Ascl2 knockdown results in tumor growth arrest by mirna-302b-related inhibition of colon cancer progenitor cells

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Zhu, Rong ^a   Yang, Yongtao ^a   Tian, Yin ^a   Bai, Jianying ^a   Zhang, Xin ^a   Li, Xiaohuan ^a   Peng, Zhihong ^a   He, Yonghong ^a   Chen, Lei ^a   Pan, Qiong ^a   Fang, Dianchun ^a   Chen, Wensheng ^a   Qian, Chen ^a   Bian, Xiuwu ^a   Wang, Rongquan ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACHAETE SCUTE LIKE 2 PROTEIN; BMI1 PROTEIN; CD133 ANTIGEN; MICRORNA; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN LGR5; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG; ASCL2 PROTEIN, HUMAN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; GLYCOPROTEIN; LEUKOCYTE ANTIGEN; MIRN302 MICRORNA, HUMAN; PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER INVASION; CANCER STEM CELL; CELL MIGRATION; CELL PROLIFERATION; COLON ADENOCARCINOMA; COLONY FORMATION; COLORECTAL CARCINOMA; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; RNA INTERFERENCE; TUMOR XENOGRAFT; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CANCER TRANSPLANTATION; CELL MOTION; COLON TUMOR; CYTOLOGY; IMMUNOHISTOCHEMISTRY; METABOLISM; NUDE MOUSE; STEM CELL; TUMOR CELL LINE;

ANIMALS; ANTIGENS, CD; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; COLONIC NEOPLASMS; GLYCOPROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MICRORNAS; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; PEPTIDES; RNA INTERFERENCE; STEM CELLS;

EID: 84863163710     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032170     Document Type: Article

References (37)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, et al. (2009) Cancer statistics, 2009. CA Cancer J Clin 59: 225-249.
2. Huang EH, Wicha MS, (2008) Colon cancer stem cells: implications for prevention and therapy. Trends Mol Med 14: 503-509.
3. Tan BT, Park CY, Ailles LE, Weissman IL, (2006) The cancer stem cell hypothesis: a work in progress. Lab Invest 86: 1203-1207.
4. O'Brien CA, Pollett A, Gallinger S, Dick JE, (2007) A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445: 106-110.
5. Ricci-Vitiani L, Lombardi DG, Pilozzi E, Biffoni M, Todaro M, et al. (2007) Identification and expansion of human colon-cancer-initiating cells. Nature 445: 111-115.
6. Gangemi RM, Griffero F, Marubbi D, Perera M, Capra MC, et al. (2009) SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity. Stem Cells 27: 40-48.
7. Todaro M, Alea MP, Di Stefano AB, Cammareri P, Vermeulen L, et al. (2007) Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. Cell Stem Cell 1: 389-402.
8. Clevers H, (2011) The cancer stem cell: premises, promises and challenges. Nat Med 17: 313-319.
9. de Sousa EM, Vermeulen L, Richel D, Medema JP, (2011) Targeting Wnt signaling in colon cancer stem cells. Clin Cancer Res 17: 647-653.
10. Jubb AM, Chalasani S, Frantz GD, Smits R, Grabsch HI, et al. (2006) Achaete-scute like 2 (ascl2) is a target of Wnt signaling and is upregulated in intestinal neoplasia. Oncogene 25: 3445-3457.
11. van der Flier LG, van Gijn ME, Hatzis P, Kujala P, Haegebarth A, et al. (2009) Transcription factor achaetescute-like 2 controls intestinal stem cell fate. Cell 136: 903-912.
12. Jubb AM, Hoeflich KP, Haverty PM, Wang J, Koeppen H, (2010) Ascl2 and 11p15.5 amplification in colorectal cancer. Gut [Epub ahead of print].
13. van der Flier LG, van Gijn ME, Hatzis P, Kujala P, Haegebarth A, et al. (2010) Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain. Gut 59: 1236-1244.
14. Takebe N, Warren RQ, Ivy SP, (2011) Breast cancer growth and metastasis: interplay between cancer stem cells, embryonic signaling pathways and epithelial-to-mesenchymal transition. Breast Cancer Res 13: 211.
15. Tabatabai G, Weller M, (2011) Glioblastoma stem cells. Cell Tissue Res 343: 459-465.
16. Ji Q, Hao X, Zhang M, Tang W, Yang M, et al. (2009) MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PLoS One 4: e6816.
17. Dreesen O, Brivanlou AH, (2007) Signaling Pathways in Cancer and Embryonic Stem Cells. Stem Cell Rev Rep 3: 7-17.
18. Elsaba TM, Martinez-Pomares L, Robins AR, Crook S, Seth R, et al. (2010) The stem cell marker CD133 associates with enhanced colony formation and cell motility in colorectal cancer. PLoS One 5: e10714.
19. Haraguchi N, Ohkuma M, Sakashita H, Matsuzaki S, Tanaka F, et al. (2008) CD133+CD44+ population efficiently enriches colon cancer initiating cells. Ann Surg Oncol 15: 2927-2933.
20. Ieta K, Tanaka F, Haraguchi N, Kita Y, Sakashita H, et al. (2008) Biological and genetic characteristics of tumor-initiating cells in colon cancer. Ann Surg Oncol 15: 638-648.
21. Yin AH, Miraglia S, Zanjani ED, Almeida-Porada G, Ogawa M, et al. (1997) AC133, a novel marker for human hematopoietic stem and progenitor cells. Blood 90: 5002-5012.
22. Croker AK, Goodale D, Chu J, Postenka C, Hedley BD, et al. (2009) High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability. J Cell Mol Med 13: 2236-2252.
23. Kim MP, Fleming JB, Wang H, Abbruzzese JL, Choi W, et al. (2011) ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma. PLoS One 6: e20636.
24. Ma S, Tang KH, Chan YP, Lee TK, Kwan PS, et al. (2010) miR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1. Cell Stem Cell 7: 694-707.
25. Nicoloso MS, Spizzo R, Shimizu M, Rossi S, Calin GA, (2009) MicroRNAs-the micro steering wheel of tumour metastases. Nat Rev Cancer 9: 293-302.
26. Gal H, Pandi G, Kanner AA, Ram Z, Lithwick-Yanai G, et al. (2008) miR-451 and imatinib mesylate inhibit tumor growth of glioblastoma stem cells. Biochem Biophys Res Commun 376: 86-90.
27. Lee NS, Kim JS, Cho WJ, Lee MR, Steiner R, et al. (2008) miR-302b maintains "stemness" of human embryonal carcinoma cells by post-transcriptional regulation of CyclinD2 expression. Biochem Biophys Res Commun 377: 434-440.
28. Yu F, Yao H, Zhu P, Zhang X, pang Q, et al. (2007) Let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 131: 1109-1123.
29. Ieta K, Tanaka F, Haraguchi N, Kita Y, Sakashita H, et al. (2008) Biological and genetic characteristics of tumor-initiating cells in colon cancer. Ann Surg Oncol 15: 638-648.
30. Guillemot F, Nagy A, Auerbach A, Rossant J, Joyner AL, (1994) Essential role of Mash-2 in extraembryonic development. Nature 371: 333-336.
31. Shimono Y, Zabala M, Cho RW, Lobo N, Dalerba P, et al. (2009) Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell 138: 592-603.
32. Wang J, Lu M, Qiu C, Cui Q, (2010) TransmiR: a transcription factor-microRNA regulation database. Nucleic Acids Res 38: D119-D122.
33. Yamakuchi M, Lowenstein CJ, (2009) MiR-34, SIRT1 and p53: the feedback loop. Cell Cycle 8: 712-715.
34. Dickstein J, Senyuk V, Premanand K, Laricchia-Robbio L, Xu P, et al. (2010) Methylation and silencing of miRNA-124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome. Proc Natl Acad Sci U S A 107: 9783-9788.
35. Solozobova V, Blattner C, (2010) Regulation of p53 in embryonic stem cells. Exp Cell Res 316: 2434-2446.
36. Wang J, Greene SB, Bonilla-Claudio M, Tao Y, Zhang J, et al. (2010) Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism. Dev Cell 19: 903-912.
37. Subramanyam D, Lamouille S, Judson RL, Liu JY, Bucay N, et al. (2011) Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol 29: 443-448.