Sweet and bitter taste of ethanol in C57BL/6J and DBA2/J mouse strains

Behavior Genetics

Volumn 37, Issue 1, 2007, Pages 146-159

  Blizard, David A ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

C57BL 6J DBA 2J Conditioned taste aversion Quinine Sucrose Ethanol

Indexed keywords

ALCOHOL; QUININE; SUCROSE;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ARTICLE; AVOIDANCE BEHAVIOR; BITTER TASTE; C57BL 6 MOUSE; CONDITIONING; CONTROLLED STUDY; DBA 2 MOUSE; FEMALE; MALE; MOUSE; NONHUMAN; STIMULUS RESPONSE; STRAIN DIFFERENCE; SWEETNESS; TASTE AVERSION;

ANIMALS; ETHANOL; FOOD PREFERENCES; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; QUININE; SPECIES SPECIFICITY; STIMULATION, CHEMICAL; SUCROSE; TASTE;

MUS; RATTUS;

EID: 33846429177     PISSN: 00018244     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10519-006-9121-4     Document Type: Article

References (58)

1. Adams N, Shihabi Z, Blizard DA (1991) Ethanol preference in the Harrington derivation of the Maudsley Reactive and Non-Reactive strains. Alcohol Clin Exp Res 15:170-174
2. Bachmanov AA, Tordoff MG, Beauchamp GK (1996a) Ethanol consumption and taste preferences in C57BL/6ByJ and 129/J mice. Alcohol Clin Exp Res 20:201-206
3. Bachmanov AA, Reed DR, Tordoff MG, Price RA, Beauchamp GK (1996b) Intake of ethanol, sodium chloride, sucrose, citric acid, and quinine hydrochloric solutions by mice: a genetic analysis. Behav Genet 26:563-573
4. Bachmanov AA, Kiefer SW, Molina JC, Tordoff MG, Duffy VB, Bartoshuk LM, Mennella JA (2003) Chemosensory factors influencing alcohol perception, preferences and consumption. Alcohol Clin Exp Res 27:220-231
5. Badia-Elder NE, Kiefer SW (1999) Taste reactivity in alcohol-preferring AA and alcohol-avoiding ANA rats. Alcohol 18:159-163
6. Belknap JK, Belknap ND, Berg JH, Coleman R (1977) Preabsorptive vs postabsorptive control of ethanol intake in C57BL/6J and DBA/2J mice. Behav Genet 7:413-425
7. Belknap JK, Coleman RR, Foster K (1978) Alcohol consumption and sensory threshold differences between C57BL/6J and DBA/2J mice. Physiol Psychol 6:71-74
8. Belknap JK, Crabbe JC, Young ER (1993) Voluntary consumption of ethanol in 15 inbred mouse strains. Psychopharmacology 112:503-510
9. Bice P, Foroud T, Bo R, Castelluccio P, Lumeng L, Li TK, Carr LG (1998) Genomic screen for QTLs underlying alcohol consumption in the P and NP rat lines. Mamm Genome 9:949-955
10. Blizard DA (1992) Analyzing phenotypic correlations in studies with selected lines. Behav Genet 22:29-33
11. Blizard DA (1998) Chromosomal location of genes affecting gustation. Renewal of R01DC002230, July 1st 1998
12. Blizard DA, Chang A, DiFabio B, Taylor BA (1977) Genetic analysis of taste preference. Eastern Psychological Association, Boston, Massachusetts
13. Blizard DA, Kotlus B, Frank ME (1999) Quantitative trait loci (QTL) associated with short-term intake of sucrose, saccharin and quinine solutions in laboratory mice. Chem Senses 24 373-385
14. Blizard DA, McClearn GE (2000) Association between ethanol and sucrose intake in the laboratory mouse: exploration via congenic strains and conditioned taste aversion. Alcohol Clin Exp Res 24:253-258
15. Broadbent J, Muccino KJ, Cunningham CL (2002) Ethanol-induced conditioned taste aversion in 15 inbred mouse strains. Behav Neurosci 116:138-148
16. Clarke SN, Koh MT, Bernstein IL (2001) NaCl detection thresholds: comparison of Fischer 344 and Wistar rats. Chem Senses 26:253-257
17. Cooper CW (1966) The relationship of taste sensitivity to taste preference for two non-nutritive substances in two inbred strains of mice and their hybrid. Smith College Department of Psychology Honor's thesis
18. Dess NK, Badia-Elder NE, Thiele TL, Kiefer SW, Blizard DA (1998) Ethanol consumption in rats selectively bred for differential saccharin intake. Alcohol 16:275-278
19. DiLorenzo PM, Kiefer SW, Rice AG, Garcia J (1986) Neural and behavioral responsivity to ethyl alcohol as a tastant. Alcohol 3:55-61
20. Duffy VB, Davidson AC, Kidd JR, Kidd KK, Speed WC, Pakstis AJ, Reed DR, Snyder DJ, Bartoshuk LM (2004) Bitter receptor gene (TAS2R38) 6-n-propylthiouracil (PROP) bitterness and alcohol intake . Alcohol Clin Exp Res 28:1629-1637
21. Eriksson K, Rusi M (1981) Finnish selection studies on alcohol-related behaviors: general outline, In: McClearn GE, Deitrich RA, Erwin EG (eds) Development of animal models as pharmacogenetic tools. US DHHS Publications, Washington DC, pp 87-117
22. Frank ME, Formaker BK, Hettinger TP (2003) Taste responses to mixtures: analytic processing of quality. Behav Neurosci 117:228-235
23. Frank ME, Nowlis GH (1989) Learned aversions and taste qualities in hamsters. Chem Senses 14:379-394
24. Fuller JL (1974) Single locus control of saccharin preference in mice. J Hered 65:33-36
25. Grill HJ, Norgren R (1978) The taste reactivity test I Mimetic responses to gustatory stimuli in neurologically normal rats. Brain Res 143:263-279
26. Harder DB, Capeless CG, Maggio JC, Boughter JD, Gannon KS, Whitney G, Azen EA (1992) Intermediate sucroseoctaacetate sensitivity suggests a third allele at mouse bitter taste locus Soa and Soa-Rua identity. Chem Senses 17:391-401
27. Henderson ND (1989) Interpreting studies that compare high-and low-selected lines on new characters. Behav Genet 19:473-502
28. Kampov-Polevoy AB, Garbutt JC, Janowsky DS (1999) Association between preference for sweets and excessive alcohol intake: a review of animal and human studies. Alcohol Alcohol 34:386-395
29. Kiefer SW (1995) Alcohol, palatability and taste reactivity. Biobehav Rev 19:133-141
30. Kiefer SW, Lawrence GJ (1988) The sweet-bitter taste of alcohol: aversion generalization to various sweet-quinine mixtures in the rat. Chem Senses 13:633-641
31. Kiefer SW, Mahadevan RS (1993) The taste of alcohol for rats as revealed by aversion generalization tests. Chem Senses 18:509-522
32. Kiefer SW, Morrow NS, Metzler CW (1988) Alcohol aversion generalization in rats: specific disruption of taste and odor cues with gustatory neocortex or olfactory bulb ablations. Behav Neurosci 102:733-739
33. Kotlus BS, Blizard DA (1998) Measuring gustatory variation in mice: a short-term fluid-intake test. Physiol Behav 64:37-47
34. Lawrence GJ, Kiefer SW (1987) Generalization of specific taste aversions to alcohol in the rat. Chem Senses 12:591-599
35. Lemon CH, Brasser SM, Smith DV (2004) Alcohol activates a sucrose-responsive gustatory neural pathway. J Neurophysiol 92:536-544
36. T-K, Lumeng L, McBride WJ, Waller MB (1981) Indiana selection studies on alcohol-related behaviors, In: McClearn GE, Deitrich RA, Erwin EG (eds) Development of animal models as pharmacogenetic tools. US DHHS Publications, Washington DC, pp 171-191
37. T-K, Lumeng L (1984) Alcohol preference and voluntary alcohol intakes of inbred rat strains and the National Institutes of Health heterogeneous stock of rats. Alcohol Clin Exp Res 8:485-486
38. Lush IE (1984) The genetics of tasting in mice III Quinine. Genet Res (Camb) 44:151-160
39. Lush IE (1989) The genetics of tasting in mice VI Saccharin, acesulfame, dulcin and sucrose. Genet Res (Camb) 53:95-99
40. MacKinnon BI, Frank ME, Hettinger TP, Rehnberg BG (1999) Taste qualities of solutions preferred by hamsters. Chem Senses 24:23-35
41. McClearn GE, Rodgers DA (1959) Differences in alcohol preference among inbred strains of mice. Quart J Stud Alcohol 20:691-695
42. Nachman M, Larue C, Le Magnen J (1971) The role of olfactory and orosensory factors in the alcohol preference of inbred strains of mice. Physiol Behav 6:53-59
43. Ninomiya K, Funakoshi M (1988) Behavioral discrimination between glutamate and the four basic taste substances in mice Comp. Biochem Physiol 92A:365-370
44. Overstreet DH, Kampov-Polevoy AB, Rezvani AH, Murrelle L, Halikas JA, Janowsky DS (1993) Saccharin intake predicts ethanol intake in genetically heterogeneous rats as well as different rat strains. Alcohol Clin Exp Res 17:366-369
45. Peirce JL, Derr R, Shendure J, Kolata T, Silver LM (1998) A major influence of sex-specific loci on alcohol preference in C57BL/6J and DBA/2J inbred mice. Mamm Genome 9:942-948
46. Pelchat ML, Danowski S (1992) A possible genetic association between PROP-tasting and alcoholism. Physiol Behav 51:1261-1266
47. Pelz W, Whitney G, Smith JC (1973) Genetic influences on saccharin preferences in mice. Physiol Behav 10:263-265
48. Phillips TJ, Crabbe JC, Metten P, Belknap JK (1994) Localization of genes affecting alcohol drinking in mice. Alcohol Clin Exp Res 18:931-941
49. Phillips TJ, Belknap JK, Buck KJ, Cunningham CL (1998) Genes on mouse chromosomes 2 and 9 determine variation in ethanol consumption. Mamm Genome 9:936-941
50. Rodgers DA, McClearn GE (1964) Sucrose versus ethanol appetite in inbred strains of mice. Quart J Stud Alcohol 25:26-35
51. Rodgers DA (1966) Alcohol preference in mice. In: Zubin J (eds) Comparative psychopathology - animals humans. Grune, New York
52. Rodriguez LA, Plomin R, Blizard DA, Jones BC, McClearn GE (1994) Alcohol acceptance, preference, and sensitivity in mice: I Quantitative genetic analysis using BXD recombinant-inbred strains. Alcohol Clin Exp Res 18:1416-1422
53. Rodriguez LA, Plomin R, Blizard DA, Jones BC, McClearn GE (1995) Alcohol acceptance, preference, and sensitivity in mice: II Quantitative trait loci (QTL) mapping analysis using BXD recombinant-inbred strains. Alcohol Clin Exp Res 19:367-373
54. Sinclair JD, Kampov-Polevoy A, Stewart R, Li TK (1992) Taste preferences in rat lines selected for low and high alcohol consumption. Alcohol 9:155-160
55. Stewart RB, Russell RN, Lumeng L, Li T-K, Murphy JM (1994) Consumption of sweet, salty, sour, and bitter solutions by selectively bred alcohol-preferring and alcohol non-preferring lines of rats. Alcohol Clin Exp Res 18:375-381
56. Tarantino LM, McClearn GE, Rodriguez LA, Plomin R (1998) Confirmation of quantitative trait loci for alcohol preference in mice. Alcohol Clin Exp Res 22:1099-1105
57. Thomas K (1969) Selection avoidance of alcohol solutions by two strains of inbred mice and derived generations. Quart J Stud Alcohol 30:849-861
58. Thompson WR (1957) Traits, factors and genes. Eugen Q 4:8-16