Specific posttranslational modification regulates early events in mammary carcinoma formation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 49, 2010, Pages 21116-21121

  Guo, Hua Bei ^a   Johnson, Heather ^a   Randolph, Matthew ^a   Nagy, Tamas ^a   Blalock, Ryan ^a   Pierce, Michael ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Breast cancer; Morphogenesis; N glycosylation; Oncogene; Tumor initiating cells

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; PROTEIN; PROTEIN GNT V; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CARCINOMA; CONTROLLED STUDY; FEMALE; MALE; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PROCESSING; SCID MOUSE; TRANSGENIC MOUSE;

ANIMALS; CULTURE TECHNIQUES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, TRANSGENIC; N-ACETYLGLUCOSAMINYLTRANSFERASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION;

MUS; MUS MUSCULUS;

EID: 78650451823     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1013405107     Document Type: Article

References (34)

1. Carlsson J, et al. (2004) HER2 expression in breast cancer primary tumours and corresponding metastases. Original data and literature review. Br J Cancer 90:2344-2348.
2. Ménard S, et al. (2001) HER2 overexpression in various tumor types, focussing on its relationship to the development of invasive breast cancer. Ann Oncol 12(Suppl 1):S15-S19.
3. Guy CT, et al. (1992) Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc Natl Acad Sci USA 89: 10578-10582.
4. Sorkin A, Goh LK (2009) Endocytosis and intracellular trafficking of ErbBs. Exp Cell Res 315:683-696.
5. Holbro T, Civenni G, Hynes NE (2003) The ErbB receptors and their role in cancer progression. Exp Cell Res 284:99-110.
6. Muthuswamy SK, Li D, Lelievre S, Bissell MJ, Brugge JS (2001) ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nat Cell Biol 3:785-792.
7. Debnath J, et al. (2002) The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell 111:29-40.
8. Hynes NE, Stern DF (1994) The biology of erbB-2/neu/HER-2 and its role in cancer. Biochim Biophys Acta 1198:165-184.
9. Korkaya H, Paulson A, Iovino F, Wicha MS (2008) HER2 regulates the mammary stem/ progenitor cell population driving tumorigenesis and invasion. Oncogene 27: 6120-6130.
10. Nakanishi T, et al. (2010) Side-population cells in luminal-type breast cancer have tumour-initiating cell properties, and are regulated by HER2 expression and signalling. Br J Cancer 102:815-826.
11. Liu JC, Deng T, Lehal RS, Kim J, Zacksenhaus E (2007) Identification of tumorsphereand tumor-initiating cells in HER2/Neu-induced mammary tumors. Cancer Res 67: 8671-8681.
12. Cao Y, Luo JL, Karin M (2007) IkappaB kinase alpha kinase activity is required for selfrenewal of ErbB2/Her2-transformed mammary tumor-initiating cells. Proc Natl Acad Sci USA 104:15852-15857.
13. Hakomori S (2004) Carbohydrate-to-carbohydrate interaction in basic cell biology: A brief overview. Arch Biochem Biophys 426:173-181.
14. Zhao YY, et al. (2008) Functional roles of N-glycans in cell signaling and cell adhesion in cancer. Cancer Sci 99:1304-1310.
15. Brockhausen I, Carver JP, Schachter H (1988) Control of glycoprotein synthesis. The use of oligosaccharide substrates and HPLC to study the sequential pathway for Nacetylglucosaminyltransferases I, II, III, IV, V, and VI in the biosynthesis of highly branched N-glycans by hen oviduct membranes. Biochem Cell Biol 66:1134-1151.
16. Hakomori S (2002) Glycosylation defining cancer malignancy: New wine in an old bottle. Proc Natl Acad Sci USA 99:10231-10233.
17. Granovsky M, et al. (2000) Suppression of tumor growth and metastasis in Mgat5- deficient mice. Nat Med 6:306-312.
18. Ihara S, et al. (2002) Prometastatic effect of N- acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding beta 1-6 GlcNAc branching. J Biol Chem 277:16960-16967.
19. Guo HB, Lee I, Kamar M, Akiyama SK, Pierce M (2002) Aberrant N-glycosylation of beta1 integrin causes reduced alpha5beta1 integrin clustering and stimulates cell migration. Cancer Res 62:6837-6845.
20. Guo HB, Lee I, Kamar M, Pierce M (2003) N-acetylglucosaminyltransferase V expression levels regulate cadherin-associated homotypic cell-cell adhesion and intracellular signaling pathways. J Biol Chem 278:52412-52424.
21. Vagin O, Tokhtaeva E, Yakubov I, Shevchenko E, Sachs G (2008) Inverse correlation between the extent of N-glycan branching and intercellular adhesion in epithelia. Contribution of the Na,K-ATPase beta1 subunit. J Biol Chem 283:2192-2202.
22. Partridge EA, et al. (2004) Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis. Science 306:120-124.
23. Guo HB, Johnson H, Randolph M, Lee I, Pierce M (2009) Knockdown of GnT-Va expression inhibits ligand-induced downregulation of the epidermal growth factor receptor and intracellular signaling by inhibiting receptor endocytosis. Glycobiology 19:547-559.
24. Handerson T, Camp R, Harigopal M, Rimm D, Pawelek J (2005) Beta1,6-branched oligosaccharides are increased in lymph node metastases and predict poor outcome in breast carcinoma. Clin Cancer Res 11:2969-2973.
25. Debnath J, Muthuswamy SK, Brugge JS (2003) Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 30:256-268.
26. Al-Hajj M, Clarke MF (2004) Self-renewal and solid tumor stem cells. Oncogene 23: 7274-7282.
27. Ponti D, Zaffaroni N, Capelli C, Daidone MG (2006) Breast cancer stem cells: An overview. Eur J Cancer 42:1219-1224.
28. Charafe-Jauffret E, et al. (2008) Cancer stem cells in breast: Current opinion and future challenges. Pathobiology 75:75-84.
29. Luo M, et al. (2009) Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. Cancer Res 69:466-474.
30. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF (2003) Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 100:3983-3988. (Pubitemid 36418143)
31. Dontu G, et al. (2003) In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 17:1253-1270.
32. Dontu G, et al. (2004) Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res 6:R605-R615.
33. Liu S, et al. (2006) Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res 66:6063-6071.
34. YokoeS, etal. (2007)TheAsn418-linkedN-glycanofErbB3 playsacrucial role inpreventing spontaneous heterodimerization and tumor promotion. Cancer Res 67:1935-1942.