Polymorphisms in TRPV1 and TAS2Rs Associate with Sensations from Sampled Ethanol

Alcoholism: Clinical and Experimental Research

Volumn 38, Issue 10, 2014, Pages 2550-2560

  Allen, Alissa L ^a   Mcgeary, John E ^b,c,d   Hayes, John E ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b PROVIDENCE VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c RHODE ISLAND HOSPITAL   (United States)

^d BROWN UNIVERSITY   (United States)

Author keywords

Bitterness; Burn; Ethanol; Taste Phenotype; TRPV1

Indexed keywords

ALCOHOL; G PROTEIN COUPLED RECEPTOR; TASTE RECEPTORS, TYPE 2; TRPV1 PROTEIN, HUMAN; VANILLOID RECEPTOR;

ADOLESCENT; ADULT; AREA UNDER THE CURVE; COHORT ANALYSIS; COMPARATIVE STUDY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETICS; HAPLOTYPE; HUMAN; MALE; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; SENSATION; SINGLE NUCLEOTIDE POLYMORPHISM; TASTE; TIME; YOUNG ADULT;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AREA UNDER CURVE; COHORT STUDIES; ETHANOL; FEMALE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, G-PROTEIN-COUPLED; SENSATION; TASTE; TASTE PERCEPTION; TIME FACTORS; TRPV CATION CHANNELS; YOUNG ADULT;

EID: 84911363948     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.12527     Document Type: Article

References (55)

1. Allen AL, McGeary JE, Knopik VS, Hayes JE (2013) Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31. Chem Senses 38:379-389.
2. Bandell M, Dubin AE, Petrus MJ, Orth A, Mathur J, Hwang SW, Patapoutian A (2006) High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol. Nat Neurosci 9:493-500.
3. Barber JG, Grichting WL (1987) The assessment of drug attitudes among university students using the short form of the drug attitude scale. Subst Use Misuse 22:1033-1039.
4. Barrett J, Fry B, Maller J, Daly M (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-265.
5. Bartoshuk LM, Conner E, Grubin D, Karrer T, Kochenbach K, Palcso M, Snow D, Pelchat M, Danowski S, (1993) PROP supertasters and the perception of ethyl alcohol. Chem Senses, 18: 526-527.
6. Bartoshuk LM, Duffy VB, Fast K, Green BG, Prutkin J, Snyder DJ (2003) Labeled scales (eg, category, Likert, VAS) and invalid across-group comparisons: what we have learned from genetic variation in taste. Food Qual Prefer 14:125-138.
7. Bartoshuk LM, Duffy VB, Green BG, Hoffman HJ, Ko CW, Lucchina LA, Marks LE, Snyder DJ, Weiffenbach JM (2004) Valid across- group comparisons with labeled scales: the gLMS versus magnitude matching. Physiol Behav 82:109-114.
8. Bennett SM, Zhou L, Hayes JE (2012) Using milk fat to reduce the irritation and bitter taste of ibuprofen. Chemosens Percept 5: 231-236.
9. Blednov Y, Harris R (2009) Deletion of vanilloid receptor (TRPV1) in mice alters behavioral effects of ethanol. Neuropharmacology 56:814-820.
10. Blizard DA (2007) Sweet and bitter taste of ethanol in C57BL/6J and DBA2/J mouse strains. Behav Genet 37:146-159.
11. Bufe B, Breslin PA, Kuhn C, Reed DR, Tharp CD, Slack JP, Kim UK, Drayna D, Meyerhof W (2005) The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr Biol 15:322-327.
12. Byrnes NK, Hayes JE (2013) Personality factors predict spicy food liking and intake. Food Qual Prefer 28:213-221.
13. Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D (1999) A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 398:436-441.
14. Dotson CD, Wallace MR, Bartoshuk LM, Logan HL (2012) Variation in the gene TAS2R13 is associated with differences in alcohol consumption in patients with head and neck cancer. Chem Senses 37:737-744.
15. Duffy VB (2007) Variation in oral sensation: implications for diet and health. Curr Opin Gastroenterol 23:171-177.
16. Duffy VB, Davidson AC, Kidd JR, Kidd KK, Speed WC, Pakstis AJ, Reed DR, Snyder DJ, Bartoshuk LM (2004a) Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake. Alcohol Clin Exp Res 28:1629-1637.
17. Duffy VB, Hayes JE, Davidson AC, Kidd JR, Kidd KK, Bartoshuk LM (2010) Vegetable intake in college-aged adults is explained by oral sensory phenotypes and TAS2R38 genotype. Chemosens Percept, 3: 137-148.
18. Duffy VB, Hayes JE, Sullivan BS, Faghri P (2009) Surveying food and beverage liking. Ann N Y Acad Sci 1170:558-568.
19. Duffy VB, Peterson JM, Bartoshuk LM (2004b) Associations between taste genetics, oral sensation and alcohol intake. Physiol Behav 82:435-445.
20. Feeney E (2011) The impact of bitter perception and genotypic variation of TAS2R38 on food choice. Nutr Bull 36:20-33.
21. Feeney EL, Hayes JE (2014) Exploring associations between taste perception, oral anatomy and polymorphisms in the carbonic anhydrase (gustin) gene CA6. Physiol Behav 128:148-154.
22. García-Sanz N, Valente P, Gomis A, Fernández-Carvajal A, Fernández-Ballester G, Viana F, Belmonte C, Ferrer-Montiel A (2007) A role of the transient receptor potential domain of vanilloid receptor I in channel gating. J Neurosci 27:11641-11650.
23. Gaudet R (2007) Structural insights into the function of TRP channels, in TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades (Liedtke W ed), pp. 349-359. CRC Press, Boca Raton, FL.
24. Glanz K, Basil M, Maibach E, Goldberg J, Snyder D (1998) Why Americans eat what they do: taste, nutrition, cost, convenience, and weight control concerns as influences on food consumption. J Am Diet Assoc 98:1118-1126.
25. Green BG (1987) The sensitivity of the tongue to ethanol. Ann N Y Acad Sci 510:315-317.
26. Green BG (1988) Spatial and temporal factors in the perception of ethanol irritation on the tongue. Percept Psychophys 44: 108-116.
27. Green BG (2012) Chemesthesis and the chemical senses as components of a "chemofensor complex". Chem Senses 37:201-206.
28. Green BG, Hayes JE (2004) Individual differences in perception of bitterness from capsaicin, piperine and zingerone. Chem Senses 29:53-60.
29. Green BG, Lim J, Osterhoff F, Blacher K, Nachtigal D (2010) Taste mixture interactions: surpression, additivity, and the predominance of sweetnenss. Physiol Behav 101:731-737.
30. Green BG, Schullery MT (2003) Stimulation of bitterness by capsaicin and menthol: differences between lingual areas innervated by the glossopharyngeal and chorda tympani nerves. Chem Senses 28:45.
31. Hayes JE, Allen AL, Bennett SM (2013a) Direct comparison of the generalized visual analog scale (gVAS) and general labeled magnitude scale (gLMS). Food Qual Prefer 28:36-44.
32. Hayes JE, Bartoshuk LM, Kidd JR, Duffy VB (2008) Supertasting and PROP bitterness depends on more than the TAS2R38 gene. Chem Senses 33:255-265.
33. Hayes JE, Feeney EL, Allen AL (2013b) Do polymorphisms in chemosensory genes matter for human ingestive behavior? Food Qual Prefer 30:202-216.
34. Hayes JE, Wallace MR, Knopik VS, Herbstman DM, Bartoshuk LM, Duffy VB (2011) Allelic variation in TAS2R bitter receptor genes associates with variation in sensations from and ingestive behaviors toward common bitter beverages in adults. Chem Senses 36:311-319.
35. Hellekant G, Danilova V, Roberts T, Ninomiya Y (1997) The taste of ethanol in a primate model: I. Chorda tympani nerve response in Macaca mulatta. Alcohol 14:473-484.
36. Hinrichs AL, Wang JC, Bufe B, Kwon JM, Budde J, Allen R, Bertelsen S, Evans W, Dick D, Rice J (2006) Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. Am J Med Genet A 78:103-111.
37. IFIC (2011) Food & Health Survey: consumer attitudes toward food safety, nutrition & health. Available at: http://www.foodinsight.org/2011_Food_Health_Survey_Consumer_Attitudes_Toward_Food_Safety_Nutrition_Health. Accessed September 18, 2014.
38. Kim U, Jorgenson E, Coon H, Leppert M, Risch N, Drayna D (2003) Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science 299:1221.
39. Lanier SA, Hayes JE, Duffy VB (2005) Sweet and bitter tastes of alcoholic beverages mediate alcohol intake in of-age undergraduates. Physiol Behav 83:821-831.
40. Lawless H, Stevens DA (1984) Effects of oral chemical irritation on taste. Physiol Behav 32:995-998.
41. Lemon CH, Brasser SM, Smith DV (2004) Alcohol activates a sucrose-responsive gustatory neural pathway. J Neurophysiol 92:536-544.
42. Lim J, Green BG (2007) The psychophysical relationship between bitter taste and burning sensation: evidence of qualitative similarity. Chem Senses 32:31-39.
43. Lucas L, Riddell L, Liem G, Whitelock S, Keast R (2011) The influence of sodium on liking and consumption of salty food. J Food Sci 76:S72-S76.
44. Mattes RD, DiMeglio D (2001) Ethanol perception and ingestion. Physiol Behav 72:217-229.
45. Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, Appendino G, Behrens M (2010) The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35:157-170.
46. Moore M, Weiss S (1995) Reasons for non-drinking among Israeli adolescents of four religions. Drug Alcohol Depend 38:45-50.
47. Prescott J, Swain-Campbell N (2000) Responses to repeated oral irritation by capsaicin, cinnamaldehyde and ethanol in PROP tasters and non-tasters. Chem Senses 25:239.
48. Riera C (2007) Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors. Am J Physiol Regul Integr Comp Physiol 293:R626-R634.
49. Riera CE, Vogel H, Simon SA, Damak S, le Coutre J (2008) The capsaicin receptor participates in artificial sweetener aversion. Biochem Biophys Res Commun 376:653-657.
50. Scinska A, Koros E, Habrat B, Kukwa A, Kostowski W, Bienkowski P (2000) Bitter and sweet components of ethanol taste in humans. Drug Alcohol Depend 60:199-206.
51. Snyder D, Fast K, Bartoshuk LM (2004) Valid comparisons of suprathreshold sensations. J Conscious Stud 11:7-8.
52. Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner K, Raumann BE, Basbaum AI, Julius D (1998) The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21:531-543.
53. Trevisani M, Smart D, Gunthorpe MJ, Tognetto M, Barbieri M, Campi B, Amadesi S, Gray J, Jerman JC, Brough SJ (2002) Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1. Nat Neurosci 5:546-551.
54. Valente P, García-Sanz N, Gomis A, Fernández-Carvajal A, Fernández-Ballester G, Viana F, Belmonte C, Ferrer-Montiel A (2008) Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor I. FASEB J 22:3298-3309.
55. Wang JC, Hinrichs AL, Bertelsen S, Stock H, Budde JP, Dick DM, Bucholz KK, Rice J, Saccone N, Edenberg HJ (2007) Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin. Alcohol Clin Exp Res 31:209-215.