Metabolites characterization of chamaechromone in vivo and in vitro by using ultra-performance liquid chromatography/Xevo G2 quadrupole time-of-flight tandem mass spectrometry

Journal of Ethnopharmacology

Volumn 151, Issue 1, 2014, Pages 242-252

  Lou, Yan ^a,b   Zheng, Jinqi ^c   Wang, Baohong ^d   Zhang, Xingguo ^b   Zhang, Xia ^a   Zeng, Su ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c Zhejiang Institute for Food and Drug Control   (China)

^d ZHEJIANG UNIVERSITY   (China)

Author keywords

Chamaechromone; Metabolic route; Metabolite; Stellera chamaejasme L.; UPLC Xevo G2 Q TOF MS

Indexed keywords

BETA GLUCURONIDASE; CATECHOL METHYLTRANSFERASE; CHAMAECHROMONE; DRUG METABOLITE; HERBACEOUS AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE; BLOOD ANALYSIS; CHROMATOGRAPH; CONTROLLED STUDY; DRUG DEGRADATION; DRUG DETERMINATION; DRUG GLUCURONIDATION; DRUG HYDROXYLATION; DRUG METABOLISM; FECES ANALYSIS; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; INTESTINE FLORA; LIVER METABOLISM; MASS SPECTROMETER; METHYLATION; NONHUMAN; QUADRUPOLE MASS SPECTROMETRY; RAT; TANDEM MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS;

HEPATITIS B VIRUS; RATTUS; STELLERA CHAMAEJASME; THYMELAEACEAE;

CHAMAECHROMONE; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; HPLC; MEOH; METABOLIC ROUTE; METABOLITE; METHANOL; Q-TOF MS; QUADRUPOLE TIME-OF-FLIGHT MASS SPECTROMETER; STELLERA CHAMAEJASME L.; TCM; TRADITIONAL CHINESE MEDICINE; ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHY; UPLC; UPLC/XEVO G2 Q-TOF MS;

ANIMALS; BACTERIA; CHROMATOGRAPHY, LIQUID; FECES; FLAVONES; INTESTINES; LIVER; MALE; MOLECULAR STRUCTURE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY; THYMELAEACEAE;

EID: 84891486096     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.10.027     Document Type: Article

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