Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the determination of adefovir in human plasma and its application to a pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 23, 2010, Pages 2111-2116

  Xiong, Zhili ^a   Zhang, Yi ^a   Qin, Feng ^a   Qin, Ting ^a   Yang, Shuyan ^a   Li, Famei ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Adefovir; HILIC MS MS; Human plasma; Pharmacokinetic study

Indexed keywords

ACQUITY; ADEFOVIR; CHROMATOGRAPHIC SEPARATIONS; CLINICAL PHARMACOKINETICS; CONCENTRATION RANGES; HILIC-MS/MS; HUMAN PLASMAS; HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHIES; LINEAR CALIBRATION CURVE; LOWER LIMIT OF QUANTIFICATIONS; METHANOL-WATER-FORMIC ACID; MOBILE PHASE; MULTIPLE-REACTION MONITORING MODES; ORAL ADMINISTRATION; PHARMACOKINETIC STUDIES; PLASMA SAMPLES; PROTEIN PRECIPITATION; QUADRUPOLES; RELATIVE ERRORS; RELATIVE STANDARD DEVIATIONS; RUNTIMES;

CUSTOMER SATISFACTION; DICHLOROMETHANE; ELECTROSPRAY IONIZATION; HYDROPHILICITY; IONIC LIQUIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHANOL; ORGANIC ACIDS; PHARMACOKINETICS; PLASMA (HUMAN); TOTAL QUALITY MANAGEMENT;

PLASMAS;

ADEFOVIR DIPIVOXIL; DICHLOROMETHANE; FORMIC ACID; METHANOL; WATER; ADEFOVIR; ADENINE; ANTIVIRUS AGENT; PHOSPHONIC ACID DERIVATIVE; PIDOTIMOD; PYROGLUTAMIC ACID; THIAZOLIDINE DERIVATIVE;

ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG DETERMINATION; DRUG HALF LIFE; DRUG STABILITY; ELECTROSPRAY; HUMAN; HYDROPHILIC INTERACTION CHROMATOGRAPHY; MALE; NORMAL HUMAN; PRECIPITATION; PRIORITY JOURNAL; QUALITY CONTROL; TANDEM MASS SPECTROMETRY; ANALOGS AND DERIVATIVES; BLOOD; CHEMISTRY; CLINICAL TRIAL; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; ORAL DRUG ADMINISTRATION; PROCEDURES; REPRODUCIBILITY; STANDARD; TIME;

ADENINE; ADMINISTRATION, ORAL; ANTIVIRAL AGENTS; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HUMANS; LIMIT OF DETECTION; MALE; PHOSPHONIC ACIDS; PYRROLIDONECARBOXYLIC ACID; QUALITY CONTROL; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY; THIAZOLIDINES; TIME FACTORS; ORGANOPHOSPHONATES;

EID: 77955054221     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.06.024     Document Type: Article

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