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Volumn 7, Issue 1, 2012, Pages

A molecular signature in blood identifies early Parkinsons disease

Author keywords

Alzheimers disease; Blood Biomarker; CSF Biomarkers; E3 ubiquitin ligase; Early diagnosis; Heat shock protein Hsc 70; SCF; SKP1; Sporadic Parkinsons disease

Indexed keywords

19 S PROTEASOMAL PROTEIN; ALDEHYDE DEHYDROGENASE; HEAT SHOCK COGNATE PROTEIN 70; HUNTINGTIN INTERACTING PROTEIN 2; P19 S PHASE KINASE ASSOCIATED PROTEIN 1A; PROTEIN; PROTEIN KINASE P60; UNCLASSIFIED DRUG;

EID: 84861651595     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/1750-1326-7-26     Document Type: Article
Times cited : (97)

References (45)
  • 1
    • 0026514953 scopus 로고
    • Accuracy of clinical diagnosis of idiopathic Parkinsons disease: A clinico-pathological study of 100 cases
    • 10.1136/jnnp.55.3.181 1564476
    • Accuracy of clinical diagnosis of idiopathic Parkinsons disease: a clinico-pathological study of 100 cases. Hughes AJ, Daniel SE, Kilford L, Lees AJ, J Neurol Neurosurg Psychiatry 1992 55 181 184 10.1136/jnnp.55.3.181 1564476
    • (1992) J Neurol Neurosurg Psychiatry , vol.55 , pp. 181-184
    • Hughes, A.J.1    Daniel, S.E.2    Kilford, L.3    Lees, A.J.4
  • 2
    • 0000224448 scopus 로고
    • Unified Parkinsons disease rating scale
    • Macmillan, New York Fahn S, Marsden CD, Goldstein M 22704258
    • Unified Parkinsons disease rating scale. Fahn S, Elton R, UPDRS Development Committee, In Recent Developments in Parkinsons Disease. Volume 2 Macmillan, New York, Fahn S, Marsden CD, Goldstein M, 1987 153 167 22704258
    • (1987) Recent Developments in Parkinsons Disease , vol.2 , pp. 153-167
    • Fahn, S.1    Elton, R.2
  • 5
    • 0014082977 scopus 로고
    • Parkinsonism: Onset, progression and mortality
    • 10.1212/WNL.17.5.427 6067254
    • Parkinsonism: onset, progression and mortality. Hoehn MM, Yahr MD, Neurology 1967 17 427 442 10.1212/WNL.17.5.427 6067254
    • (1967) Neurology , vol.17 , pp. 427-442
    • Hoehn, M.M.1    Yahr, M.D.2
  • 6
    • 0026629509 scopus 로고
    • What features improve the accuracy of clinical diagnosis in Parkinsons disease: A clinicopathologic study
    • 10.1212/WNL.42.6.1142 1603339
    • What features improve the accuracy of clinical diagnosis in Parkinsons disease: a clinicopathologic study. Hughes AJ, Ben-Shlomo Y, Daniel SE, Lees AJ, Neurology 1992 42 1142 1146 10.1212/WNL.42.6.1142 1603339
    • (1992) Neurology , vol.42 , pp. 1142-1146
    • Hughes, A.J.1    Ben-Shlomo, Y.2    Daniel, S.E.3    Lees, A.J.4
  • 7
    • 0037323212 scopus 로고    scopus 로고
    • Routine MRI for the differential diagnosis of Parkinson's disease, MSA, PSP, and CBD
    • DOI 10.1007/s00702-002-0785-5
    • Routine MRI for the differential diagnosis of Parkinsons disease, MSA, PSP, and CBD. Yekhlef F, Ballan G, Macia F, Delmer O, Sourgen C, Tison F, J Neural Transm 2003 110 151 169 10.1007/s00702-002-0785-5 12589575 (Pubitemid 36216498)
    • (2003) Journal of Neural Transmission , vol.110 , Issue.2 , pp. 151-169
    • Yekhlef, F.1    Ballan, G.2    Macia, F.3    Delmer, O.4    Sourgen, C.5    Tison, F.6
  • 8
    • 0028830961 scopus 로고
    • Differentiation of multiple system atrophy from idiopathic Parkinsons disease using proton magnetic resonance spectroscopy
    • 10.1002/ana.410370211 7847862
    • Differentiation of multiple system atrophy from idiopathic Parkinsons disease using proton magnetic resonance spectroscopy. Davie CA, Wenning GK, Barker GJ, Tofts PS, Kendall BE, Quinn N, McDonald WI, Marsden CD, Miller DH, Ann Neurol 1995 37 204 210 10.1002/ana.410370211 7847862
    • (1995) Ann Neurol , vol.37 , pp. 204-210
    • Davie, C.A.1    Wenning, G.K.2    Barker, G.J.3    Tofts, P.S.4    Kendall, B.E.5    Quinn, N.6    McDonald, W.I.7    Marsden, C.D.8    Miller, D.H.9
  • 9
    • 0033431719 scopus 로고    scopus 로고
    • Phosphorus magnetic resonance spectroscopy in multiple system atrophy and Parkinson's disease
    • DOI 10.1002/1531-8257(199905)14:3<430::AID-MDS1007>3.0.CO;2-S
    • Phosphorus magnetic resonance spectroscopy in multiple system atrophy and Parkinsons disease. Barbiroli B, Martinelli P, Patuelli A, Lodi R, Iotti S, Cortelli P, Montagna P, Mov Disord 1999 14 430 435 10.1002/1531-8257(199905)14: 3<430::AID-MDS1007>3.0.CO;2-S 10348465 (Pubitemid 30011652)
    • (1999) Movement Disorders , vol.14 , Issue.3 , pp. 430-435
    • Barbiroli, B.1    Martinelli, P.2    Patuelli, A.3    Lodi, R.4    Iotti, S.5    Cortelli, P.6    Montagna, P.7
  • 10
    • 0034063907 scopus 로고    scopus 로고
    • The evolution of diagnosis in early Parkinson disease
    • The evolution of diagnosis in early Parkinson disease. Parkinson Study Group. Jankovic J, Rajput AH, McDermott MP, Perl DP, Arch Neurol 2000 57 369 372 10.1001/archneur.57.3.369 10714663 (Pubitemid 30140525)
    • (2000) Archives of Neurology , vol.57 , Issue.3 , pp. 369-372
    • Jankovic, J.1    Rajput, A.H.2    McDermott, M.P.3    Perl, D.P.4
  • 11
    • 19944428747 scopus 로고    scopus 로고
    • Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes
    • DOI 10.1007/s00702-004-0212-1
    • Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes. Grunblatt E, Mandel S, Jacob-Hirsch J, Zeligson S, Amariglo N, Rechavi G, Li J, Ravid R, Roggendorf W, Riederer P, Youdim MB, J Neural Transm 2004 111 1543 1573 10.1007/s00702-004-0212-1 15455214 (Pubitemid 40068786)
    • (2004) Journal of Neural Transmission , vol.111 , Issue.12 , pp. 1543-1573
    • Grunblatt, E.1    Mandel, S.2    Jacob-Hirsch, J.3    Zeligson, S.4    Amariglo, N.5    Rechavi, G.6    Li, J.7    Ravid, R.8    Roggendorf, W.9    Riederer, P.10    Youdim, M.B.H.11
  • 13
    • 30744451670 scopus 로고    scopus 로고
    • Robust dysregulation of gene expression in substantia nigra and striatum in Parkinson's disease
    • DOI 10.1016/j.nbd.2005.07.010, PII S0969996105002093
    • Robust dysregulation of gene expression in substantia nigra and striatum in Parkinsons disease. Miller RM, Kiser GL, Kaysser-Kranich TM, Lockner RJ, Palaniappan C, Federoff HJ, Neurobiol Dis 2006 21 305 313 10.1016/j.nbd.2005.07. 010 16143538 (Pubitemid 43099854)
    • (2006) Neurobiology of Disease , vol.21 , Issue.2 , pp. 305-313
    • Miller, R.M.1    Kiser, G.L.2    Kaysser-Kranich, T.M.3    Lockner, R.J.4    Palaniappan, C.5    Federoff, H.J.6
  • 14
    • 33644658492 scopus 로고    scopus 로고
    • Whole genome expression profiling of the medial and lateral substantia nigra in Parkinson's disease
    • DOI 10.1007/s10048-005-0020-2
    • Whole genome expression profiling of the medial and lateral substantia nigra in Parkinsons disease. Moran LB, Duke DC, Deprez M, Dexter DT, Pearce RK, Graeber MB, Neurogenetics 2006 7 1 11 10.1007/s10048-005-0020-2 16344956 (Pubitemid 43327678)
    • (2006) Neurogenetics , vol.7 , Issue.1 , pp. 1-11
    • Moran, L.B.1    Duke, D.C.2    Deprez, M.3    Dexter, D.T.4    Pearce, R.K.B.5    Graeber, M.B.6
  • 15
    • 23044502947 scopus 로고    scopus 로고
    • Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms
    • DOI 10.1002/ajmg.b.30195
    • Transcriptional analysis of multiple brain regions in Parkinsons disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms. Zhang Y, James M, Middleton FA, Davis RL, Am J Med Genet B Neuropsychiatr Genet 2005 137 5 16 (Pubitemid 41076605)
    • (2005) American Journal of Medical Genetics - Neuropsychiatric Genetics , vol.B137 , Issue.1 , pp. 5-16
    • Zhang, Y.1    James, M.2    Middleton, F.A.3    Davis, R.L.4
  • 16
    • 68649110032 scopus 로고    scopus 로고
    • Mendelian forms of Parkinsons disease
    • 10.1016/j.bbadis.2008.12.007 19168133
    • Mendelian forms of Parkinsons disease. Gasser T, Biochim Biophys Acta 2009 1792 587 596 10.1016/j.bbadis.2008.12.007 19168133
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 587-596
    • Gasser, T.1
  • 18
    • 0030695025 scopus 로고    scopus 로고
    • A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p
    • DOI 10.1016/S0092-8674(00)80404-3
    • A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Feldman RM, Correll CC, Kaplan KB, Deshaies RJ, Cell 1997 91 221 230 10.1016/S0092-8674(00)80404-3 9346239 (Pubitemid 27456389)
    • (1997) Cell , vol.91 , Issue.2 , pp. 221-230
    • Feldman, R.M.R.1    Correll, C.C.2    Kaplan, K.B.3    Deshaies, R.J.4
  • 19
    • 0037401714 scopus 로고    scopus 로고
    • CHIP: A quality-control E3 ligase collaborating with molecular chaperones
    • DOI 10.1016/S1357-2725(02)00394-1
    • CHIP: a quality-control E3 ligase collaborating with molecular chaperones. Murata S, Chiba T, Tanaka K, Int J Biochem Cell Biol 2003 35 572 578 10.1016/S1357-2725(02)00394-1 12672450 (Pubitemid 36369506)
    • (2003) International Journal of Biochemistry and Cell Biology , vol.35 , Issue.5 , pp. 572-578
    • Murata, S.1    Chiba, T.2    Tanaka, K.3
  • 20
    • 70349731404 scopus 로고    scopus 로고
    • Biological fluid biomarkers in neurodegenerative parkinsonism
    • 10.1038/nrneurol.2009.135 19724250
    • Biological fluid biomarkers in neurodegenerative parkinsonism. Eller M, Williams DR, Nat Rev Neurol 2009 5 561 570 10.1038/nrneurol.2009.135 19724250
    • (2009) Nat Rev Neurol , vol.5 , pp. 561-570
    • Eller, M.1    Williams, D.R.2
  • 22
    • 79951720856 scopus 로고    scopus 로고
    • Alpha-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: A cohort study
    • 10.1016/S1474-4422(11)70014-X 21317042
    • alpha-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study. Mollenhauer B, Locascio JJ, Schulz-Schaeffer W, Sixel-Doring F, Trenkwalder C, Schlossmacher MG, Lancet Neurol 2011 10 230 240 10.1016/S1474-4422(11)70014-X 21317042
    • (2011) Lancet Neurol , vol.10 , pp. 230-240
    • Mollenhauer, B.1    Locascio, J.J.2    Schulz-Schaeffer, W.3    Sixel-Doring, F.4    Trenkwalder, C.5    Schlossmacher, M.G.6
  • 28
    • 33646010307 scopus 로고    scopus 로고
    • Evaluating the comparability of gene expression in blood and brain
    • 10.1002/ajmg.b.30272 16526044
    • Evaluating the comparability of gene expression in blood and brain. Sullivan PF, Fan C, Perou CM, Am J Med Genet B Neuropsychiatr Genet 2006 141B 261 268 10.1002/ajmg.b.30272 16526044
    • (2006) Am J Med Genet B Neuropsychiatr Genet , vol.141 , pp. 261-268
    • Sullivan, P.F.1    Fan, C.2    Perou, C.M.3
  • 29
    • 77949444966 scopus 로고    scopus 로고
    • Plasma protein biomarkers for depression and schizophrenia by multi analyte profiling of case-control collections
    • 10.1371/journal.pone.0009166 20161799
    • Plasma protein biomarkers for depression and schizophrenia by multi analyte profiling of case-control collections. Domenici E, Wille DR, Tozzi F, Prokopenko I, Miller S, McKeown A, Brittain C, Rujescu D, Giegling I, Turck CW, et al. PLoS One 2010 5 9166 10.1371/journal.pone.0009166 20161799
    • (2010) PLoS One , vol.5 , pp. 59166
    • Domenici, E.1    Wille, D.R.2    Tozzi, F.3    Prokopenko, I.4    Miller, S.5    McKeown, A.6    Brittain, C.7    Rujescu, D.8    Giegling, I.9    Turck, C.W.10
  • 31
    • 77949342573 scopus 로고    scopus 로고
    • SRRM2, a potential blood biomarker revealing high alternative splicing in Parkinsons disease
    • 10.1371/journal.pone.0009104 20161708
    • SRRM2, a potential blood biomarker revealing high alternative splicing in Parkinsons disease. Shehadeh LA, Yu K, Wang L, Guevara A, Singer C, Vance J, Papapetropoulos S, PLoS One 2010 5 9104 10.1371/journal.pone.0009104 20161708
    • (2010) PLoS One , vol.5 , pp. 59104
    • Shehadeh, L.A.1    Yu, K.2    Wang, L.3    Guevara, A.4    Singer, C.5    Vance, J.6    Papapetropoulos, S.7
  • 33
    • 33344454373 scopus 로고    scopus 로고
    • The peripheral blood transcriptome dynamically reflects system wide biology: A potential diagnostic tool
    • DOI 10.1016/j.lab.2005.10.005, PII S0022214305003835
    • The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool. Liew CC, Ma J, Tang HC, Zheng R, Dempsey AA, J Lab Clin Med 2006 147 126 132 10.1016/j.lab.2005.10.005 16503242 (Pubitemid 43288168)
    • (2006) Journal of Laboratory and Clinical Medicine , vol.147 , Issue.3 , pp. 126-132
    • Liew, C.-C.1    Ma, J.2    Tang, H.-C.3    Zheng, R.4    Dempsey, A.A.5
  • 34
    • 0022844901 scopus 로고
    • Human class I alcohol dehydrogenases catalyze the interconversion of alcohols and aldehydes in the metabolism of dopamine
    • Human class I alcohol dehydrogenases catalyze the interconversion of alcohols and aldehydes in the metabolism of dopamine. Mardh G, Vallee BL, Biochemistry 1986 25 7279 7282 10.1021/bi00371a005 2432930 (Pubitemid 17220436)
    • (1986) Biochemistry , vol.25 , Issue.23 , pp. 7279-7282
    • Maardh, G.1    Vallee, B.L.2
  • 35
    • 0021166316 scopus 로고
    • Hepatic aldehyde dehydrogenases and lipid peroxidation
    • 6634832
    • Hepatic aldehyde dehydrogenases and lipid peroxidation. Hjelle JJ, Petersen DR, Pharmacol Biochem Behav 1983 18 Suppl 1 155 160 6634832
    • (1983) Pharmacol Biochem Behav , vol.18 , Issue.SUPPL. 1 , pp. 155-160
    • Hjelle, J.J.1    Petersen, D.R.2
  • 36
    • 33845898194 scopus 로고    scopus 로고
    • Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases
    • DOI 10.1016/j.mcn.2006.09.006, PII S1044743106002090
    • Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases. de Pril R, Fischer DF, Roos RA, van Leeuwen FW, Mol Cell Neurosci 2007 34 10 19 10.1016/j.mcn.2006.09.006 17092742 (Pubitemid 46026926)
    • (2007) Molecular and Cellular Neuroscience , vol.34 , Issue.1 , pp. 10-19
    • De Pril, R.1    Fischer, D.F.2    Roos, R.A.C.3    Van Leeuwen, F.W.4
  • 38
    • 70450280570 scopus 로고    scopus 로고
    • A sporadic parkinsons disease model via silencing of the ubiquitin-proteasome/E3-ligase component, SKP1A
    • 10.1074/jbc.M109.034223 19748892
    • A sporadic parkinsons disease model via silencing of the ubiquitin-proteasome/E3-ligase component, SKP1A. Fishman-Jacob T, Reznichenko L, Youdim MB, Mandel SA, J Biol Chem 2009 284 47 32835 32845 10.1074/jbc.M109. 034223 19748892
    • (2009) J Biol Chem , vol.284 , Issue.47 , pp. 32835-32845
    • Fishman-Jacob, T.1    Reznichenko, L.2    Youdim, M.B.3    Mandel, S.A.4
  • 39
    • 0348109455 scopus 로고    scopus 로고
    • ALDH1 mRNA: Presence in human dopamine neurons and decreases in substantia nigra in Parkinson's disease and in the ventral tegmental area in schizophrenia
    • DOI 10.1016/j.nbd.2003.09.001
    • ALDH1 mRNA: presence in human dopamine neurons and decreases in substantia nigra in Parkinsons disease and in the ventral tegmental area in schizophrenia. Galter D, Buervenich S, Carmine A, Anvret M, Olson L, Neurobiol Dis 2003 14 637 647 10.1016/j.nbd.2003.09.001 14678778 (Pubitemid 37547970)
    • (2003) Neurobiology of Disease , vol.14 , Issue.3 , pp. 637-647
    • Galter, D.1    Buervenich, S.2    Carmine, A.3    Anvret, M.4    Olson, L.5
  • 40
    • 38949125133 scopus 로고    scopus 로고
    • Gene and protein signatures in sporadic Parkinsons disease and a novel genetic model of PD
    • 18267243
    • Gene and protein signatures in sporadic Parkinsons disease and a novel genetic model of PD. Mandel SA, Fishman T, Youdim MB, Parkinsonism Relat Disord 2007 13 Suppl 3 242 S247 18267243
    • (2007) Parkinsonism Relat Disord , vol.13 , Issue.SUPPL. 3
    • Mandel, S.A.1    Fishman, T.2    Youdim, M.B.3
  • 41
    • 78651237174 scopus 로고    scopus 로고
    • Pilot study: Peripheral biomarkers for diagnosing sporadic Parkinsons disease
    • 10.1007/s00702-010-0509-1 21069393
    • Pilot study: peripheral biomarkers for diagnosing sporadic Parkinsons disease. Grunblatt E, Zehetmayer S, Jacob CP, Muller T, Jost WH, Riederer P, J Neural Transm 2010 117 12 1387 1393 10.1007/s00702-010-0509-1 21069393
    • (2010) J Neural Transm , vol.117 , Issue.12 , pp. 1387-1393
    • Grunblatt, E.1    Zehetmayer, S.2    Jacob, C.P.3    Muller, T.4    Jost, W.H.5    Riederer, P.6
  • 43
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease
    • Clinical diagnosis of Alzheimers disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimers Disease. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM, Neurology 1984 34 939 944 10.1212/WNL.34.7.939 6610841 (Pubitemid 14076461)
    • (1984) Neurology , vol.34 , Issue.7 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3
  • 44
    • 57249101994 scopus 로고    scopus 로고
    • Quantitative Real-Time PCR detection of TRPV1-4 gene expression in human leukocytes from healthy and hyposensitive subjects
    • 10.1186/1744-8069-4-51 18983665
    • Quantitative Real-Time PCR detection of TRPV1-4 gene expression in human leukocytes from healthy and hyposensitive subjects. Spinsanti G, Zannolli R, Panti C, et al. Mol Pain 2008 4 51 10.1186/1744-8069-4-51 18983665
    • (2008) Mol Pain , vol.4 , pp. 51
    • Spinsanti, G.1    Zannolli, R.2    Panti, C.3
  • 45
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • 12184808
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Vandesompele J, De Preter K, Pattyn F, et al. Genome Biol 2002 3 7 ESEARCH0034 12184808
    • (2002) Genome Biol , vol.3 , Issue.7
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3


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