Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31

Chemical Senses

Volumn 38, Issue 5, 2013, Pages 379-389

  Allen, Alissa L ^a   McGeary, John E ^b,d   Knopik, Valerie S ^c,d   Hayes, John E ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b PROVIDENCE VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c RHODE ISLAND HOSPITAL   (United States)

^d BROWN UNIVERSITY   (United States)

Author keywords

Bitterness; Genetics; Noncaloric sweetener; Project GIANT CS; Saccharin; Taste phenotype

Indexed keywords

ACESULFAME;

ADULT; ARTICLE; BITTER TASTE; CHROMOSOME 12; CHROMOSOME 7; FEMALE; GENE; GENE LINKAGE DISEQUILIBRIUM; GENOTYPE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PREDICTION; PRIORITY JOURNAL; PSYCHOPHYSICS; QUANTITATIVE TRAIT; SINGLE NUCLEOTIDE POLYMORPHISM; SWEETNESS; TAS2R31 GENE; TAS2R9 GENE;

BITTERNESS; GENETICS; NONCALORIC SWEETENER; PROJECT GIANT-CS; SACCHARIN; TASTE PHENOTYPE;

ADOLESCENT; ADULT; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, G-PROTEIN-COUPLED; SWEETENING AGENTS; TASTE; THIAZINES; YOUNG ADULT;

EID: 84878438759     PISSN: 0379864X     EISSN: 14643553     Source Type: Journal    
DOI: 10.1093/chemse/bjt017     Document Type: Article

References (58)

1. Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJP, Zuker CS. 2000. A novel family of mammalian taste receptors. Cell. 100(6):693-702.
2. Anderson GH, Foreyt J, Sigman-Grant M, Allison DB. 2012. The use of lowcalorie sweeteners by adults: impact on weight management. J Nutr. 142(6):1163S-1169S.
3. Bartoshuk LM. 1979. Bitter taste of saccharin related to the genetic ability to taste the bitter substance 6-n-propylthiouracil. Science. 205(4409):934-935.
4. Bufe B, Breslin PAS, Kuhn C, Reed DR, Tharp CD, Slack JP, Kim UK, Drayna D, Meyerhof W. 2005. The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr Biol. 15(4):322-327.
5. Barrett JC, Fry B, Maller J, Daly MJ. 2005. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21(2):263-5.
6. Carey G. 2007. The association design and a continous phenotype [Internet]. Institute for Behavioral Genetics, University of Colorado. Updated 4 April 2007. Available from: http://psych.colorado.edu/~carey/Courses/ PSYC5102/handouts/Association-Quantitative.pdf
7. Calo C, Padiglia A, Zonza A, Corrias L, Contu P, Tepper BJ, Barbarossa IT. 2011. Polymorphisms in TAS2R38 and the taste bud trophic factor, gustin gene co-operate in modulating PROP taste phenotype. Physiol Behav. 104(5):1065-1071.
8. Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJP. 2000. T2Rs function as bitter taste receptors. Cell. 100(6):703-711.
9. Clark CC, Lawless HT. 1994. Limiting response alternatives in time-intensity scaling: an examination of the halo-dumping effect. Chem Senses. 19(6):583-594.
10. De la Hunty A, Gibson S, Ashwell M. 2006. A review of the effectiveness of aspartame in helping with weight control. Nutr Bull. 31(2):115-128.
11. de Snoo K. 1937. Das trikende Kind im Uterus. Monatsschrift fur Geburtshilfe und Gynakologie. 105:88-97.
12. Dinehart M, Hayes J, Bartoshuk L, Lanier S, Duffy V. 2006. Bitter taste markers explain variability in vegetable sweetness, bitterness, and intake. Physiol Behav. 87(2):304-313.
13. Dotson CD, Zhang L, Xu H, Shin YK, Vigues S, Ott SH, Elson AET, Choi HJ, Shaw H, Egan JM. 2008. Bitter taste receptors influence glucose homeostasis. PLoS ONE. 3(12):e3974.
14. DuBois GE, Walters DE, Schiffman SS, Warwick ZS, Booth BJ, Pecore SD, Gibes K, Carr BT, Brands LM. 1991. Concentration-response relationships of sweeteners: a systematic study. In Walters, D.E., Orthoefer, F.T. and Dubois, G.E. (eds), ACS Symposium Series 450. Sweeteners: Discovery, Molecular Design and Chemoreception. Boston, MA, American Chemical Society, pp. 261-276.
15. Duffy VB, Anderson G. 1998. Position of the American Dietetic Association: use of nutritive and nonnutritive sweeteners. J Am Diet Assoc. 98(5):580-587.
16. Duffy VB, Davidson AC, Kidd JR, Kidd KK, Speed WC, Pakstis AJ, Reed DR, Snyder DJ, Bartoshuk LM. 2004. Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake. Alcohol Clin Exp Res. 28(11):1629-1637.
17. Duffy VB, Hayes JE, Davidson AC, Kidd JR, Kidd KK, Bartoshuk LM. 2010. Vegetable intake in college-aged adults is explained by oral sensory phenotypes and TAS2R38 genotype. Chemosens Percept. 3(3):137-148.
18. Duffy VB, Hayes JE, Dinehart ME. 2006. Genetic differences in sweet taste perception. In: Spillane WJ, editor. Optimising the sweet taste in foods. Cambridge (UK): Woodhead Publishing, pp. 30-53
19. Duffy VB, Peterson JM, Bartoshuk LM. 2004. Associations between taste genetics, oral sensation and alcohol intake. Physiol Behav. 82(2-3):435-445.
20. Glanz K, Basil M, Maibach E, Goldberg J, Snyder D. 1998. Why Americans eat what they do: taste, nutrition, cost, convenience, and weight control concerns as influences on food consumption. J Am Diet Assoc. 98(10):1118-1126.
21. Green BG, George P. 2004. 'Thermal taste' predicts higher responsiveness to chemical taste and flavor. Chem Senses. 29(7):617-628.
22. Hamer D, Sirota L. 2000. Beware the chopsticks gene. Mol Psychiatry. 5(1):11-13.
23. Hanger L, Lotz A, Lepeniotis S. 1996. Descriptive profiles of selected high intensity sweeteners (HIS), HIS blends, and sucrose. J Food Sci. 61(2):456-459.
24. Harwood ML, Ziegler GR, Hayes JE. 2012. Rejection thresholds in chocolate milk: evidence for segmentation. Food Qual Prefer. 26(1):128-133.
25. Hayes JE. 2008. Transdisciplinary perspectives on sweetness. Chemosens Percept. 1(1):48-57.
26. Hayes JE, Allen AL, Bennett SM. 2013. Direct comparison of the generalized Visual Analog Scale (gVAS) and general Labeled Magnitude Scale (gLMS). Food Qual Prefer. 28(1):36-44.
27. Hayes JE, Bartoshuk LM, Kidd JR, Duffy VB. 2008. Supertasting and PROP bitterness depends on more than the TAS2R38 gene. Chem Senses. 33(3):255-265.
28. Hayes JE, Keast RSJ. 2011. Two decades of supertasting: where do we stand? Physiol Behav. 104(5):1072-1074.
29. Hayes JE, Sullivan BS, Duffy VB. 2010. Explaining variability in sodium intake through oral sensory phenotype, salt sensation and liking. Physiol Behav. 100(4):369-380.
30. Hayes JE, Wallace MR, Knopik VS, Herbstman DM, Bartoshuk LM, Duffy VB. 2011. Allelic variation in TAS2R bitter receptor genes associates with variation in sensations from and ingestive behaviors toward common bitter beverages in adults. Chem Senses. 36(3):311-319.
31. Henkin RI, Gillis WT. 1977. Divergent taste responsiveness to fruit of the tree Antidesma bunius. Nature. 265(5594):536-537.
32. Hill JO, Prentice AM. 1995. Sugar and body weight regulation. Am J Clin Nutr. 62(1):264S-273S.
33. Horne J, Lawless HT, Speirs W, Sposato D. 2002. Bitter taste of saccharin and acesulfame-K. Chem Senses. 27(1):31-38.
34. Howard BV, Wylie-Rosett J. 2002. Sugar and cardiovascular disease. Circulation. 106(4):523-527.
35. IFIC. 2011. Consumer attitudes toward food safety, nutrition & health International Food Information Council Foundation. Washington DC.
36. Kamerud JK, Delwiche JF. 2007. Individual differences in perceived bitterness predict liking of sweeteners. Chem Senses. 32(9):803-810.
37. Kim U, Jorgenson E, Coon H, Leppert M, Risch N, Drayna D. 2003. Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science. 299(5610):1221-1225.
38. Kim U, Wooding S, Ricci D, Jorde LB, Drayna D. 2005. Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci. Hum Mutat. 26(3):199-204.
39. Kuhn C, Bufe B, Winnig M, Hofmann T, Frank O, Behrens M, Lewtschenko T, Slack JP, Ward CD, Meyerhof W. 2004. Bitter taste receptors for saccharin and acesulfame K. J Neurosci. 24(45):10260-10265.
40. Lanier SA, Hayes JE, Duffy VB. 2005. Sweet and bitter tastes of alcoholic beverages mediate alcohol intake in of-age undergraduates. Physiol Behav. 83(5):821-831.
41. Lotsch J, Geisslinger G, Tegeder I. 2009. Genetic modulation of the pharmacological treatment of pain. Pharmacol Ther. 124(2):168-184.
42. Lucas L, Riddell L, Liem G, Whitelock S, Keast R. 2011. The influence of sodium on liking and consumption of salty food. J Food Sci. 76(1):S72-S76.
43. Mennella JA, Pepino MY, Duke FF, Reed DR. 2010. Age modifies the genotype- phenotype relationship for the bitter receptor TAS2R38. BMC Genet. 11(1):60.
44. Mennella JA, Pepino MY, Duke FF, Reed DR. 2011. Psychophysical dissection of genotype effects on human bitter perception. Chem Senses. 36(2):161-167.
45. Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, Appendino G, Behrens M. 2010. The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses. 35(2):157-170.
46. Pronin AN, Xu H, Tang H, Zhang L, Li Q, Li X. 2007. Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin. Curr Biol. 17(16):1403-1408.
47. Raben A, Vasilaras TH, Møller AC, Astrup A. 2002. Sucrose compared with artificial sweeteners: different effects on ad libitum food intake and body weight after 10 wk of supplementation in overweight subjects. Am J Clin Nutr. 76(4):721-729.
48. Reed DR, Zhu G, Breslin PAS, Duke FF, Henders AK, Campbell MJ, Montgomery GW, Medland SE, Martin NG, Wright MJ. 2010. The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12. Hum Mol Genet. 19(21):4278-4285.
49. Roudnitzky N, Bufe B, Thalmann S, Kuhn C, Gunn HC, Xing C, Crider BP, Behrens M, Meyerhof W, Wooding SP. 2011. Genomic, genetic and functional dissection of bitter taste responses to artificial sweeteners. Hum Mol Genet. 20(17):3437-3449.
50. Schiffman SS, Reilly DA, Clark TB. 1979. Qualitative differences among sweeteners. Physiol Behav. 23(1):1-9.
51. Snyder D, Fast K., Bartoshuk LM. 2004. Valid comparisons of suprathreshold sensations. J Conscious Stud. 11(7-8):96-112.
52. Steiner JE, Glaser D, Hawilo ME, Berridge KC. 2001. Comparative expression of hedonic impact: affective reactions to taste by human infants and other primates. Neurosci Biobehav Rev. 25(1):53-74.
53. Stellman SD, Garfinkel L. 1986. Artificial sweetener use and one-year weight change among women. Prev Med. 15(2):195-202.
54. Stephens M, Donnelly P. 2003. A comparison of Bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet. 73(5):1162-1169.
55. Stephens M, Smith NJ, Donnelly P. 2001. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet. 68(4):978-989.
56. Tordoff MG, Alleva AM. 1990. Effect of drinking soda sweetened with aspartame or high-fructose corn syrup on food intake and body weight. Am J Clin Nutr. 51(6):963-969.
57. Wooding S, Kim U, Bamshad MJ, Larsen J, Jorde LB, Drayna D. 2004. Natural selection and molecular evolution in PTC, a bitter-taste receptor gene. Am J Hum Genet. 74(4):637-646.
58. Zuniga JR, Davis SH, Englehardt RA, Miller IJ, Schiffman SS, Phillips C. 1993. Taste performance on the anterior human tongue varies with fungiform taste bud density. Chem Senses. 18(5):449-460.