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Volumn 24, Issue 1, 2013, Pages 59-68

Regulation of pancreatic function by connective tissue growth factor (CTGF, CCN2)

Author keywords

cell; Acinar cell; CCN; CCN2; Connective tissue growth factor; CTGF; Desmoplasia; Fibrosis; Islets; Matricellular; Pancreatic ductal adenocarcinoma; Pancreatic stellate cell; TGF

Indexed keywords

1 (2 BROMOPHENYL) 3 (2 HYDROXY 4 NITROPHENYL)UREA; CONNECTIVE TISSUE GROWTH FACTOR; FG 3019; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; REPARIXIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84874256781     PISSN: 13596101     EISSN: 18790305     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2012.07.001     Document Type: Short Survey
Times cited : (58)

References (75)
  • 1
    • 0032787927 scopus 로고    scopus 로고
    • The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family
    • Brigstock D.R. The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family. Endocr Rev 1999, 20:189-206.
    • (1999) Endocr Rev , vol.20 , pp. 189-206
    • Brigstock, D.R.1
  • 3
    • 0027219381 scopus 로고
    • The modular architecture of a new family of growth regulators related to connective tissue growth factor
    • Bork P. The modular architecture of a new family of growth regulators related to connective tissue growth factor. FEBS Lett 1993, 327:125-130.
    • (1993) FEBS Lett , vol.327 , pp. 125-130
    • Bork, P.1
  • 4
    • 20444504753 scopus 로고    scopus 로고
    • Structural and functional properties of CCN proteins
    • Rachfal A.W., Brigstock D.R. Structural and functional properties of CCN proteins. Vitam Horm 2005, 70:69-103.
    • (2005) Vitam Horm , vol.70 , pp. 69-103
    • Rachfal, A.W.1    Brigstock, D.R.2
  • 5
    • 59649107705 scopus 로고    scopus 로고
    • Functions and mechanisms of action of CCN matricellular proteins
    • Chen C.C., Lau L.F. Functions and mechanisms of action of CCN matricellular proteins. Int J Biochem Cell Biol 2009, 41:771-783.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 771-783
    • Chen, C.C.1    Lau, L.F.2
  • 6
    • 80052925829 scopus 로고    scopus 로고
    • CCN1/CYR61: the very model of a modern matricellular protein
    • Lau L.F. CCN1/CYR61: the very model of a modern matricellular protein. Cell Mol Life Sci 2011, 68:3149-3163.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 3149-3163
    • Lau, L.F.1
  • 7
    • 0033541389 scopus 로고    scopus 로고
    • The CCN family of angiogenic regulators: the integrin connection
    • Lau L.F., Lam S.C. The CCN family of angiogenic regulators: the integrin connection. Exp Cell Res 1999, 248:44-57.
    • (1999) Exp Cell Res , vol.248 , pp. 44-57
    • Lau, L.F.1    Lam, S.C.2
  • 8
    • 0242690484 scopus 로고    scopus 로고
    • Low density lipoprotein receptor-related protein (LRP) is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells
    • Gao R., Brigstock D.R. Low density lipoprotein receptor-related protein (LRP) is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells. Hepatol Res 2003, 27:214-220.
    • (2003) Hepatol Res , vol.27 , pp. 214-220
    • Gao, R.1    Brigstock, D.R.2
  • 9
    • 84869102065 scopus 로고    scopus 로고
    • Role of low-density lipoprotein receptor related protein 1 (LRP1) in CCN2/connective tissue growth factor (CTGF) protein transport in chondrocytes
    • [Epub ahead of print] PMID: 22454511
    • Kawata K., Kubota S., Eguchi T., Aoyama E., Moritani N.H., Kondo S., et al. Role of low-density lipoprotein receptor related protein 1 (LRP1) in CCN2/connective tissue growth factor (CTGF) protein transport in chondrocytes. J Cell Sci 2012, [Epub ahead of print] PMID: 22454511. 10.1242/jcs.101956.
    • (2012) J Cell Sci
    • Kawata, K.1    Kubota, S.2    Eguchi, T.3    Aoyama, E.4    Moritani, N.H.5    Kondo, S.6
  • 10
    • 20444384532 scopus 로고    scopus 로고
    • Connective tissue growth factor CCN2 interacts with and activates the tyrosine kinase receptor TrkA
    • Wahab N.A., Weston B.S., Mason R.M. Connective tissue growth factor CCN2 interacts with and activates the tyrosine kinase receptor TrkA. J Am Soc Nephrol 2005, 16:340-351.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 340-351
    • Wahab, N.A.1    Weston, B.S.2    Mason, R.M.3
  • 11
    • 33750480252 scopus 로고    scopus 로고
    • The matricellular protein CCN1 is essential for cardiac development
    • Mo F.E., Lau L.F. The matricellular protein CCN1 is essential for cardiac development. Circ Res 2006, 99:961-969.
    • (2006) Circ Res , vol.99 , pp. 961-969
    • Mo, F.E.1    Lau, L.F.2
  • 13
    • 39749083530 scopus 로고    scopus 로고
    • Pulmonary hypoplasia in the connective tissue growth factor (Ctgf) null mouse
    • Baguma-Nibasheka M., Kablar B. Pulmonary hypoplasia in the connective tissue growth factor (Ctgf) null mouse. Dev Dyn 2008, 237:485-493.
    • (2008) Dev Dyn , vol.237 , pp. 485-493
    • Baguma-Nibasheka, M.1    Kablar, B.2
  • 14
    • 0038093327 scopus 로고    scopus 로고
    • Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development
    • Ivkovic S., Yoon B.S., Popoff S.N., Safadi F.F., Libuda D.E., Stephenson R.C., et al. Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development 2003, 130:2779-2791.
    • (2003) Development , vol.130 , pp. 2779-2791
    • Ivkovic, S.1    Yoon, B.S.2    Popoff, S.N.3    Safadi, F.F.4    Libuda, D.E.5    Stephenson, R.C.6
  • 15
    • 61449178818 scopus 로고    scopus 로고
    • Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis
    • Crawford L.A., Guney M.A., Oh Y.A., Deyoung R.A., Valenzuela D.M., Murphy A.J., et al. Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis. Mol Endocrinol 2009, 23:324-336.
    • (2009) Mol Endocrinol , vol.23 , pp. 324-336
    • Crawford, L.A.1    Guney, M.A.2    Oh, Y.A.3    Deyoung, R.A.4    Valenzuela, D.M.5    Murphy, A.J.6
  • 16
    • 43149111611 scopus 로고    scopus 로고
    • Abnormal skeletal and cardiac development, cardiomyopathy, muscle atrophy and cataracts in mice with a targeted disruption of the Nov (Ccn3) gene
    • Heath E., Tahri D., Andermarcher E., Schofield P., Fleming S., Boulter C.A. Abnormal skeletal and cardiac development, cardiomyopathy, muscle atrophy and cataracts in mice with a targeted disruption of the Nov (Ccn3) gene. BMC Dev Biol 2008, 8:18.
    • (2008) BMC Dev Biol , vol.8 , pp. 18
    • Heath, E.1    Tahri, D.2    Andermarcher, E.3    Schofield, P.4    Fleming, S.5    Boulter, C.A.6
  • 18
    • 80053059611 scopus 로고    scopus 로고
    • Connective tissue growth factor acts within both endothelial cells and beta cells to promote proliferation of developing beta cells
    • Guney M.A., Petersen C.P., Boustani A., Duncan M.R., Gunasekaran U., Menon R., et al. Connective tissue growth factor acts within both endothelial cells and beta cells to promote proliferation of developing beta cells. Proc Natl Acad Sci USA 2011, 108:15242-15247.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 15242-15247
    • Guney, M.A.1    Petersen, C.P.2    Boustani, A.3    Duncan, M.R.4    Gunasekaran, U.5    Menon, R.6
  • 19
    • 1542267814 scopus 로고    scopus 로고
    • Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development
    • Prado C.L., Pugh-Bernard A.E., Elghazi L., Sosa-Pineda B., Sussel L. Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc Natl Acad Sci USA 2004, 101:2924-2929.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2924-2929
    • Prado, C.L.1    Pugh-Bernard, A.E.2    Elghazi, L.3    Sosa-Pineda, B.4    Sussel, L.5
  • 20
    • 0031842971 scopus 로고    scopus 로고
    • Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture
    • Apte M.V., Haber P.S., Applegate T.L., Norton I.D., McCaughan G.W., Korsten M.A., et al. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut 1998, 43:128-133.
    • (1998) Gut , vol.43 , pp. 128-133
    • Apte, M.V.1    Haber, P.S.2    Applegate, T.L.3    Norton, I.D.4    McCaughan, G.W.5    Korsten, M.A.6
  • 21
    • 80054031046 scopus 로고    scopus 로고
    • The fibrosis of chronic pancreatitis: new insights into the role of pancreatic stellate cells
    • Apte M., Pirola R., Wilson J. The fibrosis of chronic pancreatitis: new insights into the role of pancreatic stellate cells. Antioxid Redox Signal 2011, 15:2711-2722.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 2711-2722
    • Apte, M.1    Pirola, R.2    Wilson, J.3
  • 22
    • 0032829703 scopus 로고    scopus 로고
    • Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis
    • Haber P.S., Keogh G.W., Apte M.V., Moran C.S., Stewart N.L., Crawford D.H., et al. Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis. Am J Pathol 1999, 155:1087-1095.
    • (1999) Am J Pathol , vol.155 , pp. 1087-1095
    • Haber, P.S.1    Keogh, G.W.2    Apte, M.V.3    Moran, C.S.4    Stewart, N.L.5    Crawford, D.H.6
  • 23
    • 24144461303 scopus 로고    scopus 로고
    • Connective tissue growth factor (CCN2) in rat pancreatic stellate cell function: integrin alpha5beta1 as a novel CCN2 receptor
    • Gao R., Brigstock D.R. Connective tissue growth factor (CCN2) in rat pancreatic stellate cell function: integrin alpha5beta1 as a novel CCN2 receptor. Gastroenterology 2005, 129:1019-1030.
    • (2005) Gastroenterology , vol.129 , pp. 1019-1030
    • Gao, R.1    Brigstock, D.R.2
  • 24
    • 33646821004 scopus 로고    scopus 로고
    • A novel integrin alpha5beta1 binding domain in module 4 of connective tissue growth factor (CCN2/CTGF) promotes adhesion and migration of activated pancreatic stellate cells
    • Gao R., Brigstock D.R. A novel integrin alpha5beta1 binding domain in module 4 of connective tissue growth factor (CCN2/CTGF) promotes adhesion and migration of activated pancreatic stellate cells. Gut 2006, 55:856-862.
    • (2006) Gut , vol.55 , pp. 856-862
    • Gao, R.1    Brigstock, D.R.2
  • 25
    • 66949168191 scopus 로고    scopus 로고
    • Ethanol-mediated expression of connective tissue growth factor (CCN2) in mouse pancreatic stellate cells
    • Lawrencia C., Charrier A., Huang G., Brigstock D.R. Ethanol-mediated expression of connective tissue growth factor (CCN2) in mouse pancreatic stellate cells. Growth Factors 2009, 27:91-99.
    • (2009) Growth Factors , vol.27 , pp. 91-99
    • Lawrencia, C.1    Charrier, A.2    Huang, G.3    Brigstock, D.R.4
  • 26
    • 0036689698 scopus 로고    scopus 로고
    • Establishment of a novel collagenase perfusion method to isolate rat pancreatic stellate cells and investigation of their gene expression of TGF-beta1, type I collagen, and CTGF in primary culture or freshly isolated cells
    • Shinji T., Ujike K., Ochi K., Kusano N., Kikui T., Matsumura N., et al. Establishment of a novel collagenase perfusion method to isolate rat pancreatic stellate cells and investigation of their gene expression of TGF-beta1, type I collagen, and CTGF in primary culture or freshly isolated cells. Acta Med Okayama 2002, 56:211-218.
    • (2002) Acta Med Okayama , vol.56 , pp. 211-218
    • Shinji, T.1    Ujike, K.2    Ochi, K.3    Kusano, N.4    Kikui, T.5    Matsumura, N.6
  • 27
    • 79951648873 scopus 로고    scopus 로고
    • Pancreas organogenesis: from bud to plexus to gland
    • Pan F.C., Wright C. Pancreas organogenesis: from bud to plexus to gland. Dev Dyn 2011, 240:530-565.
    • (2011) Dev Dyn , vol.240 , pp. 530-565
    • Pan, F.C.1    Wright, C.2
  • 29
    • 0036777339 scopus 로고    scopus 로고
    • Signaling and transcriptional control of pancreatic organogenesis
    • Kim S.K., MacDonald R.J. Signaling and transcriptional control of pancreatic organogenesis. Curr Opin Genet Dev 2002, 12:540-547.
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 540-547
    • Kim, S.K.1    MacDonald, R.J.2
  • 30
    • 0034652287 scopus 로고    scopus 로고
    • Neurogenin 3 is required for the development of the four endocrine cell lineages of the pancreas
    • Gradwohl G., Dierich A., LeMeur M., Guillemot F. Neurogenin 3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci USA 2000, 97:1607-1611.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1607-1611
    • Gradwohl, G.1    Dierich, A.2    LeMeur, M.3    Guillemot, F.4
  • 31
    • 0037219411 scopus 로고    scopus 로고
    • Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    • Butler A.E., Janson J., Bonner-Weir S., Ritzel R., Rizza R.A., Butler P.C. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003, 52:102-110.
    • (2003) Diabetes , vol.52 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 32
    • 0038707331 scopus 로고    scopus 로고
    • Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea
    • Yoon K.H., Ko S.H., Cho J.H., Lee J.M., Ahn Y.B., Song K.H., et al. Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea. J Clin Endocrinol Metab 2003, 88:2300-2308.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2300-2308
    • Yoon, K.H.1    Ko, S.H.2    Cho, J.H.3    Lee, J.M.4    Ahn, Y.B.5    Song, K.H.6
  • 33
    • 0033405368 scopus 로고    scopus 로고
    • Immunohistochemical localization of connective tissue growth factor (CTGF) in the mouse embryo between days 7.5 and 14.5 of gestation
    • Surveyor G.A., Brigstock D.R. Immunohistochemical localization of connective tissue growth factor (CTGF) in the mouse embryo between days 7.5 and 14.5 of gestation. Growth Factors 1999, 17:115-124.
    • (1999) Growth Factors , vol.17 , pp. 115-124
    • Surveyor, G.A.1    Brigstock, D.R.2
  • 35
    • 53649110095 scopus 로고    scopus 로고
    • Identification of phylogenetically conserved enhancer elements implicated in pancreas development in the WISP1 and CTGF orthologs
    • Kapasa M., Serafimidis I., Gavalas A., Kossida S. Identification of phylogenetically conserved enhancer elements implicated in pancreas development in the WISP1 and CTGF orthologs. Genomics 2008, 92:301-308.
    • (2008) Genomics , vol.92 , pp. 301-308
    • Kapasa, M.1    Serafimidis, I.2    Gavalas, A.3    Kossida, S.4
  • 37
    • 0028295094 scopus 로고
    • Progression of alcoholic acute to chronic pancreatitis
    • Ammann R.W., Muellhaupt B. Progression of alcoholic acute to chronic pancreatitis. Gut 1994, 35:552-556.
    • (1994) Gut , vol.35 , pp. 552-556
    • Ammann, R.W.1    Muellhaupt, B.2
  • 38
    • 2142646426 scopus 로고    scopus 로고
    • TGF-beta signaling and the fibrotic response
    • Leask A., Abraham D.J. TGF-beta signaling and the fibrotic response. FASEB J 2004, 18:816-827.
    • (2004) FASEB J , vol.18 , pp. 816-827
    • Leask, A.1    Abraham, D.J.2
  • 39
    • 34447271736 scopus 로고    scopus 로고
    • Transforming growth factor-beta and fibrosis
    • Verrecchia F., Mauviel A. Transforming growth factor-beta and fibrosis. World J Gastroenterol 2007, 13:3056-3062.
    • (2007) World J Gastroenterol , vol.13 , pp. 3056-3062
    • Verrecchia, F.1    Mauviel, A.2
  • 40
    • 0031941038 scopus 로고    scopus 로고
    • Enhanced expression of TGF-betas and their receptors in human acute pancreatitis
    • Friess H., Lu Z., Riesle E., Uhl W., Brundler A.M., Horvath L., et al. Enhanced expression of TGF-betas and their receptors in human acute pancreatitis. Ann Surg 1998, 227:95-104.
    • (1998) Ann Surg , vol.227 , pp. 95-104
    • Friess, H.1    Lu, Z.2    Riesle, E.3    Uhl, W.4    Brundler, A.M.5    Horvath, L.6
  • 41
    • 0031956961 scopus 로고    scopus 로고
    • Comparison of epidermal growth factor and transforming growth factor-beta1 expression in hormone-induced acute pancreatitis in rats
    • Konturek P.C., Dembinski A., Warzecha Z., Ihlm A., Ceranowicz P., Konturek S.J., et al. Comparison of epidermal growth factor and transforming growth factor-beta1 expression in hormone-induced acute pancreatitis in rats. Digestion 1998, 59:110-119.
    • (1998) Digestion , vol.59 , pp. 110-119
    • Konturek, P.C.1    Dembinski, A.2    Warzecha, Z.3    Ihlm, A.4    Ceranowicz, P.5    Konturek, S.J.6
  • 42
    • 0031010387 scopus 로고    scopus 로고
    • Extracellular matrix is reduced by inhibition of transforming growth factor beta1 in pancreatitis in the rat
    • Menke A., Yamaguchi H., Gress T.M., Adler G. Extracellular matrix is reduced by inhibition of transforming growth factor beta1 in pancreatitis in the rat. Gastroenterology 1997, 113:295-303.
    • (1997) Gastroenterology , vol.113 , pp. 295-303
    • Menke, A.1    Yamaguchi, H.2    Gress, T.M.3    Adler, G.4
  • 43
    • 0342275170 scopus 로고    scopus 로고
    • The influence of transforming growth factor beta 1 on the expression of genes coding for matrix metalloproteinases and tissue inhibitors of metalloproteinases during regeneration from cerulein-induced pancreatitis
    • Muller-Pillasch F., Gress T.M., Yamaguchi H., Geng M., Adler G., Menke A. The influence of transforming growth factor beta 1 on the expression of genes coding for matrix metalloproteinases and tissue inhibitors of metalloproteinases during regeneration from cerulein-induced pancreatitis. Pancreas 1997, 15:168-175.
    • (1997) Pancreas , vol.15 , pp. 168-175
    • Muller-Pillasch, F.1    Gress, T.M.2    Yamaguchi, H.3    Geng, M.4    Adler, G.5    Menke, A.6
  • 44
    • 0031043113 scopus 로고    scopus 로고
    • Increased expression of transforming growth factor beta s after acute oedematous pancreatitis in rats suggests a role in pancreatic repair
    • Riesle E., Friess H., Zhao L., Wagner M., Uhl W., Baczako K., et al. Increased expression of transforming growth factor beta s after acute oedematous pancreatitis in rats suggests a role in pancreatic repair. Gut 1997, 40:73-79.
    • (1997) Gut , vol.40 , pp. 73-79
    • Riesle, E.1    Friess, H.2    Zhao, L.3    Wagner, M.4    Uhl, W.5    Baczako, K.6
  • 45
    • 0029017902 scopus 로고
    • Accumulation of extracellular matrix and developmental dysregulation in the pancreas by transgenic production of transforming growth factor-beta 1
    • Lee M.S., Gu D., Feng L., Curriden S., Arnush M., Krahl T., et al. Accumulation of extracellular matrix and developmental dysregulation in the pancreas by transgenic production of transforming growth factor-beta 1. Am J Pathol 1995, 147:42-52.
    • (1995) Am J Pathol , vol.147 , pp. 42-52
    • Lee, M.S.1    Gu, D.2    Feng, L.3    Curriden, S.4    Arnush, M.5    Krahl, T.6
  • 46
    • 0030063574 scopus 로고    scopus 로고
    • Transforming growth factor beta promotes development of fibrosis after repeated courses of acute pancreatitis in mice
    • Van Laethem J.L., Robberecht P., Resibois A., Deviere J. Transforming growth factor beta promotes development of fibrosis after repeated courses of acute pancreatitis in mice. Gastroenterology 1996, 110:576-582.
    • (1996) Gastroenterology , vol.110 , pp. 576-582
    • Van Laethem, J.L.1    Robberecht, P.2    Resibois, A.3    Deviere, J.4
  • 47
    • 0442291674 scopus 로고    scopus 로고
    • The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology
    • Leask A., Abraham D.J. The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology. Biochem Cell Biol 2003, 81:355-363.
    • (2003) Biochem Cell Biol , vol.81 , pp. 355-363
    • Leask, A.1    Abraham, D.J.2
  • 48
    • 0036142755 scopus 로고    scopus 로고
    • Connective tissue growth factor is involved in pancreatic repair and tissue remodeling in human and rat acute necrotizing pancreatitis
    • di Mola F.F., Friess H., Riesle E., Koliopanos A., Buchler P., Zhu Z., et al. Connective tissue growth factor is involved in pancreatic repair and tissue remodeling in human and rat acute necrotizing pancreatitis. Ann Surg 2002, 235:60-67.
    • (2002) Ann Surg , vol.235 , pp. 60-67
    • di Mola, F.F.1    Friess, H.2    Riesle, E.3    Koliopanos, A.4    Buchler, P.5    Zhu, Z.6
  • 50
    • 77955165771 scopus 로고    scopus 로고
    • Connective tissue growth factor production by activated pancreatic stellate cells in mouse alcoholic chronic pancreatitis
    • Charrier A.L., Brigstock D.R. Connective tissue growth factor production by activated pancreatic stellate cells in mouse alcoholic chronic pancreatitis. Lab Invest 2010, 90:1179-1188.
    • (2010) Lab Invest , vol.90 , pp. 1179-1188
    • Charrier, A.L.1    Brigstock, D.R.2
  • 51
    • 0034997788 scopus 로고    scopus 로고
    • Effects of fibrogenic mediators on the development of pancreatic fibrosis in a TGF-beta1 transgenic mouse model
    • Vogelmann R., Ruf D., Wagner M., Adler G., Menke A. Effects of fibrogenic mediators on the development of pancreatic fibrosis in a TGF-beta1 transgenic mouse model. Am J Physiol Gastrointest Liver Physiol 2001, 280:G164-G172.
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.280
    • Vogelmann, R.1    Ruf, D.2    Wagner, M.3    Adler, G.4    Menke, A.5
  • 52
    • 33847176982 scopus 로고    scopus 로고
    • Inhibitory effects of interferon-gamma on activation of rat pancreatic stellate cells are mediated by STAT1 and involve down-regulation of CTGF expression
    • Fitzner B., Brock P., Nechutova H., Glass A., Karopka T., Koczan D., et al. Inhibitory effects of interferon-gamma on activation of rat pancreatic stellate cells are mediated by STAT1 and involve down-regulation of CTGF expression. Cell Signal 2007, 19:782-790.
    • (2007) Cell Signal , vol.19 , pp. 782-790
    • Fitzner, B.1    Brock, P.2    Nechutova, H.3    Glass, A.4    Karopka, T.5    Koczan, D.6
  • 53
    • 34247895516 scopus 로고    scopus 로고
    • Hyperglycemia and hyperinsulinemia have additive effects on activation and proliferation of pancreatic stellate cells: possible explanation of islet-specific fibrosis in type 2 diabetes mellitus
    • Hong O.K., Lee S.H., Rhee M., Ko S.H., Cho J.H., Choi Y.H., et al. Hyperglycemia and hyperinsulinemia have additive effects on activation and proliferation of pancreatic stellate cells: possible explanation of islet-specific fibrosis in type 2 diabetes mellitus. J Cell Biochem 2007, 101:665-675.
    • (2007) J Cell Biochem , vol.101 , pp. 665-675
    • Hong, O.K.1    Lee, S.H.2    Rhee, M.3    Ko, S.H.4    Cho, J.H.5    Choi, Y.H.6
  • 54
    • 49549122634 scopus 로고    scopus 로고
    • Molecular insights into connective tissue growth factor action in rat pancreatic stellate cells
    • Karger A., Fitzner B., Brock P., Sparmann G., Emmrich J., Liebe S., et al. Molecular insights into connective tissue growth factor action in rat pancreatic stellate cells. Cell Signal 2008, 20:1865-1872.
    • (2008) Cell Signal , vol.20 , pp. 1865-1872
    • Karger, A.1    Fitzner, B.2    Brock, P.3    Sparmann, G.4    Emmrich, J.5    Liebe, S.6
  • 55
    • 33646164421 scopus 로고    scopus 로고
    • High glucose increases extracellular matrix production in pancreatic stellate cells by activating the renin-angiotensin system
    • Ko S.H., Hong O.K., Kim J.W., Ahn Y.B., Song K.H., Cha B.Y., et al. High glucose increases extracellular matrix production in pancreatic stellate cells by activating the renin-angiotensin system. J Cell Biochem 2006, 98:343-355.
    • (2006) J Cell Biochem , vol.98 , pp. 343-355
    • Ko, S.H.1    Hong, O.K.2    Kim, J.W.3    Ahn, Y.B.4    Song, K.H.5    Cha, B.Y.6
  • 56
    • 34648852355 scopus 로고    scopus 로고
    • Pancreatic cancer-associated stroma production
    • Korc M. Pancreatic cancer-associated stroma production. Am J Surg 2007, 194:S84-S86.
    • (2007) Am J Surg , vol.194
    • Korc, M.1
  • 58
    • 0033611584 scopus 로고    scopus 로고
    • Expression and differential regulation of connective tissue growth factor in pancreatic cancer cells
    • Wenger C., Ellenrieder V., Alber B., Lacher U., Menke A., Hameister H., et al. Expression and differential regulation of connective tissue growth factor in pancreatic cancer cells. Oncogene 1999, 18:1073-1080.
    • (1999) Oncogene , vol.18 , pp. 1073-1080
    • Wenger, C.1    Ellenrieder, V.2    Alber, B.3    Lacher, U.4    Menke, A.5    Hameister, H.6
  • 59
    • 0036142720 scopus 로고    scopus 로고
    • Exploring the host desmoplastic response to pancreatic carcinoma: gene expression of stromal and neoplastic cells at the site of primary invasion
    • Iacobuzio-Donahue C.A., Ryu B., Hruban R.H., Kern S.E. Exploring the host desmoplastic response to pancreatic carcinoma: gene expression of stromal and neoplastic cells at the site of primary invasion. Am J Pathol 2002, 160:91-99.
    • (2002) Am J Pathol , vol.160 , pp. 91-99
    • Iacobuzio-Donahue, C.A.1    Ryu, B.2    Hruban, R.H.3    Kern, S.E.4
  • 60
    • 59149092493 scopus 로고    scopus 로고
    • The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth
    • Bennewith K.L., Huang X., Ham C.M., Graves E.E., Erler J.T., Kambham N., et al. The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth. Cancer Res 2009, 69:775-784.
    • (2009) Cancer Res , vol.69 , pp. 775-784
    • Bennewith, K.L.1    Huang, X.2    Ham, C.M.3    Graves, E.E.4    Erler, J.T.5    Kambham, N.6
  • 61
    • 77958171910 scopus 로고    scopus 로고
    • Stromal SPARC expression and patient survival after chemoradiation for non-resectable pancreatic adenocarcinoma
    • Mantoni T.S., Schendel R.R., Rodel F., Niedobitek G., Al-Assar O., Masamune A., et al. Stromal SPARC expression and patient survival after chemoradiation for non-resectable pancreatic adenocarcinoma. Cancer Biol Ther 2008, 7:1806-1815.
    • (2008) Cancer Biol Ther , vol.7 , pp. 1806-1815
    • Mantoni, T.S.1    Schendel, R.R.2    Rodel, F.3    Niedobitek, G.4    Al-Assar, O.5    Masamune, A.6
  • 62
    • 54949125004 scopus 로고    scopus 로고
    • Analysis of CCN2 promoter activity in PANC-1 cells: regulation by ras/MEK/ERK
    • Pickles M., Leask A. Analysis of CCN2 promoter activity in PANC-1 cells: regulation by ras/MEK/ERK. J Cell Commun Signal 2007, 1:85-90.
    • (2007) J Cell Commun Signal , vol.1 , pp. 85-90
    • Pickles, M.1    Leask, A.2
  • 63
    • 35848957047 scopus 로고    scopus 로고
    • Expression of connective tissue growth factor in pancreatic cancer cell lines
    • Kwon S., Munroe X., Crawley S.C., Lee H.Y., Spong S., Bradham D., et al. Expression of connective tissue growth factor in pancreatic cancer cell lines. Int J Oncol 2007, 31:693-703.
    • (2007) Int J Oncol , vol.31 , pp. 693-703
    • Kwon, S.1    Munroe, X.2    Crawley, S.C.3    Lee, H.Y.4    Spong, S.5    Bradham, D.6
  • 64
    • 0028081120 scopus 로고
    • K-ras mutations in pancreatic ductal proliferative lesions
    • Klimstra D.S., Longnecker D.S. K-ras mutations in pancreatic ductal proliferative lesions. Am J Pathol 1994, 145:1547-1550.
    • (1994) Am J Pathol , vol.145 , pp. 1547-1550
    • Klimstra, D.S.1    Longnecker, D.S.2
  • 66
    • 33751247898 scopus 로고    scopus 로고
    • Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression
    • Ijichi H., Chytil A., Gorska A.E., Aakre M.E., Fujitani Y., Fujitani S., et al. Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Genes Dev 2006, 20:3147-3160.
    • (2006) Genes Dev , vol.20 , pp. 3147-3160
    • Ijichi, H.1    Chytil, A.2    Gorska, A.E.3    Aakre, M.E.4    Fujitani, Y.5    Fujitani, S.6
  • 67
    • 80053405625 scopus 로고    scopus 로고
    • Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma
    • Ijichi H., Chytil A., Gorska A.E., Aakre M.E., Bierie B., Tada M., et al. Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma. J Clin Invest 2011, 121:4106-4117.
    • (2011) J Clin Invest , vol.121 , pp. 4106-4117
    • Ijichi, H.1    Chytil, A.2    Gorska, A.E.3    Aakre, M.E.4    Bierie, B.5    Tada, M.6
  • 68
    • 77958494724 scopus 로고    scopus 로고
    • The reactive tumor microenvironment: MUC1 signaling directly reprograms transcription of CTGF
    • Behrens M.E., Grandgenett P.M., Bailey J.M., Singh P.K., Yi C.H., Yu F., et al. The reactive tumor microenvironment: MUC1 signaling directly reprograms transcription of CTGF. Oncogene 2010, 29:5667-5677.
    • (2010) Oncogene , vol.29 , pp. 5667-5677
    • Behrens, M.E.1    Grandgenett, P.M.2    Bailey, J.M.3    Singh, P.K.4    Yi, C.H.5    Yu, F.6
  • 69
    • 0035266179 scopus 로고    scopus 로고
    • Invasion-specific genes in malignancy: serial analysis of gene expression comparisons of primary and passaged cancers
    • Ryu B., Jones J., Hollingsworth M.A., Hruban R.H., Kern S.E. Invasion-specific genes in malignancy: serial analysis of gene expression comparisons of primary and passaged cancers. Cancer Res 2001, 61:1833-1838.
    • (2001) Cancer Res , vol.61 , pp. 1833-1838
    • Ryu, B.1    Jones, J.2    Hollingsworth, M.A.3    Hruban, R.H.4    Kern, S.E.5
  • 70
    • 33745078936 scopus 로고    scopus 로고
    • Connective tissue growth factor-specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer
    • Aikawa T., Gunn J., Spong S.M., Klaus S.J., Korc M. Connective tissue growth factor-specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer. Mol Cancer Ther 2006, 5:1108-1116.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1108-1116
    • Aikawa, T.1    Gunn, J.2    Spong, S.M.3    Klaus, S.J.4    Korc, M.5
  • 71
    • 33745247375 scopus 로고    scopus 로고
    • Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis
    • Dornhofer N., Spong S., Bennewith K., Salim A., Klaus S., Kambham N., et al. Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis. Cancer Res 2006, 66:5816-5827.
    • (2006) Cancer Res , vol.66 , pp. 5816-5827
    • Dornhofer, N.1    Spong, S.2    Bennewith, K.3    Salim, A.4    Klaus, S.5    Kambham, N.6
  • 72
    • 78649727958 scopus 로고    scopus 로고
    • Transcript profiling identifies novel key players mediating the growth inhibitory effect of NS-398 on human pancreatic cancer cells
    • Youns M., Efferth T., Hoheisel J.D. Transcript profiling identifies novel key players mediating the growth inhibitory effect of NS-398 on human pancreatic cancer cells. Eur J Pharmacol 2011, 650:170-177.
    • (2011) Eur J Pharmacol , vol.650 , pp. 170-177
    • Youns, M.1    Efferth, T.2    Hoheisel, J.D.3
  • 73
    • 82455198983 scopus 로고    scopus 로고
    • Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets
    • Jun J.I., Lau L.F. Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets. Nat Rev Drug Discov 2011, 10:945-963.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 945-963
    • Jun, J.I.1    Lau, L.F.2
  • 75
    • 77956609028 scopus 로고    scopus 로고
    • NOV/CCN3 upregulates CCL2 and CXCL1 expression in astrocytes through beta1 and beta5 integrins
    • Le Dreau G., Kular L., Nicot A.B., Calmel C., Melik-Parsadaniantz S., Kitabgi P., et al. NOV/CCN3 upregulates CCL2 and CXCL1 expression in astrocytes through beta1 and beta5 integrins. Glia 2010, 58:1510-1521.
    • (2010) Glia , vol.58 , pp. 1510-1521
    • Le Dreau, G.1    Kular, L.2    Nicot, A.B.3    Calmel, C.4    Melik-Parsadaniantz, S.5    Kitabgi, P.6


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