TRF1 negotiates TTAGGG repeatassociated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling

Genes and Development

Volumn 28, Issue 22, 2014, Pages 2477-2491

  Zimmermann, Michal ^a,b   Kibe, Tatsuya ^a   Kabir, Shaheen ^a   de Lange, Titia ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b MASARYK UNIVERSITY   (Czech Republic)

Author keywords

BLM; G quadruplex; Replication; Shelterin; Telomere; TRF1

Indexed keywords

ATR PROTEIN; BINDING PROTEIN; BLOOM SYNDROME HELICASE; DNA BINDING PROTEIN; HETERODIMER; PROTEIN POT1; PROTEIN TIN2; PROTEIN TPP1; RAP1 PROTEIN; TELOMERIC REPEAT BINDING FACTOR 1; UNCLASSIFIED DRUG; AMINOPEPTIDASE; ATM PROTEIN; ATR PROTEIN, MOUSE; DIPEPTIDYL PEPTIDASE; MICROSATELLITE DNA; POT1 PROTEIN, MOUSE; PROTEIN BINDING; RECQ HELICASE; SERINE PROTEINASE; TELOMERE BINDING PROTEIN; TINF2 PROTEIN, MOUSE; TRIPEPTIDYL-PEPTIDASE 1;

ARTICLE; DNA SYNTHESIS; EMBRYO; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN SECONDARY STRUCTURE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TELOMERE; CELL CULTURE; DNA REPLICATION; ENZYME ACTIVATION; GENE INACTIVATION; GENETICS; METABOLISM; MUTATION;

AMINOPEPTIDASES; ATAXIA TELANGIECTASIA MUTATED PROTEINS; CELLS, CULTURED; DIPEPTIDYL-PEPTIDASES AND TRIPEPTIDYL-PEPTIDASES; DNA REPLICATION; DNA-BINDING PROTEINS; ENZYME ACTIVATION; GENE KNOCKOUT TECHNIQUES; MICROSATELLITE REPEATS; MUTATION; PROTEIN BINDING; RECQ HELICASES; SERINE PROTEASES; SIGNAL TRANSDUCTION; TELOMERE; TELOMERE-BINDING PROTEINS; TELOMERIC REPEAT BINDING PROTEIN 1;

EID: 84910628583     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.251611.114     Document Type: Article

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