In vivo and in vitro metabolism of a novel β2-adrenoceptor agonist, trantinterol: Metabolites isolation and identification by LC-MS/MS and NMR

Analytical and Bioanalytical Chemistry

Volumn 405, Issue 8, 2013, Pages 2619-2634

  Li, Kunjie ^a   Qin, Feng ^a   Jing, Lijuan ^a   Li, Famei ^a   Guo, Xingjie ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

In vitro; In vivo; Mass spectrometry; Metabolism; Nuclear magnetic resonance; Trantinterol

Indexed keywords

CUNNINGHAMELLA BLAKESLEANA; IN-VITRO; IN-VIVO; ISOLATION AND IDENTIFICATION; LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (LC MS/MS); MICROBIAL TRANSFORMATION; NUCLEAR MAGNETIC RESONANCE(NMR); TRANTINTEROL;

BODY FLUIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METABOLITES; NUCLEAR MAGNETIC RESONANCE; PHYSIOLOGY; RATS;

BIOMOLECULES;

BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CLENBUTEROL; DRUG DERIVATIVE; TRANTINTEROL;

ANIMAL; ARTICLE; CHEMISTRY; EVALUATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIVER MICROSOME; MALE; METABOLISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; SPRAGUE DAWLEY RAT; TANDEM MASS SPECTROMETRY; URINE;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLENBUTEROL; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA-2; TANDEM MASS SPECTROMETRY;

CUNNINGHAMELLA; CUNNINGHAMELLA BLAKESLEEANA; RATTUS;

EID: 84878389239     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-012-6652-9     Document Type: Article

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