Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice

Neuropharmacology

Volumn 70, Issue , 2013, Pages 156-167

  Li, Xia ^a   Risbrough, Victoria B ^a,c   Cates Gatto, Chelsea ^b   Kaczanowska, Katarzyna ^b   Finn, M G ^b   Roberts, Amanda J ^b   Markou, Athina ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Anxiety; GABAB receptor; Learning; Memory; Positive allosteric modulator

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; BACLOFEN; BHF 177; CHLORDIAZEPOXIDE; GABAERGIC RECEPTOR AFFECTING AGENT; N (BICYCLO[2.2.1]HEPT 2 YL) 2 METHYL 5 (4 [TRIFLUOROMETHYL]PHENYL) 4 PYRIMIDINAMINE; UNCLASSIFIED DRUG; N-(BICYCLO(2.2.1)HEPT-2-YL)-2-METHYL-5-(4-(TRIFLUOROMETHYL)PHENYL)-4-PYRIMIDINAMINE; NORBORNANE DERIVATIVE; PENTETRAZOLE; PYRIMIDINE DERIVATIVE; N (BICYCLO(2.2.1)HEPT 2 YL) 2 METHYL 5 (4 (TRIFLUOROMETHYL)PHENYL) 4 PYRIMIDINAMINE;

ANALGESIC ACTIVITY; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; CONVULSION; DOSE RESPONSE; DRINKING BEHAVIOR; DRUG DOSE COMPARISON; DRUG MEGADOSE; DRUG SYNTHESIS; FEAR; LEARNING; LEARNING DISORDER; LOCOMOTION; MALE; MEMORY; MEMORY CONSOLIDATION; MEMORY DISORDER; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SEDATION; SPATIAL LEARNING; TRANQUILIZING ACTIVITY; TREATMENT RESPONSE; ANIMAL; CHEMICALLY INDUCED; COMPARATIVE STUDY; DRUG EFFECTS; MAZE TEST; MOTOR ACTIVITY; SEIZURES; SYNTHESIS; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; SEIZURE;

ANIMALS; ANXIETY; BACLOFEN; CHLORDIAZEPOXIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; GABA-B RECEPTOR AGONISTS; MALE; MAZE LEARNING; MEMORY; MICE; MOTOR ACTIVITY; NORBORNANES; PENTYLENETETRAZOLE; PYRIMIDINES; RATS; SEIZURES;

EID: 84876964988     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.01.018     Document Type: Article

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