Simultaneous determination of pimpinellin, isopimpinellin and phellopterin in rat plasma by a validated UPLC-MS/MS and its application to a pharmacokinetic study after administration of Toddalia asiatica extract

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 891-892, Issue , 2012, Pages 102-108

  Liu, Zhigang ^a,b   Jiang, Minyan ^a   Lu, Xiumei ^a   Qin, Feng ^a   Song, Yang ^a   Wen, Jing ^a   Li, Famei ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b GUIYANG UNIVERSITY   (China)

Author keywords

Coumarins; Pharmacokinetics; Rat plasma; Toddalia asiatica; UPLC MS MS

Indexed keywords

ACQUITY; AMMONIUM ACETATE; ANALYTES; CHROMATOGRAPHIC SEPARATIONS; CORRELATION COEFFICIENT; COUMARINS; INTERNAL STANDARDS; IONIZATION MODES; ISOCRATIC MOBILE PHASE; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID-LIQUID EXTRACTION; LOWER LIMITS; METHYL TERT BUTYL ETHER; MULTIPLE REACTION MONITORING; ORAL ADMINISTRATION; PHARMACOKINETIC STUDIES; PLASMA SAMPLES; RAT PLASMA; SENSITIVE METHOD; SIMULTANEOUS DETERMINATIONS; TODDALIA ASIATICA; TRIPLE QUADRUPOLE; UPLC-MS/MS;

AMMONIUM COMPOUNDS; BODY FLUIDS; CHROMATOGRAPHY; ELECTROSPRAY IONIZATION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; METHANOL; PHARMACOKINETICS;

SOLVENT EXTRACTION;

COUMARIN DERIVATIVE; ISOPIMPINELLIN; PHELLOPTERIN; PHENACETIN; PIMPINELLIN; PLANT EXTRACT; TERT BUTYL METHYL ETHER; TODDALIA ASIATICA EXTRACT; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG ELIMINATION; DRUG HALF LIFE; ELECTROSPRAY; LIMIT OF QUANTITATION; LIQUID LIQUID EXTRACTION; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; MEDICINAL PLANT; NONHUMAN; PHARMACOKINETICS; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; TODDALIA ASIATICA; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; CHROMATOGRAPHY, LIQUID; COUMARINS; METHOXSALEN; PLANT EXTRACTS; PSORALENS; RATS; RUTACEAE; TANDEM MASS SPECTROMETRY;

RATTUS; TODDALIA ASIATICA;

EID: 84862806174     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.02.022     Document Type: Article

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