Screening for in vitro metabolites of kakkalide and irisolidone in human and rat intestinal bacteria by ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 947-948, Issue , 2014, Pages 117-124

  Zhang, Guozhe ^a   Gong, Tianxing ^b   Kano, Yoshihiro ^a   Yuan, Dan ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Biotransformation; Intestinal bacteria; Irisolidone; Kakkalide; Metabolic profile; UHPLC Q TOF MS

Indexed keywords

BIOTRANSFORMATION; INTESTINAL BACTERIA; IRISOLIDONE; KAKKALIDE; METABOLIC PROFILES; UHPLC/Q-TOF MS;

BIOMOLECULES; CHROMATOGRAPHY; FLAVONOIDS; LIQUIDS; MASS SPECTROMETRY; METABOLISM; METABOLITES; RATS;

BACTERIA;

BIOCHANIN A; DRUG METABOLITE; IRISOLIDONE; ISOFLAVONE DERIVATIVE; KAKKALIDE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DEMETHYLATION; HUMAN; HYDROLYSIS; HYDROXYLATION; IN VITRO STUDY; INCUBATION TIME; INTESTINE FLORA; ISOMER; METABOLISM; METABOLITE; NONHUMAN; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; SCREENING; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

BIA; BIOCHANIN A; BIOTRANSFORMATION; CALCULATED 1-OCTANOL/WATER PARTITION COEFFICIENT; CLOGP; ELECTRO SPRAY IONIZATION; ESI; GLC; GLUCOSE; INTESTINAL BACTERIA; IR; IRISOLIDONE; KA; KAKKALIDE; METABOLIC PROFILE; TE; TECTORIGENIN; UHPLC/Q-TOF MS; ULTRA-HIGH PERFORMANCE LIQUID CHROMATOGRAPHY/QUADRUPOLE TIME-OF-FLIGHT MASS SPECTROMETRY; XYL; XYLOSE;

ADULT; ANIMALS; BACTERIA; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FECES; FLAVONOIDS; FLOWERS; GLYCOSIDES; HUMANS; INTESTINES; ISOFLAVONES; MALE; MASS SPECTROMETRY; MOLECULAR STRUCTURE; PLANT EXTRACTS; PUERARIA; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84891899896     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2013.12.017     Document Type: Article

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