The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin

Human Molecular Genetics

Volumn 18, Issue 14, 2009, Pages 2599-2608

  Pinho, Salomé S ^a   Reis, Celso A ^a,b   Paredes, Joana ^a   Magalhães, Ana Maria ^a   Ferreira, António Carlos ^a   Figueiredo, Joana ^a   Xiaogang, Wen ^a,b   Carneiro, Fátima ^a,b   Gartner F Fatima ^a   Seruca, Raquel ^a,b  

^a UNIVERSITY OF PORTO   (Portugal)

^b University of Porto   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1,3(6) MANNOSYLGLYCOPROTEIN BETA 1,6 N ACETYLGLUCOSAMINYLTRANSFERASE; BETA 1,6 ACETYLGLUCOSAMINE; GENE PRODUCT; N ACETYLGLUCOSAMINE; N ACETYLGLUCOSAMINYLTRANSFERASE; N ACETYLGLUCOSAMINYLTRANSFERASE III; OLIGOSACCHARIDE; PROTEIN MGAT3; UNCLASSIFIED DRUG; UVOMORULIN;

ARTICLE; CANCER CELL; CONTROLLED STUDY; CYTOPLASM; ENZYME STRUCTURE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GLYCOSYLATION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; REGULATORY MECHANISM; WILD TYPE;

CADHERINS; CARCINOMA; CELL LINE, TUMOR; GENE EXPRESSION; GLYCOSYLATION; HUMANS; N-ACETYLGLUCOSAMINYLTRANSFERASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; STOMACH NEOPLASMS;

EID: 67649859659     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddp194     Document Type: Article

References (33)

1. Taniguchi, N., Yoshimura, M., Miyoshi, E., Ihara, Y., Nishikawa, A., Kang, R. and Ikeda, Y. (1998) Gene expression and regulation of N-acetylglucosaminyltransferases III and V in cancer tissues. Adv. Enzyme Regul., 38, 223-232.
2. Gu, J., Sato, Y., Kariya, Y., Isaji, T., Taniguchi, N. and Fukuda, T. (2009) A mutual regulation between cell-cell adhesion and N-glycosylation: Implication of the bisecting GlcNAc for biological functions. J. Proteome. Res., 8, 431-435.
3. Taniguchi, N., Ekuni, A., Ko, J.H., Miyoshi, E., Ikeda, Y., Ihara, Y., Nishikawa, A., Honke, K. and Takahashi, M. (2001) A glycomic approach to the identification and characterization of glycoprotein function in cells transfected with glycosyltransferase genes. Proteomics, 1 239-247.
4. Geyer, H. and Geyer, R. (2006) Strategies for analysis of glycoprotein glycosylation. Biochim. Biophys. Acta, 1764, 1853-1869.
5. Helenius, A. and Aebi, M. (2001) Intracellular functions of N-linked glycans. Science, 291, 2364-2369.
6. Stanley, P. (2002) Biological consequences of overexpressing or eliminating N-acetylglucosaminyltransferase-TIII in the mouse. Biochim. Biophys. Acta, 1573, 363-368.
7. Zhao, Y., Nakagawa, T., Itoh, S., Inamori, K., Isaji, T., Kariya, Y., Kondo, A., Miyoshi, E., Miyazaki, K., Kawasaki, N. et al. (2006) N-acetylglucosaminyltransferase III antagonizes the effect of N-acetylglucosaminyltransferase V on alpha3beta1 integrin-mediated cell migration. J. Biol. Chem., 281, 32122-32130.
8. Zhao, Y.Y., Takahashi, M., Gu, J.G., Miyoshi, E., Matsumoto, A., Kitazume, S. and Taniguchi, N. (2008) Functional roles of N-glycans in cell signaling and cell adhesion in cancer. Cancer Sci., 99, 1304-1310.
9. Yoshimura, M., Nishikawa, A., Ihara, Y., Taniguchi, S. and Taniguchi, N. (1995) Suppression of lung metastasis of B16 mouse melanoma by N-acetylglucosaminyltransferase III gene transfection. Proc. Natl Acad. Sci. USA, 92, 8754-8758.
10. Taniguchi, N., Miyoshi, E., Ko, J.H., Ikeda, Y. and Ihara, Y. (1999) Implication of N-acetylglucosaminyltransferases III and V in cancer: gene regulation and signaling mechanism. Biochim. Biophys. Acta, 1455, 287-300.
11. Granovsky, M., Fata, J., Pawling, J., Muller, W.J., Khokha, R. and Dennis, J.W. (2000) Suppression of tumor growth and metastasis in Mgat5-deficient mice. Nat. Med., 6, 306-312.
12. Iijima, J., Zhao, Y., Isaji, T., Kameyama, A., Nakaya, S., Wang, X., Ihara, H., Cheng, X., Nakagawa, T., Miyoshi, E. et al. (2006) Cell-cell interaction-dependent regulation of N-acetylglucosaminyltransferase III and the bisected N-glycans in GE11 epithelial cells. Involvement of E-cadherin-mediated cell adhesion. J. Biol. Chem., 281, 13038-13046.
13. Yoshimura, M., Ihara, Y., Matsuzawa, Y. and Taniguchi, N. (1996) Aberrant glycosylation of E-cadherin enhances cell-cell binding to suppress metastasis. J. Biol. Chem., 271, 13811-13815.
14. Guo, H.B., Lee, I., Kamar, M. and Pierce, M. (2003) N-acetylglucosaminyltransferase V expression levels regulate cadherin-associated homotypic cell-cell adhesion and intracellular signaling pathways. J. Biol. Chem., 278, 52412-52424.
15. Machado, J.C., Oliveira, C., Carvalho, R., Soares, P., Berx, G., Caldas, C., Seruca, R., Carneiro, F. and Sobrinho-Simoes, M. (2001) E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma. Oncogene, 20, 1525-1528.
16. Mateus, A.R., Seruca, R., Machado, J.C., Keller, G., Oliveira, M.J., Suriano, G. and Luber, B. (2007) EGFR regulates RhoA-GTP dependent cell motility in E-cadherin mutant cells. Hum. Mol. Genet., 16, 1639-1647.
17. Oliveira, C., Sousa, S., Pinheiro, H., Karam, R., Carrico, R., Senz, J., Kaurah, P., Carvalho, J., Pereira, R., Gusmao, L. et al. (2009) Quantification of epigenetic and genetic second hits in CDH1 during hereditary diffuse gastric cancer syndrome progression. Gastroenterology. Published online ahead of print.
18. Oliveira, C., Senz, J., Kaurah, P., Pinheiro, H., Sanges, R., Haegert, A., Corso, G., Schouten, J., Fitzgerald, R., Vogelsang, H. et al. (2009) Germline CDH1 deletions in hereditary diffuse gastric cancer families. Hum. Mol. Genet. Published online ahead of print.
19. Simoes-Correia, J., Figueiredo, J., Oliveira, C., van, H.J., Seruca, R., van, R.F. and Suriano, G. (2008) Endoplasmic reticulum quality control: a new mechanism of E-cadherin regulation and its implication in cancer. Hum. Mol. Genet., 17, 3566-3576.
20. Suriano, G., Oliveira, C., Ferreira, P., Machado, J.C., Bordin, M.C., De, W.O., Bruyneel, E.A., Moguilevsky, N., Grehan, N., Porter, T.R. et al. (2003) Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands. Hum. Mol. Genet., 12, 575-582.
21. Liwosz, A., Lei, T. and Kukuruzinska, M.A. (2006) N-glycosylation affects the molecular organization and stability of E-cadherin junctions. J. Biol. Chem., 281, 23138-23149.
22. Zhao, H., Liang, Y., Xu, Z., Wang, L., Zhou, F., Li, Z., Jin, J., Yang, Y., Fang, Z., Hu, Y. et al. (2008) N-glycosylation affects the adhesive function of E-Cadherin through modifying the composition of adherens junctions (AJs) in human breast carcinoma cell line MDA-MB-435. J. Cell Biochem., 104, 162-175.
23. Christofori, G. (2003) Changing neighbours, changing behaviour: Cell adhesion molecule-mediated signalling during tumour progression. EMBO J., 22, 2318-2323.
24. Jeanes, A., Gottardi, C.J. and Yap, A.S. (2008) Cadherins and cancer: how does cadherin dysfunction promote tumor progression? Oncogene, 27, 6920-6929.
25. Vercoutter-Edouart, A.S., Slomianny, M.C., keyzer-Beseme, O., Haeuw, J.F. and Michalski, J.C. (2008) Glycoproteomics and glycomics investigation of membrane N-glycosylproteins from human colon carcinoma cells. Proteomics, 8, 3236-3256.
26. Pinho, S.S., Osorio, H., Nita-Lazar, M., Gomes, J., Lopes, C., Gartner, F. and Reis, C.A. (2009) Role of E-cadherin N-glycosylation profile in a mammary tumor model. Biochem. Biophys. Res. Commun., 379, 1091-1096.
27. Akama, R., Sato, Y., Kariya, Y., Isaji, T., Fukuda, T., Lu, L., Taniguchi, N., Ozawa, M. and Gu, J. (2008) N-acetylglucosaminyltransferase III expression is regulated by cell-cell adhesion via the E-cadherin-catenin-actin complex. Proteomics, 8, 3221-3228.
28. Kitada, T., Miyoshi, E., Noda, K., Higashiyama, S., Ihara, H., Matsuura, N., Hayashi, N., Kawata, S., Matsuzawa, Y. and Taniguchi, N. (2001) The addition of bisecting N-acetylglucosamine residues to E-cadherin down-regulates the tyrosine phosphorylation of beta-catenin. J. Biol. Chem., 276, 475-480.
29. Le, T.L., Yap, A.S. and Stow, J.L. (1999) Recycling of E-cadherin: A potential mechanism for regulating cadherin dynamics. J. Cell Biol. 146, 219-232.
30. Carneiro, F., Huntsman, D.G., Smyrk, T.C., Owen, D.A., Seruca, R., Pharoah, P., Caldas, C. and Sobrinho-Simoes, M. (2004) Model of the early development of diffuse gastric cancer in E-cadherin mutation carriers and its implications for patient screening. J. Pathol., 203, 681-687.
31. Oliveira, C., Bordin, M.C., Grehan, N., Huntsman, D., Suriano, G., Machado, J.C., Kiviluoto, T., Aaltonen, L., Jackson, C.E., Seruca, R. and Caldas, C. (2002) Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred. Hum. Mutat., 19, 510-517.
32. Lauren, P. (1965) The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol. Microbiol. Scand., 64, 31-49.
33. Carneiro, F., Seixas, M. and Sobrinho-Simoes, M. (1995) New elements for an updated classification of the carcinomas of the stomach. Pathol. Res. Pract., 191, 571-584.