Post-translational glycoprotein modifications regulate colon cancer stem cells and colon adenoma progression in Apcmin/+ mice through altered Wnt receptor signaling

Journal of Biological Chemistry

Volumn 289, Issue 45, 2014, Pages 31534-31549

  Guo, Huabei ^a   Nagy, Tamas ^a   Pierce, Michael ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; DISEASES; GENE EXPRESSION; MAMMALS; POLYSACCHARIDES; SIGNALING; STEM CELLS; TUMORS;

CANCER STEM CELLS; CATENIN SIGNALING; COLON CANCER CELLS; EXPRESSION LEVELS; NUCLEAR TRANSLOCATIONS; RECEPTOR SIGNALING; TUMOR FORMATION; TUMOR PROGRESSIONS;

GENE EXPRESSION REGULATION;

ALDEHYDE DEHYDROGENASE ISOENZYME 1; APC PROTEIN; BETA CATENIN; CD24 ANTIGEN; COMPLEMENTARY DNA; CYTOKERATIN 20; FRIZZLED PROTEIN; FZD 7 RECEPTOR; HERMES ANTIGEN; KI 67 ANTIGEN; MESSENGER RNA; MYC PROTEIN; N ACETYLGLUCOSAMINYLTRANSFERASE; N ACETYLGLUCOSAMINYLTRANSFERASE V; OCTAMER TRANSCRIPTION FACTOR 4; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SOX4; UNCLASSIFIED DRUG; ALPHA-1,6-MANNOSYLGLYCOPROTEIN BETA 1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE; GLYCOSIDASE; WNT PROTEIN;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCL2 GENE; AXIN2 GENE; CANCER GROWTH; CANCER INHIBITION; CANCER STEM CELL; CARCINOGENICITY; CELL PROLIFERATION; CELL RENEWAL; CELLULAR DISTRIBUTION; COLON ADENOMA; COLON CANCER CANCER STEM CELL; COLON CARCINOGENESIS; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE; GENE DELETION; GENE EXPRESSION REGULATION; GENE INACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LGR5 GENE; MALE; MOLECULAR DYNAMICS; MOUSE; N LINKED GLYCAN BRANCHING; NOD SCID MOUSE; NONHUMAN; ONCOGENE MYC; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN PROCESSING; SURVIVAL RATE; SURVIVAL TIME; TUMOR VOLUME; TUMOR XENOGRAFT; WNT SIGNALING PATHWAY; ACTIVE TRANSPORT; ADENOMA; ANIMAL; C57BL MOUSE; CANCER TRANSPLANTATION; COLON TUMOR; CYTOLOGY; GENETICS; GLYCOSYLATION; METABOLISM; NONOBESE DIABETIC MOUSE; SCID MOUSE; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

ACTIVE TRANSPORT, CELL NUCLEUS; ADENOMA; ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, APC; GLYCOSIDE HYDROLASES; GLYCOSYLATION; HUMANS; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, SCID; MICE, TRANSGENIC; N-ACETYLGLUCOSAMINYLTRANSFERASES; NEOPLASM TRANSPLANTATION; NEOPLASTIC STEM CELLS; PHENOTYPE; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 84909953198     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.602680     Document Type: Article

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