Simultaneous determination of limonin, dictamnine, obacunone and fraxinellone in rat plasma by a validated UHPLC-MS/MS and its application to a pharmacokinetic study after oral administration of Cortex Dictamni extract

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 928, Issue , 2013, Pages 44-51

  Wang, Pei ^a   Sun, Jianbo ^b   Gao, Enze ^a   Zhao, Yunli ^a   Qu, Wei ^b   Yu, Zhiguo ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Cortex Dictamni; Furoquinoline alkaloids; Limonoids; Pharmacokinetics; Quantitative analysis; UHPLC MS MS

Indexed keywords

CORTEX DICTAMNI; ION ELECTROSPRAY IONIZATION; LIMONOIDS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MULTIPLE-REACTION MONITORING MODES; PHARMACOKINETIC STUDIES; SIMULTANEOUS DETERMINATIONS; U-HPLC-MS;

BODY FLUIDS; CARBOXYLIC ACIDS; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS;

CHEMICAL ANALYSIS;

CORTEX DICTAMNI EXTRACT; DICTAMNINE; FRAXINELLONE; HERBACEOUS AGENT; LIMONIN; NIMODIPINE; OBACUNONE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORTEX DICTAMNI; DICTANMNUS DASYCARPUS; DRUG BLOOD LEVEL; ELECTROSPRAY; LIMIT OF QUANTITATION; MALE; NONHUMAN; PLANT ROOT; PRIORITY JOURNAL; RAT; RUTACEAE; SENSITIVITY ANALYSIS; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION STUDY;

ADMINISTRATION, ORAL; ANIMALS; BENZOFURANS; BENZOXEPINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; LIMONINS; MALE; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; RUTACEAE; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 84876703871     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2013.03.018     Document Type: Article

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