-
1
-
-
80052318632
-
Promoter hypermethylation of RASSF1A MGMT, and HIC-1 genes in benign and malignant colorectal tumors
-
H.E. Abouzeid, A.M. Kassem, A.H. Abdel Wahab, H.A. El-mezayen, H. Sharad, and S. Abdel Rahman Promoter hypermethylation of RASSF1A MGMT, and HIC-1 genes in benign and malignant colorectal tumors Tumour Biol 32 5 2011 845 852
-
(2011)
Tumour Biol
, vol.32
, Issue.5
, pp. 845-852
-
-
Abouzeid, H.E.1
Kassem, A.M.2
Abdel Wahab, A.H.3
El-Mezayen, H.A.4
Sharad, H.5
Abdel Rahman, S.6
-
2
-
-
44649120132
-
Chemokine signaling via the CXCR2 receptor reinforces senescence
-
J.C. Acosta, A. O'Loghlen, A. Banito, M.V. Guijarro, A. Augert, and S. Raguz Chemokine signaling via the CXCR2 receptor reinforces senescence Cell 133 6 2008 1006 1018
-
(2008)
Cell
, vol.133
, Issue.6
, pp. 1006-1018
-
-
Acosta, J.C.1
O'Loghlen, A.2
Banito, A.3
Guijarro, M.V.4
Augert, A.5
Raguz, S.6
-
3
-
-
0028980494
-
P53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts
-
M.L. Agarwal, A. Agarwal, W.R. Taylor, and G.R. Stark p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts Proc Natl Acad Sci U S A 92 18 1995 8493 8497
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, Issue.18
, pp. 8493-8497
-
-
Agarwal, M.L.1
Agarwal, A.2
Taylor, W.R.3
Stark, G.R.4
-
4
-
-
0032568608
-
CYR61: A product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth
-
A.M. Babic, M.L. Kireeva, T.V. Kolesnikova, and L.F. Lau CYR61: a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth Proc Natl Acad Sci U S A 95 11 1998 6355 6360
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, Issue.11
, pp. 6355-6360
-
-
Babic, A.M.1
Kireeva, M.L.2
Kolesnikova, T.V.3
Lau, L.F.4
-
5
-
-
33645824724
-
Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse
-
N. Bardeesy, A.J. Aguirre, G.C. Chu, K.H. Cheng, L.V. Lopez, and A.F. Hezel Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse Proc Natl Acad Sci U S A 103 15 2006 5947 5952
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.15
, pp. 5947-5952
-
-
Bardeesy, N.1
Aguirre, A.J.2
Chu, G.C.3
Cheng, K.H.4
Lopez, L.V.5
Hezel, A.F.6
-
6
-
-
0035495401
-
Putting tumours in context
-
M.J. Bissell, and D. Radisky Putting tumours in context Nat Rev Cancer 1 1 2001 46 54
-
(2001)
Nat Rev Cancer
, vol.1
, Issue.1
, pp. 46-54
-
-
Bissell, M.J.1
Radisky, D.2
-
7
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
A.G. Bodnar, M. Ouellette, M. Frolkis, S.E. Holt, C.-P. Chiu, and G.B. Morin Extension of life-span by introduction of telomerase into normal human cells Science 279 5349 1998 349 352
-
(1998)
Science
, vol.279
, Issue.5349
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
Holt, S.E.4
Chiu, C.-P.5
Morin, G.B.6
-
8
-
-
84896952141
-
Telomerase inhibitor Imetelstat (GRN163L) limits the lifespan of human pancreatic cancer cells
-
K.M. Burchett, Y. Yan, and M.M. Ouellette Telomerase inhibitor Imetelstat (GRN163L) limits the lifespan of human pancreatic cancer cells PLOS ONE 9 1 2014 e85155
-
(2014)
PLOS ONE
, vol.9
, Issue.1
, pp. 85155
-
-
Burchett, K.M.1
Yan, Y.2
Ouellette, M.M.3
-
9
-
-
84860389717
-
Cellular features of senescence during the evolution of human and murine ductal pancreatic cancer
-
M.E Caldwell, G.M. DeNicola, C.P. Martins, M.A. Jacobetz, A. Maitra, R.H. Hruban, and D.A. Tuveson Cellular features of senescence during the evolution of human and murine ductal pancreatic cancer Oncogene 31 12 2012 1599 1608
-
(2012)
Oncogene
, vol.31
, Issue.12
, pp. 1599-1608
-
-
Caldwell, M.E.1
Denicola, G.M.2
Martins, C.P.3
Jacobetz, M.A.4
Maitra, A.5
Hruban, R.H.6
Tuveson, D.A.7
-
10
-
-
13944270339
-
Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
-
J. Campisi Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors Cell 120 4 2005 513 522
-
(2005)
Cell
, vol.120
, Issue.4
, pp. 513-522
-
-
Campisi, J.1
-
11
-
-
79551683487
-
Cellular senescence: Putting the paradoxes in perspective
-
J. Campisi Cellular senescence: putting the paradoxes in perspective Curr Opin Genet Dev 21 1 2011 107 112
-
(2011)
Curr Opin Genet Dev
, vol.21
, Issue.1
, pp. 107-112
-
-
Campisi, J.1
-
12
-
-
34548186667
-
Cellular senescence: When bad things happen to good cells
-
J. Campisi, and F. d'Adda di Fagagna Cellular senescence: when bad things happen to good cells Nat Rev Mol Cell Biol 8 9 2007 729 740
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, Issue.9
, pp. 729-740
-
-
Campisi, J.1
D'Adda Di Fagagna, F.2
-
13
-
-
80052127297
-
Deletion of Rb accelerates pancreatic carcinogenesis by oncogenic KRAS and impairs senescence in premalignant lesions
-
C. Carrière, A.J. Gore, A.M. Norris, J.R. Gunn, A.L. Young, D.S. Longnecker, and M. Korc Deletion of Rb accelerates pancreatic carcinogenesis by oncogenic KRAS and impairs senescence in premalignant lesions Gastroenterology 141 3 2011 1091 1101
-
(2011)
Gastroenterology
, vol.141
, Issue.3
, pp. 1091-1101
-
-
Carrière, C.1
Gore, A.J.2
Norris, A.M.3
Gunn, J.R.4
Young, A.L.5
Longnecker, D.S.6
Korc, M.7
-
14
-
-
84874256781
-
Regulation of pancreatic function by connective tissue growth factor (CTGF, CCN2)
-
A. Charrier, and D.R. Brigstock Regulation of pancreatic function by connective tissue growth factor (CTGF, CCN2) Cytokine Growth Factor Rev 24 1 2013 59 68
-
(2013)
Cytokine Growth Factor Rev
, vol.24
, Issue.1
, pp. 59-68
-
-
Charrier, A.1
Brigstock, D.R.2
-
15
-
-
0028345161
-
Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells
-
Q. Chen, and B.N. Ames Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells Proc Natl Acad Sci U S A 91 10 1994 4130 4134
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, Issue.10
, pp. 4130-4134
-
-
Chen, Q.1
Ames, B.N.2
-
16
-
-
34447543913
-
Cellular senescence in cancer and aging
-
M. Collado, M.A. Blasco, and M. Serrano Cellular senescence in cancer and aging Cell 130 2 2007 223 233
-
(2007)
Cell
, vol.130
, Issue.2
, pp. 223-233
-
-
Collado, M.1
Blasco, M.A.2
Serrano, M.3
-
17
-
-
79955921754
-
FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
-
T. Conroy, F. Desseigne, M. Ychou, O. Bouché, R. Guimbaud, and Y. Bécouarn FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer N Engl J Med 364 19 2011 1817 1825
-
(2011)
N Engl J Med
, vol.364
, Issue.19
, pp. 1817-1825
-
-
Conroy, T.1
Desseigne, F.2
Ychou, M.3
Bouché, O.4
Guimbaud, R.5
Bécouarn, Y.6
-
18
-
-
84891713034
-
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
-
J.-P. Coppé, C.K Patil, F. Rodier, Y. Sun, D.P. Muñoz, and J. Goldstein Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor PLoS Biol 6 12 2008 e301
-
(2008)
PLoS Biol
, vol.6
, Issue.12
, pp. 301
-
-
Coppé, J.-P.1
Patil, C.K.2
Rodier, F.3
Sun, Y.4
Muñoz, D.P.5
Goldstein, J.6
-
19
-
-
0037180757
-
Inflammation and cancer
-
L.M. Coussens, and Z. Werb Inflammation and cancer Nature 420 6917 2002 860 867
-
(2002)
Nature
, vol.420
, Issue.6917
, pp. 860-867
-
-
Coussens, L.M.1
Werb, Z.2
-
20
-
-
45849099050
-
Living on a break: Cellular senescence as a DNA-damage response
-
F. d'Adda di Fagagna Living on a break: cellular senescence as a DNA-damage response Nat Rev Cancer 8 7 2008 512 522
-
(2008)
Nat Rev Cancer
, vol.8
, Issue.7
, pp. 512-522
-
-
D'Adda Di Fagagna, F.1
-
21
-
-
0037148277
-
Protection of mammalian telomeres
-
T. de Lange Protection of mammalian telomeres Oncogene 21 4 2002 532 540
-
(2002)
Oncogene
, vol.21
, Issue.4
, pp. 532-540
-
-
De Lange, T.1
-
22
-
-
30144443269
-
Paradoxical roles of the immune system during cancer development
-
K.E. de Visser, A. Eichten, and L.M. Coussens Paradoxical roles of the immune system during cancer development Nat Rev Cancer 6 1 2006 24 37
-
(2006)
Nat Rev Cancer
, vol.6
, Issue.1
, pp. 24-37
-
-
De Visser, K.E.1
Eichten, A.2
Coussens, L.M.3
-
23
-
-
70349142170
-
RAS in cellular transformation and senescence
-
G.M. DeNicola, and D.A. Tuveson RAS in cellular transformation and senescence Eur J Cancer 45 Suppl. 1 2009 211 216
-
(2009)
Eur J Cancer
, vol.45
, pp. 211-216
-
-
Denicola, G.M.1
Tuveson, D.A.2
-
24
-
-
0344441890
-
A DNA damage checkpoint response in telomere-initiated senescence
-
F.D.A. di Fagagna A DNA damage checkpoint response in telomere-initiated senescence Nature 426 6963 2003 194 198
-
(2003)
Nature
, vol.426
, Issue.6963
, pp. 194-198
-
-
Di Fagagna, F.D.A.1
-
25
-
-
84909971733
-
Transcriptional repression of Sin3B by Bmi-1 prevents cellular senescence and is relieved by oncogene activation
-
T. DiMauro, D.J. Cantor, A.J. Bainor, and G. David Transcriptional repression of Sin3B by Bmi-1 prevents cellular senescence and is relieved by oncogene activation Oncogene 2014
-
(2014)
Oncogene
-
-
Dimauro, T.1
Cantor, D.J.2
Bainor, A.J.3
David, G.4
-
26
-
-
84896484068
-
Alternative lengthening of telomeres predicts site of origin in neuroendocrine tumor liver metastases
-
E. Dogeas, G. Karagkounis, C.M. Heaphy, K. Hirose, T.M. Pawlik, and C.L. Wolfgang Alternative lengthening of telomeres predicts site of origin in neuroendocrine tumor liver metastases J Am Coll Surg 218 4 2014 628 635
-
(2014)
J Am Coll Surg
, vol.218
, Issue.4
, pp. 628-635
-
-
Dogeas, E.1
Karagkounis, G.2
Heaphy, C.M.3
Hirose, K.4
Pawlik, T.M.5
Wolfgang, C.L.6
-
27
-
-
0033672470
-
Telomere maintenance by recombination in human cells
-
M.A. Dunham, A.A. Neumann, C.L. Fasching, and R.R. Reddel Telomere maintenance by recombination in human cells Nat Genet 26 4 2000 447 450
-
(2000)
Nat Genet
, vol.26
, Issue.4
, pp. 447-450
-
-
Dunham, M.A.1
Neumann, A.A.2
Fasching, C.L.3
Reddel, R.R.4
-
28
-
-
52149094275
-
The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma
-
M. Erkan, G. Adler, M.V. Apte, M.G. Bachem, M. Buchholz, and S. Detlefsen The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma Clin Gastroenterol Hepatol 6 10 2008 1155 1161
-
(2008)
Clin Gastroenterol Hepatol
, vol.6
, Issue.10
, pp. 1155-1161
-
-
Erkan, M.1
Adler, G.2
Apte, M.V.3
Bachem, M.G.4
Buchholz, M.5
Detlefsen, S.6
-
29
-
-
84855201311
-
StellaTUM: Current consensus and discussion on pancreatic stellate cell research
-
M. Erkan, C.W. Michalski, S. Rieder, C. Reiser-Erkan, I. Abiatari, and A. Kolb StellaTUM: current consensus and discussion on pancreatic stellate cell research Gut 61 2 2012 172 178
-
(2012)
Gut
, vol.61
, Issue.2
, pp. 172-178
-
-
Erkan, M.1
Michalski, C.W.2
Rieder, S.3
Reiser-Erkan, C.4
Abiatari, I.5
Kolb, A.6
-
30
-
-
84884675260
-
Cdkn1a is a key mediator of rat pancreatic stellate cell senescence
-
B. Fitzner, A. Lange, S. Müller, and R. Jaster Cdkn1a is a key mediator of rat pancreatic stellate cell senescence Pancreatology 13 3 2013 262 2630
-
(2013)
Pancreatology
, vol.13
, Issue.3
, pp. 262-2630
-
-
Fitzner, B.1
Lange, A.2
Müller, S.3
Jaster, R.4
-
31
-
-
84866456413
-
Senescence determines the fate of activated rat pancreatic stellate cells
-
B. Fitzner, S. Muller, M. Walther, M. Fischer, R. Engelmann, and B. Muller-Hilke Senescence determines the fate of activated rat pancreatic stellate cells J Cell Mol Med, 16 11 2012 2620 2630
-
(2012)
J Cell Mol Med
, vol.16
, Issue.11
, pp. 2620-2630
-
-
Fitzner, B.1
Muller, S.2
Walther, M.3
Fischer, M.4
Engelmann, R.5
Muller-Hilke, B.6
-
32
-
-
77952105389
-
Inflammatory networks during cellular senescence: Causes and consequences
-
A. Freund, A.V. Orjalo, P.-Y. Desprez, and J. Campisi Inflammatory networks during cellular senescence: causes and consequences Trends Mol Med 16 5 2010 238 246
-
(2010)
Trends Mol Med
, vol.16
, Issue.5
, pp. 238-246
-
-
Freund, A.1
Orjalo, A.V.2
Desprez, P.-Y.3
Campisi, J.4
-
34
-
-
69249125298
-
Sin3B expression is required for cellular senescence and is up-regulated upon oncogenic stress
-
K.B. Grandinetti, P. Jelinic, T. DiMauro, J. Pellegrino, R. Fernandez Rodriguez, and P.M. Finnerty Sin3B expression is required for cellular senescence and is up-regulated upon oncogenic stress Cancer Res 69 16 2009 6430 6437
-
(2009)
Cancer Res
, vol.69
, Issue.16
, pp. 6430-6437
-
-
Grandinetti, K.B.1
Jelinic, P.2
Dimauro, T.3
Pellegrino, J.4
Fernandez Rodriguez, R.5
Finnerty, P.M.6
-
35
-
-
49549121648
-
Senescence: Not just for tumor suppression
-
M.R. Green Senescence: not just for tumor suppression Cell 134 4 2008 562 564
-
(2008)
Cell
, vol.134
, Issue.4
, pp. 562-564
-
-
Green, M.R.1
-
36
-
-
79958710624
-
Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence
-
C. Guerra, M. Collado, C. Navas, A.J. Schuhmacher, I. Hernandez-Porras, and M. Canamero Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence Cancer Cell 19 6 2011 728 739
-
(2011)
Cancer Cell
, vol.19
, Issue.6
, pp. 728-739
-
-
Guerra, C.1
Collado, M.2
Navas, C.3
Schuhmacher, A.J.4
Hernandez-Porras, I.5
Canamero, M.6
-
37
-
-
0033614998
-
Creation of human tumour cells with defined genetic elements
-
W.C. Hahn, C.M. Counter, A.S. Lundberg, R.L. Beijersbergen, M.W. Brooks, and R.A. Weinberg Creation of human tumour cells with defined genetic elements Nature 400 6743 1999 464 468
-
(1999)
Nature
, vol.400
, Issue.6743
, pp. 464-468
-
-
Hahn, W.C.1
Counter, C.M.2
Lundberg, A.S.3
Beijersbergen, R.L.4
Brooks, M.W.5
Weinberg, R.A.6
-
39
-
-
78651272644
-
Cyr61/CCN1 signaling is critical for epithelial-mesenchymal transition and stemness and promotes pancreatic carcinogenesis
-
I. Haque, S. Mehta, M. Majumder, K. Dhar, A. De, and D. McGregor Cyr61/CCN1 signaling is critical for epithelial-mesenchymal transition and stemness and promotes pancreatic carcinogenesis Mol Cancer 10 2011 8
-
(2011)
Mol Cancer
, vol.10
, pp. 8
-
-
Haque, I.1
Mehta, S.2
Majumder, M.3
Dhar, K.4
De, A.5
McGregor, D.6
-
40
-
-
50549218525
-
The limited in vitro lifetime of human diploid cell strains
-
L. Hayflick The limited in vitro lifetime of human diploid cell strains Exp Cell Res 37 3 1965 614 636
-
(1965)
Exp Cell Res
, vol.37
, Issue.3
, pp. 614-636
-
-
Hayflick, L.1
-
41
-
-
81055124827
-
Expression of DNMT1 and DNMT3a are regulated by GLI1 in human pancreatic cancer
-
S. He, F. Wang, L. Yang, C. Guo, R. Wan, and A. Ke Expression of DNMT1 and DNMT3a are regulated by GLI1 in human pancreatic cancer PLoS One 6 11 2011 e27684
-
(2011)
PLoS One
, vol.6
, Issue.11
, pp. 27684
-
-
He, S.1
Wang, F.2
Yang, L.3
Guo, C.4
Wan, R.5
Ke, A.6
-
42
-
-
19944428332
-
A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas
-
J.D. Henson, J.A. Hannay, S.W. McCarthy, J.A. Royds, T.R. Yeager, and R.A. Robinson A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas Clin Cancer Res 11 1 2005 217 225
-
(2005)
Clin Cancer Res
, vol.11
, Issue.1
, pp. 217-225
-
-
Henson, J.D.1
Hannay, J.A.2
McCarthy, S.W.3
Royds, J.A.4
Yeager, T.R.5
Robinson, R.A.6
-
43
-
-
77954243065
-
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
-
J.I. Jun, and L.F. Lau The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing Nat Cell Biol 12 7 2010 676 685
-
(2010)
Nat Cell Biol
, vol.12
, Issue.7
, pp. 676-685
-
-
Jun, J.I.1
Lau, L.F.2
-
44
-
-
79953315567
-
Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis
-
A.L. Kennedy, J.P. Morton, I. Manoharan, D.M. Nelson, N.B. Jamieson, and J.S. Pawlikowski Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis Mol Cell 42 1 2011 36 49
-
(2011)
Mol Cell
, vol.42
, Issue.1
, pp. 36-49
-
-
Kennedy, A.L.1
Morton, J.P.2
Manoharan, I.3
Nelson, D.M.4
Jamieson, N.B.5
Pawlikowski, J.S.6
-
45
-
-
0035834121
-
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
-
A. Krtolica, S. Parrinello, S. Lockett, P.-Y. Desprez, and J. Campisi Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging Proc Natl Acad Sci 98 21 2001 12072 12077
-
(2001)
Proc Natl Acad Sci
, vol.98
, Issue.21
, pp. 12072-12077
-
-
Krtolica, A.1
Parrinello, S.2
Lockett, S.3
Desprez, P.-Y.4
Campisi, J.5
-
46
-
-
44649101304
-
Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
-
T. Kuilman, C. Michaloglou, L.C. Vredeveld, S. Douma, R. van Doorn, and C.J. Desmet Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network Cell 133 6 2008 1019 1031
-
(2008)
Cell
, vol.133
, Issue.6
, pp. 1019-1031
-
-
Kuilman, T.1
Michaloglou, C.2
Vredeveld, L.C.3
Douma, S.4
Van Doorn, R.5
Desmet, C.J.6
-
47
-
-
78349257844
-
The essence of senescence
-
T. Kuilman, C. Michaloglou, W.J. Mooi, and D.S. Peeper The essence of senescence Genes Dev 24 22 2010 2463 2479
-
(2010)
Genes Dev
, vol.24
, Issue.22
, pp. 2463-2479
-
-
Kuilman, T.1
Michaloglou, C.2
Mooi, W.J.3
Peeper, D.S.4
-
48
-
-
0037093346
-
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
-
E. Langley Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence EMBO J 21 10 2002 2383 2396
-
(2002)
EMBO J
, vol.21
, Issue.10
, pp. 2383-2396
-
-
Langley, E.1
-
49
-
-
78249289929
-
Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells
-
K.E. Lee, and D. Bar-Sagi Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells Cancer Cell 18 5 2010 448 458
-
(2010)
Cancer Cell
, vol.18
, Issue.5
, pp. 448-458
-
-
Lee, K.E.1
Bar-Sagi, D.2
-
50
-
-
0033583242
-
Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species
-
A.C. Lee, B.E. Fenster, H. Ito, K. Takeda, N.S. Bae, and T. Hirai Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species J Biol Chem 274 12 1999 7936 7940
-
(1999)
J Biol Chem
, vol.274
, Issue.12
, pp. 7936-7940
-
-
Lee, A.C.1
Fenster, B.E.2
Ito, H.3
Takeda, K.4
Bae, N.S.5
Hirai, T.6
-
51
-
-
84876291823
-
Non-cell-autonomous tumor suppression by p53
-
A. Lujambio, L. Akkari, J. Simon, D. Grace, D.F. Tschaharganeh, and J.E. Bolden Non-cell-autonomous tumor suppression by p53 Cell 153 2 2013 449 460
-
(2013)
Cell
, vol.153
, Issue.2
, pp. 449-460
-
-
Lujambio, A.1
Akkari, L.2
Simon, J.3
Grace, D.4
Tschaharganeh, D.F.5
Bolden, J.E.6
-
53
-
-
70349158747
-
The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma
-
C. Martinez-Romero, I. Rooman, A. Skoudy, C. Guerra, X. Molero, and A. Gonzalez The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma J Pathol 219 2 2009 205 213
-
(2009)
J Pathol
, vol.219
, Issue.2
, pp. 205-213
-
-
Martinez-Romero, C.1
Rooman, I.2
Skoudy, A.3
Guerra, C.4
Molero, X.5
Gonzalez, A.6
-
54
-
-
80955151448
-
Senescence in intraductal papillary mucinous neoplasm of the pancreas
-
Y. Miyasaka, E. Nagai, K. Ohuchida, H. Fujita, K. Nakata, and A. Hayashi Senescence in intraductal papillary mucinous neoplasm of the pancreas Hum Pathol 42 12 2011 2010 2017
-
(2011)
Hum Pathol
, vol.42
, Issue.12
, pp. 2010-2017
-
-
Miyasaka, Y.1
Nagai, E.2
Ohuchida, K.3
Fujita, H.4
Nakata, K.5
Hayashi, A.6
-
55
-
-
76249108357
-
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
-
J.P. Morton, P. Timpson, S.A. Karim, R.A. Ridgway, D. Athineos, and B. Doyle Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer Proc Natl Acad Sci U S A 107 1 2010 246 251
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.1
, pp. 246-251
-
-
Morton, J.P.1
Timpson, P.2
Karim, S.A.3
Ridgway, R.A.4
Athineos, D.5
Doyle, B.6
-
56
-
-
84889600900
-
Programmed cell senescence during mammalian embryonic development
-
D. Muñoz-Espín, M. Cañamero, A. Maraver, G. Gómez-López, J. Contreras, and S. Murillo-Cuesta Programmed cell senescence during mammalian embryonic development Cell 155 5 2013 1104 1118
-
(2013)
Cell
, vol.155
, Issue.5
, pp. 1104-1118
-
-
Muñoz-Espín, D.1
Cañamero, M.2
Maraver, A.3
Gómez-López, G.4
Contreras, J.5
Murillo-Cuesta, S.6
-
57
-
-
27744527486
-
The first molecular details of ALT in human tumor cells
-
A. Muntoni, and R.R. Reddel The first molecular details of ALT in human tumor cells Hum Mol Genet 14 Suppl. 2 2005 R191 R196
-
(2005)
Hum Mol Genet
, vol.14
, pp. 191-R196
-
-
Muntoni, A.1
Reddel, R.R.2
-
58
-
-
0037667702
-
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
-
M. Narita, S. Nuñez, E. Heard, M. Narita, A.W. Lin, and S.A. Hearn Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence Cell 113 6 2003 703 716
-
(2003)
Cell
, vol.113
, Issue.6
, pp. 703-716
-
-
Narita, M.1
Nuñez, S.2
Heard, E.3
Narita, M.4
Lin, A.W.5
Hearn, S.A.6
-
59
-
-
35148812601
-
Complex engagement of DNA damage response pathways in human cancer and in lung tumor progression
-
P.G. Nuciforo, C. Luise, M. Capra, G. Pelosi, and F. d'Adda di Fagagna Complex engagement of DNA damage response pathways in human cancer and in lung tumor progression Carcinogenesis 28 10 2007 2082 2088
-
(2007)
Carcinogenesis
, vol.28
, Issue.10
, pp. 2082-2088
-
-
Nuciforo, P.G.1
Luise, C.2
Capra, M.3
Pelosi, G.4
D'Adda Di Fagagna, F.5
-
60
-
-
84902469661
-
Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
-
B.C. Ozdemir, T. Pentcheva-Hoang, J.L. Carstens, X. Zheng, C.C. Wu, and T.R. Simpson Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival Cancer Cell 25 6 2014 719 734
-
(2014)
Cancer Cell
, vol.25
, Issue.6
, pp. 719-734
-
-
Ozdemir, B.C.1
Pentcheva-Hoang, T.2
Carstens, J.L.3
Zheng, X.4
Wu, C.C.5
Simpson, T.R.6
-
61
-
-
84879335579
-
The role of cellular senescence in the gastrointestinal mucosa
-
J.D. Penfield, M. Anderson, L. Lutzke, and K.K. Wang The role of cellular senescence in the gastrointestinal mucosa Gut Liver 7 3 2013 270 277
-
(2013)
Gut Liver
, vol.7
, Issue.3
, pp. 270-277
-
-
Penfield, J.D.1
Anderson, M.2
Lutzke, L.3
Wang, K.K.4
-
62
-
-
84856478313
-
Tumor suppressor p16INK4a controls oncogenic K-Ras function in human pancreatic cancer cells
-
A. Rabien, H. Sanchez-Ruderisch, P. Schulz, N. Otto, A. Wimmel, B. Wiedenmann, and K.M. Detjen Tumor suppressor p16INK4a controls oncogenic K-Ras function in human pancreatic cancer cells Cancer Sci 103 2 2012 169 175
-
(2012)
Cancer Sci
, vol.103
, Issue.2
, pp. 169-175
-
-
Rabien, A.1
Sanchez-Ruderisch, H.2
Schulz, P.3
Otto, N.4
Wimmel, A.5
Wiedenmann, B.6
Detjen, K.M.7
-
63
-
-
84902435628
-
Stromal elements act to restrain: Rather than support, pancreatic ductal adenocarcinoma
-
A.D. Rhim, P.E. Oberstein, D.H. Thomas, E.T. Mirek, C.F. Palermo, and S.A. Sastra Stromal elements act to restrain: rather than support, pancreatic ductal adenocarcinoma Cancer Cell 25 6 2014 735 747
-
(2014)
Cancer Cell
, vol.25
, Issue.6
, pp. 735-747
-
-
Rhim, A.D.1
Oberstein, P.E.2
Thomas, D.H.3
Mirek, E.T.4
Palermo, C.F.5
Sastra, S.A.6
-
64
-
-
84899736929
-
Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression
-
M. Rielland, D.J. Cantor, R. Graveline, C. Hajdu, L. Mara, and D. Diaz Bde Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression J Clin Invest 124 5 2014 2125 2135
-
(2014)
J Clin Invest
, vol.124
, Issue.5
, pp. 2125-2135
-
-
Rielland, M.1
Cantor, D.J.2
Graveline, R.3
Hajdu, C.4
Mara, L.5
Diaz Bde, D.6
-
65
-
-
79955636534
-
P16Ink4a overexpression in cancer: A tumor suppressor gene associated with senescence and high-grade tumors
-
C. Romagosa, S. Simonetti, L. Lopez-Vicente, A. Mazo, M.E. Lleonart, J. Castellvi, and S. Ramon y Cajal p16Ink4a overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors Oncogene 30 18 2011 2087 2097
-
(2011)
Oncogene
, vol.30
, Issue.18
, pp. 2087-2097
-
-
Romagosa, C.1
Simonetti, S.2
Lopez-Vicente, L.3
Mazo, A.4
Lleonart, M.E.5
Castellvi, J.6
Ramon Cajal Y, S.7
-
66
-
-
0027743438
-
Pancreatic adenocarcinomas frequently show p53 gene mutations
-
A. Scarpa, P. Capelli, K. Mukai, G. Zamboni, T. Oda, C. Iacono, and S. Hirohashi Pancreatic adenocarcinomas frequently show p53 gene mutations Am J Pathol 142 5 1993 1534 1543
-
(1993)
Am J Pathol
, vol.142
, Issue.5
, pp. 1534-1543
-
-
Scarpa, A.1
Capelli, P.2
Mukai, K.3
Zamboni, G.4
Oda, T.5
Iacono, C.6
Hirohashi, S.7
-
67
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
M. Serrano, A.W. Lin, M.E. McCurrach, D. Beach, and S.W. Lowe Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a Cell 88 5 1997 593 602
-
(1997)
Cell
, vol.88
, Issue.5
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
68
-
-
0031010342
-
A survey of telomerase activity in human cancer
-
J.W. Shay, and S. Bacchetti A survey of telomerase activity in human cancer Eur J Cancer 33 5 1997 787 791
-
(1997)
Eur J Cancer
, vol.33
, Issue.5
, pp. 787-791
-
-
Shay, J.W.1
Bacchetti, S.2
-
69
-
-
0032191393
-
Tumor surveillance via the ARF-p53 pathway
-
C.J. Sherr Tumor surveillance via the ARF-p53 pathway Genes Dev 12 19 1998 2984 2991
-
(1998)
Genes Dev
, vol.12
, Issue.19
, pp. 2984-2991
-
-
Sherr, C.J.1
-
70
-
-
0034682721
-
Cellular senescence: Mitotic clock or culture shock?
-
C.J. Sherr, and R.A. DePinho Cellular senescence: mitotic clock or culture shock? Cell 102 4 2000 407 410
-
(2000)
Cell
, vol.102
, Issue.4
, pp. 407-410
-
-
Sherr, C.J.1
Depinho, R.A.2
-
71
-
-
84881549844
-
Senescence in pancreatic carcinogenesis: From signalling to chromatin remodelling and epigenetics
-
S.K. Singh, and V. Ellenrieder Senescence in pancreatic carcinogenesis: from signalling to chromatin remodelling and epigenetics Gut 62 9 2013 1364 1372
-
(2013)
Gut
, vol.62
, Issue.9
, pp. 1364-1372
-
-
Singh, S.K.1
Ellenrieder, V.2
-
72
-
-
0037102234
-
Different telomere damage signaling pathways in human and mouse cells
-
A. Smogorzewska, and T. de Lange Different telomere damage signaling pathways in human and mouse cells EMBO J 21 16 2002 4338 4348
-
(2002)
EMBO J
, vol.21
, Issue.16
, pp. 4338-4348
-
-
Smogorzewska, A.1
De Lange, T.2
-
73
-
-
84889565689
-
Senescence is a developmental mechanism that contributes to embryonic growth and patterning
-
M. Storer, A. Mas, A. Robert-Moreno, M. Pecoraro, M.C. Ortells, and V. Di Giacomo Senescence is a developmental mechanism that contributes to embryonic growth and patterning Cell 155 5 2013 1119 1130
-
(2013)
Cell
, vol.155
, Issue.5
, pp. 1119-1130
-
-
Storer, M.1
Mas, A.2
Robert-Moreno, A.3
Pecoraro, M.4
Ortells, M.C.5
Di Giacomo, V.6
-
74
-
-
84861337082
-
-
Available from: [cited February 2014]
-
UK C.R. Pancreatic Cancer Statistics-Cruk 2014 Available from: http://www.cancerresearchuk.org/cancer-info/cancerstats/types/pancreas [cited February 2014]
-
(2014)
C.R. Pancreatic Cancer Statistics-Cruk
-
-
-
75
-
-
0036841802
-
Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia
-
N.T. van Heek, A.K. Meeker, S.E. Kern, C.J. Yeo, K.D. Lillemoe, and J.L. Cameron Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia Am J Pathol 161 5 2002 1541 1547
-
(2002)
Am J Pathol
, vol.161
, Issue.5
, pp. 1541-1547
-
-
Van Heek, N.T.1
Meeker, A.K.2
Kern, S.E.3
Yeo, C.J.4
Lillemoe, K.D.5
Cameron, J.L.6
-
76
-
-
33846899456
-
Restoration of p53 function leads to tumour regression in vivo
-
A. Ventura, D.G. Kirsch, M.E. McLaughlin, D.A. Tuveson, J. Grimm, and L. Lintault Restoration of p53 function leads to tumour regression in vivo Nature 445 7128 2007 661 665
-
(2007)
Nature
, vol.445
, Issue.7128
, pp. 661-665
-
-
Ventura, A.1
Kirsch, D.G.2
McLaughlin, M.E.3
Tuveson, D.A.4
Grimm, J.5
Lintault, L.6
-
77
-
-
0034676455
-
Surfing the p53 network
-
B. Vogelstein, D. Lane, and A.J. Levine Surfing the p53 network Nature 408 6810 2000 307 310
-
(2000)
Nature
, vol.408
, Issue.6810
, pp. 307-310
-
-
Vogelstein, B.1
Lane, D.2
Levine, A.J.3
-
78
-
-
54249088477
-
Pancreatic stellate cells and pancreatic cancer cells: An unholy alliance
-
A. Vonlaufen, P.A. Phillips, Z. Xu, D. Goldstein, R.C. Pirola, J.S. Wilson, and M.V. Apte Pancreatic stellate cells and pancreatic cancer cells: an unholy alliance Cancer Res 68 19 2008 7707 7710
-
(2008)
Cancer Res
, vol.68
, Issue.19
, pp. 7707-7710
-
-
Vonlaufen, A.1
Phillips, P.A.2
Xu, Z.3
Goldstein, D.4
Pirola, R.C.5
Wilson, J.S.6
Apte, M.V.7
-
79
-
-
0036674617
-
Live or let die: The cell's response to p53
-
K.H. Vousden, and X. Lu Live or let die: the cell's response to p53 Nat Rev Cancer 2 8 2002 594 604
-
(2002)
Nat Rev Cancer
, vol.2
, Issue.8
, pp. 594-604
-
-
Vousden, K.H.1
Lu, X.2
-
80
-
-
77953096072
-
Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a
-
K.L. Yap, S. Li, A.M. Muñoz-Cabello, S. Raguz, L. Zeng, and S. Mujtaba Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a Mol Cell 38 5 2010 662 674
-
(2010)
Mol Cell
, vol.38
, Issue.5
, pp. 662-674
-
-
Yap, K.L.1
Li, S.2
Muñoz-Cabello, A.M.3
Raguz, S.4
Zeng, L.5
Mujtaba, S.6
-
81
-
-
84892779770
-
Hypermethylation of hic1 promoter and aberrant expression of HIC1/SIRT1 might contribute to the carcinogenesis of pancreatic cancer
-
G. Zhao, Q. Qin, J. Zhang, Y. Liu, S. Deng, and L. Liu Hypermethylation of hic1 promoter and aberrant expression of HIC1/SIRT1 might contribute to the carcinogenesis of pancreatic cancer Ann Surg Oncol 20 3 2013 301 311
-
(2013)
Ann Surg Oncol
, vol.20
, Issue.3
, pp. 301-311
-
-
Zhao, G.1
Qin, Q.2
Zhang, J.3
Liu, Y.4
Deng, S.5
Liu, L.6
|