Interference by metabolites and the corresponding troubleshooting during the LC-MS/MS bioanalysis of G004, a bromine-containing hypoglycemic agent

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 899, Issue , 2012, Pages 8-13

  Hu, Linlin ^a   Ding, Li ^a   Li, Xiaobing ^a   Zhou, Na ^a   Zhong, Shuisheng ^a   Wu, Guanzhong ^a   Zhang, Huibin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Bromine or chlorine containing compounds; G004; Liquid chromatography tandem mass spectrometry; Metabolite interference; Metabolite related matrix effect; Pharmacokinetics

Indexed keywords

BEAGLE DOG; BIO-SAMPLES; BIOANALYSIS; G004; HIGH-THROUGHPUT; HYDROXYLATED METABOLITES; LC-MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LOWER LIMIT OF QUANTITATIONS; MATRIX EFFECTS; PARENT COMPOUNDS; PHARMACOKINETIC PROFILES; PLASMA SAMPLES; PRECURSOR IONS; QUANTITATIVE DETERMINATIONS; STANDARD ADDITION METHOD;

BIOMOLECULES; BROMINE; BROMINE COMPOUNDS; CHLORINE; CHLORINE COMPOUNDS; HYDROXYLATION; IMPURITIES; ISOTOPES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS;

METABOLITES;

ANTIDIABETIC AGENT; BROMINE; CHLORINE; DRUG METABOLITE; G 004; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; DOG; DRUG BLOOD LEVEL; DRUG HYDROXYLATION; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDATION PROCESS;

ANIMALS; BROMINE; DOGS; HYDROXYLATION; HYPOGLYCEMIC AGENTS; PLASMA; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

CANIS FAMILIARIS;

EID: 84862140489     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.04.027     Document Type: Article

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