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Volumn 63, Issue , 2014, Pages 170-179

UHPLC-MS strategies and applications for bioanalyses related to pharmacokinetics and drug metabolism

Author keywords

Bioanalysis; Drug metabolism; High throughput analysis; Mass spectrometry; MS; Pharmacokinetics; Sample treatment; UHPLC; UHPLC MS; Ultra high performance liquid chromatography

Indexed keywords

DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; METABOLISM; PHYSIOLOGY;

EID: 84911920427     PISSN: 01659936     EISSN: 18793142     Source Type: Journal    
DOI: 10.1016/j.trac.2014.08.006     Document Type: Review
Times cited : (18)

References (82)
  • 1
    • 84877115807 scopus 로고    scopus 로고
    • Challenges in the development of bioanalytical liquid chromatography-mass spectrometry method with emphasis on fast analysis
    • Nováková L. Challenges in the development of bioanalytical liquid chromatography-mass spectrometry method with emphasis on fast analysis. J. Chromatogr. A 2013, 1292:25-37.
    • (2013) J. Chromatogr. A , vol.1292 , pp. 25-37
    • Nováková, L.1
  • 2
    • 84866309522 scopus 로고    scopus 로고
    • Recent developments in liquid chromatography-mass spectrometry and related techniques
    • Holčapek M., Jirásko R., Lísa M. Recent developments in liquid chromatography-mass spectrometry and related techniques. J. Chromatogr. A 2012, 1259:3-15.
    • (2012) J. Chromatogr. A , vol.1259 , pp. 3-15
    • Holčapek, M.1    Jirásko, R.2    Lísa, M.3
  • 3
    • 77953476888 scopus 로고    scopus 로고
    • New trends in fast and high-resolution liquid chromatography: a critical comparison of existing approaches
    • Guillarme D., Ruta J., Rudaz S., Veuthey J.L. New trends in fast and high-resolution liquid chromatography: a critical comparison of existing approaches. Anal. Bioanal. Chem 2010, 397:1069-1082.
    • (2010) Anal. Bioanal. Chem , vol.397 , pp. 1069-1082
    • Guillarme, D.1    Ruta, J.2    Rudaz, S.3    Veuthey, J.L.4
  • 4
    • 4644265806 scopus 로고    scopus 로고
    • Ultra-performance liquid chromatography coupled to quadrupole-orthogonal time-of-flight mass spectrometry
    • Plumb R., Castro-Perez J., Granger J., Beattie I., Joncour K., Wright A. Ultra-performance liquid chromatography coupled to quadrupole-orthogonal time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom 2004, 18:2331-2337.
    • (2004) Rapid Commun. Mass Spectrom , vol.18 , pp. 2331-2337
    • Plumb, R.1    Castro-Perez, J.2    Granger, J.3    Beattie, I.4    Joncour, K.5    Wright, A.6
  • 5
    • 14844293921 scopus 로고    scopus 로고
    • Increasing throughput and information content for in vitro drug metabolism experiments using ultra-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer
    • Castro-Perez J., Plumb R., Granger J.H., Beattie I., Joncour K., Wright A. Increasing throughput and information content for in vitro drug metabolism experiments using ultra-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer. Rapid Commun. Mass Spectrom 2005, 19:843-848.
    • (2005) Rapid Commun. Mass Spectrom , vol.19 , pp. 843-848
    • Castro-Perez, J.1    Plumb, R.2    Granger, J.H.3    Beattie, I.4    Joncour, K.5    Wright, A.6
  • 8
    • 34250196870 scopus 로고    scopus 로고
    • The role of UHPLC in pharmaceutical development
    • Chesnut S.M., Salisbury J.J. The role of UHPLC in pharmaceutical development. J. Sep. Sci 2007, 30:1183-1190.
    • (2007) J. Sep. Sci , vol.30 , pp. 1183-1190
    • Chesnut, S.M.1    Salisbury, J.J.2
  • 9
    • 84877106925 scopus 로고    scopus 로고
    • Ultrahigh pressure liquid chromatography-(tandem) mass spectrometry in human sports drug testing: possibilities and limitations
    • Thevis M., Thomas A., Pop V., Schänzer W. Ultrahigh pressure liquid chromatography-(tandem) mass spectrometry in human sports drug testing: possibilities and limitations. J. Chromatogr. A 2013, 1292:38-50.
    • (2013) J. Chromatogr. A , vol.1292 , pp. 38-50
    • Thevis, M.1    Thomas, A.2    Pop, V.3    Schänzer, W.4
  • 10
    • 84876973252 scopus 로고    scopus 로고
    • Ultra high performance liquid chromatography tandem mass spectrometry determination and profiling of prohibited steroids in human biological matrices. A review
    • Gosetti F., Mazzucco E., Gennaro M.C., Marengo E. Ultra high performance liquid chromatography tandem mass spectrometry determination and profiling of prohibited steroids in human biological matrices. A review. J. Chromatogr. B 2013, 927:22-36.
    • (2013) J. Chromatogr. B , vol.927 , pp. 22-36
    • Gosetti, F.1    Mazzucco, E.2    Gennaro, M.C.3    Marengo, E.4
  • 11
    • 84877116849 scopus 로고    scopus 로고
    • The use of ultra-high pressure liquid chromatography with tandem mass spectrometric detection in the analysis of agrochemical residues and mycotoxins in food-challenges and applications
    • O'Mahony J., Clarke L., Whelan M., Kennedy R.O., Lehotay S.J., Danaher M. The use of ultra-high pressure liquid chromatography with tandem mass spectrometric detection in the analysis of agrochemical residues and mycotoxins in food-challenges and applications. J. Chromatogr. A 2013, 1292:83-95.
    • (2013) J. Chromatogr. A , vol.1292 , pp. 83-95
    • O'Mahony, J.1    Clarke, L.2    Whelan, M.3    Kennedy, R.O.4    Lehotay, S.J.5    Danaher, M.6
  • 12
    • 84876973477 scopus 로고    scopus 로고
    • Ultra high performance liquid chromatography as a tool for the discovery and the analysis of biomarkers of diseases: a review
    • Denoroy L., Zimmer L., Renaud B., Parrot S. Ultra high performance liquid chromatography as a tool for the discovery and the analysis of biomarkers of diseases: a review. J. Chromatogr. B 2013, 927:37-53.
    • (2013) J. Chromatogr. B , vol.927 , pp. 37-53
    • Denoroy, L.1    Zimmer, L.2    Renaud, B.3    Parrot, S.4
  • 13
    • 73249131951 scopus 로고    scopus 로고
    • Coupling ultra-high-pressure liquid chromatography with mass spectrometry
    • Guillarme D., Schappler J., Rudaz S., Veuthey J.L. Coupling ultra-high-pressure liquid chromatography with mass spectrometry. Trends Anal. Chem 2010, 29:15-27.
    • (2010) Trends Anal. Chem , vol.29 , pp. 15-27
    • Guillarme, D.1    Schappler, J.2    Rudaz, S.3    Veuthey, J.L.4
  • 14
    • 84859267316 scopus 로고    scopus 로고
    • Simultaneous determination of antidementia drugs in human plasma: procedure transfer from HPLC-MS to UPLC-MS-MS
    • Noetzli M., Ansermot N., Dobrinas M., Eap C.B. Simultaneous determination of antidementia drugs in human plasma: procedure transfer from HPLC-MS to UPLC-MS-MS. J. Pharm. Biomed. Anal 2012, 64-65:16-25.
    • (2012) J. Pharm. Biomed. Anal , pp. 16-25
    • Noetzli, M.1    Ansermot, N.2    Dobrinas, M.3    Eap, C.B.4
  • 15
    • 26444507780 scopus 로고    scopus 로고
    • MS sensitivity through increases in chromatographic performance: comparisons of UPLC-ES-MS-MS to HPLC-ES-MS-MS
    • Churchwell M.I., Twaddle N.C., Meeker L.R., Doerge D.R., Improving L.C. MS sensitivity through increases in chromatographic performance: comparisons of UPLC-ES-MS-MS to HPLC-ES-MS-MS. J. Chromatogr. B 2005, 825:134-143.
    • (2005) J. Chromatogr. B , vol.825 , pp. 134-143
    • Churchwell, M.I.1    Twaddle, N.C.2    Meeker, L.R.3    Doerge, D.R.4    Improving, L.C.5
  • 16
    • 32544446573 scopus 로고    scopus 로고
    • High-throughput quantification for a drug mixture in rat plasma-a comparison of Ultra Performance liquid chromatography/tandem mass spectrometry with high-performance liquid chromatography/tandem mass spectrometry
    • Yu K., Little D., Plumb R., Smith B. High-throughput quantification for a drug mixture in rat plasma-a comparison of Ultra Performance liquid chromatography/tandem mass spectrometry with high-performance liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom 2006, 20:544-552.
    • (2006) Rapid Commun. Mass Spectrom , vol.20 , pp. 544-552
    • Yu, K.1    Little, D.2    Plumb, R.3    Smith, B.4
  • 17
    • 84877127791 scopus 로고    scopus 로고
    • Coupling ultra high-pressure liquid chromatography with mass spectrometry: constraints and possible applications
    • Rodriguez-Aller M., Gurny R., Veuthey J.L., Guillarme D. Coupling ultra high-pressure liquid chromatography with mass spectrometry: constraints and possible applications. J. Chromatogr. A 2013, 1292:2-18.
    • (2013) J. Chromatogr. A , vol.1292 , pp. 2-18
    • Rodriguez-Aller, M.1    Gurny, R.2    Veuthey, J.L.3    Guillarme, D.4
  • 18
    • 33846450306 scopus 로고    scopus 로고
    • High performance liquid chromatography-electrospray ionization mass spectrometric determination of isosorbide 5-mononitrate in human plasma
    • Sun X.H., Li X., Cai S., Qin F., Lu X.M., Li F.M. High performance liquid chromatography-electrospray ionization mass spectrometric determination of isosorbide 5-mononitrate in human plasma. J. Chromatogr. B 2007, 846:323-328.
    • (2007) J. Chromatogr. B , vol.846 , pp. 323-328
    • Sun, X.H.1    Li, X.2    Cai, S.3    Qin, F.4    Lu, X.M.5    Li, F.M.6
  • 19
    • 84856330758 scopus 로고    scopus 로고
    • A fast, sensitive, and high throughput method for the determination of cefuroxime lysine in dog plasma by UPLC-MS-MS
    • Zhao L.S., Zhao Y.L., Li Q., Chen X.H., Xiao F., He B.S., et al. A fast, sensitive, and high throughput method for the determination of cefuroxime lysine in dog plasma by UPLC-MS-MS. Talanta 2012, 89:84-90.
    • (2012) Talanta , vol.89 , pp. 84-90
    • Zhao, L.S.1    Zhao, Y.L.2    Li, Q.3    Chen, X.H.4    Xiao, F.5    He, B.S.6
  • 20
    • 37749053827 scopus 로고    scopus 로고
    • Determination of nimodipine in human plasma by ultra performance liquid chromatography-tandem mass spectrometry and pharmacokinetic application
    • Qin F., Ma Y.Y., Wang Y.Q., Chen L.Y., Wang D., Li F.M. Determination of nimodipine in human plasma by ultra performance liquid chromatography-tandem mass spectrometry and pharmacokinetic application. J. Pharm. Biomed. Anal 2008, 46:557-562.
    • (2008) J. Pharm. Biomed. Anal , vol.46 , pp. 557-562
    • Qin, F.1    Ma, Y.Y.2    Wang, Y.Q.3    Chen, L.Y.4    Wang, D.5    Li, F.M.6
  • 21
    • 58249137332 scopus 로고    scopus 로고
    • Simultaneous quantification of enalapril and enalaprilat in human plasma by high-performance liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study
    • Lu S., Jiang K., Qin F., Lu X.M., Li F.M. Simultaneous quantification of enalapril and enalaprilat in human plasma by high-performance liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study. J. Pharm. Biomed. Anal 2009, 49:163-167.
    • (2009) J. Pharm. Biomed. Anal , vol.49 , pp. 163-167
    • Lu, S.1    Jiang, K.2    Qin, F.3    Lu, X.M.4    Li, F.M.5
  • 22
    • 67650753253 scopus 로고    scopus 로고
    • High-performance liquid chromatography-tandem mass spectrometry for the determination of pidotimod in human plasma and its application to a pharmacokinetic study
    • Zhang Y., Xiong Z.L., Qin F., Lu S., Liu W., Li F.M. High-performance liquid chromatography-tandem mass spectrometry for the determination of pidotimod in human plasma and its application to a pharmacokinetic study. J. Chromatogr. B 2009, 877:2566-2570.
    • (2009) J. Chromatogr. B , vol.877 , pp. 2566-2570
    • Zhang, Y.1    Xiong, Z.L.2    Qin, F.3    Lu, S.4    Liu, W.5    Li, F.M.6
  • 23
    • 84856500096 scopus 로고    scopus 로고
    • Therapeutic drug monitoring and LC-MS-MS
    • Adaway J.E., Keevil B.G. Therapeutic drug monitoring and LC-MS-MS. J. Chromatogr. B 2012, 883-884:33-49.
    • (2012) J. Chromatogr. B , pp. 33-49
    • Adaway, J.E.1    Keevil, B.G.2
  • 24
    • 84871739841 scopus 로고    scopus 로고
    • Determination of glibenclamide and puerarin in rat plasma by UPLC-MS-MS: application to their pharmacokinetic interaction study
    • Li N., Deng Y., Wang D., Qiao Y., Li F.M. Determination of glibenclamide and puerarin in rat plasma by UPLC-MS-MS: application to their pharmacokinetic interaction study. Talanta 2013, 104:109-115.
    • (2013) Talanta , vol.104 , pp. 109-115
    • Li, N.1    Deng, Y.2    Wang, D.3    Qiao, Y.4    Li, F.M.5
  • 25
    • 39749129773 scopus 로고    scopus 로고
    • A novel 'peak parking' strategy for ultra-performance liquid chromatography/tandem mass spectrometric detection for enhanced performance of bioanalytical assays
    • Li F.M., Maguigad J., Pelzer M., Jiang X.Y., Ji Q.C. A novel 'peak parking' strategy for ultra-performance liquid chromatography/tandem mass spectrometric detection for enhanced performance of bioanalytical assays. Rapid Commun. Mass Spectrom 2008, 22:486-494.
    • (2008) Rapid Commun. Mass Spectrom , vol.22 , pp. 486-494
    • Li, F.M.1    Maguigad, J.2    Pelzer, M.3    Jiang, X.Y.4    Ji, Q.C.5
  • 26
    • 58349090627 scopus 로고    scopus 로고
    • Determination of opiates and cocaine in urine by high pH mobile phase reversed phase UPLC-MS-MS
    • Berg T., Lundanes E., Christophersen A.S., Strand D.H. Determination of opiates and cocaine in urine by high pH mobile phase reversed phase UPLC-MS-MS. J. Chromatogr. B 2009, 877:421-432.
    • (2009) J. Chromatogr. B , vol.877 , pp. 421-432
    • Berg, T.1    Lundanes, E.2    Christophersen, A.S.3    Strand, D.H.4
  • 27
    • 45949097631 scopus 로고    scopus 로고
    • Potential of HILIC-MS in quantitative bioanalysis of drugs and drug metabolites
    • Hsieh Y. Potential of HILIC-MS in quantitative bioanalysis of drugs and drug metabolites. J. Sep. Sci 2008, 31:1481-1491.
    • (2008) J. Sep. Sci , vol.31 , pp. 1481-1491
    • Hsieh, Y.1
  • 28
    • 77955054221 scopus 로고    scopus 로고
    • Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the determination of adefovir in human plasma and its application to a pharmacokinetic study
    • Xiong Z.L., Zhang Y., Qin F., Qin T., Yang S.Y., Li F.M. Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the determination of adefovir in human plasma and its application to a pharmacokinetic study. J. Chromatogr. B 2010, 878:2111-2116.
    • (2010) J. Chromatogr. B , vol.878 , pp. 2111-2116
    • Xiong, Z.L.1    Zhang, Y.2    Qin, F.3    Qin, T.4    Yang, S.Y.5    Li, F.M.6
  • 29
    • 84866313490 scopus 로고    scopus 로고
    • Highly sensitive fast determination of entecavir in rat urine by means of hydrophilic interaction chromatography-ultra-high-performance liquid chromatography-tandem mass spectrometry
    • Nováková L., Gottvald T., Vlčková H., Trejtnar F., Mandíková J., Solich P. Highly sensitive fast determination of entecavir in rat urine by means of hydrophilic interaction chromatography-ultra-high-performance liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 2012, 1259:237-243.
    • (2012) J. Chromatogr. A , vol.1259 , pp. 237-243
    • Nováková, L.1    Gottvald, T.2    Vlčková, H.3    Trejtnar, F.4    Mandíková, J.5    Solich, P.6
  • 30
    • 84898871245 scopus 로고    scopus 로고
    • Solid-phase extraction based on hydrophilic interaction liquid chromatography with acetone as eluent for eliminating matrix effects in the analysis of biological fluids by LC-MS
    • Van Damme T., Lachová M., Lynen F., Szucs R., Sandra P. Solid-phase extraction based on hydrophilic interaction liquid chromatography with acetone as eluent for eliminating matrix effects in the analysis of biological fluids by LC-MS. Anal. Bioanal. Chem 2014, 406:401-407.
    • (2014) Anal. Bioanal. Chem , vol.406 , pp. 401-407
    • Van Damme, T.1    Lachová, M.2    Lynen, F.3    Szucs, R.4    Sandra, P.5
  • 31
    • 84856335878 scopus 로고    scopus 로고
    • Development and validation of UHPLC-ESI-MS-MS method for the determination of selected cardiovascular drugs, polyphenols and their metabolites in human urine
    • Magiera S., Baranowska I., Kusa J. Development and validation of UHPLC-ESI-MS-MS method for the determination of selected cardiovascular drugs, polyphenols and their metabolites in human urine. Talanta 2012, 89:47-56.
    • (2012) Talanta , vol.89 , pp. 47-56
    • Magiera, S.1    Baranowska, I.2    Kusa, J.3
  • 32
    • 84862806174 scopus 로고    scopus 로고
    • Simultaneous determination of pimpinellin, isopimpinellin and phellopterin in rat plasma by a validated UPLC-MS-MS and its application to a pharmacokinetic study after administration of Toddalia asiatica extract
    • Liu Z.G., Jiang M.Y., Lu X.M., Qin F., Song Y., Wen J., et al. Simultaneous determination of pimpinellin, isopimpinellin and phellopterin in rat plasma by a validated UPLC-MS-MS and its application to a pharmacokinetic study after administration of Toddalia asiatica extract. J. Chromgtogr. B 2012, 891-892:102-108.
    • (2012) J. Chromgtogr. B , pp. 102-108
    • Liu, Z.G.1    Jiang, M.Y.2    Lu, X.M.3    Qin, F.4    Song, Y.5    Wen, J.6
  • 33
    • 79959330280 scopus 로고    scopus 로고
    • Analyte and internal standard cross signal contributions and their impact on quantitation in LC-MS based bioanalysis
    • Tan A., Lévesque I.A., Lévesque I.M., Viel F., Boudreau N., Lévesque A. Analyte and internal standard cross signal contributions and their impact on quantitation in LC-MS based bioanalysis. J. Chromatogr. B 2011, 879:1954-1960.
    • (2011) J. Chromatogr. B , vol.879 , pp. 1954-1960
    • Tan, A.1    Lévesque, I.A.2    Lévesque, I.M.3    Viel, F.4    Boudreau, N.5    Lévesque, A.6
  • 34
    • 84862140489 scopus 로고    scopus 로고
    • Interference by metabolites and the corresponding troubleshooting during the LC-MS-MS bioanalysis of G004, a bromine-containing hypoglycemic agent
    • Hu L., Ding L., Li X., Zhou N., Zhong S., Wu G., et al. Interference by metabolites and the corresponding troubleshooting during the LC-MS-MS bioanalysis of G004, a bromine-containing hypoglycemic agent. J. Chromatogr. B 2012, 899:8-13.
    • (2012) J. Chromatogr. B , vol.899 , pp. 8-13
    • Hu, L.1    Ding, L.2    Li, X.3    Zhou, N.4    Zhong, S.5    Wu, G.6
  • 35
    • 0003484310 scopus 로고    scopus 로고
    • EMA, London, UK, last accessed 2011.07.21
    • Committee for Medicinal Products for Human Use Guideline on Bioanalytical Method Validation 2001, EMA, London, UK, last accessed 2011.07.21. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2011/08/WC500109686.pdf.
    • (2001) Guideline on Bioanalytical Method Validation
  • 36
    • 85071529369 scopus 로고    scopus 로고
    • Food and Drug Administration, Guidance for Industry
    • (last accessed 2001.05)
    • U.S Department of Health and Human Services, Food and Drug Administration, Guidance for Industry Bioanalytical method validation (last accessed 2001.05). http://www.fda.gov/downloads/Drugs/Guidances/ucm070107.pdf.
    • Bioanalytical method validation
  • 38
    • 77955919081 scopus 로고    scopus 로고
    • last accessed 2009.11.19
    • EMA Guideline on validation of bioanalytical methods last accessed 2009.11.19. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/12/WC500018062.pdf.
    • Guideline on validation of bioanalytical methods
  • 40
    • 77953350741 scopus 로고    scopus 로고
    • Signal suppression/enhancement in high-performance liquid chromatography tandem mass spectrometry
    • Gosetti F., Mazzucco E., Zampieri D., Gennaro M.C. Signal suppression/enhancement in high-performance liquid chromatography tandem mass spectrometry. J. Chromatogr. A 2010, 1217:3929-3937.
    • (2010) J. Chromatogr. A , vol.1217 , pp. 3929-3937
    • Gosetti, F.1    Mazzucco, E.2    Zampieri, D.3    Gennaro, M.C.4
  • 42
    • 33847092589 scopus 로고    scopus 로고
    • Determination and pharmacokinetic study of amlodipine in human plasma by ultra performance liquid chromatography-electrospray ionization mass spectrometry
    • Ma Y.Y., Qin F., Sun X.H., Lu X.M., Li F.M. Determination and pharmacokinetic study of amlodipine in human plasma by ultra performance liquid chromatography-electrospray ionization mass spectrometry. J. Pharm. Biomed. Anal 2007, 43:1540-1545.
    • (2007) J. Pharm. Biomed. Anal , vol.43 , pp. 1540-1545
    • Ma, Y.Y.1    Qin, F.2    Sun, X.H.3    Lu, X.M.4    Li, F.M.5
  • 43
    • 76549103621 scopus 로고    scopus 로고
    • Simultaneous quantification of venlafaxine and O-desmethylvenlafaxine in human plasma by ultra performance liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study
    • Qin F., Li N., Qin T., Zhang Y., Li F.M. Simultaneous quantification of venlafaxine and O-desmethylvenlafaxine in human plasma by ultra performance liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study. J. Chromatogr. B 2010, 878:689-694.
    • (2010) J. Chromatogr. B , vol.878 , pp. 689-694
    • Qin, F.1    Li, N.2    Qin, T.3    Zhang, Y.4    Li, F.M.5
  • 44
    • 84861330587 scopus 로고    scopus 로고
    • LC-MS-MS determination and pharmacokinetic study of four lignan components in rat plasma after oral administration of Acanthopanax sessiliflorus extract
    • Song Y., Deng Y., Huang D.X., Wen J., Liu Z.G., Li F.M. LC-MS-MS determination and pharmacokinetic study of four lignan components in rat plasma after oral administration of Acanthopanax sessiliflorus extract. J. Ethnopharmacol 2012, 141:957-963.
    • (2012) J. Ethnopharmacol , vol.141 , pp. 957-963
    • Song, Y.1    Deng, Y.2    Huang, D.X.3    Wen, J.4    Liu, Z.G.5    Li, F.M.6
  • 45
    • 34547668737 scopus 로고    scopus 로고
    • Quantitative determination of azithromycin in human plasma by ultra performance liquid chromatography-electrospray ionization mass spectrometry and its application in a pharmacokinetic study
    • Chen L.Y., Qin F., Ma Y.Y., Li F.M. Quantitative determination of azithromycin in human plasma by ultra performance liquid chromatography-electrospray ionization mass spectrometry and its application in a pharmacokinetic study. J. Chromatogr. B 2007, 855:255-261.
    • (2007) J. Chromatogr. B , vol.855 , pp. 255-261
    • Chen, L.Y.1    Qin, F.2    Ma, Y.Y.3    Li, F.M.4
  • 46
    • 44449152033 scopus 로고    scopus 로고
    • Quantitative determination of mitiglinide in human plasma by ultra-performance liquid chromatography/electrospray ionization tandem mass spectrometry
    • Cai S., Huo T.G., Feng W.Y., Chen L.Y., Qin F., Li F.M. Quantitative determination of mitiglinide in human plasma by ultra-performance liquid chromatography/electrospray ionization tandem mass spectrometry. J. Chromatogr. B 2008, 868:83-87.
    • (2008) J. Chromatogr. B , vol.868 , pp. 83-87
    • Cai, S.1    Huo, T.G.2    Feng, W.Y.3    Chen, L.Y.4    Qin, F.5    Li, F.M.6
  • 47
    • 78651463420 scopus 로고    scopus 로고
    • UPLC MS-MS method for quantification of mycophenolic acid and metabolites in human plasma: application to pharmacokinetic study
    • Delavenne X., Juthier L., Pons B., Mariat C., Basset T. UPLC MS-MS method for quantification of mycophenolic acid and metabolites in human plasma: application to pharmacokinetic study. Clin. Chim. Acta 2011, 412:59-65.
    • (2011) Clin. Chim. Acta , vol.412 , pp. 59-65
    • Delavenne, X.1    Juthier, L.2    Pons, B.3    Mariat, C.4    Basset, T.5
  • 48
    • 84879381598 scopus 로고    scopus 로고
    • Determination of colistin A and colistin B in human plasma by UPLC-ESI high resolution tandem MS: application to a pharmacokinetic study
    • Gikas E., Bazoti F.N., Katsimardou M., Anagnostopoulos D., Papanikolaou K., Inglezos I., et al. Determination of colistin A and colistin B in human plasma by UPLC-ESI high resolution tandem MS: application to a pharmacokinetic study. J. Pharm. Biomed. Anal 2013, 83:228-236.
    • (2013) J. Pharm. Biomed. Anal , vol.83 , pp. 228-236
    • Gikas, E.1    Bazoti, F.N.2    Katsimardou, M.3    Anagnostopoulos, D.4    Papanikolaou, K.5    Inglezos, I.6
  • 49
    • 84876703871 scopus 로고    scopus 로고
    • Simultaneous determination of limonin, dictamnine, obacunone and fraxinellone in rat plasma by a validated UHPLC-MS-MS and its application to a pharmacokinetic study after oral administration of Cortex Dictamni extract
    • Wang P., Sun J.B., Gao E.Z., Zhao Y.L., Qu W., Yu Z.G. Simultaneous determination of limonin, dictamnine, obacunone and fraxinellone in rat plasma by a validated UHPLC-MS-MS and its application to a pharmacokinetic study after oral administration of Cortex Dictamni extract. J. Chromatogr. B 2013, 928:44-51.
    • (2013) J. Chromatogr. B , vol.928 , pp. 44-51
    • Wang, P.1    Sun, J.B.2    Gao, E.Z.3    Zhao, Y.L.4    Qu, W.5    Yu, Z.G.6
  • 50
    • 84857369947 scopus 로고    scopus 로고
    • Determination of pravastatin and pravastatin lactone in rat plasma and urine using UHPLC-MS-MS and microextraction by packed sorbent
    • Vlčková H., Rabatinová M., Mikšová A., Kolouchová G., Mičuda S., Solich P., et al. Determination of pravastatin and pravastatin lactone in rat plasma and urine using UHPLC-MS-MS and microextraction by packed sorbent. Talanta 2012, 90:22-29.
    • (2012) Talanta , vol.90 , pp. 22-29
    • Vlčková, H.1    Rabatinová, M.2    Mikšová, A.3    Kolouchová, G.4    Mičuda, S.5    Solich, P.6
  • 51
    • 84871777302 scopus 로고    scopus 로고
    • Pre-column derivatization combined withUHPLC-MS-MS for rapid and sensitive quantification of bakuchiol in rat plasma
    • Zhuang X., Zhong Y., Yuan M., Li H. Pre-column derivatization combined withUHPLC-MS-MS for rapid and sensitive quantification of bakuchiol in rat plasma. J. Pharm. Biomed. Anal 2013, 75:18-24.
    • (2013) J. Pharm. Biomed. Anal , vol.75 , pp. 18-24
    • Zhuang, X.1    Zhong, Y.2    Yuan, M.3    Li, H.4
  • 53
    • 84877328027 scopus 로고    scopus 로고
    • Simultaneous determination of bioactive components in essential oil of Xiang-Fu-Si-Wu Formula in Beagle dog plasma by UPLC-MS-MS and its application to pharmacokinetics
    • Liu P., Li Z.H., Qian D.W., Li W., Shang E.X., Duan J.A. Simultaneous determination of bioactive components in essential oil of Xiang-Fu-Si-Wu Formula in Beagle dog plasma by UPLC-MS-MS and its application to pharmacokinetics. J. Chromatogr. B 2013, 929:63-69.
    • (2013) J. Chromatogr. B , vol.929 , pp. 63-69
    • Liu, P.1    Li, Z.H.2    Qian, D.W.3    Li, W.4    Shang, E.X.5    Duan, J.A.6
  • 54
    • 84872399741 scopus 로고    scopus 로고
    • Determination of phenylephrine in human plasma using ultra-performance liquid chromatography-tandem mass spectrometry
    • Feng S., Zhao Q., Jiang J., Hu P. Determination of phenylephrine in human plasma using ultra-performance liquid chromatography-tandem mass spectrometry. J. Chromatogr. B 2013, 915-916:28-32.
    • (2013) J. Chromatogr. B , pp. 28-32
    • Feng, S.1    Zhao, Q.2    Jiang, J.3    Hu, P.4
  • 55
    • 84887550889 scopus 로고    scopus 로고
    • Systematic development of an UPLC-MS-MS method for the determination of tricyclic antidepressants in human urine
    • Chambers E.E., Woodcock M.J., Wheaton J.P., Pekol T.M., Diehl D.M. Systematic development of an UPLC-MS-MS method for the determination of tricyclic antidepressants in human urine. J. Pharm. Biomed. Anal 2014, 88:660-665.
    • (2014) J. Pharm. Biomed. Anal , vol.88 , pp. 660-665
    • Chambers, E.E.1    Woodcock, M.J.2    Wheaton, J.P.3    Pekol, T.M.4    Diehl, D.M.5
  • 56
    • 0034973773 scopus 로고    scopus 로고
    • Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity
    • Guengerich F.P. Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. Chem. Res. Toxicol 2001, 14:611-650.
    • (2001) Chem. Res. Toxicol , vol.14 , pp. 611-650
    • Guengerich, F.P.1
  • 57
    • 79951990726 scopus 로고    scopus 로고
    • Bioactivation of drugs: risk and drug design
    • Walsh J.S., Miwa G.T. Bioactivation of drugs: risk and drug design. Annu. Rev. Pharmacol. Toxicol 2011, 51:145-167.
    • (2011) Annu. Rev. Pharmacol. Toxicol , vol.51 , pp. 145-167
    • Walsh, J.S.1    Miwa, G.T.2
  • 58
    • 84894097423 scopus 로고    scopus 로고
    • Rapid screening and identification of metabolites of quercitrin produced by the human intestinal bacteria using ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry
    • Jiang S., Yang J., Qian D., Guo J., Shang E.X., Duan J.A., et al. Rapid screening and identification of metabolites of quercitrin produced by the human intestinal bacteria using ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry. Arch. Pharm. Res 2014, 37:204-213.
    • (2014) Arch. Pharm. Res , vol.37 , pp. 204-213
    • Jiang, S.1    Yang, J.2    Qian, D.3    Guo, J.4    Shang, E.X.5    Duan, J.A.6
  • 59
    • 80054990445 scopus 로고    scopus 로고
    • Identification of metabolites of geniposide in rat urine using ultra-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry
    • Han H., Yang L., Xu Y., Ding Y., Bligh S.W., Zhang T., et al. Identification of metabolites of geniposide in rat urine using ultra-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Rapid Commun. Mass Spectrom 2011, 25:3339-3350.
    • (2011) Rapid Commun. Mass Spectrom , vol.25 , pp. 3339-3350
    • Han, H.1    Yang, L.2    Xu, Y.3    Ding, Y.4    Bligh, S.W.5    Zhang, T.6
  • 60
    • 84891899896 scopus 로고    scopus 로고
    • Screening for in vitro metabolites of kakkalide and irisolidone in human and rat intestinal bacteria by ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry
    • Zhang G., Gong T., Kano Y., Yuan D. Screening for in vitro metabolites of kakkalide and irisolidone in human and rat intestinal bacteria by ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry. J. Chromatogr. B 2014, 947-948:117-124.
    • (2014) J. Chromatogr. B , pp. 117-124
    • Zhang, G.1    Gong, T.2    Kano, Y.3    Yuan, D.4
  • 61
    • 56949090796 scopus 로고    scopus 로고
    • Analysis of nine drugs and their cytochrome P450-specific probe metabolites from urine by liquid chromatography-tandem mass spectrometry utilizing sub 2 microm particle size column
    • Petsalo A., Turpeinen M., Pelkonen O., Tolonen A. Analysis of nine drugs and their cytochrome P450-specific probe metabolites from urine by liquid chromatography-tandem mass spectrometry utilizing sub 2 microm particle size column. J. Chromatogr. A 2008, 1215:107-115.
    • (2008) J. Chromatogr. A , vol.1215 , pp. 107-115
    • Petsalo, A.1    Turpeinen, M.2    Pelkonen, O.3    Tolonen, A.4
  • 62
    • 34250169044 scopus 로고    scopus 로고
    • Comparison of sub-2-μm particle columns for fast metabolite ID
    • Walles M., Gauvin C., Morin P.E., Panetta R., Ducharme J. Comparison of sub-2-μm particle columns for fast metabolite ID. J. Sep. Sci 2007, 30:1191-1199.
    • (2007) J. Sep. Sci , vol.30 , pp. 1191-1199
    • Walles, M.1    Gauvin, C.2    Morin, P.E.3    Panetta, R.4    Ducharme, J.5
  • 64
    • 51949105732 scopus 로고    scopus 로고
    • 1H NMR and UPLC-MSE Statistical Heterospectroscopy: Characterization of Drug Metabolites (Xenometabolome) in Epidemiological Studies
    • Crokford D.J., Maher A.D., Ahmadi K.R., Barrett A., Plumb R.S., Wilson I.D., et al. 1H NMR and UPLC-MSE Statistical Heterospectroscopy: Characterization of Drug Metabolites (Xenometabolome) in Epidemiological Studies. Anal. Chem 2008, 80:6835-6844.
    • (2008) Anal. Chem , vol.80 , pp. 6835-6844
    • Crokford, D.J.1    Maher, A.D.2    Ahmadi, K.R.3    Barrett, A.4    Plumb, R.S.5    Wilson, I.D.6
  • 65
    • 84893383571 scopus 로고    scopus 로고
    • Identification of metabolites of deoxyschizandrin in rats by UPLC-Q-TOF-MS-MS based on multiple mass defect filter data acquisition and multiple data processing techniques
    • Liu M.Y., Zhao S.H., Wang Z.Q., Wang Y.F., Liu T., Li S., et al. Identification of metabolites of deoxyschizandrin in rats by UPLC-Q-TOF-MS-MS based on multiple mass defect filter data acquisition and multiple data processing techniques. J. Chromatogr. B 2014, 949-950:115-126.
    • (2014) J. Chromatogr. B , pp. 115-126
    • Liu, M.Y.1    Zhao, S.H.2    Wang, Z.Q.3    Wang, Y.F.4    Liu, T.5    Li, S.6
  • 66
    • 84866519272 scopus 로고    scopus 로고
    • Identification of the urinary metabolites of glionitrin A in rats using ultra-performance liquid chromatography combined with quadrupole time-of-flight mass spectrometry
    • Lee S.H., Yang H.O., Kwon H.C., Jung B.H. Identification of the urinary metabolites of glionitrin A in rats using ultra-performance liquid chromatography combined with quadrupole time-of-flight mass spectrometry. J. Chromatogr. B 2012, 906:33-40.
    • (2012) J. Chromatogr. B , vol.906 , pp. 33-40
    • Lee, S.H.1    Yang, H.O.2    Kwon, H.C.3    Jung, B.H.4
  • 67
    • 84881113560 scopus 로고    scopus 로고
    • High-throughput ultra-performance liquid chromatography-mass spectrometry characterization of metabolites guided by a bioinformatics program
    • Zhang A.H., Wang P., Sun H., Yan G.L., Han Y., Wang X.J. High-throughput ultra-performance liquid chromatography-mass spectrometry characterization of metabolites guided by a bioinformatics program. Mol. Biosyst 2013, 9:2259-2265.
    • (2013) Mol. Biosyst , vol.9 , pp. 2259-2265
    • Zhang, A.H.1    Wang, P.2    Sun, H.3    Yan, G.L.4    Han, Y.5    Wang, X.J.6
  • 68
    • 84878389239 scopus 로고    scopus 로고
    • In vivo and in vitro metabolism of a novel β2-adrenoceptor agonist, trantinterol: metabolites isolation and identification by LC-MS-MS and NMR
    • Li K.J., Qin F., Jing L., Li F.M., Guo X.J. In vivo and in vitro metabolism of a novel β2-adrenoceptor agonist, trantinterol: metabolites isolation and identification by LC-MS-MS and NMR. Anal. Bioanal. Chem 2013, 405:2619-2634.
    • (2013) Anal. Bioanal. Chem , vol.405 , pp. 2619-2634
    • Li, K.J.1    Qin, F.2    Jing, L.3    Li, F.M.4    Guo, X.J.5
  • 69
    • 37649005083 scopus 로고    scopus 로고
    • High-temperature ultra-performance liquid chromatography coupled to hybrid quadrupole time-of-flight mass spectrometry applied to ibuprofen metabolites in human urine
    • Plumb R.S., Rainville P.D., Potts W.B., Castro-Perez J.M., Johnson K.A., Wilson I.D. High-temperature ultra-performance liquid chromatography coupled to hybrid quadrupole time-of-flight mass spectrometry applied to ibuprofen metabolites in human urine. Rapid Commun. Mass Spectrom 2007, 21:4079-4085.
    • (2007) Rapid Commun. Mass Spectrom , vol.21 , pp. 4079-4085
    • Plumb, R.S.1    Rainville, P.D.2    Potts, W.B.3    Castro-Perez, J.M.4    Johnson, K.A.5    Wilson, I.D.6
  • 70
    • 84886242931 scopus 로고    scopus 로고
    • Identification of acteoside and its major metabolites in rat urine by ultra-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem massspectrometry
    • Qi M., Xiong A., Li P., Yang Q., Yang L., Wang Z. Identification of acteoside and its major metabolites in rat urine by ultra-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem massspectrometry. J. Chromatogr. B 2013, 940:77-85.
    • (2013) J. Chromatogr. B , vol.940 , pp. 77-85
    • Qi, M.1    Xiong, A.2    Li, P.3    Yang, Q.4    Yang, L.5    Wang, Z.6
  • 71
    • 84891486096 scopus 로고    scopus 로고
    • Metabolites characterization of chamaechromone in vivo and in vitro by using ultra-performance liquid chromatography/Xevo G2 quadrupole time-of-flight tandem mass spectrometry
    • Lou Y., Zheng J., Wang B., Zhang X., Zhang X., Zeng S. Metabolites characterization of chamaechromone in vivo and in vitro by using ultra-performance liquid chromatography/Xevo G2 quadrupole time-of-flight tandem mass spectrometry. J. Ethnopharmacol 2014, 151:242-252.
    • (2014) J. Ethnopharmacol , vol.151 , pp. 242-252
    • Lou, Y.1    Zheng, J.2    Wang, B.3    Zhang, X.4    Zhang, X.5    Zeng, S.6
  • 72
    • 84897725966 scopus 로고    scopus 로고
    • Identification and quantification of grapefruit juice furanocoumarin metabolites in urine: an approach based on ultra performance liquid chromatography coupled to linear ion trap-orbitrap mass spectrometry and solid-phase extraction coupled to ultraperformance liquid chromatography coupled to triple quadrupole-tandem mass spectrometry
    • Regueiro J., Vallverdú-Queralt A., Negreira N., Simal-Gándara J., Lamuela-Raventós R.M. Identification and quantification of grapefruit juice furanocoumarin metabolites in urine: an approach based on ultra performance liquid chromatography coupled to linear ion trap-orbitrap mass spectrometry and solid-phase extraction coupled to ultraperformance liquid chromatography coupled to triple quadrupole-tandem mass spectrometry. J. Agric. Food Chem 2014, 62:2134-2140.
    • (2014) J. Agric. Food Chem , vol.62 , pp. 2134-2140
    • Regueiro, J.1    Vallverdú-Queralt, A.2    Negreira, N.3    Simal-Gándara, J.4    Lamuela-Raventós, R.M.5
  • 73
    • 84904018013 scopus 로고    scopus 로고
    • Structure identification and elucidation of mosapride metabolites in human urine, feces and plasma by ultra performance liquid chromatography-tandem mass spectrometry method
    • Sun X.H., Zhao L.S., Niu L.L., Qin F., Lu X.M., Xiong Z.L., et al. Structure identification and elucidation of mosapride metabolites in human urine, feces and plasma by ultra performance liquid chromatography-tandem mass spectrometry method. Xenobiotica 2014, 44:734-742.
    • (2014) Xenobiotica , vol.44 , pp. 734-742
    • Sun, X.H.1    Zhao, L.S.2    Niu, L.L.3    Qin, F.4    Lu, X.M.5    Xiong, Z.L.6
  • 74
    • 84886613530 scopus 로고    scopus 로고
    • Metabolite analysis of toosendanin by an ultra-high performance liquid chromatography-quadrupole-time of flight mass spectrometry technique
    • Wu J.L., Leung E.L., Zhou H., Liu L., Li N. Metabolite analysis of toosendanin by an ultra-high performance liquid chromatography-quadrupole-time of flight mass spectrometry technique. Molecules 2013, 18:12144-12153.
    • (2013) Molecules , vol.18 , pp. 12144-12153
    • Wu, J.L.1    Leung, E.L.2    Zhou, H.3    Liu, L.4    Li, N.5
  • 75
    • 84892720336 scopus 로고    scopus 로고
    • Identification of metabolites of fosinopril produced by human and rat liver microsomes with liquid chromatography-mass spectrometry
    • Uutela P., Monto M., Iso-Mustajärvi I., Madetoja M., Yliperttula M., Ketola R.A. Identification of metabolites of fosinopril produced by human and rat liver microsomes with liquid chromatography-mass spectrometry. Eur. J. Pharm. Sci 2014, 53:86-94.
    • (2014) Eur. J. Pharm. Sci , vol.53 , pp. 86-94
    • Uutela, P.1    Monto, M.2    Iso-Mustajärvi, I.3    Madetoja, M.4    Yliperttula, M.5    Ketola, R.A.6
  • 76
    • 84869015280 scopus 로고    scopus 로고
    • Rapid characterization of chemical constituents and rats metabolites of the traditional Chinese patent medicine Gegen-Qinlian-Wan by UHPLC/DAD/qTOF-MS
    • Miao W.J., Wang Q., Bo T., Ye M., Qiao X., Yang W.Z., et al. Rapid characterization of chemical constituents and rats metabolites of the traditional Chinese patent medicine Gegen-Qinlian-Wan by UHPLC/DAD/qTOF-MS. J. Pharm. Biomed. Anal 2013, 72:99-108.
    • (2013) J. Pharm. Biomed. Anal , vol.72 , pp. 99-108
    • Miao, W.J.1    Wang, Q.2    Bo, T.3    Ye, M.4    Qiao, X.5    Yang, W.Z.6
  • 77
    • 77957320560 scopus 로고    scopus 로고
    • UPLC-QTOF-MS-based screening and identification of the constituents and their metabolites in rat plasma and urine after oral administration of Glechoma longituba extract
    • Ni S., Qian D., Duan J.A., Guo J., Shang E.X., Shu Y., et al. UPLC-QTOF-MS-based screening and identification of the constituents and their metabolites in rat plasma and urine after oral administration of Glechoma longituba extract. J. Chromatogr. B 2010, 878:2741-2750.
    • (2010) J. Chromatogr. B , vol.878 , pp. 2741-2750
    • Ni, S.1    Qian, D.2    Duan, J.A.3    Guo, J.4    Shang, E.X.5    Shu, Y.6
  • 78
    • 84880731907 scopus 로고    scopus 로고
    • Characterization of metabolites of 20(S)-protopanaxadiol in rats using ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry
    • Jin X., Li S.L., Zhang Z.H., Zhu F.X., Sun E., Wei Y.J., et al. Characterization of metabolites of 20(S)-protopanaxadiol in rats using ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry. J. Chromatogr. B 2013, 933:59-66.
    • (2013) J. Chromatogr. B , vol.933 , pp. 59-66
    • Jin, X.1    Li, S.L.2    Zhang, Z.H.3    Zhu, F.X.4    Sun, E.5    Wei, Y.J.6
  • 79
    • 79959334413 scopus 로고    scopus 로고
    • Identification of hyperoside metabolites in rat using ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry
    • Guo J.M., Xue C.F., Shang E.X., Duan J.A., Tang Y.P., Qian D.W. Identification of hyperoside metabolites in rat using ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry. J. Chromatogr. B 2011, 879:1987-1992.
    • (2011) J. Chromatogr. B , vol.879 , pp. 1987-1992
    • Guo, J.M.1    Xue, C.F.2    Shang, E.X.3    Duan, J.A.4    Tang, Y.P.5    Qian, D.W.6
  • 80
    • 84862793642 scopus 로고    scopus 로고
    • Identification of liguzinediol metabolites in rats by ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry
    • Shan C.X., Li W., Wen H.M., Wang X.Z., Zhu Y.H., Cui X.B. Identification of liguzinediol metabolites in rats by ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry. J. Pharm. Biomed. Anal 2012, 62:187-190.
    • (2012) J. Pharm. Biomed. Anal , vol.62 , pp. 187-190
    • Shan, C.X.1    Li, W.2    Wen, H.M.3    Wang, X.Z.4    Zhu, Y.H.5    Cui, X.B.6
  • 81
    • 84867401308 scopus 로고    scopus 로고
    • Metabolite discovery of helicidum in rat urine with XCMS based on the data of ultra performance liquid chromatography coupled to time-of-flight mass spectrometry
    • Liu Q.F., Shi Y., Guo T., Wang Y., Cong W.J., Zhu J.J. Metabolite discovery of helicidum in rat urine with XCMS based on the data of ultra performance liquid chromatography coupled to time-of-flight mass spectrometry. J. Chromatogr. B 2012, 907:146-153.
    • (2012) J. Chromatogr. B , vol.907 , pp. 146-153
    • Liu, Q.F.1    Shi, Y.2    Guo, T.3    Wang, Y.4    Cong, W.J.5    Zhu, J.J.6
  • 82
    • 84898864976 scopus 로고    scopus 로고
    • E identification of urinary metabolites of the emerging sport nutrition supplement methoxyisoflavone in human subjects
    • E identification of urinary metabolites of the emerging sport nutrition supplement methoxyisoflavone in human subjects. J. Pharm. Biomed. Anal 2014, 96:127-134.
    • (2014) J. Pharm. Biomed. Anal , vol.96 , pp. 127-134
    • Lecompte, Y.1    Rosset, M.2    Richeval, C.3    Humbert, L.4    Arpino, P.5


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