
-
119
-
-
33845683276
-
Deep brain stimulation of the globus pallidus for generalized dystonia in GM1 Type 3 gangliosidosis: Technical case report
-
Roze, E., Navarro, S., Cornu, P., Welter, M. L. & Vidailhet, M. Deep brain stimulation of the globus pallidus for generalized dystonia in GM1 Type 3 gangliosidosis: technical case report. Neurosurgery 59, E1340 (2006).
-
(2006)
Neurosurgery
, vol.59
-
-
Roze, E.1
Navarro, S.2
Cornu, P.3
Welter, M.L.4
Vidailhet, M.5
-
120
-
-
45849089146
-
Decreased activities of lysosomal acid alpha D galactosidase A in the leukocytes of sporadic Parkinson's disease
-
Wu, G. et al. Decreased activities of lysosomal acid alpha D galactosidase A in the leukocytes of sporadic Parkinson's disease. J. Neurol. Sci. 271, 168-173 (2008).
-
(2008)
J. Neurol. Sci
, vol.271
, pp. 168-173
-
-
Wu, G.1
-
121
-
-
80555123101
-
Decreased expression of lysosomal alpha-galactosidase A gene in sporadic Parkinson's disease
-
Wu, G. et al. Decreased expression of lysosomal alpha-galactosidase A gene in sporadic Parkinson's disease. Neurochem. Res. 36, 1939-1944 (2011).
-
(2011)
Neurochem. Res
, vol.36
, pp. 1939-1944
-
-
Wu, G.1
-
122
-
-
79960009804
-
Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies
-
Mazzulli, J. R. et al. Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell 146, 37-52 (2011).
-
(2011)
Cell
, vol.146
, pp. 37-52
-
-
Mazzulli, J.R.1
-
123
-
-
34548039499
-
Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease
-
Balducci, C. et al. Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease. Mov. Disord. 22, 1481-1484 (2007).
-
(2007)
Mov. Disord
, vol.22
, pp. 1481-1484
-
-
Balducci, C.1
-
124
-
-
67349254635
-
Cerebrospinal fluid β-glucocerebrosidase activity is reduced in dementia with Lewy Bodies
-
Parnetti, L. et al. Cerebrospinal fluid β-glucocerebrosidase activity is reduced in dementia with Lewy Bodies. Neurobiol. Dis. 34, 484-486 (2009).
-
(2009)
Neurobiol. Dis
, vol.34
, pp. 484-486
-
-
Parnetti, L.1
-
125
-
-
84859819081
-
Biochemical premotor biomarkers for Parkinson's disease
-
Mollenhauer, B. & Zhang, J. Biochemical premotor biomarkers for Parkinson's disease. Mov. Disord. 27, 644-650 (2012).
-
(2012)
Mov. Disord
, vol.27
, pp. 644-650
-
-
Mollenhauer, B.1
Zhang, J.2
-
126
-
-
82755161902
-
The Parkinson Progression Marker Initiative (PPMI)
-
Parkinson Progression Marker Initiative
-
Parkinson Progression Marker Initiative. The Parkinson Progression Marker Initiative (PPMI). Prog. Neurobiol. 95, 629-635 (2011).
-
(2011)
Prog. Neurobiol
, vol.95
, pp. 629-635
-
-
-
127
-
-
84858156745
-
ITRAQ and multiple reaction monitoring as proteomic tools for biomarker search in cerebrospinal fluid of patients with Parkinson's disease dementia
-
Lehnert, S. et al. iTRAQ and multiple reaction monitoring as proteomic tools for biomarker search in cerebrospinal fluid of patients with Parkinson's disease dementia. Exp. Neurol. 234, 499-505 (2012).
-
(2012)
Exp. Neurol
, vol.234
, pp. 499-505
-
-
Lehnert, S.1
-
128
-
-
84861990380
-
Selected reaction monitoring-based proteomics: Workflows, potential, pitfalls and future directions
-
Picotti, P. & Aebersold, R. Selected reaction monitoring-based proteomics: workflows, potential, pitfalls and future directions. Nat. Methods 9, 555-566 (2012).
-
(2012)
Nat. Methods
, vol.9
, pp. 555-566
-
-
Picotti, P.1
Aebersold, R.2
-
129
-
-
1442275729
-
Clearance of α-synuclein oligomeric intermediates via the lysosomal degradation pathway
-
Lee, H. J., Khoshaghideh, F., Patel, S. & Lee, S. J. Clearance of α-synuclein oligomeric intermediates via the lysosomal degradation pathway. J. Neurosci. 24, 1888-1896 (2004).
-
(2004)
J. Neurosci
, vol.24
, pp. 1888-1896
-
-
Lee, H.J.1
Khoshaghideh, F.2
Patel, S.3
Lee, S.J.4
|