In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system

Oncogene

Volumn 32, Issue 7, 2013, Pages 883-893

  Jarde T ^a   Evans, R J ^a   McQuillan, K L ^a   Parry, L ^a   Feng, G J ^a   Alvares, B ^a   Clarke, A R ^a   Dale, T C ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

colorectal cancer; crypt culture; organoids; reversal; Wnt pathway

Indexed keywords

BETA CATENIN; BETA GALACTOSIDASE; CASPASE 3; CCT 036477; DOXYCYCLINE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CRYPT CELL; DOWN REGULATION; ENTEROPATHY; FEMALE; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; MITOSIS; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; UPREGULATION; WNT SIGNALING PATHWAY;

ANIMALS; BACTERIAL PROTEINS; BETA CATENIN; CARRIER PROTEINS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, THEORETICAL; MOLECULAR TARGETED THERAPY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; WNT SIGNALING PATHWAY;

MUS MUSCULUS;

EID: 84874111174     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.103     Document Type: Article

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