Simultaneous quantification of enalapril and enalaprilat in human plasma by high-performance liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study

Journal of Pharmaceutical and Biomedical Analysis

Volumn 49, Issue 1, 2009, Pages 163-167

  Lu, Shan ^a   Jiang, Kun ^a   Qin, Feng ^a   Lu, Xiumei ^a   Li, Famei ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Enalapril; Enalaprilat; HPLC MS MS; Human plasma; Pharmacokinetic study

Indexed keywords

BENAZEPRIL; ENALAPRIL; ENALAPRILAT; FORMIC ACID; METHANOL; WATER;

ANALYTICAL ERROR; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; DIAGNOSTIC ACCURACY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIQUID LIQUID EXTRACTION; MALE; NORMAL HUMAN; PRECIPITATION; PRIORITY JOURNAL; REACTION ANALYSIS; REFERENCE VALUE; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; VOLUNTEER;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; ENALAPRIL; ENALAPRILAT; HALF-LIFE; HUMANS; LINEAR MODELS; MALE; MOLECULAR STRUCTURE; QUALITY CONTROL; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TIME FACTORS;

EID: 58249137332     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2008.10.012     Document Type: Article

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