Cdkn1a is a key mediator of rat pancreatic stellate cell senescence

Pancreatology

Volumn 13, Issue 3, 2013, Pages 254-262

  Fitzner, Brit ^a   Lange, Andreas ^a   Müller, Sarah ^a   Jaster, Robert ^a  

^a ROSTOCK UNIVERSITY MEDICAL CENTER   (Germany)

Author keywords

Cellular ageing; Chronic pancreatitis; Fibrosis

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA GALACTOSIDASE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DOXORUBICIN; GELATINASE B; INTERLEUKIN 6; PROTEIN P53; RAD54 PROTEIN; SMALL INTERFERING RNA; TETRACYCLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE MARKER; NONHUMAN; PANCREATIC STELLATE CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENESCENCE;

EID: 84884675260     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1016/j.pan.2013.03.009     Document Type: Article

References (25)

1. Erkan M, Adler G, Apte MV, Bachem MG, Buchholz M, Detlefsen S, et al. StellaTUM: current consensus and discussion on pancreatic stellate cell research. Gut 2012;61:172-8.
2. Jaster R, Emmrich J. Crucial role of fibrogenesis in pancreatic diseases. Best Pract Res Clin Gastroenterol 2008;22:17-29.
3. McCarroll JA, Phillips PA, Santucci N, Pirola RC, Wilson JS, Apte MV. Vitamin A inhibits pancreatic stellate cell activation: implications for treatment of pancreatic fibrosis. Gut 2006;55:79-89.
4. Jaster R, Hilgendorf I, Fitzner B, Brock P, Sparmann G, Emmrich J, et al. Regulation of pancreatic stellate cell function in vitro: biological and molecular effects of all-trans retinoic acid. Biochem Pharmacol 2003;66:633-41.
5. Froeling FE, Feig C, Chelala C, Dobson R, Mein CE, Tuveson DA, et al. Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-bcatenin signaling to slow tumor progression. Gastroenterology 2011;141: 1486-97. 1497.-1-14.
6. Masamune A, Kikuta K, Satoh M, Sakai Y, Satoh A, Shimosegawa T. Ligands of peroxisome proliferator-activated receptor-γ block activation of pancreatic stellate cells. Biol Chem 2002;277:141-7.
7. Jaster R, Lichte P, Fitzner B, Brock P, Glass Ä, Karopka T, et al. Peroxisome proliferator-activated receptor γ overexpression inhibits pro-fibrogenic activities of immortalized rat pancreatic stellate cells. J Cell Mol Med 2005;3: 670-82.
8. Klonowski-Stumpe H, Fischer R, Reinehr R, Lüthen R, Häussinger D. Apoptosis in activated rat pancreatic stellate cells. Am J Physiol Gastrointest Liver Physiol 2002;283:G819-26.
9. Rickmann M, Vaquero EC, Malagelada JR, Molero X. Tocotrienols induce apoptosis and autophagy in rat pancreatic stellate cells through the mitochondrial death pathway. Gastroenterology 2007;132:2518-32.
10. Manapov F, Muller P, Rychly J. Translocation of p21(Cip1/WAF1) from the nucleus to the cytoplasm correlates with pancreatic myofibroblast to fibroblast cell conversion. Gut 2005;54:814-22.
11. Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, Miething C, et al. Senescence of activated stellate cells limits liver fibrosis. Cell 2008;134:657-67.
12. Fitzner B, Müller S, Walther M, Fischer M, Engelmann R, Müller-Hilke B, et al. Senescence determines the fate of activated rat pancreatic stellate cells. J Cell Mol Med 2012;16:2620-30.
13. Krizhanovsky V, Xue W, Zender L, Yon M, Hernando E, Lowe SW, et al. Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology. Cold Spring Harb Symp Quant Biol 2008;73: 513-22.
14. Campisi J, d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 2007;8:729-40.
15. Jaster R, Sparmann G, Emmrich J, Liebe S. Extracellular signal-regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells. Gut 2002;51:579-84.
16. Rateitschak K, Karger A, Fitzner B, Lange F, Wolkenhauer O, Jaster R. Mathematical modelling of interferon-g signalling in pancreatic stellate cells reflects and predicts dynamics of STAT1 pathway activity. Cell Signal 2010;22: 97-105.
17. Luo S, Wehr NB, Levine RL. Quantitation of protein on gels and blots by infrared fluorescence of Coomassie blue and Fast Green. Anal Biochem 2006;350:233-8.
18. Phalke S, Mzoughi S, Bezzi M, Jennifer N, Mok WC, Low DH, et al. p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6. Nucleic Acids Res 2012;40:9534-42.
19. el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, et al. WAF1, a potential mediator of p53 tumor suppression. Cell 1993;75:817-25.
20. Dulic V, Kaufmann WK, Wilson SJ, Tlsty TD, Lees E, Harper JW, et al. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 1994;76:1013-23.
21. Romanov VS, Pospelov VA, Pospelova TV. Cyclin-dependent kinase inhibitor p21(Waf1): contemporary view on its role in senescence and oncogenesis. Biochemistry (Mosc) 2012;77:575-84.
22. Mato E, Lucas M, Petriz J, Gomis R, Novials A. Identification of a pancreatic stellate cell population with properties of progenitor cells: new role for stellate cells in the pancreas. Biochem J 2009;421:181-91.
23. Kordes C, Sawitza I, Götze S, Häussinger D. Stellate cells from rat pancreas are stem cells and can contribute to liver regeneration. PLoS One 2012;7:e51878.
24. Means AL. Pancreatic stellate cells: small cells with a big role in tissue homeostasis. Lab Invest 2013;93:4-7.
25. Riopel MM, Li J, Liu S, Leask A, Wang R. β1 integrin-extracellular matrix interactions are essential for maintaining exocrine pancreas architecture and function. Lab Invest 2013;93:31-40.