Identification of metabolites of deoxyschizandrin in rats by UPLC-Q-TOF-MS/MS based on multiple mass defect filter data acquisition and multiple data processing techniques

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 949-950, Issue , 2014, Pages 115-126

  Liu, Minyan ^a,b   Zhao, Shaohua ^b   Wang, Zongquan ^b   Wang, Yufeng ^b   Liu, Ting ^c   Li, Song ^b   Wang, Cuicui ^b   Wang, Hongtao ^b   Tu, Pengfei ^a  

^a PEKING UNIVERSITY   (China)

^b Shijiazhuang Yiling Pharmaceutical Co Ltd   (China)

^c MDS SCIEX   (Canada)

Author keywords

Deoxyschizandrin; Identification; Metabolites; Multiple data processing; Multiple mass defect filter; UPLC Q TOF MS MS

Indexed keywords

AMINO ACIDS; BODY FLUIDS; CHROMATOGRAPHY; DATA ACQUISITION; DEFECTS; DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IDENTIFICATION (CONTROL SYSTEMS); ISOMERS; MASS SPECTROMETRY; METABOLISM; METABOLITES; RATS;

ACCURATE MASS MEASUREMENTS; DATA PROCESSING METHODS; DEOXYSCHIZANDRIN; MULTIPLE MASS; ON-LINE DATA ACQUISITION; STRUCTURAL CHARACTERIZATION; ULTRA-HIGH PERFORMANCE LIQUID CHROMATOGRAPHIES; UPLC-Q-TOF-MS/MS;

BIOMOLECULES;

BIPHENYL; CYSTEINE; DEOXYSCHIZANDRIN; DRUG METABOLITE; SCHIZANDRIN; SULFATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONJUGATION; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG TRANSFORMATION; FILTRATION; IN VIVO STUDY; INFORMATION PROCESSING; ION PAIR CHROMATOGRAPHY; MALE; MASS DEFECT FILTERING; METHODOLOGY; NEUTRAL LOSS FILTERING; NONHUMAN; PRIORITY JOURNAL; PRODUCT ION FILTERING; RAT; TANDEM MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

DEOXYSCHIZANDRIN; IDENTIFICATION; METABOLITES; MULTIPLE DATA PROCESSING; MULTIPLE MASS DEFECT FILTER; UPLC-Q-TOF-MS/MS;

ANIMALS; BILE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOOCTANES; LIGNANS; MALE; METABOLIC NETWORKS AND PATHWAYS; MODELS, MOLECULAR; OXIDATION-REDUCTION; POLYCYCLIC COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY;

EID: 84893383571     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2013.12.022     Document Type: Article

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