-
1
-
-
33748195107
-
A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules
-
Banaszynski L.A., Chen L.C., Maynard-Smith L.A., Ooi A.G., Wandless T.J. A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules. Cell 2006, 126:995-1004.
-
(2006)
Cell
, vol.126
, pp. 995-1004
-
-
Banaszynski, L.A.1
Chen, L.C.2
Maynard-Smith, L.A.3
Ooi, A.G.4
Wandless, T.J.5
-
2
-
-
50249115141
-
Distinct functions of POT1 at telomeres
-
Barrientos K.S., Kendellen M.F., Freibaum B.D., Armbruster B.N., Etheridge K.T., Counter C.M. Distinct functions of POT1 at telomeres. Mol. Cell. Biol. 2008, 28:5251-5264.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 5251-5264
-
-
Barrientos, K.S.1
Kendellen, M.F.2
Freibaum, B.D.3
Armbruster, B.N.4
Etheridge, K.T.5
Counter, C.M.6
-
3
-
-
3442896884
-
Replication protein A phosphorylation and the cellular response to DNA damage
-
Binz S.K., Sheehan A.M., Wold M.S. Replication protein A phosphorylation and the cellular response to DNA damage. DNA Repair (Amst.) 2004, 3:1015-1024.
-
(2004)
DNA Repair (Amst.)
, vol.3
, pp. 1015-1024
-
-
Binz, S.K.1
Sheehan, A.M.2
Wold, M.S.3
-
4
-
-
77956541101
-
Telomeres avoid end detection by severing the checkpoint signal transduction pathway
-
Carneiro T., Khair L., Reis C.C., Borges V., Moser B.A., Nakamura T.M., Ferreira M.G. Telomeres avoid end detection by severing the checkpoint signal transduction pathway. Nature 2010, 467:228-232.
-
(2010)
Nature
, vol.467
, pp. 228-232
-
-
Carneiro, T.1
Khair, L.2
Reis, C.C.3
Borges, V.4
Moser, B.A.5
Nakamura, T.M.6
Ferreira, M.G.7
-
5
-
-
22144490491
-
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion
-
Celli G.B., de Lange T. DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat. Cell Biol. 2005, 7:712-718.
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 712-718
-
-
Celli, G.B.1
de Lange, T.2
-
6
-
-
31544466516
-
Human telomeres have different overhang sizes at leading versus lagging strands
-
Chai W., Du Q., Shay J.W., Wright W.E. Human telomeres have different overhang sizes at leading versus lagging strands. Mol. Cell 2006, 21:427-435.
-
(2006)
Mol. Cell
, vol.21
, pp. 427-435
-
-
Chai, W.1
Du, Q.2
Shay, J.W.3
Wright, W.E.4
-
7
-
-
37849030208
-
Pot1 and cell cycle progression cooperate in telomere length regulation
-
Churikov D., Price C.M. Pot1 and cell cycle progression cooperate in telomere length regulation. Nat. Struct. Mol. Biol. 2008, 15:79-84.
-
(2008)
Nat. Struct. Mol. Biol.
, vol.15
, pp. 79-84
-
-
Churikov, D.1
Price, C.M.2
-
8
-
-
47749141560
-
ATR: an essential regulator of genome integrity
-
Cimprich K.A., Cortez D. ATR: an essential regulator of genome integrity. Nat. Rev. Mol. Cell Biol. 2008, 9:616-627.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 616-627
-
-
Cimprich, K.A.1
Cortez, D.2
-
9
-
-
71149093724
-
How telomeres solve the end-protection problem
-
de Lange T. How telomeres solve the end-protection problem. Science 2009, 326:948-952.
-
(2009)
Science
, vol.326
, pp. 948-952
-
-
de Lange, T.1
-
10
-
-
34250705797
-
The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1
-
Delacroix S., Wagner J.M., Kobayashi M., Yamamoto K., Karnitz L.M. The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. Genes Dev. 2007, 21:1472-1477.
-
(2007)
Genes Dev.
, vol.21
, pp. 1472-1477
-
-
Delacroix, S.1
Wagner, J.M.2
Kobayashi, M.3
Yamamoto, K.4
Karnitz, L.M.5
-
11
-
-
34548317418
-
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
-
Denchi E.L., de Lange T. Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature 2007, 448:1068-1071.
-
(2007)
Nature
, vol.448
, pp. 1068-1071
-
-
Denchi, E.L.1
de Lange, T.2
-
12
-
-
0033598133
-
Mcm2, but not RPA, is a component of the mammalian early G1-phase prereplication complex
-
Dimitrova D.S., Todorov I.T., Melendy T., Gilbert D.M. Mcm2, but not RPA, is a component of the mammalian early G1-phase prereplication complex. J. Cell Biol. 1999, 146:709-722.
-
(1999)
J. Cell Biol.
, vol.146
, pp. 709-722
-
-
Dimitrova, D.S.1
Todorov, I.T.2
Melendy, T.3
Gilbert, D.M.4
-
13
-
-
2442646547
-
Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1
-
Furuya K., Poitelea M., Guo L., Caspari T., Carr A.M. Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1. Genes Dev. 2004, 18:1154-1164.
-
(2004)
Genes Dev.
, vol.18
, pp. 1154-1164
-
-
Furuya, K.1
Poitelea, M.2
Guo, L.3
Caspari, T.4
Carr, A.M.5
-
14
-
-
0033553536
-
Mammalian telomeres end in a large duplex loop
-
Griffith J.D., Comeau L., Rosenfield S., Stansel R.M., Bianchi A., Moss H., de Lange T. Mammalian telomeres end in a large duplex loop. Cell 1999, 97:503-514.
-
(1999)
Cell
, vol.97
, pp. 503-514
-
-
Griffith, J.D.1
Comeau, L.2
Rosenfield, S.3
Stansel, R.M.4
Bianchi, A.5
Moss, H.6
de Lange, T.7
-
15
-
-
36248952723
-
Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis
-
Guo X., Deng Y., Lin Y., Cosme-Blanco W., Chan S., He H., Yuan G., Brown E.J., Chang S. Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis. EMBO J. 2007, 26:4709-4719.
-
(2007)
EMBO J.
, vol.26
, pp. 4709-4719
-
-
Guo, X.1
Deng, Y.2
Lin, Y.3
Cosme-Blanco, W.4
Chan, S.5
He, H.6
Yuan, G.7
Brown, E.J.8
Chang, S.9
-
16
-
-
33745685066
-
Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres
-
Hockemeyer D., Daniels J.P., Takai H., de Lange T. Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres. Cell 2006, 126:63-77.
-
(2006)
Cell
, vol.126
, pp. 63-77
-
-
Hockemeyer, D.1
Daniels, J.P.2
Takai, H.3
de Lange, T.4
-
17
-
-
46249089163
-
Engineered telomere degradation models dyskeratosis congenita
-
Hockemeyer D., Palm W., Wang R.C., Couto S.S., de Lange T. Engineered telomere degradation models dyskeratosis congenita. Genes Dev. 2008, 22:1773-1785.
-
(2008)
Genes Dev.
, vol.22
, pp. 1773-1785
-
-
Hockemeyer, D.1
Palm, W.2
Wang, R.C.3
Couto, S.S.4
de Lange, T.5
-
18
-
-
33644757806
-
TopBP1 activates the ATR-ATRIP complex
-
Kumagai A., Lee J., Yoo H.Y., Dunphy W.G. TopBP1 activates the ATR-ATRIP complex. Cell 2006, 124:943-955.
-
(2006)
Cell
, vol.124
, pp. 943-955
-
-
Kumagai, A.1
Lee, J.2
Yoo, H.Y.3
Dunphy, W.G.4
-
19
-
-
34948889415
-
The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR
-
Lee J., Kumagai A., Dunphy W.G. The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. J. Biol. Chem. 2007, 282:28036-28044.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 28036-28044
-
-
Lee, J.1
Kumagai, A.2
Dunphy, W.G.3
-
20
-
-
0038451396
-
POT1 as a terminal transducer of TRF1 telomere length control
-
Loayza D., de Lange T. POT1 as a terminal transducer of TRF1 telomere length control. Nature 2003, 423:1013-1018.
-
(2003)
Nature
, vol.423
, pp. 1013-1018
-
-
Loayza, D.1
de Lange, T.2
-
21
-
-
0034284104
-
The majority of human replication protein A remains complexed throughout the cell cycle
-
Loo Y.M., Melendy T. The majority of human replication protein A remains complexed throughout the cell cycle. Nucleic Acids Res. 2000, 28:3354-3360.
-
(2000)
Nucleic Acids Res.
, vol.28
, pp. 3354-3360
-
-
Loo, Y.M.1
Melendy, T.2
-
22
-
-
34247257202
-
The structural determinants of checkpoint activation
-
MacDougall C.A., Byun T.S., Van C., Yee M.C., Cimprich K.A. The structural determinants of checkpoint activation. Genes Dev. 2007, 21:898-903.
-
(2007)
Genes Dev.
, vol.21
, pp. 898-903
-
-
MacDougall, C.A.1
Byun, T.S.2
Van, C.3
Yee, M.C.4
Cimprich, K.A.5
-
23
-
-
0031000884
-
Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening
-
Makarov V.L., Hirose Y., Langmore J.P. Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell 1997, 88:657-666.
-
(1997)
Cell
, vol.88
, pp. 657-666
-
-
Makarov, V.L.1
Hirose, Y.2
Langmore, J.P.3
-
24
-
-
34249947699
-
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
-
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R., Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 2007, 316:1160-1166.
-
(2007)
Science
, vol.316
, pp. 1160-1166
-
-
Matsuoka, S.1
Ballif, B.A.2
Smogorzewska, A.3
McDonald, E.R.4
Hurov, K.E.5
Luo, J.6
Bakalarski, C.E.7
Zhao, Z.8
Solimini, N.9
Lerenthal, Y.10
-
25
-
-
0030982721
-
The terminal DNA structure of mammalian chromosomes
-
McElligott R., Wellinger R.J. The terminal DNA structure of mammalian chromosomes. EMBO J. 1997, 16:3705-3714.
-
(1997)
EMBO J.
, vol.16
, pp. 3705-3714
-
-
McElligott, R.1
Wellinger, R.J.2
-
26
-
-
0034749425
-
DNA damage-dependent nuclear dynamics of the Mre11 complex
-
Mirzoeva O.K., Petrini J.H. DNA damage-dependent nuclear dynamics of the Mre11 complex. Mol. Cell. Biol. 2001, 21:281-288.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 281-288
-
-
Mirzoeva, O.K.1
Petrini, J.H.2
-
27
-
-
44849093460
-
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
-
Mordes D.A., Glick G.G., Zhao R., Cortez D. TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev. 2008, 22:1478-1489.
-
(2008)
Genes Dev.
, vol.22
, pp. 1478-1489
-
-
Mordes, D.A.1
Glick, G.G.2
Zhao, R.3
Cortez, D.4
-
28
-
-
46249125488
-
How shelterin protects mammalian telomeres
-
Palm W., de Lange T. How shelterin protects mammalian telomeres. Annu. Rev. Genet. 2008, 42:301-334.
-
(2008)
Annu. Rev. Genet.
, vol.42
, pp. 301-334
-
-
Palm, W.1
de Lange, T.2
-
29
-
-
58249109501
-
Functional dissection of human and mouse POT1 proteins
-
Palm W., Hockemeyer D., Kibe T., de Lange T. Functional dissection of human and mouse POT1 proteins. Mol. Cell. Biol. 2009, 29:471-482.
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 471-482
-
-
Palm, W.1
Hockemeyer, D.2
Kibe, T.3
de Lange, T.4
-
30
-
-
74049122810
-
In vivo stoichiometry of shelterin components
-
Takai K.K., Hooper S., Blackwood S., Gandhi R., de Lange T. In vivo stoichiometry of shelterin components. J. Biol. Chem. 2010, 285:1457-1467.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 1457-1467
-
-
Takai, K.K.1
Hooper, S.2
Blackwood, S.3
Gandhi, R.4
de Lange, T.5
-
31
-
-
33745713451
-
Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres
-
Wu L., Multani A.S., He H., Cosme-Blanco W., Deng Y., Deng J.M., Bachilo O., Pathak S., Tahara H., Bailey S.M., et al. Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Cell 2006, 126:49-62.
-
(2006)
Cell
, vol.126
, pp. 49-62
-
-
Wu, L.1
Multani, A.S.2
He, H.3
Cosme-Blanco, W.4
Deng, Y.5
Deng, J.M.6
Bachilo, O.7
Pathak, S.8
Tahara, H.9
Bailey, S.M.10
-
32
-
-
0037567268
-
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
-
Zou L., Elledge S.J. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003, 300:1542-1548.
-
(2003)
Science
, vol.300
, pp. 1542-1548
-
-
Zou, L.1
Elledge, S.J.2
|