In vitro and in vivo characterization of the novel GABA B receptor positive allosteric modulator, 2-{1-[2-(4-chlorophenyl)-5- methylpyrazolo[1,5-a]pyrimidin-7-yl]-2-piperidinyl}ethanol (CMPPE)

Neuropharmacology

Volumn 61, Issue 5-6, 2011, Pages 957-966

  Perdona', Elisabetta ^a,c   Costantini, Vivian J A ^a   Tessari, Michela ^a   Martinelli, Prisca ^a   Carignani, Corrado ^a   Valerio, Enzo ^a   Mok, M H Selina ^b   Zonzini, Laura ^a   Visentini, Filippo ^a   Gianotti, Massimo ^a   Gordon, Laurie ^b   Rocheville, Magalie ^b   Corsi, Mauro ^a   Capelli, Anna Maria ^a  

^a GSK   (Italy)

^b GLAXOSMITHKLINE   (United Kingdom)

^c Aptuit Inc   (United States)

Author keywords

CGP7930; CMPPE; Food intake; GABA B receptor; GIRK; GS39783; Positive allosteric modulator

Indexed keywords

2 [1 [2 (4 CHLOROPHENYL) 5 METHYLPYRAZOLO [1,5 A]PYRIMIDIN 7 YL] 2 PIPERIDINYL]ETHANOL; 2,6 DI TERT BUTYL 4 (3 HYDROXY 2,2 DIMETHYLPROPYL)PHENOL; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; BACLOFEN; CPG 7930; GSK 39783; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); INWARDLY RECTIFYING POTASSIUM CHANNEL; N,N' DICYCLOPENTYL 2 METHYLTHIO 5 NITRO 4,6 PYRIMIDINEDIAMINE; SULFUR 35; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; FEMALE; FOOD INTAKE; HIPPOCAMPUS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LOCOMOTION; MALE; MEMBRANE BINDING; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BACLOFEN; BRAIN; CEREBRAL CORTEX; CHO CELLS; CRICETINAE; CYCLOPENTANES; DRUG EVALUATION, PRECLINICAL; EATING; ELECTROPHYSIOLOGICAL PHENOMENA; GABA-B RECEPTOR AGONISTS; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; HUMANS; MALE; MEMBRANE PROTEINS; MOLECULAR TARGETED THERAPY; MOTOR ACTIVITY; NEURONS; PYRAZOLES; PYRIMIDINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-B; TRANSFECTION;

EID: 80051788130     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.06.024     Document Type: Article

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