Aberrant amplification of the crosstalk between canonical Wnt signaling and N-glycosylation gene DPAGT1 promotes oral cancer

Oral Oncology

Volumn 48, Issue 6, 2012, Pages 523-529

  Jamal, Basem ^a   Sengupta, Pritam K ^a   Gao, Zhen Nan ^b   Nita Lazar, Mihai ^c   Amin, Bakr ^a   Jalisi, Sharuch ^a   Bouchie, Meghan P ^a   Kukuruzinska, Maria A ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SHANDONG UNIVERSITY   (China)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Catenin; Catenin; Canonical Wnt signaling; Dkk 1; DPAGT1; E cadherin; N Glycosylation; Oral cancer; OSCC

Indexed keywords

BETA CATENIN; DICKKOPF 1 PROTEIN; DOLICHOL PHOSPHATE DEPENDENT N ACETYLGLUCOSEAMINE 1 PHOSPHATE TRANSFERASE; ENZYME; PLAKOGLOBIN; UNCLASSIFIED DRUG; UVOMORULIN;

ARTICLE; CELL ADHESION; CELL GROWTH; CELL MIGRATION; DPAGT1 GENE; ENZYME ACTIVATION; ENZYME INHIBITION; GENE; GENE AMPLIFICATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOLECULAR INTERACTION; MOUTH CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; RNA INTERFERENCE; WNT SIGNALING PATHWAY;

BETA CATENIN; CADHERINS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; GAMMA CATENIN; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOSYLATION; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MOUTH NEOPLASMS; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS); WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84861647963     PISSN: 13688375     EISSN: 18790593     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2012.01.010     Document Type: Article

References (27)

1. S. Choi, and J.N. Myers Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy J Dent Res 87 2008 14 32
2. B. Perez-Ordonez, M. Beauchemin, and R.C. Jordan Molecular biology of squamous cell carcinoma of the head and neck J Clin Pathol 59 2006 445 453
3. N. Agrawal, M.J. Frederick, C.R. Pickering, C. Bettegowda, K. Chang, and R.J. Li Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1 Science 333 2011 1154 1157
4. N. Stransky, A.M. Egloff, A.D. Tward, A.D. Kostic, K. Cibulskis, and A. Sivachenko The mutational landscape of head and neck squamous cell carcinoma Science 333 2011 1157 1160
5. J.-H. Zuo, W. Zhu, M.-Y. Li, X.-H. Li, H. Yi, and G.-Q. Zeng Activation of EGFR promotes squamous carcinoma SCC10A cell migration and invasion via inducins EMT-like phenotypeCHange and MMP-9-mediated degradation of E-cadherin J Cell Biochem 112 2011 2508 2517
6. M. Nita-Lazar, V. Noonan, I. Rebustini, J. Walker, A.S. Menko, and M.A. Kukuruzinska Overexpression of DPAGT1 leads to aberrant N-glycosylation of E-cadherin and cellular discohesion in oral cancer Cancer Res 69 2009 5673 5680
7. M.A. Kukuruzinska, and K. Lennon Protein N-glycosylation: molecular genetics and functional significance Crit Rev Oral Biol Med 9 1998 415 448
8. R.D. Mendelsohn, E.J. Helmerhorst, J.F. Cipollo, and M.A. Kukuruzinska A hypomorphic allele of the first N-glycosylation gene, ALG7, causes mitochondrial defects in yeast Biochim Biophys Acta 1723 2005 33 44
9. X. Wu, J.S. Rush, D. Karaoglu, D. Krasnewich, M.S. Lubinsky, and C.J. Waechter Deficiency of UDP-GlcNAc:dolichol phosphate N-acetylglucosamine-1 phosphate transferase (DPAGT1) causes a novel congenital disorder of glycosylation type Ij Hum Mutat 22 2003 144 150
10. A. Liwosz, T. Lei, and M.A. Kukuruzinska N-glycosylation affects the molecular organization and stability of E-cadherin junctions J Biol Chem 281 2006 23138 23149
11. M. Takeichi Cadherin cell adhesion receptors as a morphogenetic regulator Science 251 1991 1451 1455
12. U.H. Frixen, J. Behrens, M. Sachs, G. Eberle, B. Voss, and A. Warda E-cadherin-mediated cell-cell adhesion prevents invasineness of human carcinoma cells J Cell Biol 113 1991 173 185
13. A. Margulis, F. Andriani, N. Fusenig, K. Hashimoto, Y. Hanakawa, and J.A. Garlick Abrogation of E-cadherin-mediated adhesion induces tumor cell invasion in human skin-like organotypic culture J Invest Dermatol 121 2003 1182 1190
14. M. Perez-Moreno, C. Jamora, and E. Fuchs Sticky business: orchestrating cellular signals at adherens junctions Cell 112 2003 535 548
15. A. Hartsock, and W.J. Nelson Adherens and tight junctions: structure, function and connections to the actin cytoskeleton Biochim Biophys Acta 1778 2008 660 669
16. M. Nita-Lazar, I. Rebustini, J. Walker, and M.A. Kukuruzinska Hypoglycosylated E-cadherin promotes the assembly of tight junctions through the recruitment of PP2A to adherens junctions Exp Cell Res 316 2010 1871 1884
17. P.K. Sengupta, M.P. Bouchie, and M.A. Kukuruzinska N-glycosylation gene DPAGT1 is a target of the Wnt/beta-catenin signaling pathway J Biol Chem 285 2010 31164 31173
18. R. van Amerongen, and R. Nusse Towards an integrated view of Wnt signaling in development Development 136 2009 3205 3214
19. H. Chen, N.E. Paradies, M. Fedor-Chaliken, and R. Brackenbury E-cadherin mediates adhesion and suppresses cell motility via distinct mechanisms J Cell Sci 110 1997 345 356
20. X. Qian, T. Karpova, A.M. Sheppard, J. McNally, and D.R. Lowy E-cadherin-mediated adhesion inhibits ligand-dependent activation of diverse receptor tyrosine kinases EMBO J 21 2004 1739 1748
21. J. Luo, D.M. Lubaroff, and M.J. Hendrix Suppression of prostate cancer invasive potential and matrix metalloproteinase activity by E-cadherin transfection Cancer Res 59 1999 3552 3556
22. H. Semb, and G. Christofori The tumor-suppressor function of E-cadherin Am J Hum Genet 63 1998 1588 1593
23. B.T. Jamal, M. Nita-Lazar, Z. Gao, B. Amin, J. Walker, and M.A. Kukuruzinska N-glycosylation status of E-cadherin controls cytoskeletal dynamics through the organization of distinct beta-catenin- and gamma-catenin-containing AJs Cell Health Cytoskelet 1 2009 67 80
24. O. Aguilera, M.F. Fraga, E. Ballestar, M.F. Paz, M. Herranz, and J. Espada Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (Dkk-1) gene in human colorectal cancer Oncogene 25 2006 4116 4121
25. M.D. Gordon, and R. Nusse Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors J Biol Chem 281 2006 22429 22433
26. Z. Khan, S. Vijayakumar, T.V. de la Torre, S. Rotolo, and A. Bafico Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor Mol Cell Biol 27 2007 7291 7301
27. H. Komekado, H. Yamamoto, T. Chiba, and A. Kikuchi Glycosylation and palmitoylation of Wnt-3a are coupled to produce an active form of Wnt-3a Genes Cells 12 2007 521 534